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등외품 인삼(파삼)의 유산균 발효에 의한 저분자 진세노사이드 함량 증진
최운용,이춘근,송치호,서용창,김지선,김보현,신대현,윤창순,임혜원,이현용 韓國藥用作物學會 2012 한국약용작물학회지 Vol.20 No.2
This study compared the contents of low molecular ginsenoside according to fermentation process in low grade fresh ginseng. Low grade fresh ginseng was directly inoculated with a 24 h seed culture of Bifidobacterium Longum B6., Lactobacillus casei., and incubated at 36℃ for 72 h. Bifidobacterium Longum B6 was specifically was found to show the best growth on 3,255×106 CFU/ml after 48 h of fermentation. The content of ginsenoside Rb1, Re and Rd were decreased with the fermentation but ginsenoside Rh2 and Rg2 increased after fermentation process. In the case of low molecular ginsenoside conversion yields were 56.07% of Rh2, 12.03% of Rg3 and 77.11% of Rg2, respectively. In addition, compound-K was irregular conversion yield as long as 72 h of fermentation. This results indicate that fermentation process could increase the low molecular ginsenoside in low grade fresh ginseng.
초고압 증숙처리가 산삼배양근의 진세노사이드 Rg3와 Rh2의 함량에 미치는 영향
최운용,이춘근,서용창,송치호,임혜원,이현용 한국약용작물학회 2012 한국약용작물학회지 Vol.20 No.4
This study was performed to enhance contents of low molecular weight ginsenoside Rh2 and Rg3 using an ultra high pressure and steaming process in wild cultured-Root in wild ginseng. For selective increase in contents of Rg3 and Rh2 in cultured wild ginseng roots, an ultra high extraction was applied at 500MPa for 20 min which was followed by steaming process at 90℃ for 12 hr. It was revealed that contents of ginsenosides, Rb1, Rb2, Rc and Rd, were decreased with the complex process described above, whereas contents of ginsenoside Rh2 and Rg3 were increased up to 4.918 mg/g and 6.115 mg/g, respectively. In addition, concentration of benzo[α]pyrene in extracts of the cultured wild ginseng roots treated by the complex process was 0.64 ppm but it was 0.78 ppm when it was treated with the steaming process. From the results, it was strongly suggested that low molecular weight ginsenosides, Rh2 and Rg3, are converted from Rb1, Rb2, Rc, and Rd which are easily broken down by an ultra high pressure and steaming process. This results indicate that an ultra high pressure and steaming process can selectively increase in contents of Rg3 and Rh2 in cultured wild ginseng roots and this process might enhance the utilization and values of cultured wild ginseng roots.
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 梔者蘗皮湯(치자벽피탕)을 투여한 증례 2례
최운용,이성준,Choi, Woon-yong,Lee, Sung-jun 대한상한금궤의학회 2017 대한상한금궤의학회지 Vol.9 No.1
Objective : Patients complaining of severe chills and dizziness who were diagnosed and treated with the Shanghanlun disease pattern identification diagnostic system were analyzed to report cases Methods : Based on the Shanghanlun disease pattern identification diagnostic system, we analyzed two cases treated with the Chijabackpi-tang and counseling. Results : Chijabackpi-tang showed a rapid improvement in patients. During the period of more than 2 months, all of the chief complaints were greatly improved. Conclusions : The Chijabackpi-tang, which is not well known yet, can show rapid effect and can be diagnosed frequently through the Shanghanlun disease pattern identification diagnostic system.
수면 장애 환자를 통한 『傷寒論』 陰陽易差後勞復病에 대한 고찰과 DSM-5 수면-각성 장애와의 연관성
최운용,이성준 대한상한금궤의학회 2019 대한상한금궤의학회지 Vol.11 No.1
Objective : To explore the meaning of Eumyangyeokchahunobok-byung (陰陽易差後勞復病) through two cases and finding the relationship with the DSM-5 sleep-wake disorder. Methods : Following a disease pattern identification diagnostic system based on Shanghanlun provisions (DPIDS), we analyzed cases with chronic fatigue and diplopia caused after sleep disorders. The patients were treated with the Soshiho-tang and Yijoong-tang. Results : The two herbal medicines showed remarkable improvement in the patients. The sleep disorders and the secondary pathologies were rapidly relieved within a month. Conclusions : The patterns of sleep disorders of the two patients were found to be very similar to the circadian rhythm sleep-wake disorders, as described in DSM-5. Although the etymology of the Chinese characters has not been clearly known yet, it was possible to present the original hypotheses on 更and 了due to clinical inference.
최운용,이현용 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6
The biological activities of Angelica gigasNakai can be improved using water extraction at 60oC withultra-sonication. Conventional water extraction at 100oCcan destroy heat labile active compounds in medicinal herbs. A high frequency (200 kHz) (actual intensity, 210W/m2)minimally affected the extraction yield at 40oC. A lowfrequency (40 kHz) (50W/m2) at 60oC produced better results. A. gigas Nakai extracts produced using a low frequencyshowed a 50% increase in human immune cell growth andIL-6 secretion, compared to conventional water extractionextracts. Extracts produced using 40 kHz and 60oC producedmore immune B and T cell growth than 40oC extracts. These results were confirmed using similar HPLC chromatogrampeak patterns at input intensities of 50 and 210 W/m2. A better than 50% extraction yield and cytokine secretionincrease, and better immune cell growth, was achieved inultrasonication extracts produced at low temperatures.
증숙 발효 공정에 의한 파삼의 진세노사이드 전환 수율 증진
최운용,임혜원,최근표,이현용 韓國藥用作物學會 2014 한국약용작물학회지 Vol.22 No.3
This study was performed to enhance contents of low molecular ginsenoside using steaming and fermentationprocess in low quality fresh ginseng. For increase in contents of Rg2, Rg3, Rh2 and CK in low quality fresh ginseng, a steam-ing process was applied at 90℃ for 12hr which was followed by fermentation process at Lactobacillus rhamnosus HK-9incubated at 36℃ for 72h. The contents of ginsenoside Rg1, Rb1, Rc, Re and Rd were decreased with the steaming associ-ated with fermentation process but ginsenoside Rg2, Rg3, Rh2 and CK increased after process. It was found that under thesteaming associated with fermentation process, low molecule ginsenosides such as Rg2, Rg3, Rh2 and CK were increased as3.231㎎/g, 2.585㎎/g and 1.955m/g and 2.478㎎/g, respectively. In addition, concentration of benzo[α]pyrene in extracts ofthe low quality fresh ginseng treated by the complex process was 0.11ppm but it was 0.22ppm when it was treated with thesteaming process. This result could be caused by that the most efficiently breakdown of 1,2-glucoside and 1,4-glucoside link-age to backbone of ginsenosides by steaming associated with fermentation process. This results indicate that steaming pro-cess and fermenration process can increase in contents of Rg2, Rg3, Rh2 and CK in low quality fresh ginseng.
『康平傷寒論』38條의 ‘厥逆’에 대한 임상적 해석 : 大靑龍湯으로 호전된 섭식장애 2례를 통하여
최운용,두인선,이성준 대한상한금궤의학회 2023 대한상한금궤의학회지 Vol.15 No.1
Objective : We Explored the meaning of the 厥逆 in Gangpyeong-Shanghanlun through two cases. Methods : We analyzed the original form of 厥逆 and the contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases treated with 大靑龍湯 (Daecheongryong-tang) according to the newly deduced definition of 厥逆. Results : 厥逆 can be interpreted as 'Being indulged and indigestive'. We analyzed the cases and found that both cases were related to eating disorder even though their chief complaints were different. We also found that 大靑龍湯 was effective for both bulimia nervosa and anorexia nervosa. Conclusions : 厥逆 is symptoms of reflux in human body such as, gastroesophageal reflux disease, as a result of concentration or indulgence. We analyzed the two cases with DSM-5 and found that the two cases also can be diagnosed with eating disorder along with the provision (38條, 大靑龍湯). We found out the possibility of correlation between eating disorder and 38條, however, more advanced clinical studies are needed in the future.
초고압 공정을 이용한 강황 잎 추출물의 항산화 활성 증진
최운용,이현용 韓國藥用作物學會 2014 한국약용작물학회지 Vol.22 No.2
This study was designed to evaluate antioxidant activity of Curcuma longa L. leaves treated by ultra highpressure extraction. Curcuma longa L. leaves was subjected to 5,000 bar for 5 and 15 min at 25℃ The highest phenolics andflavonoids content was observed in the treatment of high pressure extraction for 15 min (308.28㎍/㎎, 124.33㎍/㎎). TheDPPH scavenging activity was 82.34% at 1.0㎎/㎖ of Curcuma longa L. leaves treated by ultra high pressure process for 15min. The highest SOD-like acitivity of Curcuma longa L. leaves (1.0㎎/㎖) was observed at ultra high pressure extractionfor 15 min (67.54%). The high pressure extraction significantly increased the contents of phenolics and flavonoids and alsoenhanced the antioxidant activity. These results provide useful information for enhancing biological properties of Curcumalonga L. leaves.