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장문석,오명숙,이병희,양웅모,김원남,김도림,김향미,박은화,박완수,김윤경,박성규,Chang, Mun-Seog,Oh, Myung-Sook,Lee, Byong-Hee,Yang, Woong-Mo,Kim, Won-Nam,Kim, Do-Rim,Kim, Hyang-Mi,Park, Eun-Hwa,Park, Wan-Su,Kim, Yun-Kyung,Park, Seong-Ky 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.1
The purpose of this study was to investigate the effect of water extract of Dioscoreae Rhizome on the reproduction activity of Wistar male rat. The group treated with 1.0 g/kg/day oral administrations of water extract of Dioscoreae Rhizoma (SK0l6) during 8 weeks was compared with the normal group. Sperm count, sperm motility, body weight, and testis weight were investigated in two groups. Sperm count. body weight, and testis weight of two groups did not show the significant difference. But sperm motility of the treated group was reduced significantly (the normal group: 56.43 %, SK0l6 group: 53.47 %, p < 0.05). According to the results, SK0l6 have no effects on sperm count, body weight. and testis weight but reduced sperm motility significantly.
ICR계 마우스에 대한 당귀보혈탕(當歸補血湯)의 급성 경구 독성시험
강순아,장문석,오명숙,박완수,강지웅,김원남,양웅모,이병희,배오성,박성규,Kang, Soon-Ah,Chang, Mun-Seog,Oh, Myung-Sook,Park, Wan-Su,Kang, Ji-Wung,Kim, Won-Nam,Yang, Woong-Mo,Lee, Byong-Hee,Bae, Oh-Sung,Park, Seong-Kyu 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
The Dangguibohyel-tang (DBT) was used to treat anemia in traditional Korean medicine. Acute oral toxicity of DBT was studied in ICR mice. ICR mice were administered orally with dosages of 100 mg/kg (low dosage group), 200 mg/kg (middle dosage group), and 400 mg/kg (high dosage group) of DBT. We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. DBT did not show any toxic effect in ICR mice and oral LD50 value was over 400 mg/kg in ICR mice.