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정경수,이대우,양희정,이순철,김길현 충남대학교 약학대학 의약품개발연구소 1994 藥學論文集 Vol.10 No.-
To ellucidate immunologic activities of ginseng saponin, the splenic leukocytes of BALB/c mice were incubated in RPMI medium for 48hr with or without ginseng total saponin(GTS), and then analyzed flow cytometrically. Upto the concentration of 100㎍/㎖, GTS exherted stimulatory effect on the immune cells most prominently on B cells: the percentage of the surface Immunoglobulin (sIg) -positive cells (B cells) of the control was 47.l%, while that of GTS treated was 58.9%. The percentages of monoclonal antibody(mAb) J1j-reactive cells (T cells) were 28.8% and 3l.3%, those of mAb Gkl.5-reactive cells (CD4' T cells) were l8.5% and l9.l%, and those of mAb M1/70-reactive cells (mostly macrophages) were 4.4 and 5.0% at the concentration of 0 and 100㎍/㎖, respectively. However, at the concentration of 300㎍/㎖ or higher, GTS was found to be toxic to the immune cells especially to B cells in that the flow rate of the cells (gated viable cells) significantly decreased and the percentage of B cells droped from 58.9% to 31.2% and 25.4% at l00, 300, and 1000㎍/㎖, respectivelly. These data strongly suggests that GTS would exhert B-cell mitogen-like activity at physiological concentrations of 100㎍/㎖ or lower.
무우자갈버섯(Hebeloma crustulineforme)을 위시한 한국산 담자균류 46종의 용혈활성 검색
양희정,정수현,김진향,정경수 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-
To elucidate the hemolytic toxicities of Korean basidiomycetes, the cold-water extracts of 46 wild mushrooms were tested for hemolytic activity on mouse erythrocytes. Twelve species including Amanita esculenta, A. griseofarinosa, A. longistriata, A. melleicepe, A. phalloides, A. rubescence, A. spissacea, A. vaginata, Hebeloma crustuliniforme, Lepiota cygnea, Macrolepiota procera, and Oudemansiella platyphylla showed strong hemolytic activities. Of these, A. griseofarinosa and H. crustuliniforme showed no decrease in their hemolytic activity even after five minutes' boiling.
Choi, Sun-Woong,Lee, Jin-Ho,Lee, Kyu-Hee,Bang, Sung-Jin,Ahn, Jong-Sung,Lee, Keun-Hyung,Chung, Kyeong-Soo,Oh, Jung-Yeon,Kim, Jin-Hyang,Yang, Joon-Mook,Noh, Seung-Moo,Min, Byung-Moo,Kim, Young-Beak,Kim, 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A method for processing and the drug releasing behavior of 5-Fluorouracil(5FU)/ Polyglycolic Acid(PGA) composite, applicable to medical devices, was investigated. A preliminary results indicated that the method utilizing melt processing could be a simple means by which the composite can be processed without referring to more involved and difficult-to-achieve solvent processing method. It is shown that the effectiveness of 5-FU was maintained during tests, even after the processing temperature of 230℃. The release patterns from the various sized samples have indicated that the observed release may have occurred in one or two stages, depending on the sample thickness and that a longer experimental times may be required to elucidate the complete release pattern. Although a further and more detailed analysis need to be performed to better understand the controlled release behavior of 5FU/PGA composite, the current results have provided the possibility of utilizing melt processing as a tool to produce medical devices for successful drug delivery applications,