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정규원(Kyu Won Chung),정환국(Whan Kook Chung),선희식(Hee Sik Sun),정인식(In Sik Chung),양진모(Jin Mo Yang),심상인(Sang In Shim),최명규(Myung Gyu Choi),양시영(Si Young Yang),김종률(Jong Yul Kim),이교영(Kyo Young Lee) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
Primary biliary cirrhosis (PBC) is a chronic inflammatory disease of unknown cause that is characterized by the destruction of small intrahepatic bile ducts. It is rare disease in Asia, especially in Korea. We report here a case of a 64-year old female with primary biliary cirrhosis and Sjogren s syndrome who has suffered from generalized pruritis and intermittent dry eye since 6 years ago, and sudden hematemesis. She was treated with endoscopic sclerotherapy, cholestyamine and ursodeoxy- cholic acid. We report the second case of primary biliary cirrhosis withe Sjogren's syndrome in Korea.
Parkinson 씨 병 환자에서 발생한 대장 가성폐색증 1 예
추교영(Kyo Young Choo),최명규(Myung Gyu Choi),최황(Hwang Choi),방춘상(Choon Sang Bhang),최규용(Kyu Yong Choi),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
Colonic pseudo-obstruction (CPO) is a syndrome characterized by obstructive symptoms and signs without mechanical obstruction. Parkinson's disease is one of the various clinical situations developing CPO. Recently, one study group reported that neostigmine was significantly more effective than placebo in rapidly decreasing colonic dilatation in the majority of patients with acute CPO. We experienced a 69-year-old male patient with Parkinson's disease who complained abdominal distension. There was a marked colonic dilatation on plain abdominal radiographs without mechanical obstruction. Colonic dilatation failed to improve with conservative management. Immediate clinical response was achieved after patient received 2.0 mg of neostigmine intravenously under monitoring by electrocardiography. One month later, he had recurrent colonic dilatation, but no clinical response to second administration of neostigmine, leading to colonic decompression. After a third recurrence of colonic dilatation, the patient was refractory to conservative management, and he underwent surgical treatment. (Korean Journal of Gastrointestinal Motility 2001;7:251-256)
Itopride가 정상 성인에서 상부 위긴장도와 위감각능에 미치는 영향
최명규(Myung Gyu Choi),추교영(Kyo Young Choo),김병욱(Byung Wook Kim),최황(Hwang Choi),박수헌(Soo Heon Park),오정환(Jung Hwan Oh),한석원(Sok Won Han),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Background/Aims : Itopride is a newly developed prokinetic agent and has antidopaminergic and anti- acetylcholine esterase activities. Our aim was to evaluate the effect of itopride on proximal gastric tone and visceral perception. Methods: Fifteen healthy subjects participated in two experiments with 7 days interval. Randomized double blinded cross-over design with 3 days pretreatment of placebo or itopride was followed by itopride or placebo treatment. After overnight fasting, itopride was given prior to barostat study. Sensory function was assessed by scoring the perception for nausea, fullness, and abdominal discomfort/pain during random-order distensions of 4, 8, and 12 mmHg above minimal intragastric distending pressure (MDP). Effect of distensions was studied three times. Results : Compliance was not different after pretreatment of itopride or placebo. Itopride has no effect on visceral perception at MDP+4 mmHg (92.5±45.3 vs. 79.1±30.2), 8 mmHg (117.7±41.1 vs. 118.9±41.5) and at MDP+12 mmHg (159.8±43.9 vs. 149.9±53.5). MDP and fasting tone were not different between the two experimental groups. After itopride pretreatment, significantly increased intragastric volume were recorded in 60 min postprandial period (p<0.05). Conclusions: Itopride enhances the gastric accommodation to meal. This observation suggests that itopride may provide benefits to patients with impaired postprandial relaxation of proximal stomach. (Kor J Gastroenterol 2000;36:293 - 301)
보행성 24시간 식도내압검사로 진단된 미만성 식도경련 1례
최명규(Myung Gyu Choi),추교영(Kyo Young Choo),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박수헌(Soo Heon Park),장데레사(Theresa Jang),김백선(Baek Sun Kim),김선명(Sun Myung Kim),한준열(Jun Yeol Han) 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.1
Diffuse esophageal spasm (DES) is a motility disorder of the esophagus characterized by symptoms of retrosternal chest pain and intermittent dysphagia. The diagnosis of DES has relied on criteria obtained from a standard esophageal manometry (more than one simultaneous contraction in a series of l0 wet swallows with the rest being peristaltic). Because symptoms and/or typical manometric findings are not always documented during the standard manometry, 24 hour manometry may be more useful in such cases. We recently assessed a 29-year-old male patient who complained of chest pain and dysphagia. He showed nonspecific, findings on the laboratory hiwi manometry, but DES was diagncwed by his typical manometric findings on the 24 hour manometry. Therefore, a 24 hour manometry. should always he performed when the patient's history suggests the presence of DES and the laboratory based manometry failed to detect the symptomatic contractions of DES. Following we report this case with a review of the literature. (Korean Journal of Gastrointestinal Motility 2000;6:63-68)
이성희(Seong Hee Lee),최명규(Myung Gyu Choi),추교영(Kyo Young Choo),왕준호(Jun Ho Wang),문성배(Sung Bae Moon),최황(Hwang Choi),방춘상,김재광(Jae Kwang Kim),최규용(Kyu Yong Choi),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박수헌(Soo Heon 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.1
N/A Baekground/Aim: Heartburn, which was the most common symptom of reflux disease, was unreliably interpreted by Korean patients. Our aim was to evaluate the clinical spectrum of gastroesophageal reflux disease(GERD) in Korea. Methods: Patients who were diagnosed by an endosopy or ambulatory pH monitoring at a tertiary medical facility were given a validated questionnaire and the clinical spectrums were prospectively investigated. Results: Seventy one patients were included, Heartburn was occurring m 39 patients and the frequency of heartburn on two or more days a week were found in only 12 patients. Negative impact of reflux symptoms on health related well being were found in 16 patients. The reflux related atypical symptoms were hoarseness(55%), globus sensation(45%), cough(25%), and chest pain(20%). Twenty two patients complained of epigastric pain or discomfort more than 6 times a year, with 13 patients listing abdominal pain as the most bothersome one. The clinical spectrums were not different between endoscopy negative patients and those with esophagitis. Conclusions: Typical reflux symptoms are absent in a substantial proportion of Korean patients with GERD. True dyspepsia could result from gastroesophageal reflux, GERD needs to be clarified in patients with chronic laryngeal symptoms, cough or chest pain. (Korean Journal of Gastrointestinal Motility 2000;6:1-10)
박성규(Sung Gyoo Park),최명규(Myung Gyu Choi),박수헌(Soo Heon Park),추교영(Kyo Young Choo),최황(Hwang Choi),김재광(Jae Kwang Kim),한석원(Sok Won Han),손형선(Hyung Sun Son),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Background/Aims : Scintigraphic test for gastric emptying has not been widely used as a screening test for gastric motility disorders in Korea. Our aim was to develop a relatively inexpensive, accurate test using selected scintigraphic observations. Methods: Scintigraphic scans after ingestion of an egg solid meal containing 99mTc-Amberlite pellets were performed for 21 healthy volunteers and 50 patients with suspected motility disorders. Gastric emptying was analyzed by power exponential analysis. We compared the accuracy of selected scans with traditional, more detailed approaches. Results : Lag phase was well correlated with gastric residuals at 30 min and 1 hour. Half gastric emptying time was well correlated with gastric residuals at 1 hour and 2 hours. Gastric residual at 30 min was more accurate for the diagnosis of rapid gastric emptying with sensitivity and specificity over 90%. Gastric residual at 2 hours was more accurate at detecting delayed gastric emptying with sensitivity and specificity over 90%. Conclusions: Selective scintigraphic scans taken at 30 min and 2 hours provide an excellent screening method for detecting abnormal gastric emptying with acceptable sensitivity and specificity. This strategy provides a simple, inexpensive way to evaluate gastric emptying in clinical practice. (Kor J Gastroenterol 2000;36:283 - 292)
정대영 ( Dae Young Cheung ),김재광 ( Jae Kwang Kim ),김진일 ( Jin Il Kim ),한준열 ( Joon Yeol Han ),정규원 ( Kyo Won Chung ),선희식 ( Hee Sik Sun ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.4
Background/Aims: As a preliminary study to test the possibility of oral transmission of hepatitis C virus (HCV), many investigations in order to detect the extrahepatic localization of HCV have been performed. In this study, we examined the presence of HC
곽승기(Seung Ki Kwok),장우임(U Im Chang),이태규(Tae Kyu Lee),추교영(Kyo Young Choo),김진일(Jin Il Kim),박수헌(Soo Heon Park),한준열(Joon Yeol Han),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
Tuberculosis of the abdominal wall is relatively uncommon and most cases were caused by a spread of the infection from tuberculous abdominal lymph nodes. Autopsy studies have shown abdominal wall involvement in less than 1% of patients who died of tuberculosis. We have experienced a case of the tuberculous abscess in the abdominal wall. A 21-year-old woman was admitted for the evaluation of a soft mass at the right upper abdomen. A 15×5×4 cm sized abscess in the abdominal wall was detected by ultrasonogram and CT. Abscess was drained by ultrasonogram-guided aspiration. The confirmed diagnosis of tuberculous abscess was made by means of polymerase chain reaction of the aspirated fluid from the mass. The patient was successfully treated with anti-tuberculosis therapy of four drug regimens. To our knowledge, this is the first report of tuberculous abscess developed in the abdominal wall in Korea. (Korean J Gastroenterol 2001;38:220-223)
위와 대장의 선암 및 선종에서 E-cadherin/β-catenin 복합체의 발현
박수헌,김재광,정규원,최명규,한준열,선희식,문성배,강창석,이교영 대한소화기학회 2000 대한소화기학회지 Vol.36 No.4
Background/Aims: Poor expressions of E-cadherin and β-catenin complex in the immunohistochemical staining were frequently observed in the tumors. We investigated the correlation between the expressions of E-cadherin and β-catenin and the clinicopathologic factors of adenocarcinomas and adenomas in the stomach and colon. Methods: Immunohistochemical staining of E-cadherin and β-catenin was performed for the adenocarcinomas of stomach (65) and colon (98) and adenomas of stomach (39) and colon (47). Results: The abnormal stainings of E-cadherin and β-catenin were observed in the most adenocarcinomas of the stomach and colon, and in the certain numbers of adenomas of the stomach and colon. This abnormality was frequently observed in the undifferentiated and infiltrative adenocarcinoma. The abnormal staining of E-cadherin and β-catenin in gastric cancer was closely correlated with poor survival, but not in the colon cancer. Conclusions: These findings show that the decreased expression of E-cadherin and β-caare involved in progress of stomach and colon cancer. The cytoplasmic expression of E-cadherin and β-catenin in some adenocarcinoma seems to be also involved in the carcinogenesis but needs further study.