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채홍재,이형재,오세원,이성관,문재동,Chae Hong Jae,Lee Hyoung Jai,Oh Sei Won,Lee Sung Kwan,Moon Jai-Dong 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.1
Acute mercury inhalation poisoning is a rare cause of acute peripheral neuropathy. A 44-year-old female inhaled the fume from heating mercury to treat her palmar dermatitis. For 4 days, this procedure was done for 2-3 minutes after each meal. She subsequently complained flu like symptoms, such as headache, toothache, myalgia and arthralgia. She was admitted for 9 days and then symptoms disappeared. About 3 weeks after exposure, both knee pain developed and then she could not walk. To treat mercury intoxication, she was referred to our hospital. At that time, initial laboratory data were within normal limits, but blood and urinary mercury level were 5.6 11$\mu$g/dl, 132.8 $\mu$g/L. After treatment with D-penicillamine for 7 days, blood and urinary mercury level were 3.9 1$\mu$g/dl, 177.3 $\mu$g/L. During the following 1 month, both leg symptoms remained. Nerve conduction studies were performed, both leg sensory nerve amplitude decreased. These findings were suggestive of peripheral polyneuropathy.
이광훈,채홍재,윤경철,Kwang Hoon Lee,Hong Jae Chae,Kyung Chul Yoon 대한안과학회 2008 대한안과학회지 Vol.49 No.5
Purpose: To evaluate the risk factors for treatment failure in fungal keratits. Methods: A total of 109 patients with fungal keratitis, who were diagnosed by clinical findings, smears, and cultures and followed up for at least 2 months, were studied retrospectively. Age, sex, previous history of trauma, systemic diseases, corticosteroid use, previous ocular disease, features of keratitis, causative organism, and treatment results were reviewed. An initial univariate and multivariate logistic regression analysis was performed to identify and select the main prognostic risk factors. Results: Treatment was successful in 76 patients (69.7%) and failed in 33 patients (30.3%). Fusarium species was isolated in 34 eyes (40.0%), and an ulcer lesion was located in the central area of 54 eyes (49.5%). Multivariate analysis demonstrated that predictors of treatment failure were an ulcer exceeding 10 mm2 (P<0.001) and the presence of previous ocular diseases (P=0.007). Conclusions: In patients with fungal keratitis, a large ulcer size and the presence of other ocular diseases were risk factors for treatment failure.
신경독성물질에 의한 신경계장애 조기발견을 위한 색각검사의 활용가능성
이은희,최경호,채홍재,백도명,Lee, Eun-Hee,Choi, Kyung-Ho,Chae, Hong-Jae,Paek, Do-Myung 대한예방의학회 2008 예방의학회지 Vol.41 No.6
This paper reviews the published literature that is concerned with color vision impairment from industrial and environmental exposure to neurotoxic substances, and we evaluated whether testing for color vision impairment could be an affordable procedure for assessing these neurotoxic effects. In general, most cases of congenital color vision impairment are red-green, and blue-yellow impairment is extremely rare. However, most of the acquired color vision impairment that is related to age, alcohol or environmental factors is blue-yellow impairment. Therefore, many studies have been performed to identify this relationship between exposure to neurotoxic substances, such as organic solvents and heavy metals, and the prevalence of blue-yellow color vision impairment. The test for color vision impairment is known to be very sensitive to the early signs of nervous system dysfunction and this can be useful for making the early diagnosis of neurotoxic effects from exposure to very low concentrations of toxic substances.
LC/MS/MS를 이용한 산화성 스트레스 지표로써 소변 중 8-iso-PGF2α 분석
고영림(Young Lim Kho),이은희(Eun Hee Lee),채홍재(Hong Jae Chae),최경호(Kyungho Choi),백도명(Domyung Paik) 한국환경보건학회 2010 한국환경보건학회지 Vol.36 No.1
This study aimed to develop analytical method for 8-isoprostanes as biomarkers for oxidative stress with LC/MS/MS technique and to apply the method for human urine samples. Analyzed compounds for urinary oxidative stress markers were 7 stereo-isomers of prostaglandins and the internal standard (iso-PGF2α-d4) was used to adjust the recovery rate. The method for determining urinary iso-PGF2α consisted of solid phase extraction and LC/MS/MS detection. Separation of isomers of prostaglandins completed by porous graphitic carbon column and buffer solution. Detection limits for urinary markers of oxidative stress, iso-PGF2α with LC/MS/MS were 0.01 ng/ml by S/N ratio 3 and 0.028 ng/ml by calculated as to FDA method. The recovery (92.8~101.9%) and precision (8.8~20.7%) of analysis were feasible for detecting iso-PGF2α in real human urine samples. We detected 4 isomers of prostaglandins in human urine samples. Mean (standard deviation) of urinary iso-PGF2α concentration were 0.231 (0.117) ng/mg creatinine for smoking group and 0.154 (0.082) ng/mg creatinine for non-smoking group.