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기능성 소화불량증 환자의 위배출시간에 따른 위전도 ( EGG ) 에 관한 연구
박영숙(Y . S . Park),김영수(Y . S . Kim),강한걸(H . G . Kang),함기백(K . B . Hahm),김진홍(J . H . Kim),조성원(S . W . Cho),이상인(S . I . Lee),김옥화(O . H . Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.6
N/A Objectives The aim of this study was to know the clinical significance of electrogastrography(EGG) and to determine the relationship between gastric myoelectrical activity and gastric emptying time in patients with functional dyspepsia. Methods: This study included 10normal subjects and 30patients with functional dyspepsia. They were given scrambled egg with 2mCi 99m Tc-sulfur colloid for measuring gastric emptying time. We measured half time(T1/2) and remnant radio activity at 2hour after meal. Gastric myoelectrical activity was recorded by cutaneous EGG(Synetics, Digitrapper EGG) in 30patients with functional dyspepsia. EGG was recorded for at least 30minutes in fasting state and 30minutes in post prandial state (solid test meal, 618Cal), EGG was analyzed based on the running power spectra. Results: 1) In 10 normal subjects, the mean of gastric emptying time (Tl/2) was 89.0±7.9min and among 30 patients of functional dyspepsia, 14patients (46%) showed delayed GET (delayed GET group) and 16patients (53%) showed normal GET (normal GET grooup) 2) In both patients group, there was no significant difference in the percentage of normal gastric slow waves(2-4cpm) between fasting state and post prandial state. 3) In post prandial state, the ratio of slow wave in normal GET group was significantly higher than that in delayed GET group (95.5±6.2% vs 82.5±14.3%, p<0.05), but in fasting state, there was no significant difference. 4) Normal post prandial amplitude increment (1.5times higher than fasting state amplitude) was seen in 7(50%)cases of delayed GET group and in 13(80%)cases of normal GET gorup, which was statistically significant (p<0.05). Conclusion: Among patients with functional dyspepsia, delayed GET group showed higher ratio of gastric dysrhythmia and abnormal post prandial amplitude change. Electrogastrography seems to have clinical significance in evaluating the explanable cause of functional dyspepsia.
김원석 ( W. S. Kim ),이기명 ( K. M. Lee ),차충근 ( C. K. Cha ),김덕기 ( D. K. Kim ),김영배 ( Y. B. Kim ),유병무 ( B. M. Yoo ),김진홍 ( J. H. Kim ),김영수 ( Y. S. Kim ),조성원 ( S. W. Cho ),함기백 ( K. B. Hahm ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
위암의 발생에 관여하는 종양 억제 유전자로는 p53이 잘 알려져 있으며, 주요 작용 기전 중의 하나가 apoptosis 장애 및 cell cycle 조절 실패로 보고되고 있다. 그러나 위암에서 p53의 변이는 30-65% 정도로 보고되고 있어 나머지 위암에서 발암 기전은 의문으로 남아있다. 최근에는 pS2/TFF1 단백질의 변이가 암화의 초기에 관여한다는 사실과 pS2/TFF1 knockout mice에서 위암의 발생되었다는 보고로 위암 발생시 pS2/
말초혈액과 생식선에서 SRY유전자 양성을 보인 Swyer증후군 1례
남윤성,이숙환,한정희,조성원,윤태기,이정노,차광열,Nam, Y.S.,Lee, S.H.,Han, J.H.,Cho, S.W.,Yoon, T.K.,Lee, C.N.,Cha, K.Y. 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2
Male sexual differentiation involves a cascade of events initiated by the presence on the Y chromosome of the of the SRY (sex determining region of Y chromosome) gene, which causes the indifferent gonad to develop into a testis. Hormonal products of the testis, predominantly testosterone and Mullerian inhibiting subtance (MIS), then control the sexual differentiation of the developing fetus. SRY is a transcription factor; however, target genes for its action have yet to be identified, because the DNA recognition sequence for SRY is found in many genes. Therefore the study of intersex disorders is being used to identify other genes active in the pathway of sexual differentiation. Patients with 46,XY gonadal dysgenesis, or Swyer's syndrome, have streak gonads, normal stature, and a sexually infantile phenotype with Mullerian structures present. The inheritance is usually sporadic but can be autosomal dominant or X-linked recessive. Unlike 45,X patients, stigmata of Turner syndrome are rare. As many as 20 to 30% of patients are at risk for malignant gonadal tumor formation and should undergo gonadectomy soon after the diagnosis is made. We have experienced a case of Swyer syndrome which showed a positive SRY gene in peripheral blood and gonad. So we report this case with a brief review of literatures.