한약(韓藥)의 면역조절(免疫調節) 작용(作用)을 통(通)한 종양치료(腫瘍治療)에 대(對)한 연구(硏究)

이정수,이연월,조정효,손창규,유화승,조종관,Lee, Jung-Soo,Lee, Yeon-Weol,Cho, Jung-Hyo,Son, Chang-Kyu,Yoo, Hwa-Seung,Cho, Chong-Kwan 대한암한의학회 2003 大韓癌韓醫學會誌 Vol.9 No.1

The researches for tumor and the developments for new anti-tumor medicine are being continuously developed in the oriental as well as the west. The principles therapy of anti-tumor activity was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of tumor was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distinction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. In clinical study and experimental study, the effects of oriental medicine could be summarized as three that were decreasing toxicity of chemo-therapy, directly suppressing and killing cancerous cell and increasing chemo-effect through preventing metastasis. Improving organic immunity with oriental medicine could be summarized as five that were promoting phagocytosis of macrophage, inducing interferon, promoting formation of immnoglobulin, increasing number of T-cell and promoting transformation of lymphocyte. It is suggested that effective use of immune activating herbs inhibited metastasis and decreased recurrence and then we were able to expect increasing survival rate and improving clinical symptoms and quality of life(QOL) of tumor patients.

곽향(藿香) 추출물(抽出物)이 장운동(腸運動)에 미치는 영향(影響)

이정수,손창규,조정효,신장우,유화승,이연월,이남헌,윤담희,조종관,Lee, Jung-Soo,Son, Chang-Gue,Cho, Jung-Hyo,Shin, Jang-Woo,Yoo, Hwa-Seung,Lee, Yeon-Weol,Lee, Nam-Heon,Yun, Dam-Hee,Cho, Chong-Kwan 대한한방내과학회 2005 대한한방내과학회지 Vol.26 No.4

Objectives : 본 연구는 암환자의 위장관 기능장애를 개선시킬수 있는 보다 효과적인 약물개발의 일환으로 곽향 추출물의 장운동에 미치는 영향을 평가하기 위해 수행되어졌다. Methods : 생리적인 상태에서 곽향추출물이 장운동에 미치는 영향을 알아보기 위해 장운동촉진제인 carbachol과 곽향추출물을 실험쥐들에게 투여후 15분후 charcoal meal을 먹여서 charcoal meal의 소장내 통과 정도를 비교 측정하였다. 또, loperamide, scopolamine, nicotine으로 장운동을 억제시켜 놓은 실험쥐들에 15분 간격으로 곽향 추출물과 charcoal meal을 먹인 후 역시 charcoal meal의 소장내 통과 정도를 비교 측정하였다. Results : 곽향 추출물은 생리상태에서는 장운동에 영향을 미치지 않았다. 곽향추출물은 loperamide와 scopolamine으로 유발된 장운동 억제상태에 대하여 부분적으로 영향을 끼쳤다. 그러나 nicotine으로 유발된 상태에 대해서는 영항을 끼치지 않았다. Conclusion : 곽향 추출물은 소화관 기능부전 완화에 효과적으로 작용하는 천연물이라 추론할 수 있다.

'춘광' 배추의 준고랭지 여름철 재배 방법에 따른 생육과 저장 특성

이정수,Lee, Jung-Soo 한국포장학회 2021 한국포장학회지 Vol.27 No.1

This experiment was conducted to determine the effects of the pre- and post-harvest variable factors on the processed product of kimchi cabbage cultivated in semi-highland at summer time. Kimchi cabbage cultivar 'Chun Gwang' was grown in an open field and/or under a plastic greenhouse condition; it was stored at 0? after harvesting with low-density polyethylene (LDPE) film packaging. The pre-harvest characteristics growth parameters, fresh weight, head weight, no of leaves, leaf thickness, firmness, moisture content etc. were evaluated. The evaluated postharvest characteristics were fresh weight loss, appearance, trimming loss, SPAD value, moisture content and hue angle. The results show that the fresh weight and leaf thickness were higher in 'Chun Gwang' kimchi cabbages grown in the greenhouse than those in the field. However, the other evaluated factors were not affected by the type of cultural method. During the storage, the cabbage continued to decrease in fresh weight loss, trimming loss and moisture content. When compared to the kimchi cabbage showed significant difference in the fresh weight loss, trimming loss and moisture content during storage. It was confirmed that both cultural methods indoor- and outdoor did not show head growth parameters of 'Chun Gwang' kimchi cabbages on semi-high land at summer time. Although no difference in the growth before storage was observed, the evaluated characteristics like fresh weight loss etc. were influenced by cultural method as a pre-harvest factor. This study suggests that there were to be affected by pre-harvest factor during storage after harvest. In this study, an integrated management system combining relationship between processed agricultural products and their pre- and post-harvest factors.

포장과 저장온도가 '백다다기' 오이 선도에 미치는 영향

이정수,김기빈,김하연,정다혜,최다경,채예림,박미희,장민선,홍윤표,Lee, Jung-Soo,Kim, Gibin,Kim, Hayeon,Jeong, DaHye,Chei, Da Kyoung,Chea, Ye Rim,Park, Me Hea,Jang, Min Sun,Hong, Yuun Pyo 한국포장학회 2021 한국포장학회지 Vol.27 No.2

The evaluation of package temperature for fresh preservation of cucumber was investigated. The fresh cucumber is available in markets of Korea during whole seasons, for the help of farmer, distributor and consumer. Cucumbers were stored within cardboard boxes packaging covered with low density polyethylene (LDPE) at different temperatures (5, 10, 15 and 20℃). Changes in weight loss, hue angle, firmness, moisture content and general appearance (shape of cucumber) were investigated during storage of cucumbers. General appearance index with non-packaging decreased more than with LDPE film packaging at 5℃ and 10℃. During storage of cucumbers, general appearance index as freshness showed packaging effect at low temperature than room temperature. In the fresh weight loss, the packaged cucumbers were less reduced than that of the non-packaging ones. At color change, Hue angle of cucumber stored within low temperature with film packaging decreased gradually during storage. However remarkable change in hue angle were observed in cucumber within LDPE film packaging treatments of 15℃ and 20℃ storage. The effect of hue angle with packaging appears differently depending on the storage temperature conditions. The firmness and moisture content of cucumber flesh were not affected by packaging and storage temperature. In this experiment, cucumbers packaged with LDPE film at 5℃ and 10℃ were the most desirable for extending the quality. These results suggest that packaging of low temperature treatments in combination could be effective in prolonging the shelf life of cucumber.

$Fe^{++}$ 및 $H_2O_2$에 의한 hyaluronic acid 분해에 있어서 ascorbic acid의 역할

이정수,정명희,임정규,박찬웅,차인준,Lee, Jung-Soo,Chung, Myung-Hee,Lim, Jung-Kyoo,Park, Chan-Woong,Cha, In-Joon The Korean Society of Pharmacology 1985 대한약리학잡지 Vol.21 No.1

Hydroxyl raical$(OH{\cdot})$을 생성하는 것으로 알려진 iron-catalyzed Haber-Weiss rocation에서 superoxide anion $(O^{-}_{2}{\cdot})$은 주로 $Fe^{+++}$을 $Fe^{++}$로 환원시키는 데에 작용하는 것으로 추정하고 있다. 이러한 $OH{\cdot}$ 의 역할은 다른 환원제들에 의하여 대체가 가능할 것으로 추측되며 생물계의 환원제의 하나로써 ascorbate가 관심의 대상이 되고 있다. 이에 따라 본 연구에서는 $Fe^{++}$와 $H_2O_2$ 존재하에서 $OH{\cdot}$ 을 생성하는 ascorbate 의 역할을 hyaluronic acid의 변성과 methional로 부터 ethylene 생성에 대한 효과로써 관찰하였다. Ascorbate는 $Fe^{++}$와 $H_2O_2$에 의한 hyaluronic acid의 변성을 촉진하였으며, 이런 현상은 점성도 변화와 Sepharose 4B를 이용한 코로마토그라피에 의하여 확인할 수 있었다. 이때 관찰되는 변성은 catalase와 $OH{\cdot}$ scavenger에 의하여 거의 완전히 억제 되었다. 또한 ascorbate는 $Fe^{++}$와 $H_2O_2$에 의한 methional로 부터 ethylene생성을 항진시킴으로써 상기의 결과를 뒷받침 하였다. 다른 환원제들(cysteine, glutathione, NADH와 NADH와 NAKPH)도 ascorbate와 같이 hyaluronic acid의 변성과 methional로 부터 ethylene생성을 촉진하였으나, 그들의 산화형인 NAD와 NADP의 효과는 관찰 할 수 없었다. 그러므로 $OH{\cdot}$ 생성에 있어 철이온의 환원이 관여함을 시사하였다. 또한 metal ion가운데 $Fe^{++}$는 $OH{\cdot}$ 생성에 가장 강력한 촉매작용을 나타내었다. 이상의 결과는 ascorbate가 $(OH{\cdot})$ 을 생성하는 metal-catalyzed reaction에서 $Fe^{+++}$을 $Fe^{++}$로 환원하는 $O^{-}_{2}{\cdot}$의 작용을 대신할 수 있음을 증명하며 이와같은 ascorbate 의존적인 $OH{\cdot}$ 의 생성은 ascorbate가 조직손상에 관여할 가능성을 시사하였다. In tile Iron-catalyzed Haber-Weiss reaction to produce OH., the requirement for $O^{-}_{2}{\cdot}$ is only to reduce $Fe^{+++}$. Possibly, the role of $O^{-}_{2}{\cdot}$ can be replaced by other reducing agents. Ascorbate is one of them in biological system. In the present study, the ability of ascorbate to produce $OH{\cdot}$ in the presence of $Fe^{++}$ and $H_2O_2$ was investigated by observing the degradation of hyaluronic acid and ethylene production from methional. Ascorbate stimulated the degradation of hyaluronic by $Fe^{++}$ and $H_2O_2$. That was confirmed by both viscosity change and gel-permeation chromatographic analysis. The observed degradation was almost completely prevented by catalase and $OH{\cdot}$ scavengers. In support of the above results, ascorbate enhanced the prouction of ethylene from methional in the presence of $Fe^{++}$ and $H_2O_2$. Other reducing agents (cysteine, glutathione, NADH and NADPH) showed similar activities to ascorbate in the degradation of hyaluronic acid and ethylene production. But no stimulatory effects were observed with their oxidized forms such as NAD and NADP. Thus, it appears that reduction of the metal ion was needed for $OH{\cdot}$ production. Among the metal ions tested, $Fe^{++}$ showed most potent catalytic action in the production of $OH{\cdot}$ The results obtained support that ascorbate can substitute $O^{-}_{2}{\cdot}$ in the metal-catalyzed reactions, particularly with $Fe^{++}$ by which $OH{\cdot}$ is produced with $H_2O_2$. The significance of the ascorbate-dependent production of $OH{\cdot}$ was considered with respect to possible role of ascorbate in the damage of inflamed joints.

기술자료 : 시멘트 킬른에서의 페타이어 적정 소각 처리량 결정

이정수,구자공,이근성 ( Jung Soo Lee,Ja Kong Goo,Geun Seong Lee ) 한국폐기물자원순환학회(구 한국폐기물학회) 1993 한국폐기물자원순환학회지 Vol.10 No.1

오리엔탈 나리 '시베리아' 절화의 포장내 건식저장 기간별 수분함량과 품질 변화

이정수,이주희,강윤임,최지원,Lee, Jung-Soo,Rhee, JuHee,Kang, Yun-Im,Choi, Ji Weon 한국포장학회 2017 한국포장학회지 Vol.23 No.1

In order to determine the relationship between water content and flower qualities of oriental hybrid lily cv. 'Siberia' cut flower, flowers were subjected to dry and cold storage at $5^{\circ}C$ for 3, 6, and 12 days and subsequently exposed to ambient temperature ($26^{\circ}C$) in bottles with water for up to 16 days. Flowers stored at $22^{\circ}C$ in dry condition for 3 days were used as the control. Changes in fresh weight, moisture content, water balance, flowering stages, osmolality and vase life of cut flowers were observed. Flowers treated with cold and dry storage had higher moisture content compared to control sample. However, this trend was evident only for 3-day cold and dry stored sample during the whole storage period. The fresh weight of cut flowers increased gradually when the samples were transferred to ambient temperature in water bottles and then declined steadily before reaching the peak in between 6-8 days of vase life. However, the changes of fresh weight of control sample were substantially faster than samples pre-treated with cold and dry storage. This was also correlated with the water balance of cut flower as it reached the minus (-) value in 6-8 days of vase life at ambient temperature. Cut lily flowers showed high osmolality values corresponding with the duration of dry storage regardless of low or higher temperature. However, osmolality had no effect on vase life since flower stem absorbed water rapidly at the end of dry storage period. Our vase life results suggest that cold and dry storage of lily cut flowers for a certain period could ensure longer vase life at ambient temperature. It was observed that prolonging the storage period at cold and dry condition for more than a week significantly increased bud abortion, reduced longevity of flowers and reduced the vase life of cut flowers. On the other hand, the shorter cold and dry storage treatment delayed the bud opening and senescence of the flowers, thus, slowering the normal maturation and aging. Results indicated that dry and cold storage at $5^{\circ}C$ for 3 days was effective in maintaining and preserving overall quality and vase life at ambient condition of oriental hybrid lily cut flowers.

다중주물을 활용한 주얼리 제작에 관한 연구

이정수,김형성,Lee, Jung Soo,Kim, Hyeong Seong 한국결정성장학회 2012 한국결정성장학회지 Vol.22 No.5

There are many restrictions in conventional ways of Jewelry mass production which are Mokume Gane, Inlaid Technology based on a joining work of dissimilar metals. To overcome this, Multi-Casting using both Jewelry-Casting and CAD/CAM has presented. In experiment on Muti-Casting, second original sample which was produced by CAD/CAM is 5 % smaller than first one. The first and second castings are brass and silver, respectively. When making second sample, the temperature of flask was about $150{\sim}200^{\circ}C$ higher than the standard temperature of flask when making castings. Through the Multi-Casting, it was found that there was no trouble making dissimilar metals Jewelry which can be mass produced.

워터 마킹 기술을 활용한 이미지 전자화폐에 관한 연구

이정수,김회율,Lee, Jung-Soo,Kim, Whoi-Yul 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.6

본 논문에서는 이미지에 watermark를 삽입함으로써 이미지를 전자화폐로 활용할 수 있는 기술을 소개한다. 이미지에 콘텐츠ID를 부여하고 이 콘텐츠ID를 눈에 보이지 않도록 이미지에 삽입한다. 이미지 전자화폐(이후 WaterCash라 명명)를 발급하는 발급서버에서는 이 콘텐츠ID를 데이터베이스에 저장하고 전자화폐로써 관리한다. WaterCash는 익명성을 보장할 수 있고, 또한 WaterCash의 위ㆍ변조를 semi-fragile water-marking 기법을 기반으로 원천적으로 차단할 수 있다. 또한 양도가 가능하고, 워터마킹 기술을 기반으로 하기 때문에 WaterCash의 부정사용을 방지할 수 있다. 사용된 워터마킹 기술은 압축에는 강인하면서 다른 고의적, 비고의적 이미지 처리에는 연약하도록 설계되었다. This study introduces a technology utilizing digital images as electronic money by inserting watermark into the images. Watermarking technology assign contents ID to images and inserts the contents ID into the images in an unnoticeable way. The server that manages the issue and the usage of mage electronic money (called ‘WaterCash’ hereafter) stores issued contents ID to database and manage them as electronic money. WaterCash guarantees anonymity and prevents the forgery and modification of WaterCash based on semi-fragile watermarking technique. In addition, WaterCash is transferable and the illegal use of WaterCash can be prevented based on the watermarking technology. The watermarking .technology used in this paper was designed to be robust to image compression but vulnerable to intentional or non-intentional Image processing.

3D printer를 이용한 이종금속 주얼리 제작에 관한 연구

이정수,차경철,Lee, Jung-Soo,Cha, Kyung-Chul 한국결정성장학회 2016 한국결정성장학회지 Vol.26 No.1

In the late 1990's implementation of CAD/CAM systems in 3D printer has been led to many changes in the jewelry industry. Low cost 3D printer has been started advertising in the jewelry in 2009 after expiration of key patents of FDM scheme. Mass jewelry production process will vary in appliance with direct production process of 3D printer production line. The studies presented in this variation is the jewelry manufacturing process using a 3D Printer and the different metals with different colors were also produced for bonding the prototype jewelry. Increasing the possibilities of 3D printer through them, presents a variety of jewelry mass production methods.