Cefoperazone(T-1551)의 약리학적 연구

임정규,홍사악,박찬웅,김명석,서유헌,신상구,김용식,김혜원,이정수,장기철,이상국,장우현,김익상,Lim J.K.,Hong S.A.,Park C.W.,Kim M.S.,Suh Y.H.,Shin S.G.,Kim Y.S.,Kim H.W.,Lee J.S.,Chang K.C.,Lee S.K.,Chang K.C.,Kim I.S. 대한약리학회 1980 대한약리학잡지 Vol.16 No.2

The pharmacological and microbiological studies of Cefoperazone (T-1551, Toyama Chemical Co., Japan) were conducted in vitro and in vivo. The studies included stability and physicochemical characteristics, antimicrobial activity, animal and human pharmacokinetics, animal pharmacodynamics and safety evaluation of Cefoperazone sodium for injection. 1) Stability and physicochemical characteristics. Sodium salt of cefoperazone for injection had a general appearance of white crystalline powder which contained 0.5% water, and of which melting point was $187.2^{\circ}C$. The pH's of 10% and 25% aqueous solutions were 5.03 ana 5.16 at $25^{\circ}C$. The preparations of cefoperazone did not contain any pyrogenic substances and did not liberate histamine in cats. The drug was highly compatible with common infusion solutions including 5% Dextrose solution and no significant potency decrease was observed in 5 hours after mixing. Powdered cefoperazone sodium contained in hermetically sealed and ligt-shielded container was highly stable at $4^circ}C{\sim}37^{\circ}C$ for 12 weeks. When stored at $4^{\circ}C$ the potency was retained almost completely for up to one year. 2) Antimicrobial activity against clinical isolates. Among the 230 clinical isolates included, Salmonella typhi was the most susceptible to cefoperazone, with 100% inhibition at MIC of ${\leq}0.5{\mu}g/ml$. Cefoperazone was also highly active against Streptococcus pyogenes(group A), Kletsiella pneumoniae, Staphylococcus aureus and Shigella flexneri, with 100% inhibition at $16{\mu}g/ml$ or less. More than 80% of Escherichia coli, Enterobacter aerogenes and Salmonella paratyphi was inhibited at ${\leq}16{\mu}/ml$, while Enterobacter cloaceae, Serratia marcescens and Pseudomonas aerogenosa were somewhat less sensitive to cefoperagone, with inhibitions of 60%, 55% and 35% respectively at the same MIC. 3) Animal pharmacokinetics Serum concentration, organ distritution and excretion of cefoperazone in rats were observed after single intramuscular injections at doses of 20 mg/kg and 50 mg/kg. The extent of protein binding to human plasma protein was also measured in vitro br equilibrium dialysis method. The mean Peak serum concentrations of $7.4{\mu}g/ml$ and $16.4{\mu}/ml$ were obtained at 30 min. after administration of cefoperazone at doses of 20 mg/kg and 50 mg/kg respectively. The tissue concentrations of cefoperazone measured at 30 and 60 min. were highest in kidney. And the concentrations of the drug in kidney, liver and small intestine were much higher than in blood. Urinary and fecal excretion over 24 hours after injetcion ranged form 12.5% to 15.0% in urine and from 19.6% to 25.0% in feces, indicating that the gastrointestinal system is more important than renal system for the excretion of cefoperazone. The extent of binding to human plasma protein measured by equilibrium dialysis was $76.3%{\sim}76.9%$, which was somewhat lower than the others utilizing centrifugal ultrafiltration method. 4) Animal pharmacodynamics Central nervous system : Effects of cefoperazone on the spontaneous movement and general behavioral patterns of rats, the pentobarbital sleeping time in mice and the body temperature in rabbits were observed. Single intraperitoneal injections at doses of $500{\sim}2,000mg/kg$ in rats did not affect the spontaneous movement ana the general behavioral patterns of the animal. Doses of $125{\sim}500mg/kg$ of cefoperazone injected intraperitonealy in mice neither increased nor decreased the pentobarbital-induced sleeping time. In rabbits the normal body temperature was maintained following the single intravenous injections of $125{\sim}2,000mg/kg$ dose. Respiratory and circulatory system: Respiration rate, blood pressure, heart rate and ECG of anesthetized rabbits were monitored for 3 hours following single intravenous inje

부산지역의 대기중 중금속 오염도에 관한 조사 연구

임정규 인제대학교 1987 仁濟醫學 Vol.8 No.1

부산지역의 3개 지역(서면, 사상, 대신동)의 주 간선도로변에 대하여 1985년 7월부터 10개월간 대기중 중금속(현, 카드뮴, 크롬 및 바나듐)의 농도를 AAS로 정량한 결과 연중 총 평균 농도는 연; 2.40±1.32μg/m3, 카드뮴 ; 0.30±0.11μg/m3, 크롬 ; 1.52±0.52μg/m3 및 바나듐; 1.54±0.55μg/m3이었으며 지역별 평균 농도는 각 중금속 공히 사상>서면>대신동의 순이었다. For the purpose of assessing the degree of heavy metal pollution in the atmosphere in order to contribute to the health improvement of the residents in Pusan, the author measured the Pb, Cd, Cr and V levels in the ambient air at the locations by season and time (morning, afternoon and night) from July, 1985 to April, 1986 with the carbon furance atomic absorption spectrophotometer. The locations selected were Somyon, Sasang and Daeshin-dong, which have been known as commerical, industrial and residential areas respectively in Pusan. The results were as follows; 1.The average concentrations of heavy metals during a year were Pb; 2.60 ± 1.32μg/m3, Cd; 0.30 ± 0.11㎍/m3, Cr; 1.52 ± 0.52㎍/m3 and V; 1.54 ± 0.55 ㎍/m3. 2.The average concentrations of heavy metals by area were the highest at Sasang, and the lowest at Daeshin-dong. 3.The average concentations of heavy metals by season were relatively higher in the summer than in the remainder of the year. 4.The average concentrations of heavy metals during the day were relatively higher in the afternoon or at night than in the morning.

비뇨기과 영역에서의 Vibramycin Precon PT-122M의 효과

임정규,신상구,박찬웅,장대수 大韓藥理學會 1977 대한약리학잡지 Vol.13 No.1

To investigate the efficacy, tolerance of Vibramycin Precon PT-122 M and to determine the nature, incidence and severity of side effects of this formulation, 19 patients with urogenital infections were studied. 1. Vibramycin Precon PT-122 M reduced the signs and symptoms of various urogenital infections so as to determine the overall efficacy as good or satisfactory. 2. Intravenous injection of PT-122 M was generally well tolerated in all patients except 2 case of discontinuation because of adverse effect. 3. PT-122 M showed mild to moderate side effects but clinical features ana response to therapy were not influencea by those side effects.

과학탐구 자료 및 방법 개발을 위한 컴퓨터 저작도구 탐색

임정규 강원과학교육연구회 1998 강원과학교육연구회지 Vol.3 No.2

입간측영(⽴竿測影)을 통해 만들어지는 각도기 기원에 관한 연구 - 선생님, 각도기는 어떻게 만들어졌나요? -

임정규,복기대 한국초등과학교육학회 2021 한국초등과학교육학회 학술대회 Vol.80 No.-

본 연구는 학생들이 “선생님 각도기는 어떻게 만들어졌나요? 왜 직각이 100°가 아니고 90°입니까?”라고 질문을 받았을 때 각도기 기원에 관한 자신 없는 답변에서 시작되었다. 현재 학계에서는 각도기의 기원에 관해서는 365일 지구의 공전에서 360° 각도기가 나왔다는 설과 바빌로니아의 60진법에서 유래되었다는 설 등이 있다. 본 연구자는 ‘각도기 180°는 자연계에서 만들어졌고, 태양의 일주운동 및 공전과 관계가 깊을 것으로 생각한다’. 본 연구에서는 고대인들이 “그림자 관측 즉, 입간측영을 통해 달력 및 해시계를 만드는 과정 속에서 각도기가 만들어졌다.”라는 가설을 실험을 통해 세우게 되었고, 직접 검증해 보았다. 각도기의 기원을 알아보기 위해 관측 실험과 천문 자료 수집을 통해 알아보았다. 넓은 대지에 기둥을 세우고 주변에 동지 남중 기준으로 원을 그리면 자연계에서 입간측영을 통해 각도기를 만들 수 있음을 알게 되었다. 또한, 미국 해양대기국 데이터 수집 분석을 통해, 각도기는 북반구 동절기(추분∼동지∼춘분) 180일 동안 아침, 저녁으로 태양의 일주운동 결과를 동지 기준으로 반원에 나타낸 것이 각도기라는 결과를 얻어낼 수 있었다. 북반구 동절기 자연계에서 만들어지는 각도기는 현재 쓰고 있는 각도기와 매우 흡사한 형태를 갖고 있다. 매일 매일 아침, 저녁으로 그림자의 위치가 하루에 약 1°(0.98∼1.02)씩 움직이므로 180칸으로 나누어짐을 다양한 통계를 통해 확인할 수 있었다. 관측 위치는 적도 인근에서 관측한 것으로 설계하였으나, 적도식으로 각도기를 적도면과 평행하게 세워 설계하면 지구 어디에서나 같은 값을 얻을 수 있음을 알 수 있었다. 본 연구를 통해 현재 사용 중인 180° 각도기와 유사한 각도기를 자연계에서 만들 수 있음을 입증해 내는 성과가 있었다고 생각한다. 현재의 360° 각도기는 입간측영 180° 각도기를 오랜 세월 동안 보완하여 오늘날의 360°에 이르렀을 것이라는 결론에 도달하게 되었다. 앞으로 현대 물리학과 천문학 전공자와 연계하여 각도기가 만들어진 과정을 보다 깊이 있게 토론하고 연구할 필요가 있다고 생각한다.

Oxantel pamoate의 편충에 대한 구충효과

임정규 大韓藥理學會 1974 대한약리학잡지 Vol.10 No.2

The present clinical trial was performed to evaluate the anthelminthic effect and tolerance of Oxantel pamoate, a new antiwhipworm agent, in the treatment of T. trichiurus infection. Oxantel pamoate oral suspension was administered as a sing1e dose of 10 mg per kg. body weight to a total of 46 T. trichiurus infected cases selected out of 64 positives, by examining 89 fecal specimens collected from the soldiers and in-patients of xx Armed Forces General Hospital. For the evaluation, the negative conversion rate (cure rate) and the egg reduction rate were assessed 22 days after the treatment. The result obtained were as follows: 1. The prevalence rate of T. trichiurus infection in this study was 71.9%, while the mean E.P.G. of 46 treated cases was 126. 2. The egg negative conversion rate was 91.3%, and 98.4% of egg reduction rate was obtained. 3. From the observation of 107 worms expelled during 3 consecutive days after the treatment, it was known that sex ratio of male and female was about 1 : 2 and that average worm burden per capita was 2.3. 4. In all treated cases, the medication was readily accepted and well tolerated. On the hemograms, urinalysis and liver function tests, no significant differences were noted before and after the drug administration. There was also no detectable objective and subjective side effect.

도로포장에서 표면조직깊이 측정에 대한 통계적 게이지 R&R 분석

임정규,김성준,최돈화,이승우 한국도로학회 2010 한국도로학회 학술발표회 논문집 Vol.2010 No.3

Oxytetracycline과 Erythromycin Stearate의 생체유용성 검토

임정규,정명희,신상구,차인준,Lim J.K.,Chung M.H.,Shin S.G.,Cha I.J. 대한약리학회 1977 대한약리학잡지 Vol.13 No.1

The physicochemical equivalencies of drugs are not usually correlate to the generic equivalencies of drugs and the generic equivalencies of drugs produced by different manufacturers or different formulations are being called in question frequently. The bioabailability of two formulations of oxytetracycline and erythromycin stearate were performed in healthy human volunteers. At the same time, the disintegration testes were performed with randomly sampled materials in question. For the biological evaluation of new oxytetracycline formulation; tablet(250mg), two-way cross over study in 10 healthy young volunteers was performed using oxytetracycline capsule (250mg) as reference, Erythromycin stearate (250mg) tablets and capsules produced by different manufacturers were compared in a two-way cross over study in 12 subjects with same manner of oxytetracyclines. oxytetracycline tablets showed somewhat slow disintegration rate, but appeared not statistical differences in serum concentrations from the reference, up to six hours after ingestion. Erythromycin stearate capsules disintegrated more rapidly than enteric coated tablets. Serum concentrations of capsules were more variable and markedly lower (P<.005 after 2hrs) than the enteric coated tablets. Rapid disintegration of capsules may result in destruction of active chemicals owing to the interaction with gastric acid and the above factor may contribute mainly to the low serum level after ingestion of capsules.

나노임프린트 방법을 이용한 폴리머 광도파로 열 격자

임정규,이상신,이기동,Lim, Jung-Gyu,Lee, Sang-Shin,Lee, Ki-Dong 한국광학회 2006 한국광학회지 Vol.17 No.4

본 논문에서는 폴리머 광도파로 열 격자(arrayed waveguide grating: AWG)를 나노임프린트 방법을 이용하여 제안하고 구현하였다. 빔전파방법을 도입하여 소자를 설계하고 해석하였다. 균일한 접착 및 분리 특성을 갖는 임프린트용 PDMS(polydimethylsiloxane) 스탬프(stamp)를 쿼츠 글래스 물질로 만들어진 마스터 몰드를 이용하여 개발하였다. 이 PDMS 스탬프로 폴리머층을 눌러서 소자 패턴을 형성하고 폴리머를 스핀코팅하여 소자를 완성하였다. 이러한 소자는 식각공정 없이 간단한 스핀코팅과 임프린트 공정만으로 만들어지기 때문에 대량 생산에 적합할 것이다. 제작된 폴리머 AWG 소자의 출력 채널 수는 8개, 채널 간격은 0.8nm, 각 채널의 중심파장은 1543.7nm $\sim$ 1548.3nm 였다. 평균적인 채널 누화와 대역폭은 각각 $\sim$10dB와 0.8nm였다. A polymeric arrayed waveguide grating (AWG) has been proposed and demonstrated by exploiting the nanoimprint method. A PDMS(polydimethylsiloxane) stamp with device patterns engraved was developed out of a master mold made of quartz glass. The device was fabricated by transferring the pattern in the PDMS stamp to a spin-coated polymer film without using any etching process. The device had 8 output channels, while the center wavelengths of each output channel were positioned from 1543.7 nm to 1548.3 nm with the spacing of 0.8 nm. The achieved average channel crosstalk and the 3-dB bandwidth were about 10 dB and 0.8 nm respectively.

흉강 내로 전이된 뇌실 복강 단락술 도관

임정규,양지호,이일우,이진석,이형진,여인성 대한소아신경외과학회 2010 대한소아신경외과학회지 = the korean journal of pediatric neur Vol.7 No.1