http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
권운용,박준석,어은경,오범진,이미진,이성우,서주현,노형근,서길준,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Mi-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, Hyung-Keun,Suh, Gil-Joon 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1
Purpose: The aim of this study was to evaluate the characteristics and the prognostic factors of carbamate poisoned patients who visited emergency departments. Methods: From August 2005 to July 2006, we investigated the demographic feature, dose of exposure, time of exposure, alcohol intake, route of exposure, reason of exposure, site of exposure, pre-existing medical condition, time from exposure to emergency department (ED), transfer from other hospitals, vital sign at ED arrival, symptom or sign at ED arrival, and result of care of the patients who visited the ED of thirty-eight hospitals in Korea. According to the result of care, we divided the patients into two groups, the survival and the dead. To evaluated the prognostic factors, we calculated the odds ratio of each factor for the survival. Results: Among the sixty-eight patients, fifty-five patients (80.9%) were survival and thirteen patients (19.1%) were dead. The patients in the dead were older than the patients in the survival. The Glasgow coma scale (GCS) of the patients in the dead was lower than the GCS in the survival. The odds ratio of the GCS at ED arrival for the survival was 1.58 (95% CI; 1.23-2.05). Other factors showed no statistical significances. Conclusion: The GCS at emergency department arrival was the prognosis factor of the carbamate poisoned patients who visited emergency departments. If the carbamate poisoned patients showed altered mentalities, they should be provided intensive care, immediately.
국내 유기인계 농약 중독 환자의 특성 분석 - 다기관 연구 보고 분석 -
이미진,권운용,박준석,어은경,오범진,이성우,서주현,노형근,Lee, Mi-Jin,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, Hyung-Keun 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1
Purpose: Organophosphate (OP) compounds insecticides are the most commonly associated with serious human toxicity all over the world. The aim of this study was to identify sociocultural factors that contribute to high incidence of pure OP poisoning and prevent OP poisoning in order to reduce the factors responsible for deaths in South Korea. Methods: This is the 38 multi-centers survey and prospective study of pure OP poisoning by structural reporting system and hospital records from August 2005 to July 2006. 238 patients with acute pure OP poisoning were enrolled. We collected patient information regarding poisoning, clinical, and demographic features. Results: The mean age was $55.32{\pm}17.3$ years old. The most frequent site of exposure was their own residence(85.7%). Frequent compounds involving pure OP poisoning were dichlorvos(22.7%), methidathion(8.4%), and phosphamidon(6.7%). Intentional poisoning was 77.9%. The most frequently route of exposure was ingestion(94.5%). The mean arrival time to hospital after poisoning was 12.7 hours and mean hospitalization duration was 12.9 days. 2-PAM was administered to 101 patients in mean doses of 6.3 g/day intravenously. Atropine was administered to 81 patients in mean doses of 74.6 mg/day (maximal 910 mg/day). The presence of lower level of GCS score, respiratory complications, hypotension, acute renal failure, and serious dysrhythmia was associated with serious and fatal poisoning. Overall final mortality in pure OP poisoning was 9.7%(23/238). Conclusion: This study highlights the problem of pure OP poisoning in South Korea as a basic national survey. Futhermore this might help the establishment of strict policies availability of OP and the statistics of OP poison exposure in South Korea.
패혈증에서 Heat Shock Protein 70의 과도발현이 Inducible Nitric Oxide Synthase의 발현에 미치는 효과
이용근 ( Yong Keun Lee ),신효근 ( Hyo Keun Shin ),권운용 ( Woon Yong Kwon ),서길준 ( Gil Joon Suh ),윤여규 ( Yeo Kyu Youn ) 대한외상학회 2008 大韓外傷學會誌 Vol.21 No.1
Purpose: The aim of this study was to evaluate the effect of overexpression of heat shock protein 70 (HSP70) on the expression of inducible nitric oxide synthase and on the concentration of nitric oxide and to determine the mechanism for the relationship between HSP70 and inducible nitric oxide synthase (iNOS) in sepsis. Methods: Experiments were performed on male Sprague-Dawley rats, and sepsis was induced by using cecal ligation and puncture (CLP). Glutamine (GLN) or saline was administered 1 h after initiation of sepsis. We acquired serum and lung tissues from the rats 12 h or 24 h after initiation of sepsis. We analyzed the concentration of nitric oxide, the expression of HSP70 in the lung, and the gene expression of iNOS in the lung. Results: In CLP+GLN, glutamine given after initiation of sepsis enhanced the expression of HSP70 in the lung at 12 h (CLP+GLN vs. CLP:: 47.19 ± 10.04 vs. 33.22 ± 8.28, p = 0.025) and 24 h (CLP+GLN vs. CLP: 47.06 ± 10.60 vs. 31.90 ± 4.83, p = 0.004). In CLP+GLN, glutamine attenuated the expression of iNOS mRNA in the lung at 12 h (CLP+GLN vs. CLP: 4167.17 ± 951.59 vs. 5513.73 ± 1051.60, p = 0.025) and 24 h (CLP+GLN vs. CLP: 9,437.65 ± 2,521.07 vs. 18,740.27 ± 8,241.20, p = 0.016) and reduced the concentration of nitric oxide in serum at 12 h (CLP+GLN vs. CLP: 0.86 ± 0.48 vs. 3.82 ± 2.53 umol/L, p = 0.016) and 24 h (CLP+GLN vs. CLP: 0.39 ± 0.25 vs. 1.85 ± 1.70 umol/L, p = 0.025). Conclusion: The overexpression of HSP70 induced by the administration of glutamine in sepsis attenuated the gene expression of iNOS and reduced the concentration of nitric oxide.
Glufosinate 제초제 중독의 실태 조사와 임상적 특성 고찰 - 다기관 연구 -
이성우,홍윤식,권운용,박준석,어은경,오범진,이미진,서주현,노형근,Lee, Sung-Woo,Hong, Yun-Sik,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Mi-Jin,Suh, Joo-Hyun,Roh, Hyung-Keun 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1
Purpose: To assess the epidemiology and the clinical features of Glufosinate herbicide in Korea. Methods: Data was prospectively collected during 1 year since August 2005 from 38 hospital in Korea. We analyzed the epidemiologic characters and clinical manifestations of Glufosinate poisoning. In addition, the characteristics of patients with severe central nervous system toxicity were separately analyzed to find poor prognosis relating factors. Results: During study periods, there were 715 persons of poisoning of herbicides and insecticides. 6.3% (45 persons) of the agricultural chemicals poisoning had Glufosinate poisoning. There were 36 cases of suicide attempts and 7 cases of accidental exposure, The major of poisoning route was oral ingestion (44 cases). 28.9 % of the study patients had not toxic symptoms. The most common symptoms were gastrointestinal symptoms relating surfactant irritation. 67.7% of central nervous symptoms occurred lately. 10 persons showed severe central nervous system toxicity. 4 persons of them showed poor outcomes (1 death, 3 hopeless discharged). Complications of respiratory failure and renal failure related with poor outcome. Conclusion: Majority of patients ingested Glufosinate for suicide attempt. 22.2% of patients with Glufosinate poisoning showed delayed serious central nervous system toxicity. Early supportive care of altered mentality may prevent late respiratory complications and improve the outcomes.
국내 급성 dichlorvos 중독 현황과 임상상 분석
이미진,박준석,권운용,어은경,오범진,이성우,서주현,노형근,Lee, Mi-Jin,Park, Joon-Seok,Kwon, Woon-Yong,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, Hyung-Keun 대한임상독성학회 2008 대한임상독성학회지 Vol.6 No.1
Purpose: Dichlorvos has been in widespread use as an organophosphate (OP) insecticide compound. The purpose of this study was to access the epidemiology and clinical features of dichlorvos in Korea. Methods: This was a 38 multi-center prospective study of dichlorvos poisoning using surveys, a structural reporting system and review of hospital records from August 2005 to July 2006. A total of 54 patients with acute dichlorvos poisoning on a national basis were enrolled. We analyzed the epidemiologic characteristics and clinical manifestations of dichlorvos poisoning. In addition, the clinical features of dichlorvos poisoning were compared with others OP compounds. Results: During the study period, compounds involving pure OP poisoning were dichlorvos (22.7%), methidathion (8.4%), and phosphamidon (6.7%). In acute dichlorvos poisoning, all ingestion routes were oral. Intentional poisoning involved 74.1% of cases. The common initial complaints involved gastrointestinal (64.8%), systemic (61.1%), central or peripheral nervous system (53.7%), and respiratory symptoms (50.0%). The median arrival time to hospital after dichlorvos poisoning was 2.6 hours and mean hospitalization duration was 7.1 days. 2-PAM was administered in 35 patients in mean doses of 6.3 g/day intravenously. Atropine was administered in 30 patients with a mean dose of 62.8 mg/day (maximal 240 mg/day). Overall mortality rate for dichlorvos poisonings were 14.8% (8/54). Immediate causes for death included sudden cardiac arrest or ventricular dysrhythmias (50%), multi-organ failure (25%), acute renal failure (12.5%), and unknown causes (12.5%). Conclusion: When compared to previous reports, dichlorvos poisoning displayed relatively moderate severity. The presence of a lower GCS score, altered mental status, serious dysrhythmias, systemic shock, acute renal failure, and respiratory complications upon presentation were associated with a more serious and fatal poisoning.
Chlorophenoxy계 제초제 중독 환자 임상 양상
조영순,김호중,오범진,서주현,권운용,박준석,어은경,이미진,이성우,노형근,임훈,Cho, Young-Soon,Kim, Ho-Jung,Oh, Bum-Jin,Suh, Joo-Hyun,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Lee, Mi-Jin,Lee, Sung-Woo,Roh, Hyung-Keun,Lim, Hoon 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.2
Purpose: There have been relatively few reports of chlorophenoxy herbicide poisoning. The purpose of this study is to analyze the general characteristics and clinical aspects of the chlorophenoxy herbicide intoxicated patients in Korea. Methods: We prospectively evaluated the chlorophenoxy herbicide intoxicated patients visiting to the 38 emergency medical centers in Korea from the 1 August 2005 to the 31 July 2006. Results: 24 patients were enrolled during the study periods. Their mean age was 55.7 years old. The median amount of the chlorophenoxy herbicide intoxicated is 150 mL. The most frequent location where the patients obtained and took the chlorophenoxy herbicide was their home. Frequent compounds involving chlorophenoxy herbicide poisoning were dicamba(66.7%), MCPP(16.7%), and 2,4-D(12.5%). The most common symptom of the patients was confusion and vomiting. 16 patients(66.7%) intended to suicide. 3 patients out of 24 patients(13.0%) were died. Conclusion: There were 24 patients intoxicated by the chlorophenoxy herbicide during the study periods. The mortality rate was 13.0%. The suicidal attempts and the numbers of death involving chlorophenoxy herbicide were high in Korea.
국내 먹는물 중 염소소독부산물 모니터링 및 위해성 평가
황선혜 ( Sun Hye Hwang ),권운용 ( Woon Yong Kwon ),김현구 ( Hyun Koo Kim ),김태승 ( Tae Seung Kim ),김승기 ( Seung Ki Kim ),최종호 ( Jong Ho Choi ),표희수 ( Hee Soo Pyo ) 한국환경분석학회 2010 환경분석과 독성보건 Vol.13 No.1
Many disinfection by-products were produced during the chlorination of drinking water. By the law, disinfection by-products should be maintained at low level due to their potential toxicity. In this study, we conducted the monitoring of 34 treated water samples collected from water treatment facilities in Han river, Keum river, Nakdong river and Youngsan river from year 2000 to 2008 to quantify disinfection by-products (DBPs) such as trihalomethanes (THMs). Analytical results of total DBPs in four Korean rivers showed that Nakdong river`s detection frequency accounted for 72.06% of the total number and its average concentration was 2.54 ng/mL. Regarding seasonal variations, winter detection frequency was 66.91% and average concentration was 2.49 ng/mL in Summer. Lastly, the human risk assessment was performed. Dichlorobromomethane (DCBM) total excess cancer risk (ECR) was chloroform (CF) total hazard quotient (HQ) of Nakdong river was 9.71×10-6 and 1.05×10-1, respectively. The result of human risk assessment on DBPs for the past nine years showed the dirinking water safe because it was less than the WHO`s guideline.
조준호,오범진,서주현,권운용,박준석,어은경,이미진,이성우,노형근,박인철,Cho, Jun-Ho,Oh, Bum-Jin,Suh, Joo-Hyun,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Lee, Mi-Jin,Lee, Sung-Woo,Roh, Hyung-Keun,Park, In-Cheol 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1
Purpose: To analyze the general characteristics and clinical aspects of the organochlorine intoxicated patients in Korea. Methods: We prospectively evaluated the organochlorine intoxicated patients visiting to the 38 emergency medical centers in Korea from the 1, Aug. 2005 to the 31, Jul. 2006. Results: There were 38 patients intoxicated by the organochlorine during the study periods. The mean age of patients was 55.1 years old. The mean amount of the organochlorine intoxicated is 246.1 mL. The most frequent place where the patients got and took the organochlorine was their home. Twenty eight patients(73.7%) intended to suicide. Nine patients out of 38 patients(23.7%) were died and they all intended to suicide. Conclusion: There were 38 patients intoxicated by the organochlorine during the study periods. The suicidal attempts and the number of the dead were higher in Korea than the developed countries.
홍대영,백광제,이경룡,권운용,박준석,어은경,오범진,이미진,이성우,서주현,노형근,김준식,Hong, Dae-Young,Baek, Kwang-Je,Lee, Kyeong-Ryong,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Mi-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1
Purpose: Owing to organophosphate-pyrethroid mixtures are widely used, suicidal or unintentional poisoning is common. But there have been relatively few reports of poisoning. The purpose of this study is to evaluate the difference of the severity and toxicity between organophosphate-pyrethroid mixtures poisoning and single organophosphate poisoning. Methods: From August 2005 to July 2006, 65 patients presented with organophosphate-pyrethroid mixtures poisoning to emergency medical center. Date were gathered by report form it was drawn up. Results: 65 patients were enrolled in 28 hospitals and their mean age was $56.5{\pm}16.2$ years old. The most common cause of poisoning was suicide, in 52 cases(80%). Chlorpyrifos-cypermethrin, malathion-esfenvalerate were the most frequent chemicals involved, and the mean ingestion amount was 135.4ml. The most common symptom of the patients was nausea/vomiting, in 16 patients. The average GCS score was 13. The mean ICU stay was $4.4{\pm}5.2$ days, and mortality was 3.1%. Conclusion: The severity and toxicity of organophosphate-pyrethroid mixture poisoning were lower than that of single organophosphate poisoning.