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      • KCI등재

        2단계 신경망관리도

        지용훈,이종성 대한설비관리학회 1998 대한설비관리학회지 Vol.3 No.1

        Heuristic rules(sensitizing rules) provide effective decisions for detecting nonrandom patterns on the control chart. To implement these rules sucessfully, it forces user to pay careful attention to sample point patterns. Furthermore, The ability to interpret a particular pattern requires experience and knowledge of the process. This paper provides neural network approach recognize the unnatural pattern on the control chart automatically as well as to heighten the sensitivity of the process change. The proposed method consists of Two-Step Neural Network Control Chart(NNCC) to perform the (원문참조)-R chart's function simultaneously. The first step NNCC detects the change of the process by the traditional neural network approach. The second step NNCC detects the change of the process by learning heuristic rules. The proposed method's performance is compared with traditional Shewhart (원문참조) - R chart in terms of type I & Ⅱ error. Two-step NNCC's errors are calculated by the simulation result.

      • 실외 환경에서의 고도지도 기반의 전역 위치추정을 위한 Hausdorff 거리 정합 기법

        지용훈,송재복,백주현 제어로봇시스템학회 2011 제어로봇시스템학회 국내학술대회 논문집 Vol.2011 No.5

        Mobile robot localization is the task of estimating the robot pose in a given environment. This research deals with outdoor localization based on an elevation map. Since outdoor environments are large and contain many complex objects, it is difficult to robustly estimate the robot pose. This paper proposes a Hausdorff distance-based map matching method. The Hausdorff distance is exploited to measure similarity between extracted features obtained from the robot and elevation map. The experiments and simulations show that the proposed Hausdorff distance-based map matching is useful for robust outdoor localization using an elevation map. Also, it can be easily applied to other probabilistic approaches such as a Markov localization method.

      • SCOPUSKCI등재

        Human cytomegalovirus 증식에 미치는 cAMP의 영향

        지용훈,윤주현,이찬희 한국미생물학회 1993 미생물학회지 Vol.31 No.1

        Human cytomegalovirus (HCMV) 의 immediate early(IE) 유전자의 promoter/enhancer 부위에 cAMP response element가 있다는 것으부터 caMP 가 HCMV 의 증식에 관여할 것이라고 생각할 수 있다. 이러한 가능성을 알아보기 위해 8-bromoadenosine 3', 5'-cyclic monophosphate (BrA) 와 papaverine 같은 세포내 cAMP 농도를 변화시키는 약제를 사용하여 HCMV 의 증식, DNA 합성 및 IE 유전자 발현에 대한 영향을 알아보았다. HCMV 증식과 DNA 합성은 papaverine 에 의해 억제된 반면, BrA 는 HCMV 의 증식에는 큰 영향을 주지 않았고 DNA 합성은 오히려 촉진시키는 것을 알 수 있었다. HCMV IE promoter 에 의해 작동되는 CAT 유전자를 함유한 plasmid pCMVIE/CAT 을 세포내로 transfection 시켰을 때, papaverine 을 처리한 세포에서는 CAT 효소 활성도가 감소한 반면 BrA 를 처리한 세포에서는 증가하였다. HCMV 에 감수성이 없는 HeLa 세포에서는 CAT 활성도가 감소성 세포인 HEL 세포에서보다 높게 나타난 반면, Vero 세포에서는 낮게 나타났다. 이들 비감수성 세포인 HEL 세포에서 보다 높게 나타난 반면 Vero 세포에서는 낮게 나타났다. 이 들 비감수성 세포에서의 CAT 활성도는 BrA 를 처리하여 주었을 때 모두 증가하였다. 이상과 같은 결과로부터 cAMP 는 HCMV 증식과 IE 유전자 발현에 어느 정도 관여한다는 것을 알 수 있다. Since the 'promoter/enhancer region of the major immediate early (IE) ~ene of human cytomegalovirus (HCMV) contains the cyclic AMP (cAMP) response element (CRE) consensus sequence, it was reasonable to hypothesize that cAMP might affect HCMV replication. Cyclic AMP modulating drugs such as 8-bromoadenosine 3',5'-cyclic monophosphate (BrA), and papaverine were used to affect the intracellular levels of cAMP, and the effects of the drugs on HCMV replication were studied. While papaverine effectively inhibited HCMV multiplication and DNA synthesis, BrA exerted little effect on the production of infectious HCMV yields. The synthesis of DNA in HCMV-infected cells appeared to be stimulated by BrA In order to understand the effect of cAMP on the expression of HCMV major IE gene, plasmid (pCMVIE/CAT) containing a reporter gene driven by HCMV IE promoter was transfected into either permissive human embryo lung (HEL) cells or nonpermissive cells. PL,Javerine, which has been reported to block the HCMV-induced increase in cAMP, reduced the expression of pCMVIE/CA T in permissive HEL cells. Treatment of transfected cells with BrA increased the expression of HCMV major IE promoter not only in HEL cells, but also in nonpermissive HeLa and Vero cells. Therefore, it seems that the expression of HCMV major IE gene is regulated by cAMP.

      • KCI등재후보

        헌혈혈장의 효율적 활용을 위한 혈액응고인자 활성도 분석

        지용훈,김명한,권소영,조남선,조연정,최경영 대한수혈학회 2012 大韓輸血學會誌 Vol.23 No.2

        Background:The aim of present study was to assess the effect of different freezing time after phlebotomy on the activity of coagulation factors in frozen plasma and to evaluate which source plasma for clotting factor fractionation is appropriate for use. Methods:Blood plasma units rejected due to a high level of ALT were divided into four groups depending on freezing time after phlebotomy, and each unit of the four groups was assayed for six different clotting factors and blood type. SAS 9.2 was used for statistical analysis of data. Results:A decrease was observed in the activities of FVIII of the plasmas, in the following order: PL-A>FFP>FP(8-24)≈FP(24-72). Results of the assay also showed that the levels of FVIII were significantly higher in the AB type plasmas than in the O type plasmas. PL-A and FFP units met the current quality requirements of the Korean Red Cross, in which the FVIII activity should have more than 0.7 IU/mL in more than 75% of the source plasma, as 85.0% and 82.5%, respectively. On the other hand, FP24 met the Canadian (Quebec) requirements for the source plasma, in which the FVIII activity should have more than 0.52 IU/mL in more than 75% of the source plasma, as 82.6%. Conclusion:For use of plasma frozen within 24 hours after phlebotomy (FP24) and plasma of specific blood type, European Pharmacopeia and WHO guidelines on quality control should be adopted for production of plasma-derived coagulation factors in Korea.

      • KCI등재

        한국 소아청소년에서 식사 빈도에 따른 음식섭취 및 영양 평가: 제7기(2016–2018년) 국민건강영양조사

        지용훈,박준희,유준현 대한가정의학회 2022 Korean Journal of Family Practice Vol.12 No.3

        Background: Children and adolescents growth and development rapidly, thus it is critical to meet their nutritional needs. Understanding their dietarypatterns is crucial for providing proper dietary education. The goal of study is to investigate dietary and nutritional habits of children and adolescentsbased on the frequency of regular meals. Methods: Using data obtained from the 7th Korea National Health and Nutrition Examination Survey, a total of 3,036 children and adolescents aged 6to 18 years were divided into three groups based on meal intake regularity: 3 meals regular diet (MRD), 2MRD, and 1 meal regular or irregular diet. The nutrient intakes in accordance with the 2020 Korean Dietary Reference Intakes were calculated using the 24-hour recall method. A generalizedlinear model was used to perform a multivariable analysis. Results: Participants who ate three regular meals per day had better subjective health and a thinner perception of their body shape compared to otherparticipants. Meal skipping was more common in grandparents households. The 3MRD group consumed more seeds, nuts, fish, whereas the 1MRDgroup consumed more beverages and fats. As the frequency of meals decreased, the proportion of carbohydrates in nutrient uptake decreased(from 61.36% to 59.04%) and fats increased (from 23.57% to 25.26%). The proportion of people consuming less than the estimated averagerequirement for energy and all nutrients increased significantly in the 1MRD group compared to the 3MRD group. Conclusion: Regular breakfast-lunch-dinner meal group had a more adequate nutrition status and health than low frequency meal groups 연구배경: 성장 발육이 왕성한 소아청소년 시기에 적절한 영양섭취는 중요한 일이다. 급속한 성장에 필요한 영양 요구량이 불충족되거나 불균형 공급된다면 만성 성인질환을 유발하고 성장에 영향을 줄수 있다. 식습관을 형성하고 변화시킬 수 있는 소아청소년들에게 교육을 통해 올바른 식습관을 형성시키기 위해서는 많은 연구와 고찰이 필요하다. 우리는 소아청소년에서 규칙적인 식사 빈도에 따른 개인의 특성 및 식품과 영양소의 적정 섭취 여부를 확인해보고자 하였다. 방법: 제7기(2016–2018) 국민건강영양조사 결과를 활용한 단면 연구로서 6세부터 18세 까지 소아청소년 총 3,036명(남성 1,554명, 여성1,482명)이 연구대상자로 포함되었다. 규칙적 식사 빈도에 따라 총 3개 집단으로 나눠 정규 세 끼 식사, 정규 두 끼 식사, 정규 한 끼 이하 식사집단으로 분류하였다. 규칙적 식사 여부는 설문항목을 통해조사되었고 식품과 영양소 섭취는 24시간 회상 방법을 사용하여 평가되었다. 각 적정 영양소 섭취 여부는 한국인 영양소 섭취의 평균필요량을 기준으로 판단하였다. 결과: 소아청소년에서 규칙적으로 더 많은 식사를 할수록 자신을더 건강하다고 느꼈으며 뚱뚱하지 않다고 생각했다. 또한 평균신장도 더 큰 것으로 나타났다. 식품섭취에서 규칙적 식사가 많아질수록 해초류, 씨앗 견과류, 생선류, 과일의 섭취가 더 많아졌다. 반면결식이 많아질수록 음료 섭취량과 지방 섭취는 오히려 더 높아졌다. 우리의 연구는 소아청소년에서 정규식사의 빈도가 늘어나고 규칙적세 끼 식사집단으로 갈수록 영양소 섭취평가에서 평균 필요량 기준대비 적정섭취 및 열량섭취에서 더 좋은 결과를 나타냈다. 결론: 소아청소년에서 규칙적인 식사 빈도가 많아질수록 건강한 특성을 나타내었고 식품 및 영양섭취에서 규칙적 세 끼 식사집단이 다른 결식집단에 비해 더 좋은 결과를 보였다.

      • SCOPUSKCI등재

        피부 박피술후 천층 부분 식피술을 이용한 백반증 환자의 치료 결과 보고

        김석원,신극선,조성환,이훈범,지용훈 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.6

        Vitiligo is a common acquired progressive depigmented disease. The treatment modalities are cosmatic masking agents, psoralen photochemotherapy (psoralens + UVA), Trimethoxypsoralen, topical steroid injection and melanocyte grafting Various procedures have been adopted for this disease not responding to medical therapy. The epidermal grafts have been used for the treatment of vitiligo, but the result was not acceptable due to the small amount of obtainable epidermis per one procedure. Recently, it is reported that epithelial sheet grafting after dermabrasion of vitiligo lesion is available treatment method for vitiligo. We applied thin split thickness skin graft after dermabrasion to the five cases of non progressive vitiligo, not responding to medical therapy. We had good postoperative results. The lesion sites were repigmented. The complications of this operation were slight uneveness and hyperpigmentation, which subsided as time goes by. This method can be a good choice for patient with stable type of vitiligo.

      • SCOPUSKCI등재

        귀 동정맥 기형의 성공적 치험례

        박철,최홍림,지용훈 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.1

        Auricular arterio-venous malformation(AVM) is relatively rare and few have been reported in the literature. Two cases, presented here showed pulsating lesions of anterior and posterior auricular or even retroauricular mastoid area. They caused irregular macro and prominent ear compared with the opposite normal ear. After embolization of feeding arteries to the arteriovenous malformations, skin and subcutaneous masses were completely removed and grafted with full thickness skin: one was removed one stage and the other underwent a two stage operations. There were no evidence of recurrence for more than 2 years follow up and esthetic results were promising

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