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진재호,안능호,배양섭,Jin, Jae-Ho,Ahn, Neung-Ho,Bae, Yang-Seop Korean Society of Applied Entomology 2007 한국응용곤충학회지 Vol.46 No.1
포충나방과의 물명나방아과에 속하는 얼룩애기물명나방(Elophila turbata (Butler, 1881))에 대한 성충, 종령유충, 번데기의 형태적 특징과 암수생식기를 도해하여 재기재하였으며, 또한 이 종의 생태적 특징을 관찰하고, 기주식물로 개구리밥, 좀개구리밥(Lemna perpusilla), 생이가래(Salvinia natans)를 확인하였다. Morphological characters of adult and immature stages on Elophila turbata (Butler, 1881) belonging to subfamily Nymphulinae, family Crambidae are redescribed base on Korean materials. Also we observed biological characters of this species including host plants, Spirodela polyrhiza(L.) Schleiden, Salvinia natans ($Linn\acute{e}$) Allioni and Lemna perpusilla Torre. And, photographs of adult, genitalia and immature stages are provided.
U-937 세포에서 도적승기탕(導赤承氣湯) 추출물 중 부탄올 분획에 의한 Apoptosis 유도
박평범,정한솔,김호,진재호,정상훈,한웅,이문원,이광규,Park, Pyeong-Beom,Jeong, Han-Sol,Kim, Ho,Jin, Jae-Ho,Jeong, Sang-Hun,Han, Ung,Lee, Moon-Won,Lee, Kwang-Gyu 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
To investigate the anti-cancer effects of n-butanol fraction of DoJeokSeungKi-Tang extracts(nBFD) in U-937 cells. MTT assay was used to determine U-937 cells proliferation. Flow cytometry was used to detect apoptosis. Bcl-xl anti-apoptotic protein and caspase-3, p53 pro-apoptotic protein were examined by Western blot analysis. nBFD inhibited the proliferation of U-937 cells in a dose-dependent manner. The cells treated with nBFD showed a typical apoptotic process by increasing sub-Gl peak. nBFD reduced uptake of 3,3'dihexyloxacarbocyanine iodide(DiOC6) a fluorochrome which incorporates into cells dependent upon their mitochondrial transmembrane potential$({\triangle}{\psi}m)$. nBFD induced in U-937 cells apoptosis mainly via increasing sub-Gl peak, regulation of Bcl-xl, caspase-3 and p53 protein.
상륙에서 추출한 ${\alpha}-spinasterol$의 백혈병세포주(U937) 자멸사 유도 효능
양준석,정상훈,김호,한웅,진재호,정일국,김대근,정승일,정한솔,이광규,Yang, Jun-Seok,Jeong, Sang-Hun,Kim, Ho,Han, Ung,Jin, Jae-Ho,Jung, Il-Kook,Kim, Dae-Keun,Jeong, Seung-Il,Jeong, Han-Sol,Lee, Kwang-Gyu 대한동의생리학회 2007 동의생리병리학회지 Vol.21 No.5
To investigate the possible mechanism of ${\alpha}-spinasterol$ as a candidate of anti-cancer drug, I examined the effects of ${\alpha}-spinasterol$ on the apoptosis of U937 cells MTT assay, flow cytometric analysis, SDS-polyacrylamide gel electrophoresis, Western blot analysis, and RT-PCR were performed. ${\alpha}-spinasterol$ treatment reduced the cell viablilty of U937 cells in a dose-dependent manner, which was associated with the induction of apoptotic cell death. ${\alpha}-spinasterol$ treatment also reduced the levels of Bcl-xL anti-apoptotic protein expression and increased the levels of caspase-3, p53, pro-apoptotic protein, in U937 cells. After treatment the level of Bcl-xL, anti-apoptotic gene expression was decreased and the level of ICE pro-apoptotic gene expression was increased. These findings suggest that ${\alpha}-spinasterol$ induced the apoptotic cell death via regulation of several growth regulatory gene products. The abbreviations used are: FBS, fetal bovine serum; PBS, phosphate buffered saline; PI, propidium iodide; OD, optical density; DiOC6, 3,3-dihexyloxa carbcyanine iodide; MTT, 3 [4-5-dimethylthiazol-2-yl] -2-diphenyltetrazolium bromide.
재조합 사람성장호르몬(소바트로핀)의 KFDA표준품(KS 98/674) 설정연구
신원(Won Shin),정지원(Jee Won Joung),진재호(Jae Ho Jin),Adrian F. Bristow,손여원(Yeo Won Sohn) 대한약학회 2001 약학회지 Vol.45 No.2
The complexity and variability of both the biologicals and the bioassays used to test them led to the use of the reference standard- a sample of the product of defined purity and potency, against which all preparations of that product must be calibrated. In order to prepare and establish KFDA reference standard for recombinant human growth hormone(somatropin), somatropin substance was filled in ampoules in National Institute for Biological Standards and Control(NIBSC). The candidate KFDA reference standard for somatropin(designated as 98/674) was evaluated to determine the suitability of serving as a KFDA reference standard for somatropin by the collaborative study, in which 10 laboratories participated. Physicochemical analysis and in vivo bioassay were performed by direct comparison with the international somatropin standard 88/624. 98/674 was identified as somatropin by SDS-PAGE, IEF, peptide mapping, and HPLC. Determination of somatropin content by SE-HPLC yielded a mean estimate of 2.01mg somatropin per ampoule. Data from the study also yielded mean values of 0.39+/-0.26% for high molecular weight impurities by SE-HPLC and mean values of 2.13 +/- 1.29 % for somatropin related proteins by RP-HPLC. Estimates of relative potency by weight gain bioassay in the hypophysectomised rats showed that relative potency of KS 98/674 was 1.07 against IS 88/624. Based on the results of the collaborative study, the candidate reference standard for somatropin is suitable to serve as a KFDA reference standard for somatropin.