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알츠하이머병과 경도인지장애환자에서 K-MMSE와 시계그리기 동시 수행에 대한 예비연구
허재혁,박태환,안진영,김민기 대한치매학회 2011 Dementia and Neurocognitive Disorders Vol.10 No.2
Background: Korean version of Mini-Mental Status Examination (K-MMSE) and Clock Drawing Test (CDT) have been widely used as quick neuropsychological tests to screen for dementia in various clinical settings. We aimed to assess the diagnostic validity of the fusion of the two tests in Alzheimer dementia (AD) and mild cognitive impairment (MCI). Methods: A total of 91 subjects (33 AD, 24 MCI, 34 controls) who visited the neurology outpatient clinic of Seoul Medical Center were included. The receiver operating characteristic (ROC) curve was used to determine optimal cut-off score, sensitivity, and specificity in screening AD and MCI. Results: K-MMSE plus CDT and K-MMSE only showed the similar area under the curve (AUC), sensitivity, and specificity for the diagnosis of AD. The AUC, sensitivity, and specificity for K-MMSE plus CDT were 0.906, 91%, and 82% and for K-MMSE were 0.894, 85%, and 79%, respectively. The difference of AUC was not statistically significant. In addition, this combination showed poor utility in MCI. Conclusions: This study has failed to show any superiority of the combination of K-MMSE plus CDT over K-MMSE only in diagnosis of Alzheimer dementia.
건강보험심사평가원 자료를 이용한 5년간(2003-2007년) 치매 환자치료 추세동향
허재혁,김형수,배희준,이건세,배명훈,이정빈 대한치매학회 2010 Dementia and Neurocognitive Disorders Vol.9 No.1
In Korea, the elderly population and the prevalence of dementia has increased rapidly. The aim of this study is to describe and analyze the status in treatment of dementia for recent 5 yr in Korea. Methods: The Health Insurance Review & Assessment Service (HIRA)’s data which had various variables during 5 yr from 2003 to 2007 was used. Dementia was analyzed by the visit days, benefit amounts, and real patients in Out Patient Department (OPD) and admission. In addition, the distributions of the clinical department for dementia were presented. Results: The days of OPD visit and admission for dementia increased from 328,967 (2003,OPD) and 1,821,825 (2003, admission) to 765,599 (2007, OPD) and 7,433,913 (2007, admission). The benefit amounts of OPD and admission increased from 11,884,657,000 won (2003,OPD) and 64,742,232,000 won (2003, admission) to 40,849,297,000 won (2007, OPD) and 366,694,852,000 won (2007, admission). The real patients of OPD and admission increased from 59,861 (2003, OPD) and 18,515 (2003, admission) to 132,869 (2007, OPD) and 63,141(2007, admission). Among the clinical departments, in 2007, department of neurology had the greatest percentage in visit days (OPD). Conclusions: This study clarifies the magnitude of the dementia treatment in the viewpoint of visit days, benefit amounts, real patients, and the distribution of the clinical department treated at. Department of Neurology had a major role in dementia care, which had been increasing during 5 yr.
허재혁,류춘근,정은주,백진희,황대용 대한대장항문학회 2017 Annals of Coloproctolgy Vol.33 No.4
Purpose: Virtual colonoscopy is the most recently developed tool for detecting colorectal cancers and polyps, but its effectiveness is limited. In our study, we compared the result of preoperative virtual colonoscopy to result of preoperative and postoperative colonoscopy. We evaluated also the accuracy of preoperative virtual colonoscopy in patients who had obstructive colorectal cancer that did not allow passage of a colonoscope. Methods: A total of 164 patients who had undergone preoperative virtual colonoscopy and curative surgery after the diagnosis of a colorectal adenocarcinoma between November 2008 and August 2013 were pooled. We compared the result of conventional colonoscopy with that of virtual colonoscopy in the nonobstructive group and the results of preoperative virtual colonoscopy with that of postoperative colonoscopy performed at 6 months after surgery in the obstructive group. Results: Of the 164 patients, 108 were male and 56 were female patients. The mean age was 62.7 years. The average sensitivity, specificity, and accuracy of virtual colonoscopy for all patients were 31.0%, 67.2%, and 43.8%, respectively. In the nonobstructive group, the average sensitivity, specificity, and accuracy were 36.6%, 66.2%, and 48.0%, respectively, whereas in the obstructive group, they were 2%, 72.4%, and 25.4%. Synchronous cancer was detected via virtual colonoscopy in 4 of the 164 patients. Conclusion: Virtual colonoscopy may not be an effective method for the detection of proximal colon polyps, but it can be helpful in determining the therapeutic plan when its results are correlated with the results of other studies.
방풍산(防風散)이 실험동물(實驗動物)의 심혈관계(心血管系)에 미치는 영향(影響)
허재혁,김세길,Huh, Jae-Hyeok,Kim, Seh-Gil 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1
The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.