다채널 청각 사건관련전위 P300 결정에서 전부위장력측정법과 전통적방법의 비교

전양환,한상익,Jeon, Yang-Whan,Han, Sang-Ick 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

Objective : The present study was designed to compare Global Field Power Measurement and conventional method in P300 determination. Method : The subjects were composed of patients(N=20) with schizophrenia by DSM-IV and normal controls(N=20). The auditory event related potential P300 was measured by "oddball paradigm". P300 components were determined by Global Field Power Measurement and conventional method at 5 electrodes(Fz, Cz, Pz, $T_3$, $T_4$). Results : P300 amplitudes of patients were smaller than those of controls across all electrodes and in both methods, but there was no differential power in P300 determination between two methods. Asymmetry of auditory event-related potential P300 was not shown between patients with schizophrenia and normal controls. Conclusion : It is implicated that it depends on clinical situations and research purposes what method of P300 determination will be more appropriate for patients with schizophernia.

위암 수술 환자에서의 삶의 질

전양환,한상익,전철은,김진조,박승만,Jeon Yang-Whan,Han Sang-Ick,Jeon Chul-Eun,Kim Jin-Jo,Park Seung-Man 대한위암학회 2004 대한위암학회지 Vol.4 No.1

Purpose: This study was designed to explore quality of life (QOL) in patients with stomach cancer by using the World Health Organization Quality of Life (WHOQOL) Instrument- Korean version. Materials and Methods: Thirty-one (31) patients with stomach cancer after curative resection were recruited with informed consent. Age- and gender-matched hospital staff served as controls. The 100-item WHOQOL Instrument, including physical domain, psychological domain, social domain, independence domain, environment domain, and spiritual domain, was employed for the all subjects. Results: In patients with stomach cancer after operation, only two domains, physical and independence, were associated with worse quality of life. In those domains, patients with advanced stage, with total gastrectomy, with adjuvant chemotherapy, and early or late postoperative period ($\leqq$2 years or >5 years after operation), could be perceived of having a worse quality of life. Conclusion: Not only scientific objective success but also individual subjective perception of condition could be important for managing patients with stomach carcinomas after curative resection. In this context, the WHOQOL reflecting multi-dimensional state of well being could be a useful tool across a variety of cultural and value systems in the world.

우울장애 아형간에 Isoproterenol 자극후 임파구 Cyclic AMP Levels의 차이

박원명,전양환,김광수,성양숙,Bahk, Won-Myong,Jeon, Yang-Whan,Kim, Kwang-Soo,Sung, Yang-Sook 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

주요 우울장애 환자와 기분부전장애 환자에서 정상대조군과 비교하여 임파구에 isoproterenol 자극 후 cyclic AMP 생성반응에 차이가 있는지를 알아보고, 이 두 질환군에서 net cyclic AMP levels와 우울정도간의 상관성을 알아보고자 주요 우울장애군 8명, 기분부전장애군 9명, 정상대조군 10명을 대상으로 본 연구를 시행하였다. Cyclic AMP 농도는 방사면역 측정법 (radioimmunoassay)으로 측정하였다. 결과를 요약하연 다음과 같다. 1) HDRS 정수상 주요 우울장애군이 기분부전장애군보다 유의하게 우울정도가 높았다. 2) Isoproterenol 자극전 basal cyclic AMP levels는 정상대조군, 주요 우울장애군, 기분부전장애군간에 차이가 없었다. 3) Isoproterenol $10^{-5}mol/L$ 자극후 net cyclic AMP levels는 정상대조군 주요 우울장애군, 기분부전장애군간에 유의한 차이를 보였다. 4) 주요 우울장애군에서 isoproterenol $10^{-5}mol/L$ 자극후 net cyclic AMP levels와 HDRS 점수간에 유의한 역상관관계를 보였으나, 기분부전장애군에서는 상관관계를 보이지 않았다. 이상의 결과로 저자들은 기분부전장애가 임상적으로는 주요 우울장애의 우울정도가 경미한 한 형태로 보이지만 생물학적으로는 이들 두 질환이 다른 질환일 수 있다고 생각하였다. This study was designed to examine the basal cyclic AMP levels and the $10^{-5}mol/L$ isoproterenol-stimulated cyclic AMP levels of lymphocytes, by which ${\beta}$-adrenoceptor function was shown, between to normal controls and 17 drug free patients(8 major depresive patients and 9 dysthymic patients), who were diagnosed by DSM-III-R. The severity of depression was assessed by Hamilton Rating Scale for Depression (HDRS). Cyclic AMP levels were measured by radioimmunoassay(double antibody). The results were as follows ; 1) HDRS score was significantly higher in major depressive patients($41.8{\pm}4.6$) than in dysthymic patients($24.0{\pm}4.2$)(p<005). 2) There was no Significant difference in basal cyclic AMP levels among normal controls($3.9{\pm}1.7pmol/10^6cells/10min$), major depressive patients($2.1{\pm}0.5pmol/10^6cells/10min$), and dysthymic patients($3.9{\pm}1.8pmol/10^6cells/10min$). 3) There was significant difference in net cyclic AMP levels($10^{-5}mol/L$ isoproterenol-stimulated cyclic AMP levels minus basal cyclic AMP levels) among normal controls($16.5{\pm}6.0pmol/10^6cells/10min$), major depressive patients($3.0{\pm}1.4pmol/10^6cells/10min$), dysthymic patients($10.9{\pm}4.4pmol/10^6cells/10min$)(p <005). 4) The net cyclic AMP levels were significantly correlated with HDRS scores in major depressive patients(${\gamma}=-0.8^6$, p<0.05), but not in dysthymic patients(${\gamma}=0.43$, p=0.25). In conclusion, we suggested that the dysthymic disorder might differ from the molar depressive disorder not only in the severity of depressive symptoms but also in ${\beta}$-adrenergic responsiveness of lymphocytes, which was regarded as a biological marker of depressive disorder.

여성 우울증 입원 환자에서 폐경 여부에 따른 인지기능의 차이

유지영,민정아,전양환,한상익,박이진,You, Ji-Young,Min, Jung-Ah,Jeon, Yang-Whan,Han, Sang-Ick,Park, E-Jin 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4

Objectives Although forgetfulness is a common complaint among menopausal depressed women, there is still a debate about the relationship between memory impairment and menopause. The aim of this study is to examine whether menopause is related to cognitive decline among women with depressive disorders. We hypothesized that postmenopausal depressed women show generally poorer performance than premenopausal depressed women on various cognitive function tests. Methods With a retrospective chart review, we identified a total of 87 female patients (45 premenopausal patients and 42 postmenopausal patients) who were hospitalized with depressive disorders from 2000 to 2016. Demographic and clinical variables and cognitive test results were compared between two groups. Results Education year is longer in premenopausal group than postmenopausal group whereas clinical characteristics (illness duration, recurrence, and symptom severity) and mean Intelligence Quotient (IQ) were similar between two groups. The postmenopausal group took longer time for Bender-Gestalt Test (BGT) recall, Trail Making Test (TMT)-A, and TMT-B than the premenopausal group. After controlling for age and education, significant difference was remained for BGT recall (p = 0.029). Conclusions Postmenopausal state may be related with decline of visuospatial memory function, in particular, among depressed female patients. Other areas of cognitive function including complex attention, verbal memory, auditory memory, and working memory might be interpreted while considering age and education level.

충동조절장애군과 광범위 양극성 정동장애 스펙트럼간의 관계에 대한 고찰

이태경(Tae-Kyung Lee),전양환(Yang-Whan Jeon) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.2

This article reviews the current knowledge about the emerging concept of the soft bipolar spectrum and summarizes available evidence regarding a possible relationship between impulse control disorders (ICDs) and the soft bipolar spectrum. The soft bipolar spectrum is organized around bipolar II disorder and cyclothymic temperamental instability represents the common substrate underlying a ‘spectrum’ of related clinical conditions characterized by a complex combination of mood, anxiety, and impulse control disorders. In this article, studies examining the phenomenology, course, psychiatric comorbidity, family history, and treatment response of impulse control disorders are compared with the studies examining those of the soft bipolar spectrum. This review suggests that the two conditions may be related and thus may share at least one common pathophysiologic abnormality. Viewing these constructs as related entities with a common temperamental predisposition will make patients in this realm more accessible to pharmacologic and psychological approaches geared to their common temperamental attributes.

에탄올 처리에 의한 흰쥐 신경아교종(Glioma) 세포에서의 유전자 발현 - DNA 칩을 이용한 분석 -

이소희,오동열,한진희,최인근,전양환,이준노,이태경,정종현,정경화,채영규,Lee, So Hee,Oh, Dong-Yul,Han, Jin-Hee,Choi, Ihn-Geun,Jeon, Yang-Whan,Lee, Joon-Noh,Lee, Tae Kyung,Jeong, Jong-Hyun,Jung, Kyung Hwa,Chai, Young-Gyu 대한생물정신의학회 2007 생물정신의학 Vol.14 No.2

연구목적: 알코올의존에 내재된 분자생물학적 기전을 이해하고 알코올리즘 치료 약물의 새로운 표적을 알아내기 위해서는, 알코올에 반응하는 유전자 혹은 반응 경로를 알아내는 것이 필요하다. DNA microarray 기법의 발달로 고전적 연구 방법과 달리 동시에 수천 수만개의 유전자의 표현을 검사하는 것이 가능하게 되었다. 본 연구에서는 알코올을 흰쥐의 신경아교종 세포에 처리했을 때 어떤 유전자의 발현을 조절하는지 DNA microarray를 이용하여 알아보고자 하였다. 방 법: 흰쥐 신경아교종 C6 세포주를 배양하여 에탄올 처리하고 총 RNA를 분리한 후 유전자 발현 양상을 조사하기 위해 cDNA microarray를 수행하였다. 결 과: 에탄올 처리군과 대조군간의 유전자 발현의 차이를 비교 분석한 결과 에탄올이 처리된 군에서 대조군에 비해 15개의 유전자가 발현이 증가하였고 12개의 유전자가 발현이 감소하였다. 발현이 증가한 유전자는 Orthodenticle(Drosophila) homolog 1, procollagen type II, adenosine A2a receptor, GATA-bindning protein2를 포함하고 있었고, 발현이 감소한 유전자는 diacylglycerol kinase beta, PRKC, Protein phosphatase 1, clathrin-associated protein 17, nucleoporin p58, proteasome를 포함하였다. 결 론: 흰쥐의 신경아교종 세포주에 알코올을 처치하였을 때 급성기에 알코올에 반응하여 발현이 증가하거나 감소한 유전자는 전반적으로 전사의 조절, 신호전달체계, 허혈성 뇌손상의 중재, 신경세포의 퇴행에 관여하는 것들이었다. 본 연구는 유전자 발현 시스템을 이용하여 에탄올에 반응하는 새로운 후보 유전자들을 관찰하였다는데 의의가 있다. Objetives : Identification of target genes for ethanol in neurons is important for understanding its molecular and cellular mechanism of action and the neuropathological changes seen in alcoholics. The purpose of this study is to identify of altered gene expression after acute treatmet of ethanol in rat gliom cells. Methods : We used high density cDNA microarray chip to measure the expression patterns of multiple genes in cultured rat glioma cells. DNA microarrays allow for the simultaneous measurement of the expression of several hundreds of genes. Results : After comparing hybridized signals between control and ethanol treated groups, we found that treatment with ethanol increased the expression of 15 genes and decreased the expression of 12 genes. Upregulated genes included Orthodenticle(Drosophila) homolog 1, procollagen type II, adenosine A2a receptor, GATA bindning protein 2. Downregulated genes included diacylglycerol kinase beta, PRKC, Protein phosphatase 1, clathrin-associated protein 17, nucleoporin p58, proteasome. Conclusion : The gene changes noted were those related to the regulation of transcription, signal transduction, second messenger systems. modulation of ischemic brain injury, and neurodengeneration. Although some of the genes were previously known to be ethanol responsive, we have for the most part identified novel genes involved in the brain response to ethanol.

정신분열병 환자의 청각 사건관련전위에 대한 지형학적 연구

김영배 ( Young Bae Kim ),이용석 ( Yong Suk Lee ),김정미 ( Jung Mi Kim ),전양환 ( Yang Whan Jeon ) 대한임상검사과학회 2003 대한임상검사과학회지(KJCLS) Vol.35 No.2

The present study was designed to evaluate laterality of brain function and information processing abnormalities in patients with schizophrenia. In neurophysiological field, there is particular interest in the P300 component of event related potentials being recorded during discriminative task. The subjects were composed of patients(N=24) with schizophrenia by Diagnostic and Statistical Manual of Mental Disorders-IV(DSM-IV, 1994) and normal controls(N=24). The auditory event-related potentials P300 were employed by "oddball paradigm". P300 latency and amplitude were determined by conventional method at 5 electrodes(Fz, Cz, Pz, T7, T8) after grand-averaging across all subjects. P300 amplitude of patients were smaller than those of controls across all electrodes. P300 latencies were delayed in patients with schizophrenia. There are no asymmetry and laterality in the both groups. P300 ERP, known as a measure reflecting brain cognitive function, could be useful in neuroscience including schizophrenia.

의과대학생의 성격유형과 자연최면경험

이정태(Chung Tai Lee),한상익(Sang Ick Han),김광수(Kwang Soo Kim),박원명(Won Myong Bahk),유태열(Tae Yul Lew),정진복(Jin Bok Jung),전양환(Yang Whan Jeon) 한국정신병리진단분류학회 1995 精神病理學 Vol.4 No.1

N/A N/A

지형학적 청각 사건관련전위 P300 요소들의 결정방법

한상익,전양환 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

목 적 : 본 연구는 지형학적 청각사건관계전위 P300 요소들을 결정하는 방법들을 비교하기 위함이다. 방 법 : 44명의 정상인과 DSM-Ⅳ에 근거한 44명의 정신분열증 환자를 대상으로 하였다. 지형학적 청각사건관련전위 P300은 oddball paradigm으로 기록하였다. 잠복기, 전위, 그리고 X-Y 좌표에 따른 최대전위 위치 등을 포함한 P300요소들은 전산화된 Brain Mapping기기를 사용하였다. P300 잠복기는 global field power measurement와 고전적 방법으로 결정하였다. 결 과 : 잠복기(DF=1, F=35.28, P=0.0001)와 전위(DF=1, F=36.62, P=0.0001)에서 두 군간에 차이가 있었으나, X 좌표(DF=1, F=0.37, P=0.55)와 Y 좌표(DF=1, F=2.00, P=0.16)에서는 차이가 없었다. 잠복기(DF=1, F=0.04, P=0.85), 전위(DF=1, F=0.07, P=0.79), X 좌표(DF=1, F=0.07, P=0.79), Y 좌표(DF=1, F=0.03, P=0.86)에서 두 방법간에 차이가 없었다. 결 론 : 이 결과는 지형학적 청각사건관계전위 P300의 요소들을 결정하는 두 방법이 현재까지는 연구 및 임상 적용에 유용함을 시사한다. Objects : This study was designed to make a comparison between methods to determine the components of topographic auditory event related potential P300. Methods : The subjects were consisted of 44 normal controls and 44 patients with schizophrenia diagnosed by DSM-Ⅳ. The topographic auditory event related P300 was recorded in oddball paradigm. The components of P300, including latency, amplitude, and location of maximum amplitude in X-Y coordinates, were analyzed by computerized EP mapping system. The latency of P300 was determined by both global field power measurement and classic method. Results : There was difference between two groups in latency(DF=1, F=35.28, P=0.0001)and amplitude(DF=1, F=36.62, P=0.0001), but not in X coordinate(DF=1, F=0.37, P=0.55) and Y coordinate(DF=1, F=2.00, P=0.16). There was no difference between two methods in latency(DF=1, F=0.04, P=0.85), in amplitude(DF=1, F=0.07, P=0.79), in X coordinate(DF=1, F=0.07, P=0.79), and in Y coordinate(DF=1, F=0.03, P=0.86). Conclusion : The results suggested that two methods to determine the components of topographic auditory event related potential P300 should be available for both research and clinical application to date.

지형학적 청각 사건관련전위 P300과 정신분열증의 정신병리

한상익,전양환 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

목 적 : 이 연구를 통하여 정신분열증 환자에서 지형학적 청각사건관련전위 P300 요소들의 특성을 조사하고 정신병리와 P300요소들 간의 상관관계를 알아 보고자 하였다. 방 법 : 대상군은 28명의 정신분열증 환자와 나이 및 성별을 일치시킨 28명의 정상인으로 하였다. 지형학적 청각사건관련 P300은 'oddball'모형으로 기록하였고 컴퓨터화된 뇌전위검사기(brain mapping system)로 분석하였다. P300잠복기는 Global Held power measurement에 의해 결정하였다. 정신분열증 환자의 정신병리는 PAESS로 평가하였다. 결 과 : 잠복기와 전위에서 두 군간에 유의한 차이가 있었다. 그러나 P300 최고부위의 전극위치는 두 군간에 차이가 없었다. P300잠복기는 정신분열증환자에서 PANSS점수와 양의 상관관계를 보였으며 전위는 음의 상관관계를 보였다. 결 론 : 위 결과는 정신분열증 환자들에서 양성 및 음성증상에 의해 영향을 받는 인지과정 측면의 정신 기능 장애가 있음을 시사한다. 0bjects : This study was designed to investigate the characteristics of components of topographic auditory event-related potential P300 in the patients with schizophrenia and to evaluate the correlation between the findings of components of P300 and psychopathology. Methods : The subjects consisted of 28 patients with schizophrenia and 28 normal controls who were matched by age and sex. The topographic auditory event-related P300 was recorded in oddball paradigm and analized by computerized brain mapping system. The latency of P300 was determined by global field power measurement. The psychopathology of the patients with schizophrenia were rated by PANSS. Results : There were significant differences in both latency(schizophrenia : 369.5±40.6msec, normal controls 332.6± 34.8msec) and amplitude(schizophrenia 4.1 ±3.1μV, normal controls: 6.7 ± 3.2μV). However, there was no difference in the electrode location of maximum area of P300 between the patients with schizophrenia and normal controls. The latency of P300 showed positive correlation and the amplitude showed negative correlation with PANSS scores of the patients with schizophrenia. Conclusion : The results implicate that the patients with schizoprenia might have mental dysfunction in the aspects of cognitive process affected by both positive and negative symptoms.