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        • SCOPUSKCI등재후보

          한국인 다낭성 난소증후군 환자에서 $CYP11{\alpha}$ 유전자 $(tttta)_n$ 다형성 양상 및 역할

          김진주,최영민,윤상호,정선하,최두석,구승엽,지병철,서창석,김석현,김정구,문신용,Kim, Jin-Ju,Choi, Young-Min,Yoon, Sang-Ho,Choung, Seon-Ha,Choi, Doo-Seok,Ku, Seung-Yup,Jee, Byung-Chul,Suh, Chang-Suk,Kim, Seok-Hyun,Kim, Jung-Gu,Moon, Shin 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.4

          Objectives: To investigate the distribution and functional significance of $CYP11{\alpha}$ $(tttta)_n$ microsatellite polymorphism in Korean patients with polycystic ovary syndrome Materials and Methods: Analysis of $CYP11{\alpha}$ $(tttta)_n$ microsatellite polymorphism was carried out on DNA samples from 97 patients with polycystic ovary syndrome and 70 normal controls. Comparison were done between PCOS patients and controls concerning $CYP11{\alpha}$ $(tttta)_n$ microsatellite polymorphism genotype or allele frequencies. Results: The most frequent allele observed in the controls was an allele with six repeats (60.7%). Significant difference in the frequency of genotype (4R (-) genotype) having no copy of four-repeatallele were observed between PCOS patients and controls (66.0% vs 34.0%, p=0.038, OR=1.939). But no significant difference was observed in the serum levels of total testosterone or free testosterone between 4R (+) genotype and 4R (-) genotype among PCOS patients. However, hyperandrogenic PCOS patients with 4R (+) genotype showed a higher serum testosterone levels compared to controls (mean $\pm$ S.D: $0.49{\pm}0.21\;ng/ml$ vs $0.37{\pm}0.18\;ng/ml$, p=0.037). Conclusion: The alleleic distribution of $CYP11{\alpha}$ $(tttta)_n$ microsatellite polymorphism in Korean subjects were different from those reported in Caucasians. $CYP11{\alpha}$ $(tttta)_n$ microsatellite polymorphism was associated with polycystic ovary syndrome in the Korean population, and may play a role in the synthesis of androgens in patients with polycystic ovary syndrome.

        • SCOPUSKCI등재후보

          한국 여성에서 중증 자궁내막증과 Human ${\alpha}2$-Heremans Schmidt Glycoprotein (AHSG) 유전자 다형성의 연관성

          김진주,채수진,김종미,이경훈,최영민,김성훈,신정호,이택후,허준용,이병석,오성택,이규섭,임용택,Kim, Jin-Ju,Chae, Soo-Jin,Kim, Jong-Mee,Lee, Gyoung-Hoon,Choi, Young-Min,Kim, Sung-Hoon,Shin, Jung-Ho,Lee, Taek-Hoo,Hur, Jun-Young,Lee, Byoung-Suk,O 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.4

          목 적: 한국 여성에서 alpha2-Heremans Schmidt glycoprotein (AHSG) 유전자 다형성과 중증 자궁내막증의 연관성을 알아보고자 하였다. 연구방법: 자궁내막증이 없는 여성 224명과 중증 자궁내막증이 있는 여성 130명을 대상으로 하였다. 모든 여성은 복강경이나 개복수술을 시행하여 수술 소견 및 조직학적 진단으로 중증 자궁내막증의 존재 여부를 진단하였다. 환자군과 대조군의 혈액을 채취하였고 AHSG 유전자 다형성을 중합효소연쇄반응 (PCR) 및 제한효소 절편길이 다형성(restriction fragment length polymorphism; RFLP) 분석으로 조사하였다. 결 과: 자궁내막증 환자군에서 AHSG 1*1 유전자형의 빈도는 56.2% (73/130), AHSG 1*2 유전자형은 37.7% (49/130), AHSG 2*2 유전자형은 6.2% (8/130)로 정상 대조군의 55.8% (125/224), 39.3% (88/224), 4.9% (11/224)의 빈도와 차이가 없었다 (p=.864). 또한 AHSG 2 일배체형의 빈도 역시 환자군에서 25.0% (65/260), 대조군 24.6% (110/448)로 두 군간에 유의한 차이가 없었다 (p=.894). 결 론: 한국 여성에서 AHSG 유전자 다형성과 자궁내막증은 연관이 없었다. Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in $\alpha$2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.

        • 채소 기르기 활동이 만 4세 유아의 과학 관련태도 및 과학적 탐구능력에 미치는 영향

          김진주 ( Jin Ju Kim ),오은순 ( Eun Soon Oh ) 한국Montessori교육학회 2009 실천유아교육 Vol.14 No.2

          본 연구에서는 채소기르기 활동이 만4세 유아의 과학관련태도 및 과학적 탐구능력에 미치는 영향에 대해 알아보았다. 연구의 대상은 대전광역시 중구에 소재한 B유치원의 만 4세 연령 학급 유아 50명으로, 25명은 실험집단으로 채소 기르기 활동을 실시하고 25명은 통제집단으로 하였다. 본 연구의 결과는 다음과 같다. 첫째, 채소 기르기 활동은 만 4세 유아의 과학관련태도 향상에 긍정적인 영향을 준다. 과학관련 태도의 하위영역별로 살펴보면, 채소기르기 활동은 흥미의 요소 중 과학에 대한 흥미, 과학학습에 대한 흥미, 과학과 관련된 직업에 대한 흥미, 과학에 대한 불안에 긍정적인 영향을 주었으나, 과학과 관련된 활동에 대한 흥미에는 긍정적인 영향을 주지 않았다. 과학적 태도에서는 호기심, 비판성., 협동성, 자진성에서는 긍정적인 영향을 주었으나. 개방성, 끈기성, 창의성에서는 긍정적인 영향을 주지 않았다. 또한 과학에 대한 인식에는 전체적으로 긍정적인 영향을 주지 않는다. 둘째, 채소 기르기 활동은 과학적 탐구능력에는 긍정적인 영향을 준다. 구성 요소에 따라 살펴보면, 예측하기. 분류하기, 측정하기, 토의하기에는 긍정적인 영향을 주었으나, 관찰하기에서는 긍정적인 영향을 주지 않았다. The purpose of this study was to examine the effect of vegetable gardening activities for 4-years-old children. For this purpose, this study is focused on learning how effect vegetable gardening activities on 4-years-old children`s science-related attitude and scientific exploration ability. To examine this purpose, the following research questions were investigated: 1. How effects does vegetable gardening activity make on 4-years-old children`s science-related attitudes? 2. How effects does vegetable gardening activity make on 4-years-old children`s scientific exploration ability? The Subjects were fifty children from 2 classes of B kindergarten in Jung-gu, Daejeon. The subject were experimental group consisted of 25 children, while control group consisted of 25 children whose average age 4 years 10 weeks. Measuring tools for this study included the science-related attitude test and the scientific process skills test. For the science-related attitude test researcher modified `Instrument for science-related attitude test` which Che,Jung-yeon had made in 2003 on the basis of Kim, Hyo-nam`s Chung, Wan-ho`s Jeong, Jin-Woo`s national assessment system of science-related affective domain in 1999. And for the scientific exploration ability test researcher modified `Instrument for scientific exploration ability test` which Lee, Kyoug-min had made in 2000 on the basis of Martin`s scientific exploration ability evaluation benchmark in 1997. To verify young children`s science-related attitude, after coming up with score`s difference of pretest and posttest of science-related attitude, executed t-test. To verify young children`s scientific exploration ability, after coming up with frequency and percentage of scientific exploration ability, executed X2-test. The result of study are as follows. First, vegetable gardening activity theory exerted positive effects on 4-years-old children`s science-related attitude. there was also a positive effect as the children`s interest in science, desire to learning more about science, science-related jobs and science-related problems issues increased. However, there was no positive effect on science-related activities. Other positive effects on attitudes to science 4 year old children did vegetable gardening, it increased sense of curiosity, ability critically think, ability to cooperate and ability to volunteer. However, there were no effects on the children`s openness to new ideas, patience and creativity. Second, vegetable gardening activity theory exerted positive effects on 4-years-old children`s scientific exploration ability. this had positive effect as the children`s ability to predict, classify, measure, and discuss improved, but there were no effects on their ability to observe.

        • 사기오미론(四氣五味論)의 구조적 해석

          조용주,김진주,Cho, Yong-Ju,Kim, Jin-Ju 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

          Four Properties and five Flavors of Drugs is interpreted by adaptation of human body to the environmental theory(天人相應). The Structural model of the body is compared with sky, earth, sun and moon (天, 地, 日, 月). The natural changes of the four seasons give rise to that of Four Properties and five Flavors of Drugs. On equal terms it is happened in our body. On this study we can draw an analogy between sky, earth, sun & moon (天, 地, 日, 月) and the body. The six bu(六腑) is related to the earth, the five ju(五主) to the sky, the five jang(五臟) to the sun, the meridians system (經絡) to the moon. When spring, the air is warm, the water element of the earth is ascending, and the earth gives birth to the sour flavor. Like this, the water element is absorbed by six bu and then is ascended to the meridian system. When summer, the air is hot and the water element of the earth is floated, the earth make the bitter flavor. In the same way, the six bu absorbed the hot air from the five ju and the water element is quickly absorbed by six bu and then the water element is ascended to the meridian system. When rainy season (長夏), the earth creates the sweet flavor The sweet flavor give warmer energy to the five jang and the six bu. When autumn, the earth change the sweet flavor into pungent. The earth gives warmer energy to the sky, because of cool weather According to same process, the pungent flavor give warmer energy to the five jang and the six bu, and the meridian system gets back the water element from the five ju. When winter, the air is cold and the water element of the earth is hidden. The sky and the earth are not interchangeable. At that time, the earth produce the salty flavor and the water element is keeping in the meridian system.

        • KCI등재
        • KCI등재

          성호르몬과 안질환

          김진주,유형곤,구승엽,Kim, Jin-Ju,Yu, Hyeong-Gon,Ku, Seung-Yup 대한생식의학회 2010 Clinical and Experimental Reproductive Medicine Vol.37 No.2

          성호르몬은 lacrimal system, corneal anatomy and disease, aqueous humor dynamics and glaucoma, crystalline lens and cataract, retinal disease를 포함한 안과영역의 다양한 부위에 영향을 끼칠 수 있다. Androgen은 전신에 걸친 sebaceous glands의 발달, 분화, 지질생성 등에 관여하므로 androgen deficiency는 meibomian gland의 기능장애와 건성안에서 증발을 더욱더 심화시킬 수 있는 것으로 알려져 있다. 반면에 estrogens은 sebaceous glands의 크기, activity, 지질생성을 감소시켜 meibomian gland에서는 androgen과 반대되는 작용을 할 가능성이 있다. 성호르몬은 또한 각막의 구조와 질병경과에도 영향을 줄 수 있는데, 각막이 월경주기 제2일째 및 배란주위기에 두꺼워지며, 폐경 여성에서 여성호르몬 치료 시 각막두께가 증가한다는 사실은 estrogen levels과 각막 두께와의 연관을 시사하는 소견이라고 하겠다. Fuch's dystrophy 역시 폐경 후 여성에서 더 흔히 관찰되어, 나이에 따른 호르몬 변화가 그 원인 중 하나로 지목되고 있으며, vernal keratoconjunctivitis 환자의 각막조직에서는 estrogen과 progesterone 수용체의 overexpresson이 발견되어 역시 이들 질환에서의 성호르몬의 역할을 시사한다고 할 수 있겠다. 성호르몬은 안압에도 영향을 미칠 수 있는데, intraocular pressure와 혈중 luteinizing hormone, follicular stimulating hormone (FSH), estrone, estradiol, progesterone, testosterone과는 연관이 없는 것으로 보고한 결과도 있으나, 혈중 progesterone의 경우 특히 임신중인 여성에서 안압과의 연관관계가 보고되었으며, 또한 폐경 여성에서 혈중 남성호르몬 농도가 높을수록 안압이 상승하는 경향이 있음이 보고되었다. 한편 'Female sex'는 모든 종류의 백내장의 위험요소인 것으로 알려져 있다. 백내장으로 진단받은 여성의 경우 호르몬 측정 시 연령등을 보정하고도 폐경기에 가까운 호르몬 수치를 보였으며, 이들 백내장 환자군내에서는 estradiol과 FSH 농도 사이에 유의한 음의 상관관계가 보고되었다. 또한 DHEAS의 경우 백내장 위험도를 감소시키는 것으로 보고되었고, 그 기전으로 전구호르몬인 DHEA의 역할을 제시되고 있는데. 즉 백내장의 주요 기전 중 하나인 oxidative stress를 감소시키는 antioxidant activity를 DHEA가 보이기 때문일 것으로 추정되고 있다. 성호르몬은 망막 내 혈관의 흐름에도 영향을 줄 수 있는 것으로 알려져 있는데, 안구 내 혈류에서 여성호르몬의 긍정적인 효과와 남성호르몬의 부정적인 효과가 보고되었고, age-related macular degeneration (AMD)의 경우, estradiol이 ER-$\beta$ 수용체를 통해 보호효과가 있음이 보고되어, ER-$\beta$ 수용체가 향후 AMD 치료에서 치료적 target이 될 수도 있을 것으로 알려지고 있다. 또한 DHEAS의 경우 AMD 위험도를 증가시킬 가능성이 있으며, 당뇨로 진단받은 환자에서는 혈중 testosterone 농도는 당뇨병성 망막병증의 진행과 연관이 있는 것으로 보고되었다. 성호르몬은 안과영역의 다양한 질환과의 연관관계는 아직 추가연구가 필요한 실정이나 다양한 성호르몬이 안질환의 발생 및 경과에 영향을 줄 가능성이 있으며, 이와 같은 연관관계가 규명된다면 추후 호르몬을 통해 질환의 경과 및 예방의 가능성이 제시될 수도 있을 것으로 사료된다. 특히 폐경이후 다양한 안질환이 증가한다는 기존의 연구결과들을 고려 시, 안과영역에 있어 폐경기 여성호르몬 치료의 긍정적인 역할에 관해서는 지속적인 관심이 요구된다고 하겠다. Sex and its tropic hormones influence the lacrimal system, corneal anatomy and disease, aqueous humor dynamics and glaucoma, crystalline lens and cataract, and retinal disease. Dry eye occurs especially frequently during pregnancy, oral contraceptive use, and after menopause, during which androgen levels decrease. Androgen control development, differentiation, and lipid production of sebaceous glands throughout the body, and androgen deficiency also leads to meibomian gland dysfunction and evaporative dry eye. On the other hand, estrogen causes a reduction in size, activity, and lipid production of sebaceous glands. Sex and its tropic hormones also influence the corneal anatomy and disease, and corneal thickening occurred on the second day of the menstrual cycle and around the time of ovulation and appeared to be related to estrogen levels. Fuchs' dystrophy is more commonly seen in postmenopausal women than men and may be linked to hormonal changes that occur with aging. In addition, overexpression of estrogen and progesterone receptors in the conjunctiva of vernal keratoconjunctivitis patients. Serum progesterone levels also may be associated with intraocular pressure especially in pregnant women, and for the women. For women with cataracts, hormone levels were typical of menopause, and there was a significant negative correlation between estradiol and follicular stimulating hormone levels. In addition, serum testosterone levels are associated with the development of diabetic retinopathy. Although the role of sex hormones on the eye is largely unknown, and the results should be interpreted with caution until replicated, the functions of sex hormones in ocular disease remains to be investigated, because they may be involved in structure and function of the ocular components, which are important in the pathogenesis of ocular disease.

        • KCI등재

          작업치료사의 직무 스트레스와 소진

          김진주(Jin-Ju Kim),노재훈(Jae-Hoon Roh),원종욱(Jong-Uk Won),이신영(Sin-Young Lee),장세진(Sei-Jin Chang) 대한직업환경의학회 2010 대한직업환경의학회지 Vol.22 No.3

          목적: 작업치료사들을 대상으로 일반적 특성, 건강 관련 행위 특성, 직업 특성, 직무 스트레스와 소진과의 관련성을 파악하여 소진에 영향을 미치는 관련 요인을 구명하기 위해 수행되었다. 방법: 작업치료사 총 226명을 대상으로 일반적 특성, 건강 관련 행위 특성, 직업 특성, 직무 스트레스, 소진을 포함한 총 73문항의 설문지를 이용하여 자료를 수집하였다. 직무 스트레스 척도는 장세진이 개발한 한국인 직무 스트레스 단축형 26문항(KOSS-26<SUP>®</SUP>)을 사용하였고, 소진 척도는 Maslach Burnout Inventory를 최혜영이 번안한 척도를 사용하였다. SAS 9.1 version으로 분석 하였고, 직무 스트레스와 소진과의 관련성을 알아보기 위해 다중회귀분석을 실시하였다. 결과: 직무 스트레스 하부 요인과 소진 간의 관련성을 분석한 결과, 물리환경, 직무 요구도, 직무자율성 결여, 관계갈등, 직무불안정, 보상 부적절, 조직체계, 직장문화 요인의 스트레스가 높을수록 전체 소진 점수가 유의하게 증가하였다. 소진에 대한 총 변량 중 각 독립변수들의 설명력의 범위는 조직체계(R²=0.1439)에서 직장문화(R²=0.3321)로 소진에 관여하는 직무 스트레스 요인 중직장문화에 관한 스트레스가 상대적으로 많은 영향을 주었고 조직체계에 갈등 스트레스가 가장 낮았다. 결론: 작업치료사의 소진은 일반적 특성과 직업특성, 직무 스트레스 요인이 관여하는데 직무 스트레스가 큰 영향을 주는 것으로 확인되었다. 따라서 작업치료사의 소진을 줄이기 위한 다양한 회사 차원의 직무 스트레스 관리 방안의 개발 및 활용이 중요하다고 할 수 있다. Objective: A growing body of research has documented that occupational stress is associated with workers’ adverse health outcomes such as mental distress, depression and burnout. This study was performed to identify the relationship between occupational stress and burnout among occupational therapists in Korea. Methods: A total of 226 occupational therapists registered in the Korean Association of Occupational Therapist participated in the study. A self-administered questionnaire was used to assess demographics, subjective health status, work-related factors, occupational stress and burnout. Burnout was measured by Maslach Burnout Inventory (MBI). Occupational stressors were assessed using 26-items of the Korean Occupational Stress Scale (KOSS-26<SUP>®</SUP>). This scale consists of items targeting at physical environment, job demand, insufficient job control, interpersonal conflict, job insecurity, lack of reward, organizational system and occupational climate. Simple and multiple regression analyses were performed to investigate the relationship between 8 occupational stressors and burnout, separately. SAS 9.1 version was used for the analyses, and a P<0.05 was considered significant. Results: The results show that all occupational stressors were associated with burnout after adjustment for control variables. Occupational stressors accounted for from 14.39%(p<0.001, organizational system) to 33.21%(p<0.001, occupational climate) of the variance in burnout. Conclusion: These results suggest that occupational stress might play a significant role in increasing the risk of burnout among occupational therapists.

        • KCI등재

          Live-Virtual 시뮬레이션 환경차이에 따른조종사 스트레스 유발요인 분석

          김진주(Jin ju Kim),김성호(Sung ho Kim),설현주(Hyeon ju Seol),지철규(Cheol kyu Jee),홍영석(Young seok Hong) 한국산업경영시스템학회 2016 한국산업경영시스템학회지 Vol.39 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Recently, Live-Virtual-Constructive (L-V-C) integrate training system has proposed as a solution for the problems such as limitation of training areas, increase of mission complexity, rise in oil prices. In order to integrate each training system into the one effectively, we should solve the issue about stress of pilots by the environmental differences between Live and Virtual simulation which could be occurred when each system is connected together. Although it was already examined in previous study that the psychological effects on pilots was occurred by the environmental differences between actual and simulated flights, the study did not include what the causal factors affecting psychological effects are. The aim of this study is to examine which environmental factors that cause pilots’ psychological effects. This study analyzed the biochemical stress hormone, cortisol to measure the pilots’ psychological effects and cortisol was measured using Enzyme-linked immunoassay (EIA). A total of 40 pilots participated in the experiment to compare the differences in pilots’ cortisol response among live simulation, virtual simulation, and the virtual simulation applying three environmental factors (gravity force, noise, and equipment) respectively. As a result, there were significant differences in cortisol level when applied the gravity force and equipment factors to the virtual simulation, while there was no significant difference in the case of the noise factor. The results from this study can be used as a basis for the future research on how to make L-V system by providing minimum linkage errors and design the virtual simulator that can reduce the differences in the pilots’ psychological effects.

        • KCI등재

          노숙인의 삶의 경험에 관한 현상학적 연구

          김진주 ( Kim Jin Ju ),박은영 ( Park Eunyoung ),현명선 ( Hyun Myungsun ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2017 정신간호학회지 Vol.26 No.1

          Purpose: The purpose of this study was to explore the lived experiences of homeless persons. Methods: A phenomenological methodology was used for the study. Participants were people enrolled in the Center for homeless persons in Kyunggi Province and eligible for the study. Data were collected through in-depth interviews with nine participants between October 13 and November 16, 2016. Data analysis was conducted using Colaizzi`s method. Results: Five themes and twenty meanings were formulated for experiences of homeless persons. The five themes were `Abandoning their life`, `Being familiar with a free homeless life`, `Being isolated from the world`, `Being impoverished`, `Desire to break away from the life of homelessness`. Conclusion: The study results suggest the need for a holistic understanding of the essential structure of the lived experiences of homeless persons. Mental health professionals need to understand the homelessness experiences from the client view and to develop programs that can help homeless persons reintegrate into the community.

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