http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이상찬(Sang-Chan LEE) (검색결과 181 건)
- 무료
- 기관 내 무료
- 유료
-
-
김상찬 ( Sang Chan Kim ),이종록 ( Jong Rok Lee ),박숙자 ( Sook Jahr Park ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.2
Objectives : Laver (Porphyra tenera), a red algae species, is one of the most widely consumed edible seaweed in Korea. Laver contains various substances such as essential amino acid, fiber, minerals and polyphenols that benefit human health. In the present study, we prepared ethanol extracts from commercially processed product of Porphyra tenera, and evaluated the growth inhibitory effect against human oral squamous carcinoma YD-10B cells. Methods : Cell viability was measured by MTT assay. Apoptosis was confirmed by TUNEL assay and flow cytometry with the green fluorescent dye FITC annexin V entering apoptotic cells and the red fluorescent dye PI not entering. The expression of the relevant proteins was detected using Western blot. Results : Ethanol extracts of Porphyra tenera (PTE, 50-200 ㎍/㎖) caused a significant decrease of cell viability in a dose dependant manner. The cell death occurred as a result of apoptotic process as determined by TUNEL assay and flow cytometric analysis. In line with this observation, decrease in procaspase proteins and increase in cytosolic cytochrome c were observed in cells treated with PTE. In addition, exposure to PTE decreased the expression levels of Bcl-2, and induced PARP cleavage and AIF translocation from mitochondria to nucleus. Conclusions : In conclusion, PTE exerts anti-cancer effects by inducing apoptosis via caspase activation and AIF nuclear translocation in YD-10B cells. These results provide evidence for the possible therapeutic effect of Porphyra tenera in oral cancer cells.
-
김상찬(Kim Sang-Chan),이충은(Lee Choong-Eun) 한국법학회 2008 법학연구 Vol.32 No.-
우리나라는 1962년 구 이자제한법이 제정·시행되었지만, 1997년 IMF를 맞이하면서 구제금융을 받는 과정에서 고금리정책의 일환으로 1998년 구 이자제한법이 폐지되었다. 이후 대부업법이 제정되었지만, 구 이자제한법이 폐지되고 대부업법이 제정되기 전까지 약 5년간 이자제한제도가 전혀 시행되지 않아 금융시장에서 퇴출된 신용이 불량한 서민들과 중소기업들이 사채시장으로 몰리게 되었다. 이와 같이 특별법에 의하여 고율의 이자를 제한하는 규정이 없는 경우 민법의 일반조항인 민법 제103조 및 제104조에 의하여 규제를 할 수 있는지가 문제된다. 대법원은 민법 제103조를 적용하여 제한초과이자를 무효라고 판시하고 있다. 또한 임의로 지급된 고율의 이자의 반환청구에 대하여 민법 제746조 단서를 적용하여 반환청구를 인정한다. 채권자 및 채무자 모두를 보호하게 된다는 점에서는 매우 바람직한 판단이다. 2007. 3. 29. 다시 이자제한법이 제정되어 같은 해 6. 30.부터 시행됨으로써 고율의 이자 문제는 입법적으로 해결되기는 하였으나, 이러한 특별법이 상황에 따라 폐지될 수 있다고 전제하며 고율의 이자약정을 반사회성의 법리로서 해결하는 문제는 매우 중요할 수 있다. 이 논문에서는 이자제한에 관한 주요국가의 입법례와 더불어 고융의 이자약정에 관하여 반사회성의 법리에 관하여 살펴보고 있다. The old interest restriction law in Korea was established in 1962 and was enforced. But the period of IMF in 1997, from the process which receives a relief loan, the old interest restriction law was abolished as part of higher interest policy at 1998. The loan business law was established after that, but the old interest restriction law is abolished and before being established the loan business law, the interest restrictive system is not entirely enforced for about 5 years, and for bad credits, the people and small and medium enterprises that are expelled from the financial money market are driven into a private money market. Like this, according to the special law, in case of no regulation which restricts the interest of high rate by Art.103 and Art.104 of the civil law, the possibility of that would be an issue. The Supreme Court decide that excess interest limit is null and void by Art.103 of the civil law. Also it presumes a claim for recapture of high interest rate which is provided discretion by applying Art.746 of the civil law. The creditor and the debtor all are under protection, and I think that it is very desirable. The interest restriction law was established again in 2007 March 29th ,and from 2007 June 30th was enforced, and the interest problem of high rate was solved legislatively, however, depending on the abolishment of the special law, the problem which solves contracted high interest rates as a principle of law on anti-sociality is very important. Therefore, this thesis searches for major national cases legislation as well as high interest rate agreement as a principle of law on anti-sociality.
-
-
-
HepG2 세포에서 tert-butyl hydroperoxide로 유도된 간독성에 대한 kurarinone의 세포 보호 효과
김상찬,이종록,박숙자,Kim, Sang Chan,Lee, Jong Rok,Park, Sook Jahr 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.3
Objective : Kurarinone is one of the flavonoids isolated from Sophorae Radix with various biological activities including anti-microbial effect. In this study, we investigated the effects of Kurarinone on tert-butyl hydroperoxide (tBHP)-induced oxidative stress finally leading to apoptosis in human hepatoma cell line HepG2. Methods : To determine the effects on cell viability, the cells were exposed to tBHP ($100{\mu}mol/l$) after pretreatment with kurarinone (0.5 and $1{\mu}g/ml$). Cell viability was measured by MTT assay. To reveal the possible mechanism of cytoprotectivity of kurarinone, levels of reactive oxygen species, intracellular glutathione, mitochondrial membrane potential, and expression of caspase were examined. Results : tBHP-induced cell death was due to oxidative stress and the resulting apoptosis. Kurarinone dose-dependently protected cells from apoptosis when determined by MTT and TUNEL assay. Consistent with this observation, decreased expression of pro-caspase 3/9 protein by tBHP was restored by kurarinone. Kurarinone also showed anti-oxidative effects by inhibiting generation of ROS and depletion of GSH in tBHP-stimulated HepG2 cells. In addition, kurarinone significantly recovered disruption of mitochondrial membrane potential (MMP) as a start sign of hepatic apoptosis induced by oxidative stress. Conclusion : From these results, it was concluded that kurarinone protected tBHP-induced hepatotoxicity with anti-oxidative and anti-apoptotic activities. Our results suggest that kurarinone might be beneficial to hepatic disorders caused by oxidative stress.
-
-
김상찬(Kim, Sang-chan),이충은(Lee, Choong-eun) 호남대학교 인문사회과학연구소 2009 人文社會科學硏究 Vol.24 No.-
계약체결상의 과실책임이라 함은 계약체결을 위한 당사자간의 접촉개시 시부터 계약체결 시까지 계약을 성립하기 위한 협의과정에서 계약당사자 일방의 과실로 인하여 상대방이 손해를 입게 된 경우 그 손해의 배상을 인정하는 것을 말한다. 우리 민법은 제535조에서 계약체결상의 과실이라는 표제를 사용함으로써 계약체결상의 과실책임을 명문으로 규정하고 있다. 계약체결상의 과실책임은 독일 민법에서 인정되어 온 제도로써, 독일 민법은 우리 민법과 달리 계약책임과 불법행위 책임에 관한 일반규정이 없어 계약체결상의 과실책임을 인정할 실익이 있었다. 반면 우리 민법은 계약책임과 불법행위 책임에 관한 일반규정이 있어 계약체결상의 과실책임을 인정할 실이 없는데도 불구하고 독일 민법을 그대로 받아들임으로써 많은 비판을 받고 있다. 이처럼 민법 제535조는 제정 당시부터 인정실익에 관한 논란이 있었고, 최근에는 계약체결상의 과실책임을 독자적인 책임유형으로 인정할 수 있는지에 관한 문제가 제기되기도 한다. 특히 독일에서는 우리나라와 달리 학설과 판례에서 ①계약체결의 준비단계에서의 계약체결상의 과실책임, ②계약이 유효한 경우의 계약체결상의 과실책임, ③계약이 체결되었으나 그 계약이 무효이거나 또는 취소된 경우의 계약체결상의 과실책임에 대해서까지 인정하고 있다. 이에 독일의 민법을 그대로 받아들이 우리 민법의 경우에도 위의 유형에 대해 확대해석하여 유추 적용할 수 있는지가 문제된다. 그러나 우리 민법 제535조는 위의 유형에 대해 계약체결상의 과실책임 법리가 아닌 채무불이행 책임 내지 불법행위책임으로 채결하고 있다. 따라서 민법 제535조는 존재의 의미를 잃은 규정으로 삭제되어야 함이 마땅할 것이다. Liability based on fault in a contract means to admit compensation for damages in the case of suffering losses to the other party as a result of the contracting party's fault during the contract negotiation process between two parties. The civil law expressly stipulates liability based on fault in a contract by using section 535 of the law Liability based on fault in a contract is the system used in German civil law, which, unlike our civil law, has the practical advantage of admitting liability based on fault in a contract with no general regulations about contractual obligations and tort liability. On the other hand, although the civil law doesn't have the practical advantage of admitting liability based on fault in a contract because of general regulation about contractual obligations and tort liability, it is criticized for accepting German civil law Section 535 of the civil law was controversial concerning practical advantage at the time of enactment recently, questions were raised about admitting liability based on fault in a contract as a type of independent responsibility. Precedence and theory in German admit ① liability based on fault in a contract in the run-up to the conclusion of a contract, ② liability based on fault in a contract in the case of a valid contract, ③ liability based on fault in a contract in the case of a void or cancelled contract. So, the civil law recognizes that German law has a problem about making a broad interpretation of these types of liability based on fault or applies them analogously. However, section 535 of the civil law solves these types of cases not as a principle of law but as a default on an obligation or a tort liability. Therefore, section 535 of the civil law should be deleted because the regulation is losing its reason to exist.
-
-
박상찬(Sang-Chan Park),이상철(Sang-Chul Lee),박영배(Young-Bae Park),임광혁(Kwang Hyuk Im) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.3
본 연구는 한방에서 사용되는 설문데이터와 생체신호데이터를 활용한 분석을 통하여 설문데이터와 생체신호 간의 연관성을 탐색하여 고객 개개인마다 적합한 고객 맞춤형 한방 생체신호 측정을 가능케 하는데 목적이 있다. 먼저, 기 개발된 설문을 통해 수집된 설문데이터를 분석하여 변증을 판단할 수 있는 설문 문항만을 선발하여 최적화하였고, 이렇게 최적화된 설문데이터를 데이터마이닝 기법을 이용하여 변증이 있는 그룹과 없는 그룹으로 구분하였다. 각 그룹에 속한 고객들의 위전도 측정데이터를 수집·분석하여 설문과 생체신호 간 연관성을 분석하였고, 아울러 변증과의 연관성을 분석하였다. The purpose of this research is to analyze the questionnaire of oriental medicine and bio-signal data and to identify the correlation between symptoms of oriental medicine and bio-signal in order to develop the customization model for individual patients. First, this research analyzes the questionnaire data using the developed questionnaire for oriental medicine symptoms and selects the optimized questionnaires for identifying the symptoms. Using data mining technologies with the selected questionnaires, this research divides the normal group and the group with symptoms. Finally, this research identifies the correlation between the questionnaire for oriental medicine symptoms and electrogastrogram signal.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
