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鹿茸藥鍼이 LPS 誘發 關節炎의 潤滑關節膜內過多炎症反應 調節에 미치는 影響
정용래,이승덕,변혁,박인식,정찬영,이창환,김갑성 대한침구의학회 2007 대한침구의학회지 Vol.21 No.2
Objectives : To evaluate expression of MIF mRNA, MIF, TNF-α, IL-6R-α, STAT-3, NF-κB p65, COX-2 and iNOS, MMP-9mRNA after injecting deer antler herbal acupuncture solution in a LPS rat model. Methods : The experiment was divided in category of the control group, RA group, and NA group. RA was induced in the mice via injecting 300ug/kg LPS. The deer antler herbal acupuncture solution 50ug/kg was applied on ST35(犢鼻) & EX-LE201(內膝眼) for 19days from 3rdday of RA inducement. Results : 1. In the deer antler herbal acupuncture solution treated RAW 264.7cell, the mRNA expression of cytokines, RA related inflammation factors, such as the MIF, COX-2, iNOS, and MMP-9 reduced concentration dependently. 2. In the deer antler herbal acupuncture treated mice’s synovial membrane, decrease in the cell replication of synovial joint cells, regeneration of blood vessel, fibrosis and fibroblastic cells expansion were observed. 3. Positive reaction of RA-related cytokines MIF, TNF-α, IL-6R- α, STAT3, COX-2, iNOS, NF- κB p65, MMP-9 was reduced.Conclusion : On the basis of the results, it was concluded that deer antler herbal acupuncture extract has significant protecting ability against acute progressive RA by inhibiting the production of MIF, as a top in cytokines related to inflammation.
약용약침(藥茸藥鍼)이 LPS 유발(誘發) 관절염(關節炎)의 윤활관절막내(潤滑關節膜內) 과다염증반응(過多炎症反應) 조절(調節)에 미치는 영향(影響)
정용래,이승덕,변혁,박인식,정찬영,이창환,김갑성,Chung, Yong-Re,Lee, Seung-Deok,Byun, Hyuk,Park, In-Shik,Jung, Chan-Yung,Lee, Chang-Hwan,Kim, Kap-Sung 대한침구의학회 2007 대한침구의학회지 Vol.24 No.4
Objectives: To evaluate expression of MIF mRNA, MIF, $TNF-{\alpha}$, $IL-6R-{\alpha}$, STAT-3, $NF-{\kappa}B$ p65, COX-2 and iNOS, MMP-9mRNA after injecting deer antler herbal acupuncture solution in a LPS rat model. Methods: The experiment was divided in category of the control group, RA group, and NA group. RA was induced in the mice via injecting 300ug/kg LPS. The deer antler herbal acupuncture solution 50ug/kg was applied on $ST_{35}$(犢鼻) and EX-LE201(內膝眼) for 19days from $3^{rd}$ day of RA inducement. Results: 1. In the deer antler herbal acupuncture solution treated RAW 264.7cell, the mRNA expression of cytokines, RA related inflammation factors, such as the MIF, COX- 2, iNOS, and MMP-g reduced concentration dependently. 2. In the deer antler herbal acupuncture treated mice's synovial membrane, decrease in the cell replication of synovial joint cells, regeneration of blood vessel, fibrosis and fibroblastic cells expansion were observed. 3. Positive reaction of RA-related cytokines MIF, $TNF-{\alpha}$, $IL-6R-{\alpha}$, STAT3, COX-2, iNOS, $NF-\;{\kappa}B$ p65, MMP-9 was reduced. Conclusion : On the basis of the results, it was concluded that deer antler herbal acupuncture extract has significant protecting ability against acute progressive RA by inhibiting the production of MIF, as a top in cytokines related to inflammation.
마왕퇴(馬王堆) 출토(出土) 의서(醫書) 중(中) 《음양맥사후(陰陽脈死候)》에 관(關)한 연구(硏究)
정용래,황민섭,조현석,이승덕,김경호,윤종화,김갑성,Jung, Yong-rae,Hwang, Min-seob,Jo, Hyun-seog,Lee, Seong-deog,Kim, Kyung-ho,Yoon, Jong-hwa,Kim, Gap-sung 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2
Object : In this thesis we researched the transformation of five symptoms of final life stage from ${\ll}$Sumun(素問)${\gg}$, ${\ll}$Yingshu(靈樞)${\gg}$ and ${\ll}$Nanjing(難經)${\gg}$ and pulse diagnosis method. Method : We studied medical books from Mawangdui Han dynasty tomb Results and Conclusion : 1. The symptoms of final life stage according to Yinyanmaisihou(陰陽脈死候) is suggested by observation of symptoms introducting Yinyan five-elements theory. 2. The symptoms of final life stage according to Yinyanmaisihou(陰陽脈死候) and "Qijue(氣絶)" from ${\ll}$Lingshu(靈樞) Jingmai(經脈)${\gg}$ made use of twelve merdian bian(遍) diagnosis method and ${\ll}$Lingshu(靈樞) Zongshi(終始)${\gg}$, ${\ll}$Sumun(素問) Zhenyaojingzhonglun(診要經終論)${\gg}$ made use of twelve merdian biaoben(標本) diagnosis method. Afterward oriental medical biology which suggests agreement between outside and inside symptoms needs to be examined by use of science and medical theory to apply medical treatment .