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축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향
정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1
The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.
노덕영 ( Duck Yeong Ro ),신화정 ( Hwa Jeong Shin ),김길중 ( Gil Joong Kim ),권지영 ( Ji Young Kwon ),박철훈 ( Cheol Hoon Park ),김용욱 ( Yong Wook Kim ),김태웅 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
Carcinomas of Bartholin`s gland are rare tumors that account for less than 1% of all gynecological malignancies. Two major histological types, squamous cell carcinoma and adenocarcinoma, account for 80% to 90% of primary cases. The remainders are adenosquamous carcinoma, adenoid cystic carcinoma and so on. We experienced a case of squamous cell carcinoma of the Bartholin`s gland managed by wide local excision and chemotherapy with cisplatin and 5-fluorouracil (5-FU). We present this case with a brief review of the leteratures.
정상 임신과 비정상 임신의 초기 혈중 CA - 125 수치에 관한 연구
노덕영(Duck Yeong Ro),김도강(Do Kang Kim),김수평(Soo Pyung Kim),문희봉(Hee Bong Moon),강규섭(Gyu Sub Kang),황지영(Jee Young Hwang),신봉영(Bong Young Shin),장병우(Byeung Woo Jang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.
노덕영 ( Duck Yeong Ro ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),이혜영 ( Hye Young Lee ),정동섭 ( Dong Sup Chung ),이안희 ( Ah Hi Lee ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
With the exception of choriocarcinoma, the central nervous system (CNS) is rarely associated with metastases from gynecological malignancy. Cerebral involvement in ovarian carcinoma is generally regarded as occurring in 1% of cases. Overall incidence of c
Kim, Tae-Eung,Ro, Duck-Yeong,Kim, Yong-Wook,Kim, Hyun-Kyung,Lee, Hyun-Seung,Jung, Jae-Keun,Kim, Jin Woo,Namkoong, Sung-Eun 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.3
목적: Herpes Simplex 바이러스의 Thymidine Kinase (HSVtk) 유전자와 ganciclovir (GCV)를 사용한 항암 유전자치료법은 다른 종양의 치료에 많이 시도되고 있으나, 자궁경부암에 있어서는 시도가 미미하여 그 효용성에 관하여 연구하고자 한다. 연구 방법: HSVtk 유전자가 삽입된 재조합 아데노바이러스 (Ad5RSV-tk)를 3 종류의 자궁경부암 세포주 (HeLacells, CaSki cells, CUMC-3 cells)에 감염시킨 후 10 μg/ml GCV를 배양액에 첨가하여 각각의 세포주의 시험관내 성장억제를 MTT 분석을 통하여 관찰하였고, HSVtk가 이입된 세포들과 이입되지 않은 세포들을 다양한 비율 (0%, 25%, 50%, 75%, 100%)로 혼합한 후 GCV를 배양액에 첨가하여 bystander 효과를 관찰하였다. 결과: 세 종류의 자궁경부암 세포주에 대한 아데노바이러스를 사용한 HSVtk 유전자의 이입은 성공적이었고, HeLa 세포주의 경우 MOI=3, CaSki 세포주의 경우 MOI=6에서 세포들의 성장이 50% 이상 억제되었으며, CUMC-3 세포주의 경우 같은 성장억제를 얻기 위하여 다른 두 세포주보다 많은 Ad5RSV-tk가 사용되었다 (MOI=25). bystander 효과를 관찰하기 위하여, 각각의 세포주에서 25%의 세포를 Ad5RSV-tk로 감염시키고 GCV를 사용한 경우 약 70-80%의 성장억제가 유발되었다. 결론: 세 종류의 자궁경부암 세포주에서 Ad5RSV-tk와 GCV를 사용한 항암 유전자 치료법은 유효하였으나, bystander 효과는 중등도 정도를 보였으며, 이는 자궁경부암에서 향후 Ad5RSV-tk와 GCV를 사용한 항암 유전자치료법 개발 시 고려해야할 사항으로 생각되었다. Objective : Although herpes simplex virus thymidine kinase gene (HSVtk) transfer with ganciclovir (GCV) represents the commonly used suicide gene therapy of human cancers, little is known about the feasibility of this approach for the treatment of human uterine cervical cancers. We studied effects of HSVtk plus GCV gene therapy on human uterine cervical cancer in vitro. Methods : Three cell lines (HeLa cells, CaSki cells and CUMC-3 cells) from squamous carcinoma of uterine cervix were used. Cells were infected with recombinant adenovirus, containing herpes simplex virus thymidine kinase gene (Ad5RSV-tk) and 10 μg/ml of GCV was added to media to test whether infection of Ad5RSV-tk would render cervical cancer cells sensitive to cell killing by GCV. For assessment of the bystander effect, infected cells were mixed with uninfected cells at varying ratios (0%, 25%, 50%, 75%, 100%) and GCV was added to media. After 6 days, this was followed by MTT assay. Results : More than 50% of cell death was observed with an MOI of 3 in HeLa cells and with an MOI of 6 in CaSki cells. CUMC-3 cells showed less sensitivity (MOI of 25) to HSVtk plus GCV therapy in comparison with other two cell lines. 70-80% of cell death was achieved with 25% Ad5RSV-tk infected cells in mixture in all cell line, indicating the presence of a bystander effect. Conclusion : The transfer of HSVtk gene to cervical cancer cells was capable of mediating cell death in vitro, but the bystander effect appeared to be moderate. These findings should be taken into account for the future planning for HSVtk plus GCV gene therapy trials for human uterine cervical cancers.
Benzaldehyde as a new class plant growth regulator on Brassica campestris
( Geun Hyoung Choi ),( Jin Ho Ro ),( Byoung Jun Park ),( Deuk Yeong Lee ),( Mi Sun Cheong ),( Dong Yeol Lee ),( Woo Duck Seo ),( Jin Hyo Kim ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.2
Plant growth regulator is an essential pesticide to date while the available active ingredient is not well understood unlike fungicide, insecticide and herbicide. This study was aimed to evaluate a new chemical class of plant growth regulator, and the total of 92 benzene derivatives were screened for their germination and early stage of the root growth regulation on Brassica campestris. Thirty benzaldehydes, nine acids, one amide, and one ester showed potent root growth inhibitory activity (>70 % inhibition) while only salicylaldehyde showed potent germination inhibition (IC50 = 81.2 mg/L) suggesting that benzaldehyde was a key module candidate for the growth inhibition. Benzaldehydes were further evaluated for root growth inhibition. 2,3-Dihydroxybenzaldehyde and salicylaldehyde showed IC50 values of 8.0 and 83.9 mg/L, respectively. On the other hand, salicylaldehyde, and 2,4,5- trihydroxybenzaldehyde were found to have root growth promotion effects less than 10 mg/L. This result suggests that the benzaldehyde is a new class candidate for plant growth regulator.
기은영 ( Eun Young Ki ),노덕영 ( Duck Yeong Ro ),김효진 ( Hyo Jin Kim ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),이안희 ( An Hi Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.1
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, also called lymphoepithelioma or medullary carcinoma, is a very rare variant of squamous cell carcinoma. Histologically, the tumor is characterized by groups and nests of poorly differentiated tumor cells with abundant cytoplasm and ill-defined cell borders, surrounded by an intense chronic inflammatory infiltrate. Epstein-Barr virus (EBV) may be involved in the development of LELC but the exact role remains unclear. The relationship between human papillomavirus (HPV) and LELC of the uterine cervix has also not been reported. The prognosis of LELC of the uterine cervix seems to be better than that of cervical squamous cell carcinoma. We report a case of LELC of the uterine cervix with a brief review.