정신분열병의 결핍증후군과 비결핍증후군에서 QEEG와 sLORETA를 이용한 비교연구

이상은,임선진,이미경,이재원,한규희,이종일,심민영,윤해주,신병학,Lee, Sang-Eun,Yim, Seon-Jin,Lee, Mi-Gyung,Lee, Jae-Won,Han, Kyu-Hee,Lee, Jong-Il,Sim, Min-Young,Yoon, Hai-Joo,Shin, Byoung-Hak 대한수면의학회 2010 수면·정신생리 Vol.17 No.2

목 적: 본 연구는 정신분열병의 결핍증후군과 비결핍증후군이 다른 생물학적 동등성을 가진 독립된 질환일 수 있다는 가설 아래 quantitative EEG와 standardized LORETA (sLORETA)를 이용한 전기생리학적인 방법을 통하여 생물학적 병인을 파악하고자 시도되었다. 방 법: 정신분열병 환자를 대상으로 42명의 뇌파를 비교 분석하였으며 그 중 결핍증후군 환자군은 남자 10명과 여자 11명이었고 비결핍증후군 환자군은 남자 12명, 여자 9명이었다. 주파수 대역은 delta(1.5~4 Hz), theta(4~8 Hz), alpha(8~12 Hz), low beta(12~15 Hz), high beta(15~30 Hz)의 5가지로 분할하였고 EEG LAB을 이용한 파워스펙트럼 분석 및 standardized sLORETA software package를 이용하여 신호원을 국소화 하였다. 결 과: 파워 스펙트럼 분석에서 결핍증후군 집단은 비결핍증후군과 비교하였을 때 전두엽, 두정엽 및 측두엽 영역에서 delta파와 theta파의 유의한 활성도 증가를 보였으며 뇌파 스펙트럼은 간편 정신상태 평정 척도 중 철퇴/지연과 적대/의심 항목의 임상적인 특징과 유의한 상관관계를 보였다. sLORETA분석 결과에서는 배측 전대상피질에서 결핍증후군에서 유의하게 delta파의 활성도가 증가되었다. 결 론: 결핍증후군은 비결핍증후군과는 연관된 뇌 영역이 다를 수 있으며 특히 전두엽 영역의 신경회로 이상이 일차적 음성증상에 영향을 줄 것으로 생각된다. Objectives: Deficit schizophrenia (DS) constitutes a disease separate from non-deficit schizophrenia (NDS). The aim of the current study was to compare the quantitative EEG and low resolution electromagnetic tomography (LORETA) imaging between DS and NDS. Methods: This study was performed by 32 channels EEG for 42 schizophrenia patients who we categorized into DS and NDS using proxy instrument deficit syndrome (PDS). We performed the absolute power spectral analyses for delta, theta, alpha, low beta and high beta activities. We compared power spectrum between two groups using Independent t-test. Partial correlation test was performed with clinical parameters. Standardized LORETA (sLORETA) was used for comparison of cortical activity, and statistical nonparametric mapping (SnPM) was applied for the statistical analysis. Results: DS showed significantly increased delta and theta absolute power in fontal and parietal region compared with NDS (p<0.05). Power spectrum showed significant correlation with 'anergia' and 'hostility/suspiciousness' subscale of brief psychiatric rating scale (BPRS)(p<0.05). sLORETA found out the source region (anterior cingulate cortex/limbic part) that delta activity was significantly increased in DS (p=0.042). Conclusions: DS showed different cortical activity compared with NDS. Our results may suggest QEEG and LORETA could be the marker in differentiating between DS and NDS.

절사표본에서 최적 절사점에 관한 연구

이상은,조민지,신기일,Lee, Sang Eun,Cho, Min Ji,Shin, Key-Il 한국통계학회 2014 응용통계연구 Vol.27 No.3

상당수의 사업체 조사는 절사표본설계법을 사용하고 있다. 이는 절사표본설계법에서 얻은 전수층이 많은 정보를 포함하고 있어 전체 표본크기를 최소화 할 수 있는 장점이 있기 때문이다. 그러나 최근 전수층에 포함된 사업체들의 무응답률이 높아감에 따라 전수층이 가지고 있는 장점에 한계가 나타나고 있다. 이에 Lee (2011), Shin과 Lee (2013)는 표본설계 단계에서부터 주어진 허용오차를 만족하면서 전수층 규모를 최소화하는 연구를 실시하였다. 본 연구에서는 주어진 허용오차를 만족하고 Hidiroglou (1986)가 제안한 방법으로 산출 된 표본크기를 고정한 상태에서 표본층 분산에 알려진 함수를 적합하여 전수층 크기를 최소화하는 새로운 최적 절사점을 제안하였다. 또한 Hidiroglou (1986)와 Shin과 Lee (2013)가 제안한 절단분포를 이용한 방법과 본 연구에서 제안한 방법을 모의실험과 사례연구를 통해 비교하였다. Modified cut-off sampling is widely used for highly skewed data. A serious drawback of modified cut-off sampling is the difficulty of adjustment of non-response in take-all stratum. Therefore, solutions of the problems of non-response in take-all stratum have been studied in various ways such as substitute of samples, imputation or re-weight method. In this paper, a new cut-off point based on minimizing MSE being used in exponential and power functions is suggested and it can be reduced the number of take-all stratum. We also investigate another cut-off point determination method with underlying distributions such as truncated log-normal and truncated gamma distributions. Finally we suggest the optimal cut-off point which has a minimum of take-all stratum size among suggested methods. Simulation studies are performed and Labor Survey data and simulated data are used for the case study.

산화물 반도체 기반의 이종접합 광 검출기

이상은,이경남,예상철,이성호,김준동,Lee, Sang-eun,Lee, Gyeong-Nam,Ye, Sang-cheol,Lee, Sung-ho,Kim, Joondong 한국전기전자재료학회 2018 전기전자재료학회논문지 Vol.31 No.3

In this study, double-layered TCO (transparent conductive oxide) films were produced by depositing two distinct TCO materials: $SnO_2$ works as an n-type layer and ITO (indium-doped tin oxide) serves as a transparent conductor. Both transparent conductive oxide-films were sequentially deposited by sputtering. The electrical and optical properties of single-layered TCO films ($SnO_2$) and double-layered TCO ($ITO/SnO_2$) films were investigated. A TCO-embedding photodetector was realized through the formation of an $ITO/SnO_2/p-Si/Al$ layered structure. The remarkably high rectifying ratio of 400.64 was achieved with the double-layered TCO device, compared to 1.72 with the single-layered TCO device. This result was attributed to the enhanced electrical properties of the double-layered TCO device. With respect to the photoresponses, the photocurrent of the double-layered TCO photodetector was significantly improved: 1,500% of that of the single-layered TCO device. This study suggests that, due to the electrical and optical benefits, double-layered TCO films are effective for enhancing the photoresponses of TCO photodetectors. This provides a useful approach for the design of photoelectric devices, including solar cells and photosensors.

공간통계량을 활용한 베이지안 자기 포아송 모형을 이용한 소지역 통계

이상은,Lee, Sang-Eun 한국통계학회 2006 응용통계연구 Vol.19 No.3

표본조사에서는 일반적으로 지형학적 범위가 넓거나 흔히 우리가 알고 있는 지형적 범위 즉시 또는 도 단위로 표본설계가 이루어진다. 그러므로 지형학적 범위가 작은 소지역은 충분한 표본의 확보가 불가능하며 따라서 정확한 소지역 통계를 얻는 것은 매우 어렵다. 이러한 문제로 정확한 소지역 통계를 얻기 위한 연구가 활발히 진행되고 있다. 최근 신기일과 이상은(2003)은 공간통계 모형을 이용한 소지역 추정을 연구하였다. 본 논문은 신기일과 이상은(2003)의 공간자기회귀(Spatial Autoregressive: SAR) 모형을 확장한 모형인 베이지안 자기 포아송 모형 (Bayesian Auto-Poisson Model: BAPM)을 이용한 소지역 추정에 관하여 연구하였다. 분석에 사용된 자료는 호주의 1998년 장애인 통계 (Survey of Disability, Aging and Cares:SDAC)이 며 MSE, MB 그러고 회귀 분석을 이용한 편의 분석기법이 비교에 사용되었다. In sample survey sample designs are performed by geographically-based domain such as countries, states and metropolitan areas. However mostly statistics of interests are smaller domain than sample designed domain. Then sample sizes are typically small or even zero within the domain of interest. Shin and Lee(2003) mentioned Spatial Autoregressive(SAR) model in small area estimation model-based method and show the effectiveness by MSE. In this study, Bayesian Auto-Poisson Model is applied in model-based small area estimation method and compare the results with SAR model using MSE ME and bias check diagnosis using regression line. In this paper Survey of Disability, Aging and Cares(SDAC) data are used for simulation studies.

유동인구 밀집지역 인근의 도로구간별 배출량 산정 및 보행자 노출 강도 평가

이상은,신명환,이석주,홍다희,장동익,길지훈,정택호,이태우,홍유덕,Lee, Sangeun,Shin, Myunghwan,Lee, Seokjoo,Hong, Dahee,Jang, Dongik,Keel, Jihoon,Jung, Taekho,Lee, Taewoo,Hong, Youdeog 한국액체미립화학회 2018 한국액체미립화학회지 Vol.23 No.2

The objective of this study is to estimate the level of exposure of traffic-related air pollutants (TRAPs) on the pedestrians in Seoul area. The road network's link-based pollutant emission was calculated by using a set of mobile source emission factor package and associated activity information. The population information, which is the number of pedestrian, was analyzed in conjunction with the link-based traffic emissions in order to quantify exposure level by selected 23 spots. We proposed the Exposure Intensity, which is defined by the amount of traffic emission and the population, to quantify the probability of exposure of pedestrian. Link-based traffic NOx and PM emissions vary by up to four times depending on the location of each spot. The Hot-spots is estimated to be around 1.8 times higher Exposure Intensity than the average of the 23 selected spots. The information of Exposure Intensity of each spot allows us to develop localized policies for air quality and health. Even in the same area, the Exposure Intensity over time also shows a large fluctuation, which gives suggestions for establishing site-specific counter-measures.

회원갤러리 - 겨울(40F)

이상은,Lee, Sang-Eun 대한건축사협회 1996 建築士 Vol.1996 No.2

피부계 이상을 동반하는 선천성대사질환

이상은,Sang Eun, Lee 대한유전성대사질환학회 2022 대한유전성대사질환학회지 Vol.22 No.2

Congenital metabolic disorders are rare inherited disorders resulting from a defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or impaired organelle function. Depending on the abnormality of biochemical metabolism, various precursors and their abnormal metabolites can accumulate in the body and the final products which are critical in normal physiology can be deficient, resulting in disease. Congenital metabolic disorders present complicated medical conditions involving several human organ systems, including nervous system, eyes, liver, and kidneys. Various proteins and lipids are involved in the development and homeostasis of the skin, so many congenital metabolic disorders present abnormal changes in skin and hair. In this review, congenital metabolic diseases related to amino acid and lipid metabolism accompanying skin abnormalities will be discussed.

친환경제품과 지속가능한 사회

이상은,Lee, Sang-Eun 환경보전협회 2004 환경정보 Vol.26 No.5

21세기에 들어서서 전 세계인구의 1/4에 달하는 17억 명 정도가 소위 consumer class에 진입하게 되는데 20세기에는 consumer class가 유럽, 북미, 일본 등 몇 몇 부유국 사람들에게만 해당되는 용어였었다.<중략>

미래지향적 고등교육을 위한 역량기반 치의학 교육과정의 대안적 방향 탐색: 존재론적 접근을 중심으로

이상은,Lee, Sang Eun 연세대학교 의과대학 2017 의학교육논단 Vol.19 No.1

Recently, there has been active reformation of higher education. This trend has resulted in competency-based education (CBE) in many universities around the world, and dentistry education is no exception. However, it is necessary to keep in mind that CBE is both attractive and has its limitations. In particular, higher education is facing the obstacle of preparing students to survive in a supercomplex world in which nothing can be taken for granted. In addition, the frame of understanding and action lacks stability. In these circumstances, competency-based dentistry curriculum (CBDC) needs to be reestablished to deal with the changes and challenges of a supercomplex world. The purpose of this study is to explore alternatives to current CBDC practices, specifically based on an 'ontological approach.' To achieve this purpose, the importance of the ontological approach in the development of higher education curriculum in the future was examined. Then, the actual status and characteristics of CBDC in the present situation were investigated. Lastly, the development of CBCD based on an ontological approach in dentistry education was suggested.

국내적합 고도정수공정의 개발

이상은,Lee, Sang-Eun 환경보전협회 1996 환경정보 Vol.18 No.7