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안세영,박정균,Inkyung An,정승준,황정욱 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.3
A mammalian cell renovates itself by autophagy, a pro-cess through which cellular components are recycled to produce energy and maintain homeostasis. Recently, the abundance of gap junction proteins was shown to be regulated by autophagy during starvation conditions, suggesting that transmembrane proteins are also regulated by autophagy. Transient receptor potential vanilloid type 1 (TRPV1), an ion channel loca-lized to the plasma membrane and endoplasmic reticu-lum (ER), is a sensory transducer that is activated by a wide variety of exogenous and endogenous physical and chemical stimuli. Intriguingly, the abundance of cellular TRPV1 can change dynamically under pathological conditions. However, the mechanisms by which the protein levels of TRPV1 are regulated have not yet been explored. Therefore, we investigated the mechanisms of TRPV1 recycling using HeLa cells constitutively expressing TRPV1. Endogenous TRPV1 was degra-ded in starvation conditions; this degradation was blocked by chloroquine (CLQ), 3MA, or downregulation of Atg7. Interestingly, a glucocorticoid (cortisol) was capable of inducing autophagy in HeLa cells. Cortisol increased cellular conversion of LC3-I to LC-3II, leading autophagy and resulting in TRPV1 degradation, which was similarly inhibited by treatment with CLQ, 3MA, or downre-gulation of Atg7. Furthermore, cortisol treatment induced the colocalization of GFP-LC3 with endogenous TRPV1. Cumulatively, these observations provide evidence that degradation of TRPV1 is mediated by autophagy, and that this pathway can be enhanced by cortisol.
수학적 모델로 이용한 질소$\cdot$인 처리 공정 설계
안세영 한국환경기술인연합회 2002 환경기술인 Vol.19 No.9
하$\cdot$폐수처리시설의 설계에서 컴퓨터 모델링을 사용하는 목적은 처리공정을 최적화 하기 위함이다. 기존의 하$\cdot$폐수처리장을 생물학적 질소$\cdot$인 제거 (이하 BNR) 시설로 개조하거나 신설 BNR 공정을 설계하려면 계획 시설에 대한 타당성 조사를 수행해야 하는데, 여러가지 처리공법을 분석하여 처리공정을 선정하고 선정된 공정의 성능과 운영방법, 그리고 시설비용 및 운영비용을
안세영,민벙형 한국농공학회 1980 한국농공학회논문집 Vol.22 No.4
This study is carried out to estimate the rate of sediment transportation both to measure the amount of suspended and bedload sediment that moves on or near the river bed and passes through the cross section of a river in unit time, with suspended and bed load samplers used for the Milyang river and to determine the most satisfactory and convenient formula of some formulas for sediment discharge by comparing the measured rate with the calculated rate. The results of this study are summarized as follows; 1) The interrelationship (1) between the total discharge and the total sediment discharge (2) between discharge and suspended sediment load and (3) between discharge and bed load in the Milyang river are (1) i) 4$\leq$Q$\leq$100 C.M.S. Qr=0. 00272 Q0.70 (kg/sec) ii) 150$\leq$Q$\leq$800 C.M.S. Qr=0. 4807 Q0.46 (kg/sec) (2) Qs~=0. 07576 Q1.02 (kg/sec) (3) QB=0. 00957 Q0.44 (kg/sec) 2) The rate of suspended sediment load to total sediment discharge is found to be about; 99%. The suspended load is shown to be almost wash load which consists of silt and clay. 3) The relation between the total discharge and the suspended sediment load that are measured at three medium and small rivers in Korea is Qs=0. 13831 Q0.97 (kg/sec) 4) Brown's formula is determined to be the most convenient formula for application and comparison with observed data obtained for the Milyang river.
리튬이차전지 난연성 전해액 첨가제로서의 Tris(2,4,6-trimethoxyphenyl)Phosphine의 열적, 전기화학적 특성
안세영,김기택,김현수,Ahn, Se-Young,Kim, Ke-Tack,Kim, Hyun-Soo 한국전기전자재료학회 2008 전기전자재료 Vol.21 No.12
Thermal and electrochemical properties were discussed with tris(2,4,6-trimethoxyphenyl)Phosphine (TTMPP) as a flame retradant additive for Li-ion battery. TTMPP showed excellent thermal stability with charged cathodes. Addition of 1 wt.% of the additive to the electrolyte improved the thermal stability without damaging the performance of the battery. The oxygne evolution reaction delayed nearly by $60^{\circ}C$. The capacity retention ratio in cycle life tests of the battery with 1 wt.% TTMPP was slightly improved comparing to the no additive cells.
리튬이차전지 난연성 전해액 첨가제로서의 Tris(2,4,6-trimethoxyphenyl)Phosphine의 열적, 전기화학적 특성
안세영,김기택,김현수,Ahn, Se-Young,Kim, Ke-Tack,Kim, Hyun-Soo 한국전기전자재료학회 2008 전기전자재료학회논문지 Vol.21 No.12
Thermal and electrochemical properties were discussed with tris(2,4,6-trimethoxyphenyl)Phosphine (TTMPP) as a flame retradant additive for Li-ion battery. TTMPP showed excellent thermal stability with charged cathodes. Addition of 1 wt.% of the additive to the electrolyte improved the thermal stability without damaging the performance of the battery. The oxygne evolution reaction delayed nearly by $60^{\circ}C$. The capacity retention ratio in cycle life tests of the battery with 1 wt.% TTMPP was slightly improved comparing to the no additive cells.
리튬이온전지용 난연성 첨가제(TCP, TFPP)의 전기화학적 특성
안세영,김기택,김현수,남상용,Ahn, Se-Young,Kim, Ke-Tack,Kim, Hyun-Soo,Nam, Sang-Yong 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.9
Flame retardant(FR) properties were investigated with tricredyl phosphate(TCP) and tris(pentafluorophenyl)phosphine(TFPP) as additives for lithium-ion batteries. Thermal stability was improved with additives in $Li/LiNi\frac{1}{3}Mn\frac{1}{3}Co\frac{1}{3}O_2$ cells comparing to non-additive electrolytes. Oxygen evolution reaction of the cathode material was delayed to up $55^{\circ}C$, from $275^{\circ}C\;to\;330^{\circ}C$. Electrolytes with the 1 wt.% additives provided good FR properties while the resonable battery performance is maintained.
하수처리장 에너지자립화사업에서 혐기성소화공정으로부터 용출되는 용존성질소(NH3-N)의 처리 필요성 연구
안세영 유기성자원학회 2014 유기물자원화 Vol.22 No.3
Soluble nitrogen produced from anaerobic digestor is able to have a strong influence on the effluent water quality of municipal wastewater treatment plants during a winter season in particular. The modeling results using the GPS-X simulation software shows that the soluble nitrogen concentration generated from the anaerobic digestor is 214.1 mg/L in the return flow and 6.2 mg/L in the inflow of the primary settler higher than those in nonexistence of the anaerobic digestor, respectively. In the case of using a separation process (flotation thickener) in order to treat the return flow from the sludge treatment system, the soluble nitrogen concentration in the effluent from the separation process and in the inflow of the primary setter could be 6.0 mg/L higher and 0.7 mg/L lower than those of nonexistence of the process, respectively. The modeling results propose the need of the equipments to be able to remove the soluble nitrogen (NH3-N) produced from the digestor in the improvement projects of anaerobic digestor in municipal wastewater treatment plants. 하수슬러지를 혐기성 소화하는 과정에서 용출되는 용존성질소는 다시 수처리시설로 반송되어 질산화 효율이 떨어지는 동절기 법적 방류수 질소 수질기준에 영향을 준다. 컴퓨터 시뮬레이션 소프트웨어(GPS-X)를 이용하여 A하수처리시설을 대상으로 소화조에서 발생하는 용존성질소의 영향을 조사한 결과, 소화조가 있는 처리시설에서의 총 반송수와 1차침전지 유입수 용존성질소 농도는 소화조가 없는 시설에서의 농도보다 각각 214.1 mg/L, 6.2 mg/L 높게 산출되었다. 슬러지 처리시설에서의반송수를 처리하는 반송수처리시설(부상분리조)을 설치하는 경우 총반송수 용존성질소 농도는 반송수처리시설이 없는 경우보다 6.0 mg/L 높게 나타났으며 1차침전지 유입수 용존성질소 농도를 0.7 mg/L 낮게 산정되었다. 시뮬레이션 결과, 하수슬러지를 혐기성소화하여 에너지자립화율을 향상시키는 사업에서 슬러지 처리시설에서 발생하는 여액과 상등액의 용존성질소(NH3-N)를 처리할 수 있는 시설이 필요한 것으로 나타났다.