[특집2/ 김천문학을 찾아서] '나-고향-조국'의 회귀의식 - 백수 사향(思鄕)의 시(詩)를 중심으로 -

장병우 향토문학연구회 2002 향토문학연구 Vol.5 No.-

병합 임신 1예 보고

장병우,맹신숙,조지연 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

The coexistence of intrauterine and extrauterine gestation is a somewhat rare obstetric phenomenon thought to occur in 1 of 30,000 spontaneous pregnancy. Recently, Assisted reproductive technology such as IVF and ET are increasingly common in the management of infertility. There is a higher maternal morbidity and fetal loss due to delayed or missed diagnosis, so a combined pregnancy is guite difficult to diagnosis clinically. We experienced a case of intrauterine pregnancy coexisting with right tubal pregnancy as combined pregnancy in 24 year old nulliparous woman, so we reported this case with a brief review of the literature.

자궁 경부암 환자의 림파선 폐 전이 1례 보고 : A Case Report

장병우,임옥경,박미혜,신효경,김향미,손영수,우복희,정호인,서정수 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.1

Diffuse pulmonary Iymphangitic involvement secondary to cervical carcinoma is a rare form of pulmonary metastatic disease. A patient with recurrent squamous cell carcinoma of cervix presented with rapid deterioration with marked respiratory symptoms suggestive of pulmonary embolism and right heart faiure, with which the disease is often confused. Pulmonary Iymphangitic spread of the cancer was found postmortem. The pathogenesis of pulmonary Iymphangitic carcinomatosis is reviewed and diagnostic evaluation discussed.

도플러 초음파를 이용한 월경주기별 난소동맥의 혈류속도 파형의 연구

장병우,김향미,손영수,유한기 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Objective : To assess intraovarian blood flow Doppler parameter during the natural and controlled ovarian hyperstimulation cycles in early follicular, periovulatory and midluteal phase each other. Design : Serial measurement throught the menstrual phase in natural 9 cases and controlled ovarian hyperstimulation cycles 14 cases. We measure the doppler parameter which were PI, RI, and A/B ratio by transvaginal ultrasound-color flow doppler. Result : No differences were observed between the two groups. During the natural cycle, ovarian blood flow velocity has a pulsatility index(PI) was 0.68, 0.68 and A/B ratio was 3.37, 3.38 respectively, which were not statistically significant. And so, during the controlled ovarian hyperstimulation cycle blood velocity was a PI of 1.43, 1.38, 0.87 in early follicular, periovulatory and midluteal phase, RI was 0.67, 0.66, 0.77 and A/B ratio was 3.29, 2.42, 2.35 respectively, which were not statistically significan, too. Conclusion : Transvaginal ultrasound-color Doppler velocimetry is easy application and comfortable to physician and patient. And the image of pelvic organ and pathophysiologic condition are concerned by sonogram tools especially doppler measurement. We think that the sonographic information are very available to evaluated clinical result and outcome, of ART future.

흰쥐의 대뇌피질 손상후 대뇌피질척추로 신경연접의 전자현미경적 관찰

장병우,한현신 이화여자대학교 의과대학 1987 梨花醫學誌 Vol.- No.19

This study was done to identify the synapse formed by the corticospinal tract in anterior horn of the spinal cord. Normal and experimental rats were used for electron microscopic observation. Experimental rats were sacrificed on the 2 or 3 days after cortical ablation. Only synaptic bulbs with small round vesicles of axo-somatic synapse and axo-dendritic synapse show definite sign of degeneration after lesion of the motor cortex. In relation to all of results above, it suggested that some of the axo-somatic or axo-dendritic synaptic bulbs with small round vesicle were originated from corticospinal tract.

일반연제 발표 : 생식내분비 및 불임 1 ; 폐경여성에서 estrogen/progesterone 병합투여시 progesterone 용량에 따른 골밀도의 변화

장병우,전선희,김종일,유한기 대한산부인과학회 1996 대한산부인과학회 학술대회 Vol.78 No.-

인간 난소의 노화와 Mitochondrial DNA 결손의 상관관계에 대한 연구

장병우(Byeung Woo Jang),유한기(Hna Ki Yu),박혜영(Hae Young Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2

목적 : 조직의 노화과정에 미토콘드리아 유전자 결손이 밀접한 관련이 있는바, 폐경 여성의 난소는 시기적으로 여성의 노화가 가속화하는 시간으로 미토콘드리아 유전자 결손과 여성의 노화과정의 연관성을 보고자, 폐경을 전후한 여성 난소에서 미토콘드리아 유전자 결손이 노화에 미치는 상관관계를 알아보고자 하였다. 연구 방법 : 폐경 전 여성 35례와 폐경 후 여성 17례에서 얻어진 난소, 자궁근종, 자궁근육 조직에 대하여 결손된 미토콘드리아 유전자 부위에 대한 중합효소연쇄반응을 시행하였고, 증폭된 시료에 대한 전기영동을 실시하여 미토콘드리아 유전자 결손의 band를 확인하고, 그 염기서열을 분석하였다. 결과 : 미토콘드리아 유전자 결손은 4977 bp결손과 3805 bp결손, 7150 bp결손, 5777 bp결손이 있었고 난소조직에서 4977 bp결손은 폐경 후 여성 난소에서 62.5%, 폐경 전 여성 난소에서 20.0%로 폐경 후 여성의 난소에서 높은 빈도의 양성율을 보였으며, 통계적으로 유의한 차이를 보였다 (p<0.05). 4977 bp결손, 3805 bp결손, 7150 bp결손 및 5777 bp결손 모두 폐경 후 여성의 난소 조직에서 자궁근종 조직이나 자궁근육 조직에 비하여 높은 빈도를 보였고, 통계적으로 유의하였다 (p<0.05). 결론 : common deletion으로 알려진 4,977 bp결손의 경우 폐경 후 여성의 난소에서 통계적으로 유의한 결과를 확인할 수 있었다. 또한 3805 bp결손, 7150 bp결손과 5777 bp결손은 모두 보고되지 않은 새로운 결손위치이며, 그 중 5777 bp 결손은 한국인에서 많이 나타나는 것을 확인할 수 있었다. 추후 많은 연구의 가능성을 갖고 있다고 생각되며, 본 연구 결과 폐경 후 여성의 난소에서 높은 빈도로 보여지는 미토콘드리아 유전자 결손은 폐경과 관련하여 난소의 노화과정에 나타나는 원인인자로 생각된다. Objective : The age-associated changes of mtDNA include nucleotide deletion, point mutations, as well as modifications. Age associated alterations of mtDNA occur in several different species; however, their physiological relevance remains unclear. The function of human ovary changes dramatically around the menopausal period. However, the mechanism of menopause and ovarian aging is not well understood. Thus, to study the regulatory mechanism of ovarian dysfunction by aging, the accumulation of mtDNA deletions in human ovaries from pre-menopausal and menopausal women was analyzed and compared with mtDNA deletions in myoma and myometriums of the same subjects. Method : Total DNA was extracted from these tissues, an part of mtDNA were amplified by polymerase chain reaction. The detailed locations of each of the deleted mtDNA regions were identified by sequencing. Result : Four types of mtDNA deletions were identified: a 4977 bp deletion, a 3805 bp deletion, a 7150 bp deletion, and a 5777 bp deletion. In ovaries, the occurrence of a 4977 bp deletion of mtDNA in menopausal women was significantly higher than that in pre-menopausal women, i.e., 62.5% of that in menopausal women and 20.0% of that in pre-menopausal women. In menopausal women, the occurrence of all of those four mtDNA deletions identified in this study in ovaries was higher than that in myomas and myometriums. Conclusion : A 4977 bp deletion of mtDNA between the ATPase 8 and ND5 genes in ovaries can be related to ovarian aging, especially during menopause. A 4977 bp deletion in ovaries of menopausal women can be a usuful marker of natural ovarian aging and may have a relationship to dysfunction of the ovarian aging. Three other mtDNA deletions identified in this study, a 3809 bp deletion, 7150 bp deletion, and 5777 bp deletion, was newly reported. A 5777bp deletion was found in a large amount in Korean women and further studies about this racial specificity will be needed.

서울시 녹지 연결망의 시계열 분석 및 정책적 함의

장병우(Chang, Byungwoo),박신영(Park, Sinyoung),정진아(Jeong, Jina),강완모(Kang, Wanmo) 한국지적정보학회 2021 한국지적정보학회지 Vol.23 No.1

본 연구는 그래프 이론을 적용하여 지난 35년(1984~2019년)간의 서울시 녹지 연결망의 변화를 다각적으로 비교·분석하고 정책적 함의를 제시하고자 하였다. Landsat 위성영상의 다중시기 정규식생지수를 통해 녹지 패치를 도출하고, 다양한 공간규모에서 직선거리와 최소비용경로에 따른 패치 및 비-패치 기반의 연결망 분석 기법을 적용했다. 연구 결과, 1984년부터 2019년까지 녹지 연결성이 회복되고 향상되었음을 정량적으로 확인하였고, 연결망 보전·관리에 있어서 중요한 녹지를 도출하였다. 비-패치 기반의 연결망 모형을 통해 시간 흐름에 따른 서울시의 핵심 녹지축 변화를 추적하여 북악산에서 남산, 국립서울현충원, 관악산으로 이어지는 녹지축의 회복을 확인할 수 있었다. 용산공원 신규 조성에 따른 연결성 기여도 평가 결과, 녹지 면적 증가 대비 연결성 증진 효과가 매우 높은 것으로 모의되었다. 또한, 용산공원은 서울시의 핵심 녹지축을 강화시키고, 확장시킬 수 있는 녹지로도 확인되었다. 연구 결과들은 서울시 도시생태계와 시민들의 삶의 질을 높일 수 있는 생활권 녹지공간 확충과 지속 가능한 도시기본계획 체계화 및 관리계획 수립을 위한 정책결정 과정에서 많은 기여를 할 수 있을 것으로 기대된다. We analyzed the temporal changes of green space network in Seoul from 1984 to 2019 using graph theory to suggest policy implications. For the analysis, we extracted green space patches using Landsat NDVI (Normalized Difference Vegetation Index) time-series data. Patch- and non-patch-based network analyses were applied using Euclidean distance and least-cost distance at multi-spatial scales. The patch-based network analysis confirmed the notable recovery and improvement of the network connectivity during the study period. We identified the important green spaces that are pivotal in preserving and managing the green space network. In addition, based on the non-patch-based network analysis, we found the recovery trend of main green corridors connecting the area from north to south. The establishment of Yongsan Park contributed greatly to the improve the connectivity, compared to the increased area of the green space. The result also showed that Yongsan Park can strengthen and expand the green corridor. We hope our research provides useful information for policymakers to expand neighborhood green spaces and develop sustainable urban master plans.

일반연제 발표 : 산과학 1 ; 조기진통 및 조기 양막파수 임부의 혈청과 태반조직에서의 Interleukin-6 발현에 관한 연구

최인호,장병우,김향미,손영수,우복희,조수연,김성숙,변광호 대한산부인과학회 1994 대한산부인과학회 학술대회 Vol.74 No.-

국소마취하에 Le Fort Operation에 의한 자궁탈교정술

김종일,장병우 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.12

Objective: Our purpose was to evaluate and compare the Le fort partial colpocleisis in the medically compromized elderly population using intravenous sedation and local anesthesia, and conventional surgical repair using general anesthesia. Study design: A retrospective data collection sequential seriese of 10 patients performed Le Fort partial colpocleisis using local anesthesia. The patients age, operative time, change in hemoglobin, days of hospitalization, medical illness, duration of catheter insertion, complication and follow up of are retrospective group of 23 women with complete uterine prolapse who had a vaginal hysterectomy, anterior with posterior colporrhaphy performed by the same surgical team during same period. Result: The median age of Le fort partial colpocleisis was 71.2 years(range 64 to 82 years), wherease median age in the vaginal hysterectomy group was 59.6 years(range 45 to 75 years)(p$lt;0.05). The median operating time under anesthesia of Le Fort partial colpocleisis was 70.07 minutes(range 37 to 805 minutes) compared with the vaginal hysterectomy median time of 149.57 minutes(range 75 to 225 minutes)(p$lt;0.05). The amount of Median blood loss during Le Fort partial colpocleisis was 133 ml compares with vaginal hysteretomy was 327.6 ml(p$lt;0.05). The median hospital stay both Le Fort partial colpocleisis and vaginal hysterectomy was 4.7 days each other(range, Le Fort partial colpocleisis 4 to 6 days, vaginal hysterectomy 6 to 13 days)(p$lt;0.05). The Mediann duration of foley catheter insertion day in Le Fort partial colpocleisis was 1 day all cases and 4.3 days in vaginal hysterectomy(p$lt;0.05). The complications were comparable with the exception of 3 cases of mild degree urinary tract infuction in the Le Fort partial colpocleisis group. Conclusion : All 10 patients had the Le Fort partial colpocleisis offers significant advantages in selected population of eldery, medically compromised condition. The Le Fort partial colpocleisis was succesful surgical repair under local anesthesia without the need of general inhalation.