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불안정형 관동맥질환 환자에서 주요 심혈관 사건의 예측 인자로서의 심근 Troponin 1 및 Myoglobin 에 관한 연구
허재웅(Jae Woong Hur),김경현(Kyung Hyun Kim),하영준(Young Jun Ha),박찬수(Chan Su Park),서우종(Woo Jong Seo),조영재(Yeong Jae Cho),차경우(Keung Woo Cha),남시현(Si Hyun Nam),김종연(Jong Yeon Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.5
N/A Background: Patients with unstable angina or non Q wave myocardial infarction still have an elevated risk for subsequent cardiac events. Therefore early assessment of the risk of future cardiac events is important. In this study, prognostic value of troponin I and myoglobin was evaluated and compared with other known early available risk indicators. Methods: Serum troponin I and myoglobin were measured at presentation and 8 hours, 16 hours, and 24 hours thereafter in 126 patients with unstable angina (n=70) or non Q myocardial infarction (n=56) from Jan 1998, through Feb 2000. Echocardiography was performed with calculation of wall motion score index. The incidence of cardiac death or myocardial infarction was compared between patients with normal troponin I, myoglobin and abnormal ones, respectively. Results: (1) At 6 months, 1 death (2.2%) and 1 myocardial infarction (2.2%) occurred in the 45 unstable angina patient s with normal troponin I compared with 3 deaths (12.0%) and 8 myocardial infarctions (32.0%) in the 25 unstable angina patient s with elevated troponin I. (2) At 6 months, 1 death (1.7%) and 3 myocardial infarctions (5.2%) occurred in the 58 unstable angina patients with normal myoglobin compared with 3 deaths (25.0%) and 6 myocardial infarctions (50.0%) in the 12 unstable angina patient s with elevated myoglobin. (3) When the analysis was limited to patients with normal baseline troponin I (≤0.4 ng/ dl: n=45), increased myoglobin level remained significantly associated with increased incidence of cardiac deaths or myocardial infarction compared with normal myoglobin level (16.7% vs 0%). (4) Together with age, diabetes, wall motion score index, troponin I and myoglobin levels were identified as independent prognostic variables for myocardial infarction or cardiac death in a multivariate logistic regression analysis. (5) The maximal troponin I and myoglobin value obtained during the first 24 hours provides independent and import ant prognostic information regardless of whether the patient is classified as having unstable angina or non Q wave myocardial infarction. Conclusion: The maximum troponin I and myoglobin obtained during the first 24 hours provides independent and important prognostic information in patients with unstable angina or non Q wave myocardial infarction. (Korean J Med 61:496- 505, 2001)
[동력전달계] 건설차량용 자동변속기 동력전달장치의 모델링 및 해석
박정렬(Jung Yul Park),허재웅(Jae Woong Hur),정규홍(Gyu Hong Jung),이교일(Kyo Il Lee),김관수(Kwan Soo Kim) 한국자동차공학회 1999 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1999 No.11_2
In general. the transient torque takes place when the gear shifts in the vehicle equipped with automatic transmission. The modeling of the powertrain is necessary for design the control algorithm to decrease the transient torque. In this study, the modeling of powertrain dynamics for the construction vehicle is established and the velocity analysis is accomplished. Automatic transmission for this system is ALT(Automotive Layshaft Transmission) type and has many shafts and rotating members. So the velocity analysis is achieved by classitying all element into three rotating groups and dynamic modeling is accomplished with three equivalent inertia models that are always in gear with each other. And the transient shift model is obtained by using this equivalent inertia model and the kinematic constraints for each gear shift. Also, the torque and pressure of each element which is required when the gear shifts can be obtained by static characteristic analysis and the minimum line pressure in hydraulic system can be set up through this result.
[동력전달계부문] 건설 차량용 자동변속기의 동력전달계 파라미터 민감도 분석 및 식별
최길우(Gil Woo Choi),박정렬(Jung Yul Park),허재웅(Jae Woong Hur),정규홍(Gyu Hong Jung),이교일(Kyo Il Lee),김관수(Kwan Soo Kim) 한국자동차공학회 2000 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
In the precedent work, we established a mathematical modeling of powertrain dynamics for the construction vehicle. The target system has automotive layshaft transmission that consists of many shafts and rotating members. To simulate shifting mechanism with good precision, it is very important to identify the parameters of internal powertrain elements. Furthermore, so is it in point of the performance prediction, simulation analysis and control application.<br/> In this paper, we discuss sensitivity analysis to examine the effect of parameter variations on vehicle turbine speed. And we accomplish the identification of the parameters of the powertrain elements by conducting several experiments. In some cases, we made an actual device for measuring inertia moment of the rotating members. For the estimation of the other parameters, we conducted shifting experiments and used least-square-method based on the turbine speed error between simulation and experiment. We then confirm good estimation accuracy by proving that the estimated parameters can also be applied to another experimental condition.
성영호,이재성,김희식,허재웅,오현한,하영준,김경현 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1
Agenesis of the right lobe of the liver is an extremely rare anomaly of the liver, and few cases are reported in the literature. Most of the patients with this anomaly are accompanied by additional anormalies such as retrohepatic or suprahepatic gallbladder and other biliary tract diseases, including cholelithiasis, carcinoma of the gallbladder and portal hypertension. The diagnosis of this rare anatomical variant was established by ultrasonography and computed tomography. The radiological findings, clinical presentation, and differential diagnosis are reviewed.(Korean J Hepatol 2000;6:124-128)
^14C-요소 호기검사를 이용한 Helicobacter pylori의 3제요법과 2제요법의 제균율 분석
이승현,전상훈,서창균,김상현,이영석,허재웅,전석길,안성훈 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1
H. pylori 감염은 만성 활동성 위염, 위 또는 십이지장 궤양의 가장 중요한 원인이며, 위선암, 위임파선종의 발생과 관계있고 H. pylori가 제균되면 궤양치유가 촉진되고 재발율을 줄인다. H. pylori의 초기 제균요법 실시 후 ^14C-요소 호기검사를 이용하여 제균 효과를 비교 분석하였다. 이 연구에서는 H. pylori에 감염된 소화성 궤양환자 79명을 대상으로 무작위로 두 군으로 나누어 H. pylori 제균요법 중 3제요법(omeprazole, clarithromycin, amoxicillin)과 2제요법(omeprazole, clarithromycin)을 실시하였고, 치료 4-8주 경과후 ^14C-요소 호기검사를 이용하여 H. pylori의 제균 효과를 비교하였다. 치료 후 요소 호기검사에서는 3제요법을 사용한 군 59명중 52명이 음성으로 나와 88.1%의 제균율을 보였고 2제요법을 사용한 군 20명중 7명이 음성으로 나와 35%의 제균율을 보여 3제요법군이 2제요법군보다 유의한 제균율의 차이를 보였다. Helicobacter pylori (H. pylori) infection is associated with chronic active gastritis, duodenal and gastric ulcers, gastric adenocarcinoma, and gastric lymphoma. The eradication of H. pylori not only results in the healing of ulcer but also reduces recurrence of peptic ulcer. Using ^14C-urea breath test, we compared the efficacy of omeprazole-based triple therapy and dual therapy in patients with H. pylori-positive peptic ulcer. Seventy nine H. pylori-positive patients with peptic ulcer were enrolled and randomly divided into two groups. Fifty nine patients received triple therapy (omeprazole, clarithromycin and amoxicillin) for 7 days and twenty patients received dual therapy (omeprazole and clarithromycin) for 14 days. The eradication of H. pylori was assessed by ^14C-urea breath test 4-8 weeks after the completion of each therapy. The overall eradication rate of H. pylori, using ^14C-urea breath test, was 88.1% in the triple therapy group and 35% in the dual therapy group, therefore the eradication rate of triple therapy was higher than that of dual therapy.