A Comparison of the Accuracy of Different Single Plasma Sample Methods for Measuring Glomerular Filtration Rate Using 51Cr-EDTA in Children

하세진,이종진 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.4

Purpose Among the different methods of measuring glomerular filtration rate (GFR) using 51Cr-ethylenediaminetetraacetic acidclearance, the two-plasma-sample method (TPSM) is widely used, and highly accurate. The single-plasma-sample method(SPSM) is occasionally used for simplicity, at the expense of accuracy. Our aims were (1) to investigate the correlation and(2) to compare the accuracy of six known SPSMs in pediatric patients in reference to TPSM. Methods We retrospectively reviewed 122 pediatric cases (65 boys, age 7.3 ± 4.6 years) and analyzed 307 GFR measurements. SPSMs included Groth and Aasted at 120 min, Hamat 120 min, Christensen and Groth at 120 and 240 min, and Jacobsson at 120and 240 min. Reference GFR (GFRref) was defined using TPSM GFR corrected by the Jodal and Brochner-Mortensen equation. GFRref < 30 mL min−1 1.73 m−2 were excluded. The standard error of the estimate (SEE) and the number of cases withdifferences > 10% (N10%) were used to evaluate accuracy. Results SPSMs generally correlated well with GFRref (r = 0.92~0.99) and were relatively accurate (SEE = 9.21~15.60). Grothand Aasted showed the smallest SEE, while Jacobsson at 240 min showed the smallest N10% for all GFRref ranges. As for thedecreased GFRref, Ham was most accurate followed by Jacobsson at 240 min. Conclusions Jacobsson at 240 min provided good accuracy in all GFRref ranges and was well correlated with TPSM. Jacobsson at240 min might be the most appropriate method to substitute for TPSM in pediatric patients. Ham could be an alternative inpatients with impaired renal function.

Successful Localization Using 68Ga-DOTATOC PET/CT of a Phosphaturic Mesenchymal Tumor Causing Osteomalacia in a Patient with Concurrent Follicular Lymphoma

하세진,박수진,김현지,고현정,이승헌,최지윤,홍정용,류진숙 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.6

Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate theresponsible tumor. This report describes the ability of 68Ga-DOTATOC PET/CT to successfully distinguish between the responsiblephosphaturic mesenchymal tumor and concurrent lymphoma lesions. A 52-year-old man with bone pain for several yearswas diagnosed with a vitamin D-resistant hypophosphatemic osteomalacia. Whole body 18F-FDG PET/CT revealed multipleenlarged hypermetabolic lymph nodes in his bilateral cervical, axillary, mediastinal, abdominal, pelvic, and inguinal regions. Core needle biopsy of the right cervical lymph node confirmed the diagnosis of follicular lymphoma. However, lymphoma wasnot considered the cause of osteomalacia. 68Ga-DOTATOC PET/CT before chemotherapy showed a small nodule with intenselyincreased uptake in the right inguinal region, which was distinguished from the other enlarged lymph nodes. The nodule wassurgically removed and histopathologically consistent with phosphaturic mesenchymal tumor. After surgery, the patient’s serumphosphorus and alkaline phosphatase levels normalized without nutritional supplement.

Spillover from past recycling to green apparel shopping behavior: the role of environmental concern and anticipated guilt

하세진,권소연 한국의류학회 2016 Fashion and Textiles Vol.3 No.1

This study explores catalytic behavior in the context of pro-environmental behaviors by examining the occurrence of spillover that performing recycling behavior promotes the likelihood to engage in green apparel purchases. Additionally, this study incorporates a potential mediator and a moderator, environmental concern and anticipated guilt, respectively, in order to explain the nature of the spillover process. The results of online survey data confirm the development of spillover in consumer behavior that past recycling behavior does spill over into green apparel/fashion product purchase behaviors through one’s motivational belief toward the environment, environmental concern. However, anticipated guilt, a motivation factor, does not moderate spillover among pro-environmental behaviors, at least between past recycling behavior and green apparel shopping behaviors. Theoretically, this study contributes to and extends the literature on spillover in pro-environmental behaviors by testing spillover across distinctive pro-environmental behaviors. This study also provides lessons for fashion retail marketers and government agencies in learning the importance of the social and ethical aspects of consumers’ green practices, beyond price/quality-based choices. Limitations and future research directions are discussed.

Simvastatin 단독요법과 Ezetimibe/Simvastatin 병용요법의 간 손상 발현 빈도 비교

하세진,김수진,조윤숙,이혜숙,김향숙 한국병원약사회 2013 病院藥師會誌 Vol.30 No.6

Ezetimibe was approved by the FDA in 2002 and again by the KFDA in 2004 for either in hypercholesterolemia alone or in combination with statins. It was considered to be safer than statins in terms of hepatotoxicity. However, certain cases of serious cholestatic hepatitis and acute immune hepatitis are recently being reported. Also, the incidence of abnormal LFT that significantly elevated more than three times of the upper limits of normal (ULN) is being reported to be 2% with the ezetimibe and simvastatin combination therapy, and there were no reported cases with simvastatin monotherapy in the study published in 2004. Three out of four adverse events being reported in the Drug Safety Monitoring Center of SNUH are associated with liver enzyme elevations and intrahepatic cholestasis. However, the rarely published about ezetimibeinduced hepatic injury and long-term safety studies are still insufficient. This study includes the patients who were administered with either ezetimibe and simvastatin (472) or simvastatin alone (494) between July 2009 and June 2010 at SNUH, and also analyzed the incidence rate of drug-induced liver injury by using LFTs. We defined the liver injury criteria as ALT ≥ 3×ULN, ALP ≥ 2×ULN, or if ALT or ALP is elevated, the total bilirubin (TB) ≥ 3×ULN,and then assessed the incidence according to age, gender, treatment duration, and disease. Data were collected by data-mining processes, retrospectively. We observed significant increases of liver injury in the combination group as compared with the simvastatin group. It thus suggests that ezetimibe and simvastatin combination therapy may have higher rates of liver injury than simvastatin monotherapy, and for this reason, special caution is required when administering ezetimibe.

리테일 서비스 로봇의 소비자 수용에 관한 연구

정소원,하세진 복식문화학회 2020 服飾文化硏究 Vol.28 No.4

Building on Technology Readiness and Acceptance Model(TRAM), the study aimed to examine how technology readiness affects consumers’ perceptions of ease of use, usefulness, and risk, which in turn predict their intention to use retail service robots. Specifically, the study proposed that technology readiness motivators (optimism and innovativeness) would influence perceived ease of use and usefulness, while technology readiness inhibitors (discomfort and insecurity) would affect perceived risk. The study further examined if the perception factors (ease of use, usefulness, and risk) contribute to intention to use retail service robots. A survey method was used with data collected from Korean consumers. The final sample size was 418. The data was analyzed using structural equation modeling. Findings of the study revealed that technology readiness motivators positively affected perceived ease of use and usefulness while innovativeness had no impact on usefulness. All the inhibitors increased perceived risk. Lastly, as hypothesized, perceptions of ease of use, usefulness, and risk predicted intention to use retail service robots. This study extended the retail technology literature by applying and validating TRAM to the context of consumer acceptance of retail service robots. The study further helped marketers and retailers by highlighting the importance of technology readiness in improving consumer perceptions and responses towards retail service robots.

False-negative Hepatobiliary Scintigraphy for Biliary Atresia

김현지,박수진,하세진,김재승,김대연,오민영 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.5

We present the case of a patient with biliary and duodenal atresia who showed false-negative hepatobiliary scintigraphy results. The patient was born at 37 weeks and 2 days of gestation. Her mother had undergone amnioreduction after detection of a doublebubble ultrasound sign in the fetal abdomen. At 2 days of age, total serum bilirubin level was elevated. On hepatobiliary scintigraphy 4 days later, the gallbladder was visualized from 30 min and it showed duodeno-gastric reflux at 240 min. After 24 h, the radiotracer was almost washed out in the hepatic parenchyma, but there was retention in the gastroduodenal junction. Because the biliary to duodenal transit was visible, biliary atresia seemed unlikely. Abdominal ultrasonography at 7 days of age showed a small dysmorphic gallbladder, but triangular cord sign was not definite. Magnetic resonance cholangiography revealed atretic gallbladder. Although cystic and common bile ducts were visible, the proximal common hepatic bile duct was not visible. The next day, serum total bilirubin levels remained elevated (17.1 mg/dl) with direct bilirubin level of 1.2 mg/dl. Kasai portoenterostomy with duodeno-duodenostomy was performed at 10 days of age. Histopathological evaluation showed a fibrous obliteration of the common bile duct, consistent with that of biliary atresia.

Predicting Vascularized Bone Graft Viability Using 1-Week Postoperative Bone SPECT/CT After Maxillofacial Reconstructive Surgery

김현지,이고은,하세진,신언우,안강민,이지호,류진숙 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.6

Purpose We aimed to evaluate the performance of hybrid bone single-photon emission computed tomography (SPECT)/computed tomography (CT) in predicting bone graft viability after maxillary or mandibular reconstructive surgery with vascularized bone grafts. Methods We retrospectively reviewed 46 bone planar scintigraphy and SPECT/CT images of 45 adult patients taken at 1 week (5–8 days) after maxillary or mandibular reconstructive surgery with vascularized bone grafts. By visual analysis, two nuclear medicine physicians scored the uptake degrees of each bone graft segment compared with the calvarium uptake on planar bone scintigraphy and SPECT/CT, respectively (0 = absence of uptake, 1 = less uptake, 2 = similar uptake, and 3 = more uptake). The imaging results were compared with clinical follow-up for assessing bone graft viability. Results During follow-up, five bone graft segments were surgically removed and confirmed as nonviable—one had a score of 0, although the other four had a score of 1–3 on planar bone scintigraphy. All five bone graft segments were scored 0 on SPECT/CT and eventually confirmed as nonviable. All other graft segments with a score of > 1 on SPECT/CT were viable and uneventful. The anatomical CT information on SPECT/CT images was helpful in discriminating bone graft uptake from adjacent bone or soft tissue uptake. Conclusions The absence of tracer uptake by the vascularized bone graft on bone SPECT/CT at 1 week after maxillary or mandibular reconstructive surgery can predict graft failure. Bone SPECT/CT can be used to predict vascularized bone graft viability postoperatively.

Consumer evaluation of customer loyalty programs: the role of customization in customer loyalty program involvement

Erica Winters,하세진 한국마케팅과학회 2012 마케팅과학연구 Vol.22 No.4

This study investigates the role of customizing the offerings (rewards and services) of a customer loyalty program in consumers’ responses regarding perceived value (cash value and emotional value), satisfaction with the loyalty program, and loyalty intention toward the focal retailer. It also examines the moderating role that customer loyalty program involvement may play in value–satisfaction–loyalty associations. Data were collected from 174 college students using a web-based survey. Results yield overall support for the model in which customization of a loyalty program influences perceived cash value of the loyalty program, which in turn influences perceived emotional value,satisfaction with the loyalty program, and loyalty toward the retailer. Additionally,consumer involvement in customer loyalty programs moderates the effectiveness of customer loyalty programs by differentiating the degrees to which perceived emotional value and satisfaction influence loyalty intention.

P-135 The Value of 18F-FDG PET/CT in evaluating disease severity in idiopathic pulmonary fibrosis

윤희영,고의원,이석현,하세진,류진숙,김동순,송진우 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Objectives: Several biomarkers have been reported to be useful in assessing disease severity of idiopathic pulmonary fibrosis (IPF); however, the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG/PET-CT) is not well defined. The aim of study was to investigate the value of 18F-FDG PET/CT for assessing disease severity in IPF Methods: Clinical data were retrospectively reviewed in 89 IPF patients (mean age: 68.1 years, male: 94%) who performed 18F-FDG PET/CT for cancer evaluation at Asan Medical Center, Seoul. Standardized uptake value (SUV) was measured only in fibrotic area, and lesion-to-liver SUV ratio (SUVR) was also obtained. Correlation between 18F-FDG PET/CT parameters (SUV and SUVR) and clinical parameters including lung function, exercise capacity, and GAP index were analyzed. Results: Median follow-up period was 11.9 months and lung cancer was confirmed in 61 (69%) patients. SUV and SUVR were significantly correlated with forced vital capacity (r=-0.214, r=-0.275, respectively), diffusing capacity for carbon monoxide (r=-0.375, r=-0.373), distance (r=-0.297, r=-0.318) and the lowest oxygen saturation (r=-0.255, r=-0.339) during 6-minute walk test, and GAP index (r=0.343, r=0.321). SUV were also significantly correlated with decline in total lung capacity after 6 months (r=-0.501). SUVR was predictor for death (hazard ratio [HR]: 1.466; 95% confidential index: 1.009-2.131; p=0.045) on univariate analysis Conclusions: Our findings suggest that 18F-FDG PET/CT may be useful to assess disease severity in patients with IPF.

SNS 브랜드 페이지에서 소비자-브랜드 관계 형성에 미치는 영향 요인 분석 - 준사회적 상호작용 역할을 중심으로 -

박지선 ( Jee-sun Park ),하세진 ( Sejin Ha ) 복식문화학회 2017 服飾文化硏究 Vol.25 No.1

The rapid growth in the popularity of social media sites has meant that social media has become an important communication channel for brands. Brands create brand pages on social media to cultivate positive and strong relationships with consumers. This study seeks to enhance our understanding of how fashion brand pages in social media foster consumer-brand relationships by exploring the factors that affect the development of consumer-brand relationships. Drawing on the parasocial interaction theory, this study proposes parasocial interaction as a key factor of this process. Specifically, this study proposes four antecedents (vividness, interactivity, social presence, and focused attention) of consumers` parasocial interaction with brand pages, which further affects consumer responses in terms of affective engagement and brand loyalty. An online survey was administered with consumers who have followed and visited at least one fashion brand page via a social networking site (SNS). Structural equation modeling revealed that consumers` perceptions of vividness, interactivity, social presence, and focused attention on a fashion brand page positively affected their feelings towards parasocial interaction with the brand page, which in turn led to their affective engagement with the brand page and consequent brand loyalty. These findings suggest that consumers build relationships of varying degrees with brand pages in a similar manner to that with people, which leads to their development of a positive relationship with the brand. This study concludes with discussions and practical implications.