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곽향정기산(藿香正氣散)이 가토(家兎)의 수축혈관에 마치는 영향(影響)
선중기,김호현,남창규,구창모,Sun Jung-Ki,Kim Ho-Hyun,Nam Chang-Gyu,Koo Chang-Mo 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
Object : This study was undertaken to define the mechanism of GwakHyangJungGiSan-induced relaxation in rabbit common carotid artery contracted by agonists. Method : In order to investigate the effect of GwakHyangJungGiSan on rabbit's contracted vascular ring detached from common carotid artery, vascular ring intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of GwakHyangJungGiSan-induced relaxation, GwakHyangJungGiSan extract was infused into contracted vascular ring which had been pretreated by pretreatment of indomethacin(IM), tetraethylammonium chloride(TEA), $N{\omega}-nitro-L-arginine(L-NNA)$. Result : GwakHyangJungGiSan blocks an inflow of $Ca^{2+}$ and relaxes vascular ring by the action of Nitric oxide from endothelium. Consequently when GwakHyangJungGiSan is prescribed, a rise in blood pressure by the resistance of peripheral vessel may be controlled to some extent and so it is anticipated that hypertension, a disorder of blood flow from the vascular contraction and vascular disease will be treated well.
권삼(拳蔘)이 지혈(止血).소염작용(消炎作用) 및 중추신경계(中樞神經系)에 미치는 영향(影響)
선중기,이동준,Sun, Jung-Ki,Lee, Dong-Joon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5
Objective : The purpose of these research was to investigate effects of water extract of Bistortae Rhizoma(BRE) on the hemostasia, anti-inflammatory action and central nervous system. Methods : we used mice and rats administered with the extract of the above herbs. Results : BRE decreased the permeability of evans blue into peritoneal cavity and cotton pellet granuloma formation. BRE did not decrease the acetic acid induced writhing syndrome and the histamine induced mouse paw edema. BRE inhibited the pentylenetetrazole and the strychnine induced convulsion. BRE shortened the bleeding time and plasma prtrombin time. BRE did not affect on the proliferation of Balb/c 3T3 cells. Conclusions : these results suggest that the effects of BRE are the hemostasia, anti-inflammatory action, and mild depressant activity of central nervous system.
당귀용회환의 세포독성(細胞毒性)에 관(關)한 연구(硏究)
문종진,선중기,Moon, Jong-Jin,Sun, Joong-Ki 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2
The purpose of this research was to investigate cytotoxicity of DangkwiYonghoe-Hwan(DYH) and the constitutive crude drugs on several cancer cell-lines, thymocytes, splenocytes and 3T3 cells. The DYH consists of Coptidis Rhizoma, Scutellariae Radix, Phellodendri Cortex, Gardeniae Fructus, Gentianae scabrae Radix, Indigo pulverata Levis, Aloe, Rhei Rhizoma, Moschus, Saussureae Radix and Angelicae Gigantis Radix. The cytotoxicity was determined by MTT method. The DYH inhibited the proliferation of MOLT-4, K562, HL-60, Jurkat, L1210, P815, S180 and Yac-1, thymocyte, splenocyte and 3T3 cells. The cytotoxicity of Coptidis Rhizoma on the cancer cell-lines was the most potent in the constitutive crude drugs. The proliferation of cancer cell-lines was partly inhibition and partly increase by the treatment of Scutellariae Radix, Gardeniae Fructus, Gentianae scabrae Radix, Indigo pulverata Levis, Aloe, Rhei Rhizoma, Moschus and Angelicae Gigantis Radix. Phellodendri Cortex and Saussureae Radix had a poor cytotoxicity on cancer cell-lines. Coptidis Rhizoma and Phellodendri Cortex inhibited the proliferation of thymocyte, splenocyte and 3T3 cells.
저용량 He-Ne 레이저 정맥내(靜脈內) 조사(照射)가 혈중(血中) Lipoprotein(a)에 미치는 영향(影響)
이동준,선중기,최창원,임진훈,Lee, Dong-Joon,Sun, Jung-Ki,Choi, Chang-Won,Lim, Jin-Hoon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5
Objectives : The purpose of study was to investigate the effect of ILlB(intravascular laser irradiation of blood) on serum lipoprotein(a) Methods : The 12 case is diagnosed as cerebrovascular diseases on computed tomograghy. The 18 case is not observed abnormality on computed tomograghy but, they have neurological sign. Blood test was enforced on the first medical examination, The 15 case with plasma lipoprotein(a) greater than 30 mg/dl have been classified into abnormal group and the 15 case of less than 30 mg/dl have been classified into control group. after ten times ILlB, It was observed that the change of plasma lipoprotein(a) and a fibrinogen of blood clotting factor. Conclusions : 1. After ten times ILlB, plasma lipoprotein(a) numerical value was decreased on 13 case of abnormal group. 2. Plasma lipoprotein(a) numerical value was decreased on 5 case of control group. 3. The twenty in fifteen patient's with hyperlipoproteinemias have been fibrinogenemias and after ILIB treatment, in the all of 16 case with hyperfibrinogenemia in the first medical examination to both abnormal and control group, plasma fibrinogen numerical value was decreased.
청심연자탕(淸心蓮子湯)으로 치료하여 호전된 강직성 척추염을 동반한 중증 궤양성 대장염 1례
장혜진,선중기,손덕칭,Jang, Hae-Jin,Sun, Joong-Ki,Sun, Teh-Cheng 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
A 33 year-old male who had been diagnosed with severe ulcerative and ankylosing spondylitis was treated and observed. Even though he had been treated with western medicine, he still complained of severe diarrhia, hemafecia, abdominal pain, general weakness, mild fever($37.8^{\circ}C$) and lower back pain. On radiologic examination, the lumbar view revealed the sacroliac joint space are irregular with adjacent bony sclerosis on both sides. He was treated with Chengsim Yeunja-Tang. Having been treated for 99 days, severity of ulcerative colitis changed from severe to mild ade, lower back pain reduced from nine to three, and all other symptoms improved.
용담사간탕(龍膽瀉肝湯)을 이용한 대상포진(帶狀疱疹)의 급성기(急性期) 통증(痛症)에 대한 치험(治驗) 1례(例)
박영준,박주한,허금정,남창규,선중기,구창모,Park Young-Jun,Park Joo-Han,Heo Geum-Jeong,Nam Chang-Gyu,Sun Jung-Ki,Koo Chang-Mo 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1
Herpes zoster is a viral disease characterized by unilateral radicular pain and vesicular eruptions that are generally limited to the dermatome innervated by single spinal or cranial sensory ganglion. The disease causes severe pain and in particular, put elderly patients in great risks and further it develops postherpetic nenralgia. Nowadays western medicine use antiviral durg(ex: acyclovir), analgesics, nerve block and etc for treatment of herpes zoster and pain control, but the effect is not much satisfactory. A 73-year-old patient, admitted to our hospital because of severe migrain. Two days later, her illness was diagnosed as herpes zoster so we administrated Yongdamsagan-tang. After the six-day of treatment, all symptoms improved, especially headache was cleared since the four day long administration of Yongdamsagan-tang.
보중익기탕가미방으로 치료한 만성 비세균성전립선염환자의 자각증상 및 백혈구수치변화에 대한 치험 1례
조철준,구창모,김진원,이승진,선중기,박양춘,배한호,이정은,한영주,임도희,Cho Cheol-Jun,Koo Chang-Mo,Kim Jin-Won,Lee Seung-Jin,Sun Jung-Ki,Park Yang-Chun,Bae Han-Ho,Lee Joung-Eun,Han Young-Joo,Lim Do-Hui 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1
The chronic non-bacterial prostatis disease is relatively incurable, chronic and recurrent. Due to its prostatis barrier, chronic non-bacterial prostatis disease is difficult to be penetrated with Medicine. Nevertheless, we obtained the desired results using the method of iki action by Bojungiki-tang. The purpose of this study is to evaluate the effect of treatment and change of WBC numerical index using Bojungiki-tang. We investigated one chronic non-bacterial prostatis disease for about one year with NIH chronic prostatis symptom index, expressed prostatic secretion(EPS). After the treatment, symptom index score was decreased from 27 to 1. Also WBC numerical index by EPS test was decreased to zero. These results indicate that oriental medical therapy is effective in treating chronic non-bacterial prostatis disease. Therefore further study of the effect of herb-medicine is necessary.
嚴東玉,李來洪,宣中基,都京三 又石大學校 1995 論文集 Vol.17 No.-
This study was undertaken to develope a method for the determination of aconitine alkaloids from Aconitum ciliare Tuber by spectrophotometry. The complex of cobalt(Ⅱ)ion and thiocyanate ion forms tetrathiocyanatocobaltate(Ⅱ)ion in aqueous solution containing an excess of thiocyanate ion. The tetrathiocyanatocobaltate(Ⅱ)ion produces the complex with aconitine alkaloids. The complex are extracted from aqueous solution to 1. 2-dichlorethane. A spectrophotometry for determination of aconitine alkaloids with tetrathiocyanatocobaltate(Ⅱ)ion were, established by 1, 2-dichlorethane extraction. Determination of aconitine standard was possible to the rage of 0.4-0.6㎎/㎖ in 1.2-dichlorethane. To examine the determination of aconitine alkaloids in Aconitum ciliare Tuber were determined by using acid-alkali titration, spectrophotometry from ether extracts. The average recovery of aconitine standard sloution was 97.9% and standard deviation 2.97%. As this method is accurate and precise, is applicable to the determination of aconitine alkaloids in Aconitum ciliare Tuber.