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신생아 집중 치료실에서 호산구 증가증 원인에 관한 분석
김정영,임효빈,성민정,손상희,서손상 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.1
Purpose:Although eosinophilia is a common laboratory finding in many neonatal intensive care units (ICUs), its causative mechanisms remain obscure. We aimed to determine the causes of eosinophilia in the neonatal ICU environment. Methods:Serial eosinophil counts were determined weekly for 288 hospitalized, appropriately grown neonates. Infants were divided into four groups according to gestational age, and the incidence and etiologic factors of eosinophilia were retrospectively studied. Results:Absolute eosinophilia (>700/mm3) was documented in 18% (52/288) of neonates. Twenty-two infants (42.3%) exhibited mild eosinophilia (700-999 cells/mm3), 27 (51.9%) exhibited moderate eosinophilia (1,000–2,999 cells/mm3), and 3 (5.8%) exhibited severe eosinophilia (>3,000 cells/mm3). Of the 288 infants studied, 54 suffered sepsis. Thirty of these 54 infants (55.6%) showed eosinophilia, and 22 out of the remaining 234 infants (9%) without sepsis showed eosinophilia, indicating that eosinophilia was more prevalent in the sepsis group (P<0.05). All 5 infants suffering from bronchopulmonary dysplasia showed eosinophilia, and 47 out of the remaining 283 infants (16.7%) without bronchopulmonary dysplasia showed eosinophilia. Thus, eosinophilia was more prevalent in the bronchopulmonary dysplasia group (P<0.05). Furthermore, increased prevalence of eosinophilia was associated with respiratory distress syndrome, ventilator use, blood transfusion, and total parenteral nutrition (P<0.05). Conclusion:Our results suggest that eosinophilia is influenced by sepsis and bronchopulmonary dysplasia, although it can also occur idiopathically at birth. Moreover, the potential role of eosinophils in conditions such as wound healing and fibrosis in sepsis or chronic lung disease may be a cause of eosinophilia. 목적:신생아 호산구증가증은 전혈검사 상 흔하게 발견되지만 아직 정확한 원인은 규명되지 않고 있어 호산구증가증의 빈도와 원인을 확인하기위해 신생아 중환자실에 입원한 환아들을 대상으로 후향적으로 연구를 시행하였다. 방법:2006년 1월부터 12월까지 부산 좋은 문화병원에서 신생아 중환자실에 입원한 환아 전체를 대상으로 31주 미만, 31주 이상부터 34주 미만, 34주 이상부터 37주 미만, 37주 이상의 네 군으로 나누어 출생당일과 그 후 일주일 간격으로 최대 4주간 절대 호산구치를 측정하여 호산구증가군과 호산구정상군을 비교하였다. 결과:전체 대상 환아 288명 중 52명에서 호산구증가증(>700/mm3)이 발생하여 18%의 발생률을 보였다. 경증 호산구증은 22명(42.3%), 중등증 호산구증은 27명(51.9%), 중증 호산구증은 3명(5.8%) 발생하였다. 패혈증군 54명 중 30명(55.6 %)이 호산구증가증을 보였고 비패혈증군 234명 중 22(9%)명이 호산구증가증을 보였다. 패혈증 발생률이 높은 군에서 호산구증가증이 유의하게 증가하였다(P<0.05). 만성폐질환이 발생한 5명 중 5명(100%) 모두 호산구증가증이 발생하였고, 만성폐질환이 발생하지 않은 283명 중 47명(16.7%)이 호산구증가증을 보였다. 만성폐질환 발생군에서 호산구증가증이 유의하게 호발하였다(P<0.05). 그 외 신생아 호흡곤란증, 인공호흡기 사용, 수혈, 정맥 내 영양을 한 군에서 호산구증가증이 호발하였다. 결론:본 연구에서 호산구증가증은 감염 후나 만성폐질환 시 호산구증가증이 발생하였다. 또한 출생 초기 특발성으로 발생하기도 하였다. 패혈증이나 만성폐질환 시 상처 재생과 섬유화에 관여하는 호산구의 잠재적 기능이 호산구증가증의 원인으로 사료된다.
8번 염색체 단완 결실과 장완 중복을 동반한 신생아 1례
김정영,임효빈,손상희,정소영,성민정,서손상 대한신생아학회 2009 Neonatal medicine Vol.16 No.1
A male baby with intrauterine growth retardation had a short neck, small hands and feet, hypospadia, both grade I hydronephrosis, type II atrial septal defect, and moderate valvular pulmonary stenosis. The routine chromosome and banding analyses revealed a 46,XY,rec(8)del(8)(p21)dup(8) (q24.1)inv(8)(p21q24.1)pat chromosome constitution. His mother has normal chromosomes, but the father had 46,XY,inv(8)(p21q24.1). Also his uncle had an inv(8) chromosome constitution. We used lymphocytes and examined 40 mitotic cells. All mitotic cells showed deletion of 8p21-->pter and duplication of 8q24.1-->qter. Because 8p21 involves secretion of macrophage and lymphocyte against cancer cells, long-term follow-up for cancer will be needed.
김정영,이은주,서순림 보건의료산업학회 2017 보건의료산업학회지 Vol.11 No.1
Objectives : The purpose of this study was to examine the relationship between the health behavior and prevalence of chronic diseases among manufacturing workers. It would provide fundamental data in the development of health promotion programs for manufacturing workers. Methods : Data on 3,171 employees who underwent health check-ups by the National Health Insurance Service in L company, G City from March to December 2014 were analyzed. The statistical analysis of frequency, chi-square test, and multiple logistic regressions were performed using SPSS 18 program. Results : The results of this study show that obesity and over-weight are the health behaviors that influence the prevalence of chronic diseases in manufacturing employees. Conclusions : The implementation of public health projects to improve the voluntary participation of the employees can enhance their health, improve the productivity, and influence their quality of life positively by changing the health behaviors.