순비기나무 (Vitex rotundifolia L. f.) 삽수 종류 및 생장조정제 처리에 따른 발근율

Jeong Yeob Kim,Yoon Ki Hong,Song Hee Ahn,Jung Seob Moon,Eun Seok Park,Hee June Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : This study was conducted to developed the propagation method by cutting for mass cultivation of Vitex roundifolia. We were pitched the cutting two times and treated plant growth regulators to enhance the rooting percentage. Vitex roundifolia is live in beach sandy soil south of Hwanghae-Do and Gangwon-Do. Vitex roundifolia have been used to bath foam. It is good for aromatic plant. It has 0.8% essential oil content in leaf and flower. Major components of essential oil were alpha-Pinene, Sabinene, beta-Pinen, 1,8-cineole, d-Limone. Despite the superior usability, it had not yet been made by the artificial cultivation Methods and Results : We were pitched the cutting of a first-year branch on June 5, which was greenwood cutting and July 17, which was semi-hardwood cutting at Kwangseung-ri beach, Gochanggun, Jeonbuk. The length of cutting was 10cm. It had 3~4 nodes, we stuck a cutting remain 2 nodes above ground on ordinary raise seedling soil. Rooting percentage was measured at 60 days after stuck a cutting. Rooting percentage was higher greenwoody cutting(95%) than semi-hardwood cutting(57.6%). In green wood cutting, there was no significance with plant growth, but chemical injury was occurred in IBA 5,000ppm. In semi-hardwood cutting, there was significance with plant growth regulators. The rooting percentages of all the treat were higher than control(no treatment). Rooting percentage was the highest in NAA 5,000ppm treated. Conclusion : Greenwood cutting method was more proper to propagation for Vitex roundifolia than semi-hardwood cutting. The optimum time to cutting for Vitex roundifolia propagation was the early in June. If miss a time to propagation Rooting percent was elevated by plant growth regulator.

슬개골 골절의 임상적 고찰

이준규,안상로,박찬희 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

We studies the cases of 30 patients who had fracture of patella, 28 patients were male and 2 patients were female. We treated the patients with operative treatment in 27 patients and with nonoperative treatment in 3 patients. The results are as follows. 1. It was more frequent in male, and average age of patient was 38.5 years old. 2. Most frequent cause of fractures was traffic accident. 3. Open fracture was 76.7%, and transverse or bursting fracture was 66.7%. 4. The end result was dependent on the initial trauma. 5. The associated injuries were frequent nearby the knee joints.

Long-term Outcomes and Factors Affecting the Survival of Patients with Mucosal Esophageal Squamous Cell Carcinoma

( Ga Hee Kim ),( Hee Kyong Na ),( Ji Yong Ahn ),( Jeong Hoon Lee ),( Kee Wook Jung ),( Do Hoon Kim ),( Hyeong Ryul Kim ),( Kee Don Choi ),( Ho June Song ),( Yong-hee Kim ),( Gin Hyug Lee ),( Hwoon-yon 대한소화기학회 2021 Gut and Liver Vol.15 No.5

Background/Aims: Data regarding the prognosis of early esophageal cancer are lacking. This study investigated the long-term outcomes and factors affecting the survival of patients with mucosal esophageal squamous cell carcinoma (T1aESCC). Methods: We analyzed the clinical and tumor-specific parameters of 263 patients who received surgical resection (SR; n=63) or endoscopic resection (ER; n=200) for T1aESCC. Underlying comorbidities were scored using the Charlson comorbidity index (CCI). Overall survival (OS) was the primary outcome, and multivariate regression analysis was performed to predict factors for OS. Results: Of the study patients (age, 64.5±8.0 years), the CCI was 1.0±1.4 in the ER group and 0.6±0.9 in the SR group (p=0.107). The 5-year OS rate during follow-up (54.4±20.4 months) was 85.7% (ER group, 86.8%; SR group, 82.4%; p=0.631). The cumulative 5-year incidence of esophageal cancer recurrence was 10.5% in the ER group (vs 0% in the SR group). The overall mortality rate was 12.9% (ER group, 12.0%; SR group, 15.9%; p=0.399). The most common cause of mortality was second primary cancers in the ER group (75%) and organ dysfunction or postoperative complications in the SR group (70%). According to multivariate analysis, only CCI was significantly associated with OS (p< 0.001). The 5-year OS rate in patients with a CCI >2 and in those with a CCI ≤2 was 60.2% and 88.2%, respectively (p<0.001). The treatment method (ER vs SR) was not a significant affecting factor (p=0.238). Conclusions: The long-term prognosis of patients with T1aESCC was significantly associated with underlying comorbidities. (Gut Liver 2021;15:705-712)

스마트폰 중독 연구와 치료를 위한 사용량 측정 및 지속 관리 시스템

안희준(Hee june Ahn),최완복(Wan bok Choi) 한국컴퓨터게임학회 2014 한국컴퓨터게임학회논문지 Vol.27 No.1

For the recent 5-6 years, the ratio of smart phone users in South Korea has increased to over 65% of cellular subscribers and half of all population. While smartphones have given enormous convenience to our lives, pathological use of smartphones has brought a new mental health concern among the community. Therefore, huge interest sheds on the studies on the cause analysis and treatment of smartphone addiction. However, the traditional clinic approach based survey and interview has serious drawbacks of its subjectivity and inability of continual monitoring and treatment. In this paper, SAMS (smartphone addiction management system) is presented, which monitors the application usage pattern, provides statistical analysis, and policy-based usage intervention. A trail test is performed for checking he reliability and efficacy of SAMS in smartphone addiction research, and some analysis on the collected data are done: daily use count, not daily use time, has strong influence on smartphone addiction: CC=0.62 and CC =0.00 for the correlation coefficients of counts and times with total survey score, and p = 0.047 and p = 0.507 for t-test analysis of contrast group.

인터넷 기반 슬롯머신(EGM) G2S(game to systems) 프로토콜 엔진 설계

안희준(Hee june Ahn) 한국컴퓨터게임학회 2014 한국컴퓨터게임학회논문지 Vol.27 No.2

The international casino game industry has adopted G2S (game to systems) protocol for the future communication standards between slot machines and gaming hosts. G2S protocol uses the internet protocols and XML message format. Not simply G2S protocol replaces the SAS protocol currently in use but with many limitations, but provides diverse application and business chances to the casino industry. In this paper, we introduce the overview of technical features of G2S system, and describe our design and implementation experience of core G2S protocol engine for slot machine devices. The G2S engine provides key protocol stack of G2S (HTTP, XML, and SOAP) and runtime services, using open source softwares and custom classes. The protocol compatibility of the implemented G2S engine is confirmed against an openG2S host software contributed by IGT. Also the measured memory size and perfroamcne is compact enough for typical slot machine hardware specification.

VBR 영상 트래픽에서 LRD 특성의 원인에 대한 연구

안희준(Hee-june Ahn),강상혁(Sang H. Kang),김재균(jae-kyoon Kim) 대한전자공학회 1998 대한전자공학회 학술대회 Vol.1998 No.4

Clinical Significance of Epstein-Barr Virus and Helicobacter pylori Infection in Gastric Carcinoma

Noh Jin Hee,Shin Jun Young,Lee Jeong Hoon,Park Young-Soo,Lee In-Seob,Kim Ga Hee,Na Hee Kyong,Ahn Ji Yong,Jung Kee Wook,Kim Do Hoon,Choi Kee Don,Song Ho June,Lee Gin Hyug,Jung Hwoon-Yong 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1

Background/Aims: Epstein-Barr virus (EBV) and Helicobacter pylori (HP) coinfection may synergistically induce severe inflammatory responses in the stomach tissue, increasing the risk of developing gastric cancer. We aimed to analyze the effect of EBV and HP coinfection on the clinicopathologic features and prognosis of gastric cancer, as well as to evaluate the role of EBV infection in non-gastric carcinoma with lymphoid stroma (non-GCLS). Methods: Overall, 956 patients who underwent surgery for gastric cancer between September 2014 and August 2015 were eligible and divided into groups, according to GCLS morphology, EBV infection, and HP infection. Clinicopathologic characteristics and oncologic outcomes were analyzed retrospectively. Results: EBV and HP coinfection was significantly associated with male sex, proximal location, GCLS morphology, and equivocal p53 expression (p<0.001). Multivariate analysis revealed that EBV infection alone (hazard ratio [HR], 0.362; 95% CI, 0.131 to 0.996; p=0.049) and lower third location (HR, 0.624; 95% CI, 0.413 to 0.943; p=0.025) were inversely correlated with overall survival. During median follow-up period of 72 months, overall survival rate was not significantly different between the EBV and HP coinfection group and others (97.6% vs 86.8%, log-rank p=0.144). In non-GCLS patients (n=920), overall survival rate was not significantly different between the EBV infection group and others (96.9% vs 86.4%, log-rank p=0.126). Conclusions: EBV and HP coinfection is not an independent prognostic factor for gastric cancer. EBV infection status, regardless of HP infection, affects the clinicopathologic features of all types of gastric cancer. However, it does not lead to a significant difference in overall survival of non-GCLS patients.

Detection of Tumor Cell Contamination in Peripheral Blood Stem Cells by RT-PCR in High risk or Metastatic Breast Cancer Patients and its Clinical Implications

Ahn, Myung-Ju,Noh, Yun-Hee,Kim, Wo-Chul,Kim, Hyun-Soo,Lee, Young-Yul,Jung, Tae-June,Choi, Il-Young,Kim, In-Soon,Lee, Young-Sung 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.1

고용량 항암 치료와 자가조혈모세포 이식을 받은 고위험군 및 전이성 유방암 환자에서 채취한 말초조혈모세포의 암세포오염을 검출하기 위해 암세포 표지자의 하나인 CEA mRNA를 역전사중합연쇄반응을 이용하여 연구하였다. 말초혈액조혈모세포는 G-CSF 단독 또는 항암제와 G-CSF을 이용하여 가동화 하였다. 음성 대조군인 9예의 정상인의 말초혈액에서는 CEA mRNA가 검출되지 않은 반면, 7예의 고위험군 중 3예(42.8%)과 21예의 전이성 유방암 환자중 6예(28.5%)에서 각각 CEA mRNA가 검출되었다. 항암제 및 G-CSF로 가동한 18예 중 5예(27.8%)에서 CEA mRNA가 검출되었고, G-CSF만으로 가동화한 경우 10예 중 4예(40%)에서 검출되었다. 고위험군에서 CEA mRNA 양성군의 평균 림프절전이수는 32.3으로 음성군의 14보다 많았다. 전이성 유방암 환자에서 무재발생존기간 또는 생존기간에서 두군간에 차이는 없었다. 본 저자들은 많은 수의 고위험군 및 전이성 유방암 환자의 말초혈액조혈모세포에 암세포의 오염이 있음을 확인하였고, CEA mRNA를 표지자로 역전사중합연쇄반응을 이용한 암세포 검출은 향후 자가조혈모세포 이식후의 재발 등을 추적하는데 유용한 지표로 사용될 것으로 사료된다. 본 연구에서 암세포의 오염이 이식후 재발이나 생존에 어떠한 영향을 미치는가에 대하서 적은 환자수와 짧은 추적기간으로 결론 내리기는 어려우나 향후 좀 더 많은 수의 환자를 대상으로 장기적인 추적관찰을 통해 말초조혈모세포에서의 암세포 오염 임상적 의의를 밝힐수 있으리라 기대된다. We analyzed the peripheral blood stem cells obtained from patients with high risk or metastatic breast cancer undergoing high dose chemotherapy with autologous peripheral blood stem cell transplantation to assess the presence of CEA mRNA by RT-PCR(reverse transcription-polymerase chain reaction) as an indicator of malignant cell contamination and to evaluate its clinical significance. The peripheral blood stem cells were obtained from chemotherapy and/or G-CSF mobilization. A total of 7 high risk and 21 metastatic breast cancer patients and nine normal healthy subject were studied. No CEA mRNA was detected in all the nine normal subjects. Three out of 7 (42.8%) high risk and 6 out of 21 (28.5%) metastatic breast cancer were found to be positive for CEA mRNA. CEA mRNA was found in the apheresis products of 27.8%(5/18) of patients mobilized with chemotherapy plus G-CSF and 40%(4/10) of patients with G-CSF alone. In high risk patients, the number of lymph node metastasis in positive group was higher than that of negative group (mean 32.3 vs 14). In metastasis breast cancer, there was no significant difference between CEA mRNA positive and negative group in progression free or overall survival. Our study suggests that a significant number of high risk of metastatic breast cancer patients undergoing autologous transplantation are contaminated with circulating malignant cells in apheresis product. This assay may be useful in monitoring tumor cell contamination and in developing prognostic models for the risk of relapse after transplantation. Although it is unclear what role the contaminating malignant cells have in relapse in our study, further studies with large number of patients and the comparison with other prognostic factors and characteristics of the tumor may determine the significance of tumor contamination in apheresis products.

Real-world Data of Durvalumab Consolidation After CCRT in Unresectable Stage III EGFR Mutant NSCLC: A Multicenter Study

( June Hong Ahn ),( Kyung Soo Hong ),( Sun Ha Choi ),( Ji Eun Park ),( Yong Shik Kwon ),( Keum-ju Choi ),( Jung Seop Eom ),( Saerom Kim ),( Hee Yun Seol ),( Jehun Kim ),( Insu Kim ),( Jin Han Park ),( 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

Erythromycin infusion prior to endoscopy for acute nonvariceal upper gastrointestinal bleeding: a pilot randomized controlled trial

( Hee Kyong Na ),( Hwoon-yong Jung ),( Dong Woo Seo ),( Hyun Lim ),( Ji Yong Ahn ),( Jeong Hoon Lee ),( Do Hoon Kim ),( Kee Don Choi ),( Ho June Song ),( Gin Hyug Lee ),( Jin-ho Kim ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.6

Background/Aims: The aim of this study was to compare the effects of erythromycin infusion and gastric lavage in order to improve the quality of visualization during emergency upper endoscopy. Methods: We performed a prospective randomized pilot study. Patients presented with hematemesis or melena within 12 hours and were randomly assigned to the erythromycin group (intravenous infusion of erythromycin), gastric lavage group (nasogastric tube placement with gastric lavage), or erythromycin + gastric lavage group (both erythromycin infusion and gastric lavage). The primary outcome was satisfactory visualization. Secondary outcomes included identification of a bleeding source, the success rate of hemostasis, duration of endoscopy, complications related to erythromycin infusion or gastric lavage, number of transfused blood units, rebleeding rate, and bleeding-related mortality. Results: A total of 43 patients were randomly assigned: 14 patients in the erythromycin group; 15 patients in the gastric lavage group; and 14 patients in the erythromycin + gastric lavage group. Overall satisfactory visualization was achieved in 81% of patients: 92.8% in the erythromycin group; 60.0% in the gastric lavage group; and 92.9% in the erythromycin + gastric lavage group, respectively (p = 0.055). The identification of a bleeding source was possible in all cases. The success rate of hemostasis, duration of endoscopy, and number of transfused blood units did not significantly differ between groups. There were no complications. Rebleeding occurred in three patients (7.0%). Bleeding-related mortality was not reported. Conclusions: Intravenous erythromycin infusion prior to emergency endoscopy for acute nonvariceal upper gastrointestinal bleeding seems to provide satisfactory endoscopic visualization.