The Clinical Effect of Bosingunyang-tang on Chronic Non-bacterial Prostatitis/Chronic Pelvic Pain Syndrome : Randomized Double-blind, Placebo-controlled Clinical Trial

이병철,Song, Moon-Koo,Kang, Ji-Suck,Kang, Cheol-Ho,Ahn, Young-Min,Ahn, Se-Young,Doo, Ho-Kyung,Lee, Byung-Cheol 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Objective : Although chronic prostatitis/chronic pelvic pain syndrcme(CP/CPPS) is a common disease, there is no consensus on the etiology or pathology and treatment. This was a double-blinded, placebo-controlled, randomized clinical trial, investigating the therapeutic effects of the traditional Korean medicine, Bosingunyang-tang(BSGYT). Method : Participants who met US National Institutes of Health (NIH) consensus criteria for CP/CPPS were entered after applying inclusion/exclusion criteria. They were randomized to the BSGYT or placebo group. and treated three times a day for 6 weeks. NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was used to estimate the clinical symptoms of CP/CPPS. Prostaglandin E2 and ${\beta}$-endorphin in prostatic fluid, collected by 2-glass pre-massage and post-massage test, were analyzed as factors associated with pain and inflammation. Result : The mean decrease in NIH-CPSI total score of the BSGYT group was 11.0 points, which is 5.7 points more than the placebo group. (Mann Whitney test P=0.038) Also the BSGYT group showed three times higher response rate than the placebo group in NIH-CPSI pain subscale score. (Fisher's exact test P=0.027) In those responders, prostaglandin E2 decreased significantly. (Wilcoxon's signed-ranks test P=0.037). No specific side effects were observed. Conclusion : After a 6-week treatment period, BSGYT improved clinical symptoms of CP/CPPS patients by decreasing PGE2 level in prostatic fluid.

자유전자레이저의 개발현황과 전망

이병철,정영욱,박성희,한상준,Lee, Byung-Cheol,Jeong, Young-Ug,Park, Seong-Hee,Hahn, Sang-June 한국진공학회 2006 Applied Science and Convergence Technology Vol.15 No.5

자유전자레이저는 고에너지 전자빔의 운동에너지를 빛 에너지로 바꾸는 장치로서, 다른 어떤 종류의 광원으로도 제공할 수 없는 넓은 범위의 파장가변성과 우수한 분광특성을 갖고 있어, 기초연구에서부터 산업응용에 이르기까지 다양하게 활용될 수 있을 것으로 기대된다. 이 논문에서는 자유전자레이저의 원리와 특성, 요소기술을 소개하고, 최근 주목받고 있는 테라헤르츠파 자유전자레이저와 에너지 회수형 고출력 자유전자레이저에 대하여 자세하게 소개하였다. Free electron lasers (FELs) are promising sources of coherent radiation that can provide users with radiations having a wide-range frequency-tunability and good spectral characteristics for basic science and industrial applications. Especially in Terahertz or X-ray ranges of spectrum, FELs can generate much stronger radiations than conventional light sources. In this paper, we introduce the working principles and key technologies of FELs, the status and the prospects of FEL developments.

박판형 토러스를 갖은 자동차용 토크컨버터의 성능 최적화

이병철,신세현,김철,문수연,장재덕,주인식(Byung-chul Lee),Se-hyun Shin,Cheol Kim,Su-yeon Moon,Jae-duk Jang,In-sik Joo 한국자동차공학회 2003 한국자동차공학회 지부 학술대회 논문집 Vol.- No.-

Automotive torque converters have recently been designed with an increasingly narrow profile for the purpose of achieving a smaller size, which also translates into savings. New torque converter with flatted torus was designed to compare with reference torque converter having circular torus. Flatted torus has non-axisymmetrical ellipticity and a trapezoid stator created by typical blade design method. To evaluate the overall performance, CFD code was used. The present numerical analysis was performed for the full three-dimensional turbulent flows. The torque ratio and Input capacity factor of Flatted torque converter were compared with reference model having circular torus and have been good agreement with it.<br/>

해금사가 만성 비세균성 전립선엽 모델에서 혈액학적 및 세포조직학적 변화에 미치는 영향

이병철,김상우,안영민,두호경,안세영,Lee, Byung-Cheol,Kim, Sang-Woo,Ahn, Young-Min,Doo, Ho-Kyung,Ahn, Se-Young 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. Lygodium japonicum has been traditionally used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of Lygodium japonicum in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods : Five-month-old rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Lygodium japonicum and testosterone were administered as an experimental specimen and a positive control. respectively. The prostates were evaluated by histopathological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. PCNA labeling index for cyto-proliferation and a TUNEL(deoxyuridine triphosphate biotin nick end-labeling) assay for cell apoptosis. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Lygodium japonicum showed a diminished range of tissue damage. Epithelial score was improved in the Lygodium japonicum group over that of the control (P<0.05). The epithelio-stromal ratio was lower in the Lygodiutn japonicum group when compared to that of the control (P<0.05). Although there was no difference in PCNA and TUNEL positive cells of the glandular epithelia. we found an decreased number of PCNA positive cell and concurrent increase of TUNEL positive cells in the stroma of Lygodium japonicum treated rats (P<0.01). Conclusions : These findings suggest that Lygodium japonicum may protect the glandular epithelial cells and also inhibit stromal proliferation in association with suppression of cyto-proliferation and stimulation of apoptosis. We concluded that Lygodium japonicum could be a useful remedy agents for treating chronic non-bacterial prostatitis.

The Association of the -675 4G/5G and A-844G Polymorphisms of the Plasminogen Activator Inhibitor-1 Gene with a Risk of Ischemic Stroke in Korean Population

이병철,변상혁,김순일,강기훈,안세영,두호경,서정철,임강현,조성호,안영민,Lee, Byung-Cheol,Byun, Sang-Hyuk,Kim, Soon-Il,Kang, Ki-Hoon,Ahn, Se-Young,Doo, Ho-Kyung,Seo, Jung-Chul,Leem, Kang-Hyun,Cho, Seong-Ho,Oh, Chad K.,Ahn, Young-Min The Society of Internal Korean Medicine 2004 大韓韓方內科學會誌 Vol.25 No.4

연구배경 : 플라스미노겐 활성 억제인자-1 (plasminogen activator inhibitor-1; PAI-1)은 허혈성 뇌경색의 발생의 원인이 되는 섬유소 용해작용의 저하를 매개하는 인자로서, PAI-1의 작용이 촉진되면 섬유소 용해기능이 저하되어 관상동맥 및 뇌혈관질환의 발생을 증가시키게 된다. PAI-1 유전자의 촉진자(promoter) 영역에는 -675 4G/5G (4G/5G)와A -844G (A/G)의 두 개의 유전자 다형성이 존재하며, 이는 PAI-1의 유전자 전사과정에 영향을 미쳐 혈청 PAI-1의 농도를 증가시키고 결과적으로 허혈성 뇌경색의 발생확률을 높이는 작용을 하게 된다. 연구방법 : 허혈성 뇌경색으로 진단 받은 167명의 환자와 173명의 건강인의 말초혈액에서 DNA를 분리한 후 PAI-1의 4G/5G와 A/G 유전자 다형성에 대한 연쇄중합반응 및 제한효소 절편길이 다형성 (polymerase chain reaction-restriction fragment length polymorphism; PCR-RFLP) 방법을 이용하여 허혈성 뇌경색 발생과 유전자 다형성과의 관계를 비교 분석하였다. 결과 : 허혈성 뇌경색 환자에서의 4G/4G의 유전자형의 빈도는 15.0%으로 정상 대조군의 33.5%에 비해 현저하게 낮게 나타났다 (P < 0.0001). 각각의 유전자형과 허혈성 뇌경색의 발생 위험도 (odd ratio ; OR)와의 관계를 분석했을 때 4G/4G 유전자형을 가질 경우 위험도는 0.35배로 현저하게 낮아졌으며, (P < 0.0001), 5G/5G 유전자형을 가질 경우 위험도는 4.49배 로 현저하게 높아졌다 (P < 0.0001). 그러나, A/G 유전자 다형성과 허혈성 뇌경색의 발생과는 유의한 연관성을 발견하지 못하였다. 결론 : 이상의 결과로 볼 때 PAI-1 유전자의 4G/4G 유전자형은 허혈성 뇌경색의 발생 비율을 감소시키는 작용을 하는 것으로 여겨진다.

제 2형 당뇨병 및 당뇨 합병증의 발생과 Peroxisome Proliferator-Activated Receptor-$\gamma2$ C161T 유전자 다형성과의 관계

이병철,안세영,두호경,안영민,Lee, Byung-Cheol,Ahn, Se-Young,Doo, Ho-Kyung,Ahn, Young-Min 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Objective : Peroxisome proliferator-activated receptor (PPAR)-gamma, a transcription factor in adipocyte differentiation, has important effects on insulin sensitivity, atherosclerosis, endothelial cell function and inflammation. Through these effects, PPAR-gamma2 might be involved with type 2 diabetes and vascular disease, including diabetic complications. Recently, it has been reported that the C161T polymorphism in the exon 6 of PPAR-gamma is associated with type 2 diabetes interacting with uncoupling protein 2 (UCP2) gene, and is associated with acute myocardial infarction. We studied the association of this polymorphism with type 2 diabetes and its complications, such as retinopathy, ischemic stroke, nephropathy and neuropathy in Korean non-diabetic and type 2 diabetic populations. Methods : Three hundred and thirty eight type 2 diabetic patients (retinopathy: 64, ischemic stroke: 67, nephropathy: 39 and neuropathy: 76) and 152 healthy matched control subjects were evaluated. The PPAR-gamma C161T polymorphism was analyzed by PCR-RFLP. Results : PPAR-gamma C161T genotype and allele frequency did not show significant differences between type 2 diabetic patients and healthy controls (T allele: 17.0 vs. 14.5, OR= 1.21, P=0.3188). In the analysis for diabetic complications, T allele in diabetic nephropathy was significantly higher than controls (P=0.0358). T allele in the ischemic stroke patients was also higher than healthy controls, although it had no significance (P=0.1375). Conclusions : These results suggest that the C161T polymorphism of the PPAR-gamma gene might be associated with diabetic nephropathy in type 2 diabetes.

시호의 사구체 메산지움 세포 증식억제 효능 및 작용기전 연구

이병철,안영민,두호경,안세영,Lee, Byung-Cheol,Ahn, Young-Min,Doo, Ho-Kyung,Ahn, Se-Young 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4

Objective : Mesangial cell proliferation and excessive accumulation of extracellular matrix (ECM) proteins is the common pathologic feature of glomerulosclerosis, and platelet-derived growth factor (PDGF) BB-chain, transforming growth factor betal $(TGF-{\beta}1)$, cyclin dependent kinases (CDK) and CDK inhibitors mediated in these pathophysiological processes. Bupleurum falcatum which is one of the most widely used components in traditional oriental medicines, has multiple pharmacological effects, such as antipyretic, analgesic, immune modulating, anti-inflammatory, anti-allergic, anti-thrombotic, anti-atherosclerotic, and antitussive effects. Methods : In this study, we evaluated the influence of Bupleurum falcatum on mesangial cell proliferation, DNA synthesis and expression of PDGF-BB chain, $TGF-{\beta}1$, CDKI, CDK2, CDK4, p21 and p27 in fetal bovine serum (FBS)-activated human mesangial cell. Results : Bupleurum falcatum reduced the mesangial cell proliferation and DNA synthesis more than control and captopril. And in the ELISA analysis of $TGF-{\beta}1$, and RT-PCR of PDGF-BB chain, CDK1, CDK2, CDK4, p21, and p27, Bupleurum falcatum inhibited the expression of $TGF-{\beta}1$ protein and PDGF-BB, CDK1, CDK2 gene and promoted that of p21 gene in a dose-dependent manner in comparing with control and captopril. Conclusions: These results suggest that Bupleurum falcatum may inhibit the mesangial cell proliferation and DNA synthesis by regulation of PDGF-BB and $TGF-{\beta}1$ expressions, and by modulation of CDK1, CDK2 and p21 expression.

정면밀링에서의 안정성 해석 모델의 개발

이병철 ( Byung-cheol Lee ) 한국고등직업교육학회 2000 한국고등직업교육학회논문집 Vol.1 No.1

In order to design and improve a new machine tool, there is a need for a better understanding of the optimal cutting conditions under which a machine tool can be used most efficiently without deterioration of the machined surface can be determined from the stability analysis based on the dynamic characteristics of the cutting process and of the machine tool structure. In this paper, the computer programs were developed to predict the optimal cutting conditions. The results of the theoretical stability analysis are presented in the form of undeformed chip area-rotational speed in the stability chart. The theoretical optimal cutting conditions in the stability chart were verified through the analysis of the peak power of spectrum signals of the measured cutting forces in the frequency domains.

직물 미세구조의 3D 솔리드(solid) 형성 방법

이병철(Byung Cheol Lee),이예진(Yejin Lee) 한국생활과학회 2011 한국생활과학회 학술대회 Vol.2011 No.11

지능형 교통체계(ITS) 도입에 따른 효과분석기법 개발

이병철(Byung Cheol Lee),노정현(No, Jeong-Hyeon) 대한교통학회 1998 대한교통학회 학술대회지 Vol.34 No.-

ITS의 도입효과평가에 관한 외국의 사례를 검토하고, 이를 토대로 우리나라 실정에 맞는 평가항목, 기준 등 평가방안 및 운영프로그램을 마련하였다. 즉, ‘ITS’를 기능 측면, 주요기반기술 측면에서 분류하였으며, 해외 사례를 중심으로 평가항목 및 결과를 조사, 정리하였다. 또한 이 결과를 바탕으로 ITS 평가를 위한 내용적 분류 및 ITS 체계구성요소와 기반기술별 각종 ‘ITS’의 효과를 평가할 수 있는 항목, 내용 및 평가 운용 프로그램을 개발하였다.