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불멸화 인간 태아 골수 유래 간엽줄기세포주의 제작 및 특성 연구
김우경 ( Woo Kyoung Kim ),박인호 ( In Ho Park ),( A. Nagai ),홍석호 ( Seok Ho Hong ),김광세 ( Kwang Sei Kim ),장윤경 ( Yun Kyung Jang ),김승업 ( Seung U. Kim ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.4
Bone marrow mesenchymal stem cells (MSCs) have multilineage differentiation capacity potential to become various cell types, including bone, cartilage, fat, muscle and neurons. MSCs have been engrafted and survived in animal grains, raising the possibility of therapeutic potential for patients with neurological disorders. Human fetal bone marrow MSCs were transfected with a retroviral vector carrying v-myc and twelve clones of human bone marrow MSC cell lines have been generated. B10, one of the cell lines, carries normal human karyotype of 46,XX and expresses cell type specific markers for human MSCs including CD13, CD29, CD44, CD49b, CD90 and CD166. when B10 cells were grown in differentiation media, better than 80% of cells differentiated into osteocytes, chondrocytes and adipocytes, and 40% of cells expressed neuron-specific cell type markers, beta-tubulin III and neurofilaments. These results indicate that the immortalized human MSCs should serve as a powerful tool for research into development of stem cell based therapy for human neurological disorders.
18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구
장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3
Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.
NaF CPC 녹차추출액 및 솔잎 추출물을 배합한 구강양치액의 치주질환예방효과와 구취감소효과 및 치아우식증예방효과에 관한 연구
배광학,이병진,장윤경,이병렬,이원재,장덕수,문혁수,백대일,김종배 대한구강보건학회 2001 大韓口腔保健學會誌 Vol.25 No.1
The aim of this study was to assess the effect of mouthrinse products which contained 0.03% sodium fluoride, 0.05% cetylpyridinium chloride(CPC), 0.04% pine leaf extracts and 0.04% green tea extracts. The negative control was distilled water contained no antibacterial agents. The in vivo study used case control, double-blind and crossover design in which 40 healthy subjects aged from 20 to 25 participated. On baseline, subjects received a scaling and polishing to reduce plaque index to 0 and commenced rinsing three times and toothcleansing twice daily. Rinsing time was 30 seconds. Plaque, gingivitis, halitosis and the number of S. mutans(CFU/㎖) were scored at baseline, after 2 weeks, after 4 weeks and after 6 weeks. Plaque and gingivitis were score by index and halitosis by halimeter. To compare the microhardness data of differently stored enamel surfaces the in vitro study used pH Cycling Model. Each 19 bovine enamel specimens were given 17h demineralization, 0.25h immersion in mouthrinse products and control, and 6h remineralization buffer solution for 48h and 96h. Gingivitis, halitosis and S. mutans growth of the mouthrinse group were more reduced significantly than control group at 2 weeks(p<0.05). The microhardness of enamel surfaces were also more decreased in mouthrinse products than in distilled water(p<0.05).