구개열 환자 말 평가 시 검사어에 대한 고찰 : 임상현장의 말 평가 어음자료와 문헌적 고찰을 중심으로

최성희,최재남,남도현,최홍식,Choi, Seong-Hee,Choi, Jae-Nam,Nam, Do-Hyun,Choi, Hong-Shik 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.1

Differential diagnosis of articulation and resonance problems in the cleft lip and palate speech is required for evaluating various factors contribute to speech problems such as VPI, dental occlusion, palatal fistulae, learning. However, validity of speech stimuli is current issue to evaluate accurately each problem in cleft speech. This study was conducted to investigate speech stimuli using in the clinical setting and review the literatures and articles published 1990 to 2005 for helping develop standardized speech samples. The results were recommendation to evaluate properly velopharyngeal function when conducting a diagnostic evaluation as follows : 1) In identification hypernasality, the speech stimuli should be included low pressure consonants to eliminate effects of nasal emission, compensatory articulation. 2) Speech stimuli should be consist of visual, front sounds to eliminate compensatory articulation and to stimulate easily. 3) Regarding early diagnosis and treatment, speech stimuli need to develop for infants and preschooler. 4) Stimulus length on nasalance scores should be at least 6 syllables. 5) In phonetic context on nasalance scores, /i/ vowel should be take into consideration excluding paragraph. 6) Connected speech stimuli should be developed for evaluating intelligibility and VP function.

메밀녹차의 향기성분

최성희,Choi, Sung-Hee 한국생명과학회 2007 생명과학회지 Vol.17 No.8

The volatile flavor components of buckwheat (Fagopyrum esculentum Moench)-green tea were analyzed and identified. To make tea having good flavor and functional property, parched buckwheat (50%) was mixed with green tea (50%). The extraction of volatile flavor compounds of buckwheat-green tea was accomplished by a simultaneous distillation and extraction method using a Likens and Nickerson's extraction apparatus. The concentrated extract was analyzed and identified by gas chromatography and GC-mass spectrometry. The main volatile flavor components of buckwheat-green tea were compounds that originated from parched buckwheat and the green tea. The former were 15 pyrazines having roasted and nutty aroma and methylbutanals and furfural having sweet-aroma. The latter were nerolidol, linalool, indole, ${\beta}-ionone$ and geraniol etc having flower-like odor in green tea. 생리활성을 갖는 것으로 알려진 메밀을 고소하게 볶은 시판 메밀차를 중급 정도의 녹차에 혼합하여 메밀녹차를 제조하고 기호도와 관련이 있는 향기 성분을 동시증류추출(SDE) 장치를 사용하여 분석하였다. 메밀차와 녹차를 1:1로 혼합한 메밀녹차의 향기성분으로 42종류를 동정하였다. 메밀녹차에는 메밀차의 향기성분 23종류와 녹차의 향기 성분 16종류 및 공통으로 포함된 3종류의 화합물들로 구성되어 있었다. 메밀녹차의 향기성분으로는 15종류의 pyrazine류를 동정하였다. 이는 메밀녹차의 향기 성분 중 약 32%를 차지하는 비율이었다. 메밀녹차의 향기 성분은 본래 녹차가 가지고 있는 향에 구수하고 달콤한 향을 띄는 볶음 메밀의 향기성분들이 부여되어 생성된 것으로 밝혀졌다. 본 연구에서 사용한 녹차는 중급 정도에 해당되는 덖음차로 고급녹차에 많았든 linalool이나 geraniol은 적은 함량 포함되어 있었으나 녹차향에 기여하는 꽃향기를 띄는 nerolidol의 함량은 많았으며 nonanal, 2-phenylethanol, cis-jasmone, indole 및 ${\beta}-ionone$ 등도 함유되어 있었다. 복은 향의 중요성분으로는 roasted flavor인 pyrazine류와 pyrrole류, 달콤한 향을 띄는 methylbutanal류와 furan류 등으로 밝혀졌다. 특히, pyrazine류는 종류도 많고 함량도 메밀차 전체 면적의 56%로서 녹차에 혼합되었을 때 메밀녹차의 고소한 향에 크게 기여하는 것으로 나타났다.

파킨슨증의 음성진전 : 감별진단을 위한 예비연구

최성희,김향희,이원용,최홍식,Choi, Seong-Hee,Kim, Hyang-Hee,Lee, Won-Yong,Choi, Hong-Shik 한국음성학회 2005 음성과학 Vol.12 No.3

Tremor is a main factor of parkinsonism. Voice tremor may be the first, later or the only symptom of a neurological disease and its frequency, amplitude, and regularity may differ among the diseases of different neural subsystems. Differential diagnosis between idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) has been difficult. This study included three groups: (1) 6 IPD patients; (2) 6 MSA patients; and (3) 20 ageand sex-matched normal controls. The MDVP (Multidimensional Voice Program) was used to analyze the sustained /a/phonation. The results were as follows: (1) frequency perturbation parameters (jitter, sPPQ, Vf0) and FTRI of tremor parameter of two patient groups were statistically different from those of the controls (p < .01); (2) measures were higher in short-term and long-term f0 and amplitude perturbation in MSA than IPD; (3) however, any acoustic parameters between IPD and MSA were not statistically different; except for the rate of frequency tremor, 4$\sim$5 Hz in IPD, 5$\sim$11 Hz in MSA and (4) the pattern of regularity for voice tremor through histogram indicated that amplitude of IPD was irregular while both f0 and amplitude of MSA were irregular. In conclusion, F0, rate of frequency tremor, and pattern of f0 regularity may be predictors for differential diagnosis. These findings might signify that voice tremor of parkinsonism was resulted from modulation of f0.

성악가와 훈련 받지 않은 일반인의 음도, 강도, 성구 변화 시 발성 및 호흡조절 특성

최성희,남도현,김덕원,김영호,최홍식,Choi, Seong-Hee,Nam, Do-Hyun,Kim, Deak-Won,Kim, Young-Ho,Choi, Hong-Shik 대한후두음성언어의학회 2006 대한후두음성언어의학회지 Vol.17 No.2

Background and Objectives : Training of breath support and laryngeal muscles control are important components in the development of the singing voice. The purpose of this study is to compare characteristics of respiratory and phonatory control on pitch, loudness, register change with untrained males and trained male singers. Materials and Methods : The 11 untrained males and 11 trained male singers participated. Closed Quotient(CQ), fundamental frequency (fo) and relative volume contribution of the rib cage (in percentage rib cage, % RC) and relative volume contribution of abdomen (in percentage abdomen, % AB) were measured during various pitch, loudness, register tasks using /a/ vowel phonation : Legato, staccato with C3-D3-E3-F3-G3 notes and crescendo and decrescendo with C3 note as well as modal register with C3 and falsetto register with C4 note using an integrated analysis system of Respiration, EGG and Voice. Results : (1) When pitch increased with legato task, loudness also increased in untrained male group but maintained in trained male singers. CQ was also increased both untrained and trained male singers but it was not significantly different ($p>.05$). The abdomen contribution to lung volume were significantly predominant both in inhalation and exhalation in trained males singers ($p<.05$). (2) When pitch increased with staccato task, CQ was not significantly different in untrained but significantly different in trained male singers. The respiratory function of male singers were characterized by significantly predominant abdomen contribution to lung volume in exhalation except for inhalation ($p<.05$) (3) When loudness increased with crescendo, fo was significantly increased with increasing CQ in untrained males but fo was relatively consistent with increasing CQ in trained male singers. The respiratory function of male singers were characterized by significantly predominant abdomen contribution to lung volume in exhalation except for inhalation ($p<.05$). (4) Most male singers were able to change register from modal to falsetto register, but untrained males were not. Thus, CQ was significantly different between modal and falsetto register in trained male singers ($p<.05$). The respiratory function of male singers were characterized by significantly predominant abdomen contribution to lung volume in exhalation except for inhalation ($p<.05$). Conclusion : Male singers were superior to untrained males in coordination of respiratory and phonatory control on pitch, loudness, register change. Implication are offered regarding how the results might be applied to the voice therapy as well as singing training.

생식과 황련해독탕(黃連解毒湯) 외용 치료를 통한 임신신양(姙娠身痒) 환자 치험 5례

최성희,김태욱,김기배,Choi, Sung-Hee,Kim, Tae-Wook,Kim, Ki-Bae 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

Objectives : The purpose of this study is to investigate the effect of eating Saengshik and applying Hwangryunhaedok-tang on skin for pregnant woman diagnosed as Pruritus Gravidarum. Methods : This case study was done on 5 Pruritus Gravidarum patients who had visited Korean Medicine Clinic. All the patients are treated with Saengshik and Hwangryunhaedok-tang was applied on their skin. VAS(Visualanalogue scale) and photographs were used to evaluate the symptom change. Results & Conclusion : Most symptoms of patients were improved in this study. Saengshik and Hwangryunhaedok-tang can be effective in patients who were diagnosed as Pruritus Gravidarum.

보간법을 이용한 수치적분법의 평균 오차에 관한 연구

최성희,황석형,이정배,홍범일,Choi, Sung-Hee,Hwang, Suk-Hyung,Lee, Jeong-Bae,Hong, Bum-Il 한국정보처리학회 2004 정보처리학회논문지 A Vol.11 No.5

Among many algorithms for the integration problems in which one wants to compute the approximation to the definite integral in the average case setting, we study the average case errors of numerical integration rules using interpolation. In particular, we choose the composite Newton-Cotes quadratures and the function values at equally spaced sample points on the given interval as information. We compute the average case error of composite Newton-Cotes quadratures and show that it is minimal(modulo a multiplicative constant). 이 논문에서는 정적분의 근사 값을 계산하는 여러 적분 문제 중에서 보간 법을 사용하는 수치적분법의 평균오차에 대해서 연구한다. 특히 가장 널리 쓰이고 있는 방법 중의 하나인 복합 Newton-Cotes 구적법의 평균오차에 대해서 연구한다. 주어진 구간을 등 간격으로 나누었을 때, 각 점에서의 함수 값을 information으로 사용할 경우, 복합 Newton-Cotes 구적법의 평균오차를 계산하였으며, 이 때 이 오차는 가장 최소임을 이 논문에서 증명한다.

각종 음성분석기에 따른 음성장애 환자의 주기간 주파수 및 진폭변동률 분석

최성희,남도현,이승훈,정원혁,김덕원,최홍식,Choi Seong Hee,Nam Do-Hyun,Lee Seung-Hoon,Jung Won-Hyuk,Kim Deok-Won,Choi Hong-Shik 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2

Background and Objectives : Voice perturbation measures, such as jitter and shimmer has been importantly used for diagnosis and treatment efficacy of laryngeal dysfunction. This study was conducted to investigate validity of newly developed multi-channel voice analyzer program by comparing with MDVP, PRAAT, TF32. In addition, we compared the voice perturbation measures with different voice analyzer program by type of signals. Materials and Methods : Nineteen mild-severe dysphonic patients participated in our study. Fundamental frequency, jitter and shimmer values were obtained from different voice analyzer program using the same sustained/ah/phonation. Results : Fundamental frequency and shimmer were highly correlated whereas jitter was weakly correlated between newly developed multi-channel voice analyzer program and the others though different pitch computation algorithm except MDVP, In addition, Type 2 and 3 signals were weakly correlated than Type 1. Conclusion : In the clinical setting, clinician may have sufficient information of voice analyzer and control conditions properly for severity of pathologic voice before voice perturbation measure to obtain reliable results.

위 절제술 후 절제연 양성군의 임상병리학적 특성과 재발

최성희,Hyeong Geun Lee,Min Gew Choi,Jae Hyung Noh,Tae Sung Sohn,배재문,Sung Kim 대한위암학회 2010 Journal of gastric cancer Vol.10 No.3

Purpose: The purpose of this study was to analyze the clinical courses of patients with gastric cancer and positive resection margins after a gastrectomy for gastric cancer who did not undergo subsequent surgery. Materials and Methods: Among 4,452 patients who underwent surgery for gastric cancer from January 2001 to December 2007, 20patients with positive resection margins after gastrectomy for gastric cancer who did not undergo subsequent surgery were included. The recurrence patterns were confirmed by postoperative computed tomography and gastroscopy, which were performed on a planned schedule. All recurrence patterns after gastrectomy were classified as loco-regional, peritoneal, or distant metastases. Results: The patients with confirmed recurrence all had advanced stage cancer (III–IV), and the recurrence sites were variable. However,peritoneal and distant recurrences were more common than loco-regional recurrences. The patients with loco-regional recurrence also had peritoneal and/or distant recurrence. Conclusions: Patients with gastric cancer and a positive resection margin showed more frequent peritoneal and distant metastases than loco-regional recurrence. In addition, patients with loco-regional recurrence also had peritoneal and distant recurrence. A positive resection margin of gastric cancer was related with poor histological differentiation, diffuse type, and advanced stage (III–IV).

광촉매 Cds , ZnS 를 이용한 광화학반응 - DHP vesicle 분산계에서 -

최성희,한명남,차민환 ( Sung Hee Choi,Myung Nam Han,Min Whan Cha ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.2

경부형 전기인공후두 Blueton의 개발과 음향학적 성능 분석

최성희,박용재,박영관,김태정,남도현,임성은,이성은,김한수,최홍식,김광문,Choi, Seong-Hee,Park, Young-Jae,Park, Young-Kwan,Kim, Tae-Jung,Nam, Do-Hyun,Lim, Sung-Eun,Lee, Sung-Eun,Kim, Han-Soo,Choi, Hong-Shik,Kim, Kwang-Moon 대한후두음성언어의학회 2004 대한후두음성언어의학회지 Vol.15 No.1

Electrolarynx(EL), battery operated vibrators which are held against the neck by on-off button, has been widely used as a verbal communication method among post-laryngectomized patients. EL speech can produce easily without need of any additional surgery or special training and be used with any other methods. This institute developed a neck-typed EL named "Blueton" in commperation with EL Company Linkus, which consists of 3 parts : Vibrator part, Control part, Battery part. In this study we evaluated the acoustic characteristics of the produced voices by Blueton compared with Servox-inton using MDVP. Three EL users (2 full time users, 1 part time user) were participated. The results revelaed that NHR higher in Servox than Blueton and intensity is higher in Blueton than Servox. The spectra for vowels produced by EL speakers are mixed signals combined with talkers' vocal output and electrolarynx noise. The spectra pattern is similar with two ELs. High, SPI index and vowel spectra from MDVP demonstrated characteristics of both electrolarynxes related to noise signal. This finding suggests that Blueton helps to provide one of useful rehabilitation options in the post laryngectomy patients.