산수유의 최종당화산물 억제로 인한 주름 개선효과

이아름,김수현,김수지,김경조,권오준,최준영,노성수,Lee, AhReum,Kim, SooHyun,Kim, SuJi,Kim, KyeongJo,Kwon, Ojun,Choi, JoonYoung,Roh, Seong-Soo 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objectives : Corni Fructus (CF) is traditional herbal medicine used on polyuria, low back pain, and tinnitus. This study aimed to evaluate inhibits skin wrinkle formation effect of CF. Methods : To evaluate the produce inhibition effect of CF, SD-rats were distributed into four groups; normal rats (Nor), AGEs (advenced glycation end product)-induced rats (Con), AGEs-induced rats treated with 100mg/kg CF (CF). To induce AGEs, streptozotocin (50mg/kg) was administered intraperitoneally and after 3 days oral administrated 100mM methyl glyoxal for 3 weeks. Results : The oral administration of CF suppressed the reactive oxygen specis (ROS) in serum. The AGEs in skin tissues was significantly reduced through treatment of CF. Furthermore, the expressions of AGEs related proteins such as polyclonal anti-$N^e$-(carboxymethyl)lysine (CML), anti-$N^e$-(carboxyethyl)lysine (CEL), AGE receptors (RAGE) were decreased in CF treated group compared with the control group in skin tissues. Inflammation-related proteins such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) reduced in CF treatment group than control group. AGE-induced rats exhibited that the significant decreased collagen however, CF treatment (100mg/kg of body weight) up regulated collagen by improved the expression levels of skin fibril-related genes such as Matrix metalloproteinase (MMP-1). Conclusion : Taken together, our study suggests that CF regulates ROS to prevent accumulation of AGEs and inhibits skin wrinkles. Our finding indicate that CF may be an effective agent for inhibits AGEs formation, and improved skin wrinkle.

최종당화산물 억제를 통한 상엽(桑葉)의 항피부노화 효과

이아름,김수현,김수지,김경조,권오준,최준영,노성수,Lee, AhReum,Kim, SooHyun,Kim, SuJi,Kim, KyeongJo,Kwon, Ojun,Choi, JoonYoung,Roh, Seong-Soo 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objectives : Recently, numerous studies reported that excessive generation of advanced glycation end products (AGEs) stimulated expression of skin wrinkle related proteins. This study aimed to evaluate inhibits skin wrinkle formation effect of Mori Folium (MF) through decreased AGEs. Methods : To evaluate the skin wrinkle inhibition effect of MF, SD-rats were divided into three groups; normal rats (Nor), AGEs-induced rats (Con), AGEs-induce rats treated with MF at dose of 100mg/kg body weight (MF). To induced AGEs, streptozotocin (50mg/kg) was injected intraperitoneally, and after 3 days, 100mM methyl glyoxal was administered orally for 3 weeks. After the experiment, the animal's dorsal skin tissues and serum were separated and tested. Results : The oral administration of MF suppressed the AGEs level in serum. Also, the AGEs in skin tissues was significantly reduced through treatment of MF compared with control group. Moreover, the expressions of AGEs related proteins such as polyclonal anti-$N^e$-(carboxymethyl) lysine (CML), anti-$N^e$-(carboxyethyl)lysine (CEL), AGE receptors (RAGE) were reduced in MF group compared with the control group in kidney and skin tissues. The matrix metallo proteinase-1 (MMP-1) reduced by MF treatment with the result that collagen type 1 alpha 2 (COL1A2) was improved that reduced by accumulation of AGEs. Conclusion : The evidence of this study indicate that oral administration of MF reduces the levels of AGEs in serum, skin, and kidney tissues. In conclusion, MF inhibit skin wrinkle formation, suggesting the potential of anti-wrinkle material.

소아청소년의 전신마취 하 치과 치료의 추세변화 및 치과 영역 중증 장애 유무에 따른 전신마취 재시행 양상에 대한 연구

이아름,김현태,송지수,신터전,현홍근,김정욱,장기택,김영재,Ahreum Lee,Hyuntae Kim,Ji-Soo Song,Teo Jeon Shin,Hong-Keun Hyun,Jung-Wook Kim,Ki-Taeg Jang,Young-Jae Kim 대한소아치과학회 2023 大韓小兒齒科學會誌 Vol.50 No.1

이 후향적 연구는 2011년 1월부터 2020년 12월까지 서울대학교 치과병원 소아치과에서 시행된 전신마취 하 치과 치료의 추세 변화를 분석하고 치과 영역 중증 장애 여부에 따른 전신마취 재시행 양상을 비교해보고자 하였다. 1,719명의 환자에게 1,857건의 전신마취 하 치과 치료가 시행되었으며 평균 연령은 5.1세였고 남자가 59.3%였으며 ASA 2등급 이상인 환자가 52.9%, 치과 영역 중증 장애 환자는 26.8%였다. 연구 기간 동안 전신마취 시행 건수는 지속적으로 증가하였으며, 6.6%의 환자가 2회 이상의 전신마취 하 치과 치료를 받았고 10년 동안 전신마취 재시행률은 7.4%였다. ASA 2등급 이상인 환자(p < 0.0001)와 치과 영역 중증 장애 환자(p < 0.0001)에게서 전신마취 재시행의 가능성이 높았으며, 치과 영역 중증 장애 환자가 전신마취를 시행받은 시기의 연령이 더 높게 나타났다(p < 0.0001). 치과 영역 중증 장애 환자에게 첫 전신마취와 두 번째 전신마취에서 모두 영구치의 수복 치료(p = 0.002, p < 0.0001)가 더 많이 시행되었다. 최근 10년간 소아치과 영역에서 전신마취의 사용이 증가하고 있으며 치과 영역 중증 장애를 가진 소아청소년 환자의 전신마취 재시행을 줄이기 위한 정기 검진과 구강 위생 관리를 통한 예방이 중요하다.

포트 재배에 의한 화약물질 오염토양 정화용 내오염성 식물 선정

이아름,배범한,Lee, Ahreum,Bae, Bumhan 한국지하수토양환경학회 2015 지하수토양환경 Vol.20 No.6

Nine plant species were selected through vegetation survey at three military shooting ranges at northern Gyeonggi Province. Plants were germinated in normal soil and three seedlings were transplanted to a bottom sealed pot containing sandy loam soils contaminated with either RDX (291 mg/kg) or TNT (207 mg/kg). Planted, blank (without plant), and control (without explosive compound) pots were grown in triplicate at a green house for 134 days. During cultivation, transplanted plants exhibited chlorosis and necrosis in flower and leaf by explosive toxicity and stress. Only three plants, Wild soybean, Amur silver grass, Reed canary grass, survived in TNT treated pot, while seven plant species except for field penny cress and jimson weed, thrived in RDX treated pot. Appreciable amount of TNT (61.6~241.2 mg/g-D.W.) was detected only in plant roots. Up to 763.3 mg/g-D.W. along with 4-amino-2,6-dinitrotoluene, an intermediate of TNT, accumulated in the root of wild soybean. In addition, azoxy compounds, abiotic intermediates of TNT, were detected in TNT treated soils. RDX absorbed average 1,839.95 mg/kg in shoot and 204.83 mg/kg in root. Most of TNT in plant was accumulated in underground part whereas RDX was localized in aerial part. Material balance calculation showed that more than 95% of the initial TNT was removed in the planted pots whereas only 60% was removed in the blank pot. The amount of RDX removed from soil was in the order of Amur Silver Grass (51%) > Chickweed (43%) > Evening primrose (38%). Based on the results of pot cultures, Amur silver grass and Reed canary grass are selected as tolerant remedial plants for explosive toxicity.

물억새를 식재한 플러그 흐름 습지에서의 RDX 제거동역학

이아름,김범준,박지은,배범한,Lee, Ahreum,Kim, Bumjoon,Park, Jieun,Bae, Bumhan 한국지하수토양환경학회 2015 지하수토양환경 Vol.20 No.6

RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) is the most important explosive contaminant, both in concentration and in frequency, at military shooting ranges in which green technologies such as phytoremediation or constructed wetlands are the best option for mitigation of explosive compounds discharge to the environment. A study was conducted with two identical lab-scale plug flow constructed wetlands planted with Amur silver grass to treat water artificially contaminated with 40 mg/L of toxic explosive compound, RDX. The reactor was inoculated with or without RDX degrading mixed culture to evaluate plant-microorganism interactions in RDX removal, transformation products distribution, and kinetic constants. RDX and its metabolites in water, plant, and sediment were analyzed by HPLC to determine mass balance and kinetic constants. After 30 days of operation, the reactor reached steady-state at which more than 99% of RDX was removed with or without the mixed culture inoculation. The major transformation product was TNX (Trinitroso-RDX) that comprised approximately 50% in the mass balance of both reactors. It was also the major compound in the plant root and shoot system. Acute toxicity analysis of the water samples showed more than 30% of toxicity reduction in the effluent than that of influent containing 40 mg/L of RDX. In the Amur silver grass mesocosm seeded with the mixed culture, the specific RDX removal rate, that is 1st order removal rate normalized to plant fresh weight, was estimated to be 0.84 kg⁻¹ day⁻¹ which is 16.7% higher than that in the planted only mesocosm. Therefore, the results of this study proved that Amur silver grass is an effective plant for RDX removal in constructed wetlands and the efficiency can be increased even more when applied with RDX degrading microbial consortia.

포제한약재의 최종당화산물 생성 억제 활성 및 항산화 효과

이아름 ( Ahreum Lee ),권오준 ( Ojun Kwon ),최준영 ( Joonyoung Choi ),노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.3

Objectives: Advanced glycation end product (AGEs) is combine formation of glucose and protein. AGEs and reactive oxygen species are potential therapeutic targets for the various disease such as diabetic complications, renal injury, skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from 40 Korean medicines and 5 heating-processed Korean medicines. Methods: AGEs formation inhibitory activities of Korean medicines measured using bovine serum albumin (BSA), glucose, and fructose. Then, five effective Korean medicines were selected and heated with 30% ethanol. The AGEs inhibitory activities of heated Korean medicine were measured compared with not-heated Korean medicines. The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2`-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. Furthermore, we examined total phenol and flavonoids contents. Results: Scutellariae Radix, Corni Fructus, Persimmon Fruit, Paeoniae Radix, Mori Folium respectively reduced AGEs production. Morever, heating-processed Scutellariae Radix has AGEs inhibitory activities better than not-processed Scutellariae Radix. Heating- processed Scutellariae Radix scavenged DPPH and ABTS effectively and IC50 of DPPH and ABTS radical scavenging activity of Heat processed Scutellariae Radix were 15.47±0.26 ㎍/㎖ and 12.07±1.23 ㎍/㎖. It caused heat processing methods of Scutellariae Radix up regulated total phenol and flavonoids contents (26.68±0.01 to 46.15±0.10, 20.30±0.38 to 64.20 ±0.52). Conclusion: It has AGEs inhibitory activities that 20 kind of medicinal plants of 40 medicinal plants. Especially, heat processed Scutellariae Radix has excellent AGEs inhibitory activities and antioxidant effect.

실리콘 이종접합 태양전지 개발동향

이아름(Ahreum Lee),유진수(Jinsu Yoo),박성은(Sungeun Park),박주형(Joo Hyung Park),안승규(Seungkyu Ahn),조준식(Jun-Sik Cho) 한국태양광발전학회 2021 Current Photovoltaic Research Vol.9 No.4

Silicon heterojunction technology (HJT) solar cells have received considerable attention due to advantages that include high efficiency over 26%, good performance in the real world environment, and easy application to bifacial power generation using symmetric device structure. Furthermore, ultra-highly efficient perovskite/c-Si tandem devices using the HJT bottom cells have been reported. In this paper, we discuss the unique feature of the HJT solar cells, the fabrication processes and the current status of technology development. We also investigate practical challenges and key technologies of the HJT solar cell manufacturers for reducing fabrication cost and increasing productivity.

UX 전문가의 역량 모델에 기반한 수행역량유사도에 따른 UX 방법론 분류에 대한 연구

이아름 ( Lee Ahreum ),강효진 ( Kang Hyo Jin ),권규현 ( Kwon Gyu Hyun ) 디자인융복합학회 2017 디자인융복합연구 Vol.16 No.4

국내 제조업이 성장정체기에 접어들면서 사용자의 경험에 기반한 서비스 및 제품 디자인이 혁신을 위한 도구로써 제시되고 있다. 하지만 중소기업은 사용자경험에 대한 인지도가 낮을뿐더러 검증된 사용자 경험 컨설팅 전문 회사 및 전문가와의 접점을 갖기 어려워 UX라는 새로운 기회영역에 투자하는 데 한계를 갖기 때문에 여전히 어려움을 겪고 있다. 이러한 중소기업의 난점을 극복하기 위해 본 논문은 중소기업과 UX 전문가 간의 사용자 경험 컨설팅 프로젝트 체결 및 수행 지원 사이트 구축에 있어서 수요기업이 가지는 문제를 해결할 수 있는 검증된 역량을 가진 전문가를 추정할 수 있는 기반 연구를 제시하고자 한다. 이를 위해 본 연구에서는 수요기업의 문제를 해결할 수 있는 도구로써 사용되는 UX 방법론과 이를 수행하는 데 필요로 하는 UX 전문가의 역량을 선행연구와 전문가 워크숍을 통해 도출 하였다. 또한, 방법론 수행 시 필요로 하는 역량의 중요도에 따라 방법론을 분류하기 위해 추가 전문가 워크숍과 군집분석을 진행하여 총 5가지의 UX전문가 역량 단위를 도출하였다. 본 연구 결과는 향후 사용자 경험 컨설팅 프로젝트 체결 및 수행 지원 사이트 운영에 있어서 UX 전문가의 포트폴리오를 구성하고 수요기업이 원하는 전문가를 추천할 수 있는 메커니즘을 구현하기 위한 기반으로 활용하고자 한다. As the local manufacturing industry has entered a phase of stagnation, service and product design based on user experience has been highlighted as an alternative for the innovation. However, SMEs(Small and Medium-sized Enterprises) are still struggling to overcome the current crisis. One of the reasons is that SMEs do not have enough contact points with the validated UX firms and experts. Thus, SMEs has a high barrier to invest in new opportunity area, user experience. In this study, we aim to figure out UX experts` competence to perform the UX method to solve the UX problems based on the KSA framework(Knowledge, Skill, Attitude). Based on the literature review and expert workshop, we grouped the UX method according to the similarity of the competence required to conduct the method. With cluster analysis, 5 different groups of UX method were defined based on the competence, Panoramic Analysis, Meticulous Observation and Analysis, Intuitive Interpretation, Agile Visualization, and Logical Inspection. The results would be applied to compose a portfolio of UX experts and to implement a mechanism that could recommend the professional experts to the company.

학문 목적 한국어 학습자를 위한 헤지(Hedge) 표현 제시 방안

이아름(Lee, Ahreum) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.9

헤지(Hedge)는 학술 텍스트에서 필자의 주장에 직접성을 줄이고 완곡성을 더하기 위해 사용되며, 한국어 학술 텍스트에서는 덩어리로 된 동사 중심 표현을 통해 실현되는 경우가 많다. 비교적 최근 출간된 학문 목적 한국어 교재를 살펴보면 헤지 표현 을 제시하고는 있지만 체계적으로 다루고 있는 것은 아니다. 이에 따라 본고에서는 학문 목적 교재에 나타난 헤지 표현의 제시 양상을 분석하여 문제점을 발견하였으며 이를 바탕으로 학문 목적 한국어 교재에서의 헤지 표현 제시 방안을 인식의 측면과 사용의 측면으로 나누어 제안하였다. This article aims to presentation of Korean hedging expressions for Korean learners with academic purposes. Scientific writing is purely objective, impersonal and informational, designed to disguise the author and deal directly with facts. And in the academic field, writers need to present their claims cautiously, accurately and modestly to meet discourse community expectations and to gain acceptance for their statement. According to Hyland(1995a), Hedging expressions present unproven claims with caution and softening categorical assertions and they are crucial to scientific writing where statements are rarely made without subjective assessments of truth. Such pragmatic aspects of communication however are vulnerable to L2 students rarely able to able to hedge their statements appropriately. This article, therefore, will examine Korean textbooks for KAP learners and analyze ways for presenting of hedging expressions so as to discover what problems are existed. I will, thereby, suggest presentation of Korean hedging expressions in aspects of awareness and use in Korean textbooks for KAP.

급성 위염 유발 마우스 동물 모델에서 구기자(枸杞子) 에탄올 추출물의 위점막 손상보호 효과

이아름 ( Ahreum Lee ),이주영 ( Jooyoung Lee ),김민영 ( Minyeong Kim ),신미래 ( Mi Rae Shin ),신성호 ( Sungho Shin ),서부일 ( Buil Seo ),권오준 ( Ojun Kwon ),노성수 ( Seong Soo Roh ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.6

Objectives : Gastric lesions affect many people around the world and their development are results of the imbalance between destructive and protective factors in the gastric mucosa. Lycium chinense has been widely used as a traditional Korean medicine, it was recently reported that they have potent anti-inflammatory effects in chronic hepatitis models. Therefore, this study aimed to investigate the anti-inflammatory activity of Lycium chinense extract (LCE) on HCl-Ethanol induced gastric lesion mice. Methods : The ICR mice were divided randomly into five groups of six animals each. Group A was normal mice, and group B was treated orally with 0.5 ml 150 mM HCl-60% Ethanol. Mice in group C and D were pre-treatment of LCE (100 mg/kg and 200 mg/kg bodyweight, p.o before HCl/ethanol treatment) and group E was orally administered sucralfate (10 mg/kg). Results : 150mM HCl/60% ethanol-induced gastric mucosal injury mice were ameliorated mucosal damage upon histological evaluation by treatment of LCE. Pre-treatment of LCE attenuated reactive oxidative species (ROS) and produces peroxynitrite (ONOO-) in stomach tissues. As results of stomach protein analyses, LCE effectively reduce inflammatory-related factors such as cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) in gastric lesion mice. In addition, nuclear factor kappa B (NF-κB) and inhibitor of phosphorylation of nuclear factor kappa B (p-IκB) were down-regulated in LCE-administrated gastric lesion mice. Conclusions : Our discovery supports that the therapeutic activity of LCE ameliorate the development of gastric lesion via suppressing the oxidative stress and gastric partial inflammation induced by 150 mM HCl/60% ethanol.