고려 고종대 의주민의 항쟁

이정신 ( Jeong Sin Lee ) 고려대학교 역사연구소 1994 사총 Vol.43 No.-

고려시대 고종 연구 : 최이와의 관계를 중심으로

이정신(Lee Jeong Sin) 한국인물사연구소 2005 한국인물사연구 Vol.3 No.-

토론문 : 고려후기 잡척의 신분에 대한 토론

이정신 ( Lee Jeong Sin ) 고려사학회 2003 고려사학회 학술대회 Vol.- No.-

고려시대 명종 연구

이정신(Lee Jeong-Sin) 한국인물사연구소 2006 한국인물사연구 Vol.6 No.-

일개 대학병원 신경외과중환자실에서 Clostridium difficile 관련 설사 감소를 위한 CQI활동

박은숙,장경희,윤영옥,이정신,김태곤,여한승,김선호,신정원,이경원,김준명,Park, Eun Suk,Chang, Kyung Hee,Youn, Young Ok,Lee, Jung Sin,Kim, Tae Gon,Yea, Han Seung,Kim, Sun Ho,Shin, Jeong Won,Lee, Kyungwon,Kim, June Myung 한국의료질향상학회 2001 한국의료질향상학회지 Vol.8 No.2

Background : The Clostridium difficile is the most important identifiable cause of nosocomial infectious diarrhea and colitis, which lengthens hospital stay. Recently incidence of C. difficile has been increasing in an university hospital, and an intervention for prevention and control of C. difficile associated diarrhea (CDAD) was in prompt need. Methods : Subjects were the patients in the neurosurgical intensive care unit(NCU) where C. difficile was most frequently isolated. To increase participation of various departments, we used the CQI method, because management of CDAD requires a wholistic approach including control of antibiotics, barrier precaution and environmental cleaning and disinfection. Duration of the CQI activities was 9 months from April to December 1999. Results : The identified problems were misuse and overuse of antibiotics, lack of consciousness of medical personnels and the possibility of transmission from the contaminated environment and tube feeding. Education for proper use of antibiotics and management of C. difficile infection, use of precaution stickers, supplement of handwashing equipments, emphasis on environmental disinfection, and the change of the process of tube feeding were done. The CDAD rate in NCU was significantly decreased after the CQI program (8.6 case per 1,000 patient days from January to April 1999 vs 4.8 from May to December 1999). The distribution of neurosurgical wards including NCU among the total number of isolated C. difficile from the clinical specimens dropped from 49.4% in January to April to 33,7% in May to December. The average hospital stay of the neurosurgical department changed from 19.6 days to 15.2 days. Also, the effect of the CQI activities for C. difficile may have affected the incidence of vancomycin resistant enterococci (VRE). Duration and dosage of certain antibiotics used in the NS department were decreased. The distribution of neurosurgical department in the number of VRE isolated patients declined from 18.4% to 11.1%. Conclusion : Infection control of resistant organisms such as C. difficile is likely to be successful when management of environmental contamination an collaborative efforts of decreasing the patients' risk factors such as antibiotics management and decreasing the length of hospital stay come simultaneously. For this work, related departments need to actively participate in the entire process under a common target through discussions for identifying problems and bringing up solutions. In this respect, making use of a CQI team is an efficient method of infection control for gathering participation and cooperation of related departments.

갈근 중의 Polyphenol Oxidase에 관한연구

박수선(Soo Sun Park),김안근(An Keun Kim),이정신(Jeong Sin Lee) 한국생약학회 1991 생약학회지 Vol.22 No.2

Polyphenol oxidase(PPO) was purified from an extract of Puerariae Radix by ammonium sulfate fractionation followed by Sephadex G-150 column chromatography, which resulted in a 56-fold increase in specific activity. The enzyme was optimum of pH 6.5. The optimum temperature of enzymic reaction was about 40° The enzyme was thermostable with a half-life equal to 32 min at 70°. Km values of the PPO for catechol and pyrogallol from Lineweaver Burk plots were 1.3×10^(-2) M, 1.16×10^(-2) M, respectively. The substrate specificity of the Puerariae Radix PPO showed high affinity toward pyrogallol. Reducing reagents such as cysteine, potassium metabisulfite, ascorbic acid, 2-mercaptoethanol completely inhibited the PPO activity at 10^(-2)M level. Linewear-Burk analysis of inhibition data revealed that the inhibition by cysteine, 2-mercaptoethanol, 4-nitrocatechol, potassium cyanide was competitive with Ki values of 4.3×10^(-2) M, 0.73×10^-6 M, 6.9×10^-6 M, 6.4×10^(-7) M, respectively. The browning reaction by PPO was observed to decrease temporarily with the addition of sodium diethyl dithiocarbamate, a well known copper chelating agent. Among the divalent cations, Cu^(2+) ion was strong activator on PPO and Mn^(2+), Co^(2+) ions was effect on PPO activity. Zn^(2+), Mg^(2+) ions was inhibitor on PPO.

진행성 대장암에 대한 5-Fluorouracil 및 Low Dose Leucovorin 복합화학 요법

안명주 ( An Myeong Ju ),서철원 ( Seo Cheol Won ),이규형 ( Lee Gyu Hyeong ),이정신 ( Lee Jeong Sin ),김상희 ( Kim Sang Hui ),김진천 ( Kim Jin Cheon ),박건춘 ( Park Geon Chun ) 대한내과학회 1992 대한내과학회지 Vol.42 No.6

연구배경 및 방법 : 1989년 11월부터 1991년 8월까지 울산의대 서울중앙병원 내과에 내원하여 전이성 또는 재발성 대장암 환자로 진단된 29예를 대상으로 5-fluor-ouracil 및 저용량 leucovorin 화학요법을 시행하여 다음과 같은 결과를 얻었다. 결과 : 1) 계측가능병변올 가진 27예의 환자중 완전반응은 2예(7%), 부분반응은 6예(22%)로 29%의 반응율을 보였고, 불변이 15예(56%), 진행이 4예(15%)였다. 2) 반응군의 반응유지기간의 중앙치는 30주였고, 비반응군에서는 10주였으며 두군 사이에는 통계학적으로 유의한 차이가 있었다. 전체 환자의 반응유지기간은 중앙치가 17주였으며 전체 환자의 생존기간의 중앙치는 30주였다. 3) 환자의 운동능력, 항암화학요법의 과거력, 원발병소, 전이장기 및 치료개시시의 CEA치에 따른 반응율의 비교에서는 통계학적 차이가 없었다. 4) 치료로 인한 부작용은 비교적 적게 나타났으며 그 정도도 경미하였다. 결론 : 이상의 결과로 5-fluorouracil 및 저용량 leu-covorin 화학요법이 전이성 또는 재발성 대장암환자의 치료에 있어서 비교적 부작용이 경미하면서도 중등도의 항암효과가 있다고 하겠다. Background A total of 29 patients with metastatic or recurrent colorectal carcinoma were studied to evaluate the effectiveness and toxicity of low dose leucovorin modulated 5-fluorouracil (5-FU). Methods: All patients were treated with low dose leucovorin, 20 ㎎/㎡ Ⅳ bolus on Days 1-5 and 5-fluorouracil, 400 ㎎/㎡ Ⅳ bolus on Days 1-5, every 4 weeks. Results: Of the 27 patients evaluable for response, 2(7%) had complete response and 6(22%) had partial response with the objective response rate of 29%. The median duration of response was 17 weeks and the median survival of all patients was 30 weeks. In the analysis of the response according to various characteristics of the patients, there was no significant difference (p> 0.05). Toxicity was mainly gastrointestinal, especially diarrhea and mucositis, but the grade was low. Hematologic toxicity was also mild. Conclusion: This study indicates that this regimen of low dose leucovorin plus 5-FU has mild toxicity, moderate response rate and good compliance for patients with recurrent and metastatic colorectal cancer.

진행성 비소세포 폐암에 대한 Mitomycin C, Vinblastine 및 Cisplatin(MVP) 3제 복합 화학요법의 치료 효과

김상위 ( Kim Sang Wi ),안명주 ( An Myeong Ju ),서철원 ( Seo Cheol Won ),이규형 ( Lee Gyu Hyeong ),이정신 ( Lee Jeong Sin ),고윤석 ( Go Yun Seog ),김우성 ( Kim U Seong ),김원동 ( Kim Won Dong ),김상희 ( Kim Sang Hui ) 대한내과학회 1993 대한내과학회지 Vol.44 No.2

연구배경 : 진행성 비소세포 폐암은 불치성 질환으로서 암사망의 중요한 원인을 차지하고 이에 대한 치료로는 항암 화학요법을 들 수 있으나 현재 30-40% 정도의 반응율이 보고되고 있는 실정이다. 이에 본 연구는 국내에서 진행성 비소세포 폐암 환자들을 대상으로 mitomycin C, vinblastine 및 cisplatin (MVP) 3제 복합 항암 화학요법을 실시하여 그 성적과 부작용을 관찰하고자 하였다. 방법 : 병기 Ⅲb 5예 및 Ⅳ기 28예의 비소세포 폐암을 대상으로 제1일째 cisplatin 60mg/㎡을 수액요법과 같이 점적 정주하고 제2일째 mitomycin C와 vinblastine을 6mg/㎡씩 급속 정주하였다. 치료는 매 3-4주 간격으로 반복하였으며 최소한 2회이상 실시하였다. 결과 : 총 33예중 본 치료에 의한 완전관해는 없었으나 부분관해는 9예(27%), 불변 15예(45%), 그리고 진행은 9예(27%)로서 27%의 반응율을 보였고 반응기간의 중앙치는 16주(4^+ -28주)이었다. 부작용은 경한 오심, 구토 및 말초 신경엽 증상과 중등도의 백혈구 감소중 등이 있었으나 그정도는 수용할 만한 것이었다. 결론 : 이상의 결과로 진행서 비소세포 폐암에서 mitomycin C, vinblatine 및 cisplatin 3제 복합 항암 화학요법은 심한 부작용 없이 중등도의 반응을 보였다. Background : Advanced non-small cell lung cancer (NSCLC) is still a lethal disease and one of the most important causes of cancer-related death. Role of systemic chemotherapy seems to be pallicative and showed objective response of 30-40%. We treated 33 patients with advanced NSCLC with combination therapy of mitomycin C, vinblastine, and cisplatin (MVP) to evaluate the clinical activity and side effect of this combination. Mothods : Cisplatin was infused intravenously on day l at the dose of 60mg/㎡ with pre-and post-hydration and mitomycin C 6mg/㎡ (maximum 10mg) and vinblastine 6mg/㎡ (maximum 8mg) were given intravenously on day 2. The treatiment was repeated every 3-4 weeks, and at least 2 cycles of chemotherapy were administered. Results : Nine patients (27%) had partial responses and no one had complete response. Median response duration was 16 weeks, reange (4+to 28 weeks). The toxicity included mild and transient nausea/vomiting, mild to moderate leukopenia, and mild peripheral neuropathy, All of them were well tolerated and recovered fully before the next cycle of chemotherapy. Conelusion : MVP combination chemotherapy is moderately active against advanced NSCLC and relatively well tolerated.

일개 대학병원 신경외과중환자실에서 Clostridium difficile 관련 설사 감소를 위한 CQI활동

박은숙,장경희,윤영옥,이정신,김태곤,여한승,김선호,신정원,이경원,김준명 한국의료QA학회 2001 한국의료질향상학회지 Vol.8 No.1

Background : The Clostridium difficile is the most important identifiable cause of nosocomial infectious diarrhea and colitis, which lengthens hospital stay. Recently incidence of C. difficile has been increasing in an university hospital, and an intervention for prevention and control of C. difficile associated diarrhea(CDAD) was in prompt need. Methods : Subjects were the patients in the neurosurgical intensive care unit(NCU) where C.difficile was most frequently isolated. To increase participation of various departments, we used the CQI method, because management of CDAD requires a wholistic approach including control of antibiotics, barrier precaution and environmental cleaning and disinfection. Duration of the CQI activities was 9 months from April to December 1999. Results : The identified problems were misuse and overuse of antibiotics, lack of consciousness of medical personnels and the possibility of transmission from the contaminated environment and tube feeding. Education for proper use of antibiotics and management of C.difficile infection, use of precaution stickers, supplement of handwashing equipments, emphasis on environmental disinfection, and the change of the process of tube feeding were done. The CDAD rate in NCU was significantly decreased after the CQI program(8.6 case per 1,000 patient days from January to April 1999 vs 4.8 from May to December 1999). The distribution of neurosurgical wards including NCU among the total number of isolated C.difficlie from the clinical specimens dropped from 49.4% in January to April to 33,7% in May to December. The average hospital stay of the neurosurgical department changed from 19.6 days to 15.2 days. Also, the effect of the CQI activities for C.difficile may have affected the incidence of vancomycin resistant enterococci(VRE). Duration and dosage of certain antibiotics used in the NS department were decreased. The distribution of neurosurgical department in the number of VRE isolated patients declined from 18.4% to 11.1%. Conclusion : Infection control of resistant organisms such as C.difficile is likely to be successful when management of environmental contamination an collaborative efforts of decreasing the patients’ risk factors such as antibiotics management and decreasing the length of hospital stay come simultaneously. For this work, related departments need to actively participate in the entire process under a common target through discussions for identifying problems and bringing up solutions. In this respect, making use of a CQI team is an efficient method of infection control for gathering participation and cooperation of related departments.