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흰쥐의 허혈-재관류로 손상된 간에서 Alpha-Tocopherol의 효과
유운용(Wun Young Yu),김형기(Hyung Kee Kim),권준택(Jun Tack Kwon) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: Ischemia-reperfusion injury is responsible for organ damage in a variety of pathological events such as myocardial infarction, stroke and graft failure after organ transplan- tation. Reperfusion is essential for the salvage of ischemic state. But reperfusion itself is also thought to be accompanied by its own component of injury. Reperfusion is a particularly potent stimulus for free radical formation. Free radical attack on biological membranes, such as the plasma membrane, mitochondria and endoplasmic reticulum, can lead to the oxidative destruction of the polyunsaturated fatty acids of the membranes through lipid peroxidation. In the present study, the possible protective effect of alpha-tocopherol against 15 min ischemia and subsequent 60 min reperfusion in the rat liver was investigated. Methods: Ischemia of the left and median lobes was induced by ligation of the left portal vein and the hepatic artery for 1S min. 60 min after reperfusion, experiments were initiated. Results: In ischemia-reperfusion on liver, serum AST and ALT activities and the level of malondialdehyde(MDA) in the liver homogenate were significantly increased. In addition, levels of cytochrome P-450 decreased in a microsomal fraction during ischemia-reperfusion. When rats were pretreated with alpha-tocopherol(200 mg/kg p.o, daily for 3 days), alpha-tocopherol suppressed the elevation of serum AST, ALT and MDA level and the decrease in cytochrome P-450 content. Conclusions: Free radicals play a major role in ischemia- reperfusion injury in the liver. Alpha-tocopherol exerts its beneficial effect on liver ischemia-reperfusion injury. Therefore, anti-oxidative effect of alpha-tocopherol is considered a probable suppressing mechanism on liver injury caused by ischemia-reperfusion. (Korean J Gastroenterol 1995;27:323 - 330)
항공기 구조물의 절삭 가공 변형에 따른 교정 방법에 관한 연구
안지혜(Jihye An),남상규,유운용(Yunyoong Yoo),허선철(Sunchul Huh) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.7
Residual stresses in the process of cutting aircraft structures cause product deformation and dimensional mismatch. To overcome this, we use the technique of manual modification process, which stretches a part of the workpiece according to the experience of skilled workers at the machining site. However, due to the nature of the aviation components industry, there are no established methods for modificated action due to various product types and components. Therefore, developing proofing process technologies can improve productivity, such as reducing work time. In this study, the residual stress was predicted through finite element analysis, and the tendency of the product to be modificated as a result of applying a tensile load to the deformed model was confirmed.
내시경으로 진단된 위암의 갑상선 및 유방으로 전이한 1예
윤상호,김동선,김성목,한지희,유석준,유운용,정대관,강신재,김희연,이찬주,이혜경 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.4
Metastatic malignant tumors involving the thyroid gland are not as unusual as was once believed. They may in fact be more common than primary cancer of the thyroid, especially if careful screening is performed at autopsy. The origins of primary neoplasms that metasta size to the thyoid are myriad, but reports obviously indicate predminantly cancers of the kidney, breast, and lung and malignant melanoma. Occasienally, metastatic lesions from several gastrointestinal neoplasms such as colo-retal and esophageal carcinoma are seen, but metastasis from gastric cancer is very rare. We have seen one case of thyroid cancer metastasized from the stomach cancer. It simultaneously spread to the breast also and confirmed with gastrofiberscopic biopsy, fine needle aspiration cytology of the thyroid and excisonal biopsy of the breast. We report this case with reriew of literature.
이상주,윤상호,김성목,정대관,김충언,문환철,이혜경,유운용,한지희,이관섭 대한내과학회 1992 대한내과학회지 Vol.43 No.6
The tumor of spleen is rare There are numerous reviews of pubished cases but, have been reported in a few cases. The hemangioendothelioma is used to denote a true neoplasm of vasculasr origin composed predominantly of masses of endothelial cells growing in and about vascular lumina. The hemangioendothelioma represents in intergrade between the well-differentiated hemangioma and the frankly anaplastic, totally cellular hemangiosarcoma. It follows the pattern of the hemangioma and is most frequently encounted in the skin but many affect viscera, particularly the spleen and liver. Recently we are experienced clinic case of splenic hemangioendothelioma in a 31-year old male with left side subcostal pain of 6 months duration. We report it with a review of the literature.
윤상호,김성목,한지희,배영만,김대하,정대관,강신재,이찬주,유운용,김희연,이혜경,정승혜 대한내과학회 1994 대한내과학회지 Vol.46 No.5
The cystic lymphangioma of adrenal gland is a rare benign tumor. It has not been reported in Korea. The present study represents the first report of cystic lymphangioma of adrenal gland in Korea. It's exact etiology is obscure but thought to be related to a congenital abnormal development of lymphatic system. In addition, it is associated with the failure of communication with the central lymphatic system. The clinical significance of cystic lymphangioma is related to its size manifest itself as a palpable mass early in life. Preoperative clinical and laboratory characteristics are non-specific. Recently we experienced a case of cystic lymphangioma of the adrenal of the adrenal gland in 28-year-old female and reported it with a review of the literature.