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        • KCI등재

          OLETF 쥐에서 날록손의 MTII에 의한 식욕억제 증가효과

          배장호,박용훈,김성호,박소영,김종연,손조영,허정윤,원규장,김용운 대한내분비학회 2008 Endocrinology and metabolism Vol.23 No.1

          Background: Leptin, an adipocyte-derived hormone, inhibits obesity in lean subjects, but is not widely used because of leptin resistance. Thus, circumventing the arcuate nucleus of the hypothalamus, the site responsible for leptin resistance, has been evaluated for treatment of obesity. However, chronic treatment of melanotan II (MTII), a synthetic agonist of the melanocortin 3/4 receptor, induces tachyphylaxis. Here, we evaluated whether naloxone, a non-specific agouti-related peptide (AgRP) antagonist, increases the anorexic effect of MTII in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Methods: We measured food intake following intracerebroventricular (i.c.v.) infusion of MTII and/or naloxone in OLETF rats. Sprague-Dawley rats were used as a normal control group. Results: The anorexic effect of i.c.v. MTII infusion decreased with time in OLETF rats, indicating the development of tachyphylaxis. In normal control rats, naloxone alone decreased AgRP expression in the hypothalamus but failed to induce anorexia. Moreover, there was no additional anorexic effect with co-treatment of naloxone and MTII. In OLETF rats, naloxone alone did not show an anorexic effect despite increased POMC expression in the hypothalamus. However, naloxone sensitized the anorexic effect of MTII when treated together. Conclusion: These results suggest that naloxone augmented the anorexic effect of MTII when treated together in OLETF rats, but had no effect alone. These results suggest that a combination therapy of naloxone and a melanocortin receptor activator would be an effective modality for treatment of obesity. (J Kor Endocr Soc 23:18~26 2008)

        • SCOPUSSCIEKCI등재

          Galen정맥의 진성 뇌동맥류 기형 : Case Report

          배장호,고삼규,김오룡,김선용,지용철,최병연,조수호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.6

          A 27-year-old male was suffered from seizure due to Galenic aneurysmal malformation which was mainly fed by thalamoperforating circumferential(P2) and posterior cerebral artery(P4) and drained through basal vein of Rosenthal because of agenesis of straight sinus. The aneurysmal dilatation was successfully extirpated by excision of feeding arteries and draining veins including inferior sagittal sinus and straight sinus. We report a case of true aneurysmal malformation of vein of Galen.

        • SCIESCOPUSKCI등재
        • SCIESCOPUSKCI등재
        • 공간벡터 PWM의 과변조 영역에서 출력전압 선형화

          배장호,김연충,원충연,최종묵,기상우,배기훈,Bae, Jang-Ho,Kim, Yuen-Chung,Won, Chung-Yuen,Choi, Jong-Mook,Gi, Sang-Woo,Bae, Gi-Hun 대한전자공학회 1999 電子工學會論文誌, S Vol.s36 No.11

          본 논문은 6-스텝까지 인버터의 선형제어영역을 넓히기 위한 공간전압 변조방법의 선형화 기법에 대해 제안하였다. 이 방법은 인버터에서 발생시키고자 하는 전압을 연속모드에서는 보상각을 얻기 위해서 6스텝 모드를 포함하는 불연속모드에서는 불연속 스위칭이 이루어지도록 하는 유지각을 얻기 위해서 퓨리에 급수를 이용하고 있다. 이 각들의 근사화 수식들을 과변조 영역에서 기본파 전압을 보상하기 위해 사용하였다. 따라서, PWM 인버터 출력전압의 최대 활용과 선형 제어를 이룰 수 있다. This paper proposes a linearization technique for the space vector modulation method, which increases the linear control range of inverter up to the 6-step inverter. This method is based on fourier series expansion of the desired output voltage of the inverter to calculate the compensation angle in continuous switching mode and holding angle in discontinuous switching including the 6-step mode respectively. The approximation equation of these angles are used for compensation of fundamental voltage in overmodulation range. Therefore, it is possible to obtain the linear control and the maximized utilization of PWM inverter output voltage.

        • KCI등재

          Hypertension, a Low Ejection Fraction and Severe Angiographic Findings are Associated with Smooth Muscle Dysfunction in Patients with Coronary Atherosclerosis

          배장호,Charanjit S. Rihal,현대우,박기락,권택근,윤현주,Amir Lerman 대한심장학회 2007 Korean Circulation Journal Vol.37 No.10

          Background and Objectives: Nitroglycerin-mediated arterial dilation (NMD) was shown to be preserved in mostprevious studies, and this is possibly due to using a single high dose of nitroglycerin (NTG), which causes maximalarterial dilation. We sought to evaluate the clinical factors of flow-mediated dilation (FMD) and NMD atdifferent doses of NTG in the patients with coronary artery disease (CAD). Subjects and Methods: Thirty-twoconsecutive patients (mean age: 61 years old, 18 males) with angiographically proven CAD underwent FMD andNMD at total cumulative doses of 25μg, 175μg and 325μg with using high-resolution ultrasound for the imaging.Results: The FMD, NMD (25μg), NMD (175μg) and NMD (325μg) were 4.72±1.82%, 7.08±3.02%,13.33±6.14% and 15.89±7.24%, respectively (p<0.001 compared with each other). Univariate analysis showedthat the FMD is associated with the serum homocysteine level, the NMD (25μg) is associated with the bodymass index, the NMD (175μg) is associated with the fasting blood sugar and the ejection fraction, and the NMD(325μg) is associated with the fasting blood sugar, while there was no significant difference of the FMD andNMD according to the presence of CAD risk factors. Multivariate analysis disclosed that the independent factorsof FMD were the serum homocysteine and triglyceride levels, and those of NMD (25μg) were hypertension, a lowejection fraction and severe coronary angiographic findings, while there was no independent factor for NMD(175μg) and NMD (325μg). Conclusion: This study suggests that hypertension, a low ejection fraction and significantstenotic coronary lesion may be associated with endothelium-independent smooth muscle dysfunction atlow dose NTG, while the serum homocysteine and triglyceride levels are associated with endothelium-dependentendothelial dysfunction in the patients with CAD. Using low-dose NTG is important when measuring the NMD.

        • KCI등재

          급성 관동맥 증후군에서 생체내 관상동맥 경화반 조직 소견: 심혈관 초음파 연구

          배장호,권택근,김기홍,현대우,김기영,김동식 대한심장학회 2007 Korean Circulation Journal Vol.37 No.9

          Background and Objectives:Rupture-prone plaque, characterized by a large necrotic core, thin fibrous cap and large number of inflammatory cells, is known to be associated with acute coronary syndrome (ACS) from several autopsy and animal studies. We sought to assess in-vivo lesion characteristics of culprit lesions in patients with ACS. Subjects and Methods:One hundred consecutive patients (mean age 60.4 years, 70 males), who underwent percutaneous coronary intervention, were analyzed for intravascular ultrasound (IVUS) radiofrequency information using IVUS-virtual histology (VH) software. Results:Patients with ACS (n=44, mean 59.7 years, 34 males) had a lower prevalence of hypertension (45.5% vs. 67.9%, p=0.024), higher level of high-sensitivity C-reactive protein (0.36±0.36 mg/dL vs. 0.22±0.27, p=0.043), longer lesion length (22.6±8.6 mm vs. 19.3±6.9 mm, p=0.036), and more plaque rupture (63.6% vs. 10.7%, p<0.001) than those without ACS (mean 61.0 years 36 males). The lesion analysis, at a minimal luminal area, revealed that patients with ACS had a larger plaque area (12.5±5.8 mm2 vs. 10.3±4.8 mm2, p=0.043) and necrotic core (1.7±1.4mm2 vs. 1.1±0.9 mm2, p=0.013) than those patients without ACS. Volumetric analysis over the lesion length showed that patients with ACS had larger plaque volume (9.9±4.0 mm3/mm vs. 8.3±3.4 mm3/mm, p=0.031) and necrotic core volume (1.3±1.0 mm3/mm vs. 0.8±0.6 mm3/mm, p=0.002) than those without ACS. The necrotic core volume was associated with the presence of ACS (β=0.662, p=0.041) by the IVUS-VH findings. Conclusion:The results of this study suggest that the overall necrotic core volume, not the necrotic core area at the minimal luminal area, is associated with the clinical presentation of ACS. (Korean Circulation J 2007;37:437-442) 배경 및 목적:급성 관동맥 증후군과 관련이 있는 고위험 경화반은 내부 괴사 조직이 크고 경화반을 둘러 싸는 섬유막이 얇으며 염증 세포가 많다는 것이 부검 연구 등을 통해 알려져 있다. 본 연구의 목적은 급성 관동맥 증후군 환자에서 원인 병변의 조직 소견을 생체내에서 분석해 보는데 있다.방 법:관상동맥 중재술과 Virtual Histology(VH)-혈관내 초음파를 시행받은 100명의 비선택적 연속적인 환자를(평균 60.4세, 남자 70명) 대상으로 하였다. VH-혈관내 초음파는 심혈관 무선 초음파의 스펙트럼 분석을 통해 관상동맥 경화반의 조직 소견을 네가지로(섬유, 지방 섬유, 괴사, 석회화 부위) 분류하여 정보를 제공해 준다. 결 과: 급성 관동맥 증후군이 있는 환자에서 (n=44, 평균 59.7세, 남자 34명) 안정형 협심증 환자보다(평균 61.0세, 남자 36명) 고혈압의 빈도는 낮았고(45.5% vs 67.9%, p=0.024) high-sensitivity C-reactive protein은 높았다(0.36±0.36 mg/dL vs 0.22±0.27 mg/dL, p=0.043). 심혈관 초음파 검사상 급성 관동맥 증후군 환자에서 병변 길이가 길었고(22.6±8.6 mm vs 19.3±6.9 mm, p=0.036) 경화반 파열이 흔하였다(63.6% vs 10.7%, p<0.001). 협착 부위가 가장 심한 부위 분석에서 급성 관동맥 증후군 환자에서 경화반 면적과(12.5±5.8 mm2 vs 10.3±4.8 mm2, p=0.043) 괴사 부위의 면적이(1.7±1.4 mm2 vs 1.1±0.9 mm2, p=0.013) 안정형 협심증 환자보다 컸다. 병변 전체의 부피 분석에서는 급성 관동맥 증후군 환자에서 안정형 협심증 환자보다 경화반 부피가 크고(9.9±4.0 mm3/mm vs 8.3±3.4 mm3/mm, p=0.031) 괴사 조직 부피도 컸다(1.3±1.0 mm3/mm vs 0.8±0.6 mm3/mm, p=0.002). 병변 전체에서의 괴사 조직 부피는 급성 관동맥 증후군과 독립적인 상관 관계가 있었다(β=0.662, p=0.041). 결 론: 본 연구의 결과로 보아 협착이 심한 부위의 조직 소견보다는 병변 전체에서의 조직 소견, 특히 괴사 조직의 부피가 급성 관동맥 증후군의 임상 양상과 관련이 있음을 알 수 있다.

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