Herbal Medicine for the Treatment of Viral Hepatitis B and C: A Systematic Review of Randomized Controlled Trials

김승모,이유리,조나경,최홍식,김경순,Kim, Seung-mo,Lee, Yu-ri,Cho, Na-kyung,Choi, Hong-sik,Kim, Kyung-soon The Society of Internal Korean Medicine 2021 大韓韓方內科學會誌 Vol.42 No.4

본 연구는 B형 및 C형 간염에 대한 한약 치료의 효과를 평가하기 위해 무작위 임상연구를 대상으로 체계적 문헌고찰 및 메타분석을 시행하였다. 검색엔진은 EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, Oasis database를 이용하였으며 국내의 검색 엔진 키워드는 '간염' 또는 '바이러스성간염', '한약', '무작위 배정 임상시험'을, 국외 검색 엔진 키워드는 'hepatitis' or 'viral hepatitis' and 'herbal medicine' or 'traditional chinese medicine' and 'randomized controlled trial'을 이용하였다. 연구 결과 15개의 무작위배정 임상시험을 선택되었으며, 그 중 통계적으로 유의미한 결과를 나타낸 연구는 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 HBV DNA loss에서 높은 효과를 보였다. 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 HBeAg loss에서 통계적으로 유의한 효과를 보였으며, 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 ALT가 감소하였다. 본 연구는 B형 및 C형 간염환자를 대상으로 한약의 효과를 확인하기 위해 기존에 시행된 RCT 연구를 대상으로 체계적 문헌고찰을 시행하였으며, 한약과 양약의 복합치료가 양약 단독치료에 비해 치료효과가 더 높은 것으로 나타났다. The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that applied herbal medicine to treat viral hepatitis B and C in order to determine the therapeutic efficacy of herbal medicine. EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, and Oasis databases were searched to identify RCTs. The selected studies were assessed by the Cochrane group's risk of bias tool. A total of 15 RCTs were selected, and the hepatitis B virus (HBV) DNA reduction was significantly higher in patients treated with herbal medicine combined with Western medicine than in patients treated with herbal medicine. Herbal medicine combined with Western medicine was also superior to Western medicine alone in achieving hepatitis B e-antigen (HBeAg) and alanine aminotransferase [ALT] reduction. Only herbal medicine alone was not superior to Western medicine treatments in achieving HBV DNA, HBeAg, and ALT reduction.

A Clinical Observation of Oriental Medicine-Based Long Care for Terminal Rectal Cancer Patient with Multiple Metastasis

방선휘,손창규,Bang, Sun-Hwi,Son, Chang-Gue The Society of Internal Korean Medicine 2008 大韓韓方內科學會誌 Vol.29 No.3

암은 현대의 모든 선진국에서 가장 주요한 사망의 원인이다. 통상적인 암 치료의 낮은 효율과 삶의 질의 중요성의 측면에서, 보완대체의학은 말기의 암 환자들에게 전 세계적으로 널리 수용되어지고 있다. 한의학은 전통적으로 종양 자체뿐만 아니라 암을 지닌 몸 전체를 함께 강조해 왔으며, 그로 인하여 종양면역을 개선시키고 환자의 삶의 질을 개선시키며 생존기간을 연장하는데 일조한다고 여겨진다. 저자는 여기에서 전신에 전이가 이루어진 말기의 직장암 환자가 한방치료를 4년 정도 받으면서 양호한 임상경과를 보여 온 환자를 보고하는 바이다. 본 연구가 암성 질환에 있어 한의학의 임상적 효용성의 예를 통하여 한의학 기반의 암 치료법의 개발과 발전에 일조하길 희망한다. Cancer is now the leading fatal disease in every developed country. Due to very low efficiency of conventional cancer therapeutics and important aspect of quality of life (QOL), complementary/alternative medicine (CAM) has been accepted worldwide, especially by late-staged cancer patients. Oriental medicine traditionally has stressed not only the tumor itself but the body having cancer, improving cancer-related immunity and extending survival period. Herein, we report one case of a terminal staged rectal cancer patient having spread-metastasis but showing a meaningful clinical course of around four years with Oriental medicine therapies. This study aimed to report the clinical capacity of Oriental medicine for patients with cancerous disease, to help development of Oriental medicine-derived anticancer treatments.

A Case Report of Hyperhidrosis with Sympathicotonia Detected by Iris Diagnosis

왕경석,채인철,박미소,손수아,박성일,유호룡,Wang, Kyeong-seok,Chae, In-cheol,Park, Mi-so,Son, Su-a,Park, Seong-il,Yoo, Ho-ryong The Society of Internal Korean Medicine 2021 大韓韓方內科學會誌 Vol.42 No.5

목적: 국소다한증 환자의 홍채진단을 사용한 변증 및 한의 치료에 대한 연구 방법: 국소다한증을 호소하여 내원한 환자에게 한의학 기본 진단법인 사진법을 사용하여 태음인임을 진단하였다. 그리고 카메라를 사용하여 홍채를 촬영하였고, 얻어진 이미지에서 교감신경항진과 관련된 표지인 권축륜의 선명하고 굵은 모습과 다수의 신경긴장선이 존재하는 모습을 통해 교감신경이 항진되어 있음을 확인하였다. 태음인 체질방을 기본으로 교감신경 항진을 조절하는 약재를 가미한 한약처방을 1개월간 복용하도록 하였다. 결과: 다양한 치료에도 호전되지 않던 30년 가까이 된 수족 다한증이 한약치료를 통해 복약 4일차부터 감소하기 시작하여 6주 만에 치료 시작 전과 비교하여 80% 호전되었다. 결론: 만성적이고 다양한 치료에도 반응하지 않던 수족 다한증에 한약 치료가 효과적일 수 있음을 이번 연구를 통해 보고한다. Objective: The aim of this case study was to describe a case of iris diagnosis of primary hyperhidrosis and the use of Korean medicine. Methods: A patient with symptoms of hyperhidrosis was diagnosed as having Taeeumin after assessment using the four basic Korean diagnostic methods. Iris diagnosis was used for further examination. The images obtained showed a remarkably defined collarette and increased nerve rings, which suggested an overactive sympathetic nerve system. Under the diagnosis of Taeeum, a Korean herbal medicine was prescribed with additional herbs to help alleviate the hyperactivity of the sympathetic nervous system. Results: The patient had been receiving treatment for hyperhidrosis for >30 years, with various medical attempts to relieve her symptoms, which were ineffective. She showed signs of improvement from day 4 into the treatment, and 80% of her symptoms were improved after completing a 6-week treatment course. Conclusion: The herbal medicine prescribed to the patient proved effective for reducing her chronic symptoms that had been unresponsive to previous medical treatments.

Post-Stroke Oculomotor Nerve Palsy Treated by Traditional Korean Medicine: Three Case Reports

Lee, Yoo-na,An, Yu-min,Jang, Woo-seok,Baek, Kyungmin The Society of Internal Korean Medicine 2019 大韓韓方內科學會誌 Vol.40 No.6

Post-stroke oculomotor nerve palsy occurs more frequently than previously reported, but only a few studies of traditional Korean medicine treatments have been reported. The symptoms are severe and difficult to treat, and current treatments are high-cost, short-lasting, insufficient for shortening the therapeutic period and promoting better recovery, or involve the risk of post-operative over-correction or under-correction. Traditional Korean medicine treatments may be comparatively effective at lower cost and less harmful. Thus, we report three cases of post-stroke oculomotor nerve palsy treated with traditional Korean medicine.

Safety of Oriental Medical Therapy: Drug Fever of Herbal Medicine and Procedure-related Fever

문수연,임경리,손준성,Moon, Soo-youn,Lim, Kyoung Ree,Son, Jun Seong The Society of Internal Korean Medicine 2021 大韓韓方內科學會誌 Vol.42 No.6

목적: 약열과 시술관련 발열(시술열)은 원내 발열의 원인이다. 한방은 여러 라에서 시행되나, 이에 의한 약열과 시술열의 빈도에 대한 자료는 없다. 본 연구의 목적은 한방치료에 의한 약열과 시술열의 빈도를 확인하는 것이다. 방법: 2006년부터 8년간 서울의 한 대학 부속 한방병원에서 후향적으로 시행했다. 결과: 한약을 복용한 10800명의 환자 중 95건의 약열이 발생하였다(0.89%). 환자들의 체온은 38.37±0.58 ℃이었고, 발열은 평균 1일간 지속되었다. 호산구증, 독성간염, 피부발진이 각각 15.79%, 8.42%, 5.26%에서 발생하였다. 약열과 관련된 흔한 한약재는 감초, 당귀, 백출이었다. 한방 시술을 받은 8125명의 환자 중 16건의 시술열이 발생하였다(0.20%). 환자들의 체온은 38.26±0.51 ℃이었고, 발열은 평균 1일간 지속되었다. 뜸이 가장 흔한 원인으로, 침이 두 번째였다. 결론: 한방치료에 의한 약열 및 시술열의 빈도는 서양의학보다 높지 않다. Objectives: Drug fever and procedure-related fever are the causes of nosocomial fever. Oriental medicine has been practiced in Asia and is now being practiced as an alternative medicine in western countries. No data are available on the incidence of drug fever and procedure-related fever in oriental medical hospitals (OMHs). The aim of this study was to identify the incidence of drug fever related to oriental herbal medicine and oriental medical procedure-related fever. Methods: This was a retrospective study at one OMH of a university medical institute in Seoul, Korea, conducted from June 2006 to June 2013. Results: Overall, 95 episodes of drug fever occurred among 10880 patients treated with herbal medicine (0.89%). Peak body temperature was 38.37±0.58 ℃, and the fever lasted for 1.0 day (range 1.0-17.0 days). Eosinophilia was found in 15 patients (15.79%) and 8 patients developed toxic hepatitis (8.42%). Five patients had a drug-related skin rash (5.26%). The most common ingredients of the herbal medicines associated with drug fever were licorice, Angelica gigas root, and white Atractylodes rhizome. In total, 16 episodes of procedure-related fever (0.20%) occurred in 8125 patients treated with oriental medical procedures. The peak body temperature was 38.26±0.51 ℃, and the fever lasted for 1.0 day (range 1.0-3.0 days). Among various oriental medical procedures, moxibustion was the most common procedure related to fever, followed by acupuncture. Conclusions: The incidence of drug fever and procedure-related fever in oriental medicine is not high compared with the incidence in western medicine.

Apoptosis and Anti-proliferaction by Saussurea lappa and Pharbitis nil in AGS Human Gastric Cancer Cell Line

Ko Seong-Gyu,Oh Hee-Rah,Lee Sun-Dong,Hwang Gwi-Seo The Society of Internal Korean Medicine 2003 大韓韓方內科學會誌 Vol.24 No.1

Objectives : We performed this study to understand the molecular basis of the antitumor effect of Saussurea lappa, Pharbitis nil, Plantago asiatica and Taraxacum mongolicum, which have been used for cancer treatment in Korean traditional medicine. Design: We analyzed, the effect of these medicinal herbs on proliferation and apoptosis of tumor cells and its association with gene expression, We performed semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) analysis of cell cycle- and apoptosis-related genes using a gastric cancer cell line AGS. Results : Cell counting assay and $[^3H]thymidine$ uptake analysis showed that Saussurea lappa and Pharbitis nil strongly inhibit cell proliferation of AGS in a dose-dependent manner. Interestingly, gene espression assay revealed that mRNA espression levels of c-Jun, c-Fos, c-Myc, and Cyclin D1 were markedly decreased by Saussurea lappa and Pharbitis nil. Furthermore, Saussurea lappa was identified to activate expression of the p53 tumor suppressor and its downstream effector $p21^{Wafl}$, which leads to $G_1$ cell cycle arrest and apoptosis. These observations suggest that the anticancer effect of Saussurea lappa and Pharbitis nil might be associated with their regulatory capability of tumor-related gene expression.

Chronic Iron Deficiency Anemia Treated with Bojungicki-tang : A Case Report

Son, Chang-Gue The Society of Internal Korean Medicine 2009 大韓韓方內科學會誌 Vol.30 No.1

Objective : To expend the oriental medicine-based strategies or therapeutics for anemia, including iron deficiency anemia. Methods : A 23 year-old man suffering from severe and chronic iron deficiency anemia was believed to have disorder of iron absorption. He had neither specific medical cause nor positive response to western treatments. Blood and biochemical parameters such as levels of hemoglobin, ferritin, transferrin and serum iron were serially chased during treatments. Result : Bojungicki-tang was given to the patient based on diagnosis as a deficiency of spleen qi. The hemoglobin level was normalized along with administration of Bojungicki-tang. Also, the distortions of biochemical indicators (ferritin, transferrin and serum iron) reached a normal range within three months. Conclusion : Bojungicki-tang could be a curing remedy for iron deficiency anemia caused by problems in iron absorption if symptom-differentiation has deficiency of spleen qi.

Survey on Satisfaction with Korean Medicine Treatment and Motives for Visiting Korean Medicine Hospital for Cancer Patients: Report of 100 Case

오현묵,김슬기,박찬란,고명현,박소정,조종관,박지혜,유화승,이남헌,손창규,조정효,Oh, Hyeon-muk,Kim, Sul-ki,Park, Chan-ran,Ko, Myung-hyun,Park, So-jung,Cho, Chong-kwan,Park, Ji-hye,Yoo, Hwa-seung,Lee, Nam-hun,Son, Chang-gue,Cho, Jung-hyo The Society of Internal Korean Medicine 2021 大韓韓方內科學會誌 Vol.42 No.4

목적: 본 연구는 대전대학교 부속 한방병원에서 암을 주소로 입원치료를 받은 환자를 대상으로 내원 동기 및 만족도를 평가하고자 한다. 방법: 총 100명의 입원환자를 대상으로 의료서비스 만족도 측정을 위한 설문조사를 실시하였다. 통계분석은 독립표본 T검정(Independent t-test), 분산 분석(ANOVA)을 사용하였다. 결과: 암환자들이 한방병원에 내원한 주된 동기는 '암의 전이 및 재발을 예방하기 위해서'로 조사되었다. 환자들은 한방 치료 중 침과 뜸에 대해 가장 높은 만족도를 보였다. 5점 척도로 구성된 만족도 조사에서 한의사 서비스와 관련된 만족도는 평균 4.80점, 의료서비스 이용 관련 만족도는 4.68점으로 나타났다. 결론: 대부분의 암환자는 한방병원의 의료서비스에 만족하는 것으로 나타났고 성별, 연령 및 직업에 따른 한방 의료서비스 만족도에는 유의한 차이가 없었다. Objectives: This study aimed to evaluate the degree of satisfaction of cancer patients and to understand their motives for visiting Korean Medicine Hospital in order to increase satisfaction with Korean medicine among cancer patients. Methods: Data collection was conducted in the form of a survey of 100 inpatients who responded to a self-report questionnaire. Independent t-test and analysis of variance (ANOVA) were used for data analysis. Results: The main reason for visiting Korean Medicine Hospital was to prevent metastasis or recurrence of cancer. Patients showed the highest satisfaction with acupuncture and moxibustion. The average degree of satisfaction related to the doctor service was, on a 5-point scale, 4.80, and that of using procedure was 4.68. Conclusion: Most of the cancer patients are satisfied with the medical services in Korean Medicine Hospital. There were no significant differences in satisfaction degree by gender, age, or occupation.

The Effect of Traditional Korean Medicine Treatment on CREST Syndrome: A Case Report

Joung, Jin-yong,Seo, Hyun-sik,Son, Chang-gue,Lee, Nam-hun,Cho, Jung-hyo The Society of Internal Korean Medicine 2017 大韓韓方內科學會誌 Vol.38 No.2

CREST syndrome is a form of limited cutaneous scleroderma that occurs only in certain parts of the body, such as the skin of the hands and face. CREST refers to the five main features of the syndrome: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. Currently, there is no standard treatment for CREST syndrome, and there have been no studies of the use of traditional Korean medicine (TKM) for this disease. This study describes the effects of Keumsuyukun-jeon on CREST syndrome. The patient in this case had typical clinical symptoms of CREST syndrome. These symptoms improved within a relatively short period of receiving the TKM treatment. The results of Anti-centromere antibody (AI) and high sensitivity C-reactive protein (mg/L) also improved.

Yukgunja-tang for Irritable Bowel Syndrome: A Protocol for a Systematic Review and Meta-Analysis

Kangwook Lee,Seok-Jae Ko,Minjeong Kim,Chaehyun Park,Min-Seok Cho,Jae-Woo Park The Society of Internal Korean Medicine 2023 大韓韓方內科學會誌 Vol.44 No.3

Background: Irritable bowel syndrome (IBS) is a digestive disorder characterized by abdominal discomfort or pain accompanied by a change in stool condition. Owing to its complicated mechanisms, a standard treatment for IBS has not yet been established. Yukgunja-tang (YGT) is a Korean herbal medicine known in Asia to be effective in the treatment of gastrointestinal symptoms. In this study, we will conduct a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of YGT in IBS treatment. Methods and analysis: English databases, such as Embase, Medline (via PubMed), Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials, will be searched for articles published up to April 2023. Additional databases, such as five Korean, one Chinese, and one Japanese database, will be included. RCTs and quasi-RCTs will also be included in the assessment of the efficacy of YGT. The overall efficacy rate will be the primary outcome, and data such as IBS quality-of-life measurements, global symptom scores, and adverse events will be the secondary outcomes. Review Manager Version 5.3 will be used for evaluation, and the risk of bias (RoB) will be evaluated using Cochrane Collaboration's RoB tool. The Grading of Recommendations Assessment, Development, and Evaluation approach will be used to score the quality of evidence. Conclusion: This study will demonstrate the efficacy and safety of YGT for treating patients with IBS.