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Imaging of Gastric Cancer Metabolism Using 18 F-FDG PET/CT
윤미진 대한위암학회 2014 Journal of gastric cancer Vol.14 No.1
Aerobic glycolysis has been the most important hypothesis in cancer metabolism. It seems to be related to increased bioenergetic and biosynthetic needs in rapidly proliferating cancer cells. To this end, F-18 fluorodeoxyglucose (FDG), a glucose analog, became widely popular for the detection of malignancies combined with positron emission tomography/computed tomography (PET/CT). Although the potential roles of FDG PET/CT in primary tumor detection are not fully established, it seems to have a limited sensitivity in detecting early gastric cancer and mainly signet ring or non-solid types of advanced gastric cancer. In evaluating lymph node metastases, the location of lymph nodes and the degree of FDG uptake in primary tumors appear to be important factors affecting the diagnostic accuracy of PET/CT. In spite of the limited sensitivity, the high specificity of PET/CT for lymph node metastases may play an important role in changing the extent of lymphadenectomy or reducing futile laparotomies. For peritoneal metastases, PET/CT seems to have a poorer sensitivity buta better specificity than CT. The roles of PET/CT in the evaluation of other distant metastases are yet to be known. Studies including primary tumors with low FDG uptake or peritoneal recurrence seem suffer from poorer diagnostic performance for the detection of recurrent gastric cancer. There are only a few reports using FDG PET/CT to predict response to neoadjuvant or adjuvant chemotherapy. A complete metabolic response seems to be predictive of more favorable prognosis.
윤미진,이종두 대한의사협회 2009 대한의사협회지 Vol.52 No.2
In the 1920 s, Warburg reported an observation that cancer cells depend on glycolysis even in the presence of available oxygen likely due to impaired function of mitochondria. Since then, this Warburg s effect has been the most important hypothesis in cancer metabolism and is considered as a seventh hallmark of many human cancers. Aerobic glycolysis was originally attributable to increased bioenergetic needs in rapidly proliferating cancer cells. Recently, biosynthetic aspects of aerobic glycolysis, which reprograms cancer metabolism to synthesize macromolecules such as nucleotides, fatty acids, amino acids, etc., are under active investigation. Introduction of positron emission tomography (PET) and metabolic radiotracers including F-18 flurorodeoxyglucose (FDG) and C-11 acetate made it possible to image cancer metabolism in vivo and to renew the interests on this issue. Studies have found that cancer cells with highly glycolysis features are associated with resistance to many chemotherapeutic regimens and radiation treatment. Therefore, development of glycolytic inhibitors can have an incremental effect to conventional treatments. In addition, functional imaging with metabolic radiotracers will continuously play important roles in detecting cancers and monitoring therapeutic responses to novel anti-metabolic approaches to cancer cells.
간호대학생의 의사소통능력이 임상실습 스트레스에 미치는 영향에 관한 연구
윤미진,진혜경,Yun, Mi Jin,Jin, Hye Kyung 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6
The purpose of this study was to investigate the effect of Communication cpmpetence of nursing students Clinical practice stress. Data were collected among 188 nursing students in G city, from Sep 5 to 20, 2021. The collected data was analyzed a using t-test, One way ANOVA, Pearson's correation coeffcient and Stepwise multiple regression using SPSS 20.0 WIN program. The average score for Communication cpmpetence was 3.54±0.41 and Clinical practice stress was 3.32±0.85. Clinical practice stress showed Models including the variables, Communication cpmpetence, Major satisfaction, Gender explained 30.4% of the variance in the Clinical practice stress. Based on the outcome of this study, steps should be taken to design intervention program that emphasize a improve Clinical practice stress for nursing students.