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윤단규,김우진,김기풍,장우성,유광하,이점규 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0
Background: The lifetime prevalence of Chronic obstructive pulmonary disease (COPD) among adults aged >40 is 14% in Korea. However, the prevalence is 54% in the elderly participants (Age>65), generating high socio-economic burden. National Institute of Health, Centers for Disease Control and Prevention of Korea conducts various researches for identifying COPD related risk factors. Since 2016, a longitudinal follow-up study for COPD early finding and exacerbation prevention is under way. Methods: Participants were comprised of subjects from The Korea COPD Subgroup Study Team Cohort (KOCOSS) and newly recruited COPD patients. As of April 2018, there were 676 COPD patients with both clinical data and DNA. We conducted exploratory data analysis to study characteristics and selected individuals for genome analysis. Results: Following Global Initiative for chronic Obstructive Lung Disease (GOLD) criteria, there were 43, 160, 330, 91, and 17 patients for GOLD 0, I, II, III, and IV, respectively. 92% of patients, aged 41-95, were male. 90% of all patients were ever- smokers. To deal with genetic and environmental risk factors, a multi-omics approach will be conducted. All patients will be genotyped using Korea Biobank Array and methylation data will be generated based on severity and clinical data. Conclusion: In the next phase, the study will be expanded to include more patients from COPD registry and perform international collaborations with various consortia such as COPDGene. Based on these efforts, more improved models for COPD prevention and prediction are expected to be constructed.
Prevalence of Self-reported Allergic Diseases and IgE Levels: A 2010 KNHANES Analysis
박혜정,김은진,윤단규,이점규,장우성,임연미,박중원,이주실 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.4
Purpose: The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea. Methods: We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification. Results: The overall prevalence of self-reported allergic diseases was 37.6%. The prevalence rates of allergic rhinitis and atopic dermatitis decreased with age, whereas the asthma prevalence was not affected by the age of the subjects. When analyzed according to the type of allergic diseases, the prevalence of self-reported allergic disease was significantly associated with various factors (e.g. age, occupation, living in urban areas, and depression). The tIgE level decreased with age, but later increased. Elevation of tIgE was significantly associated with male sex, type of occupation, obesity, and smoking status. However, the risk factors for the increased sIgE levels to each allergen were quite different. Sensitization to D. farinae was more likely in young subjects, whereas the prevalence of sensitization to B. germanica was significantly higher in subjects with male sex, residing in a house (houses), and with glucose intolerance. Finally, young age and the smoking status were significantly associated with sensitization to dog. Conclusions: Various demographic and environmental factors were significantly associated with the prevalence of self-reported allergic diseases and the levels of tIgE and sIgE to D. farinae, B. germanica, and dog in Korea.
김은진,권지원,임연미,윤단규,서주희,장우성,김형영,박중원,조상헌,이주실 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.3
Purpose: Childhood allergies are a serious problem, as they may lead to lifetime chronic disease. Determination of total and specific IgE levels isknown to be a diagnostic tool for allergic sensitization; however, IgE levels are affected by various factors, such as age, sex, ethnicity, and geographicarea. Thus, we evaluated the distribution of total and specific serum IgE levels against seven inhalant allergens in preschool children and examinedtheir association with allergic diseases in Seoul, Korea. Methods: Total/specific serum IgE determination and skin prick tests for seven commonallergens were performed on 509 children aged 3 to 6 years from 16 child care centers in Seoul, Korea. Demographic characteristics were surveyedfrom parents using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. A diagnosis of atopic dermatitiswas made by physicians. Results: The geometric mean of total IgE was 80.48±3.80 kU/L in preschool children. IgE levels were higher in boys(boys, 102.34±3.52 kU/L; girls, 62.37±3.93 kU/L; P<0.001) and atopic subjects (atopic, 158.00±3.35 kU/L; non-atopic, 52.75±3.44 kU/L; P<0.001). An increased prevalence of atopy was associated with a high monthly household income (P=0.004) and higher maternal education level (above university-level education; P=0.009), as well as increased total IgE levels (P=0.036). Physician-diagnosed atopic dermatitis was associated with sensitizationto inhalant allergens. Conclusions: Total IgE levels were very high as compared with those in previous reports from other countries. Themost common sensitized allergen was Dermatophagoides farinae, and the positive response rate peaked at age 3 years and was maintained thereafter,particularly in boys. Specific IgE levels for seven inhalant allergens varied with age in preschool children. Although further investigations areneeded with a broad range of ages and various allergens, the distribution of the total and specific serum IgE levels in preschool children might helpto serve as a reference value to diagnose atopy.