Analyzing Factors Affecting Cognitive Function in the Elderly using Computerized Neurocognitive Tests

심주희,강승완 한국지역사회간호학회 2017 지역사회간호학회지 Vol.28 No.2

Purpose: The purpose of this study is to examine the cognitive function in the elderly and to identify the influencing factors. Methods: The design of this study was descriptive research design. A total of 139 elderly people (aged 65 years and over) visiting the electroencephalogram (EEG) center in Seoul, Korea were evaluated. Data were assessed by self-administered questionnaires and CNS Vital Signs (CNSVS). Data were analyzed using SPSS Statistics 23.0 for Windows. Results: There were significant differences in the Korean Mini-Mental State Examination (K-MMSE), executive functions and reasoning according to education level. K-MMSE, visual memory and executive functions were different depending on the jobs. Age was highly correlated with cognitive function. In addition, stepwise multiple regression analyses showed that the factor significantly associated with reaction time and visual memory was depression. Depression and Trait-Anxiety had significant impacts on executive functions and K-MMSE. Conclusion: CNSVS enabled the accurate and objective measurement of cognitive function. Therefore, this study provides useful data to improve cognitive function of the community-dwelling elderly. The results suggested that there is need for comprehensive interventional programs that manage cognitive impairment.

‘그러니까’의 맞장구 기능 형성과 출현 양상

심주희 담화·인지언어학회 2020 담화·인지언어학회 학술대회 발표논문집 Vol.2020 No.4

바이오필릭 디자인을 적용한 치유 환경 공간 특성에 관한 연구

심주희,김민경 한국문화공간건축학회 2021 한국문화공간건축학회논문집 Vol.- No.76

Recently, the redefinition of sustainable architecture has led to higher interest in Restorative Environmental Design for the built environment, considering the relationship between human beings, architectures and the nature. Biophilic design, which induces direct or indirect connection of human and nature, is an important design method in Restorative Environment Design. This study aims to represent the need for empirical research for application of biophilic design on spaces based on analysis of theoretical prior studies. Also, it considers the restorative effects on human psychology in the architectural spaces from biophilic design elements and patterns and examines the represented characteristics in the architectures through the case studies which are built in 21C with a keyword, ‘biophilic design’. Through this study, it propose the goals for future architecture and the possibilities of representing a new concept of sustainable architecture considering the relationships between human beings, architectures and nature.

‘그러니까’의 맞장구 기능 형성과 출현 양상

심주희 한국어의미학회 2020 한국어 의미학 Vol.68 No.-

Based on the discourse functional approach, this paper examined from the driving force of the backchannel of ‘geureonikka(그러니까)’ to the appearance of the discourse of it. The summary of this paper is as follows. First, the driving force of the backchannel of ‘geureonikka(그러니까)’ is the conjunctive ending ‘-nikka(-니까)’ that constitutes ‘geureonikka(그러니까)’. The ‘-nikka(-니까)’ puts the preceding clause in a premise position, which makes ‘geureonikka(그러니까)’ what the conversation participants already know about the information of the interlocutor’s utterance. In addition, due to the characteristic of ‘-nikka(-니까)’ giving a justification to the following clause, ‘geureonikka(그러니까)’ gives a justification to the preceding utterances interlocutor was speaking just before. This shows that the conjunctive ending ‘-nikka(-니까)’ is the driving force of the backchannel of ‘geureonikka(그러니까)’. Second, in the process of discourse markers, ‘geureonikka(그러니까)’ was dedicated to the meaning of the entire phrase ‘geureonikka(그러니까)’ that expresses consent and sympathy with the interlocutor’s utterances. The following utterances of the entire phrase ‘geureonikka(그러니까)’ to agree with the other person’s utterance is usually something that the speaker and listener can guess. As a result, following utterances were frequently omitted, and ultimately, only ‘geureonikka(그러니까)’ was enough to express consent and sympathy for the interlocutor’s utterances. This made ‘geureonikka(그러니까)’ to be used as a marker of backchannel in the discourse dimension. Third, ‘geureonikka(그러니까)’ was appearing in the discourse due to the interactive requirements of ‘-jan-(-잖-)’ and the rhetorical question. The ‘-jan-(-잖-)’ and the rhetorical question have assumed that the content and the answer of the utterance are already shared by the speaker and the listener. In other words, the speaker’s belief that the listener will sympathize with his thoughts in the utterance or utterance itself is revealed in the sentence of the ‘-jan-(-잖-)’ and the rhetorical question. ‘geureonikka(그러니까)’, as mentioned before, ‘-nikka(-니까)’ makes the preceding interlocutor’s utterances already known. Therefore, ‘geureonikka(그러니까)’ is a suitable marker to satisfy the speaker’s beliefs and expectations in the ‘-jan-(-잖-)’ and the rhetorical question.

Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer

심주희,남웅식,이두현,이수연,오현찬,주정민,유광현,한재윤,기성환,정태천,이태호,이상규 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5

Cytochrome P450 (CYP) is an importantenzyme that can act on xenobiotic substances such as toxicchemicals or drugs. Phenobarbital (PB) has been widelyused to induce CYP2B activity to investigate the drug–druginteraction of CYP2B substrate drugs. Leelamine is aditerpene compound, and is the current focus of efforts todevelop a treatment for diabetes. In this study, we identifiedthe selective and potent inductive effect of leelamineon CYP2B at doses of 5, 10, or 20 mg/kg in male ICR micefor 1 or 3 days. In liver, the activity of CYP2B significantlyincreased 3.6-fold after treatment with leelamine, comparedto vehicle-treated group. Activities of benzyloxyresorufinO-dealkylase and pentoxyresorufin O-dealkylasesignificantly increased 6.3- and 5.3-fold, respectively, witha single treatment of 20 mg/kg leelamine for 1 day. Furthermore,immunoblot analysis showed that significantlyand dose-dependently increased CYP2B10 protein levels inliver. However, PCR results showed that there were nosignificant changes in the CAR and CYP2B mRNA levelsafter leelamine treatment. Accordingly, we suggest thatleelamine is a novel substitute of PB for the selectiveinduction of CYP2B activity in vivo.

로마자 인명 표기의 실제 -언중의 결정 동기를 중심으로

심주희 한국어학회 2023 한국어학 Vol.100 No.-

The purpose of this study is to confirm the motives for the decision of the Romanization of personal names. In this way, we tried to reveal the reality of the expressing personal names using Roman alphabet. Through 1:1 in-depth interviews, this article looked at the concerns and motivations in the process of deciding on the Romanization of personal names. One, expressing of identity, two, customs, three, agreement with Korean pronunciation, and fourth, compliance with the Romanization System. The discussion in this paper shows a big significance compared to the previous studies based on existing normative and quantitative surveys. Given that personal names are linked to the expression of individual identities, we can properly understand the reality when we look into the life of language users. 이 연구의 목적은 언중의 로마자 인명 표기의 결정 동기를 확인하는 데 있으며 이로써 로마자 인명 표기의 실제를 드러내 보이고자 했다. 본 연구는 1:1 심층 면담을 통해 로마자 인명 표기를 결정하는 과정에서의 고민과 동기를 살펴보았는데 면담을 통해 로마자 인명 표기의 결정 동기를 4가지로 정리하였다. 하나, 정체성 표출, 둘, 다수의 관습, 셋, 한국어 발음과의 일치, 넷, <로마자 표기법> 준수이다. 본고의 논의는 기존의 규범적이며 양적 조사에 기반한 선행 연구와는 큰 차이를 갖는다. 인명 표기는 개인의 정체성 표출과 연결된다는 점에서 언중의 삶의 맥락과 결부지어 이해할 때, 그 실제를 제대로 이해할 수 있겠다.

‘미라클모닝’ 담화에 대한 비판적 담화 연구 -담화-역사적 접근법을 기반으로-

심주희 담화·인지언어학회 2022 담화와 인지 Vol.29 No.3

This study conducted a critical discourse study on a discourse related to the Miracle Morning. The Miracle Morning as a social action originated from the publication of a book called “The Miracle Morning.” This study analyzed the discourse strategy shown in “The Miracle Morning,” based on the discourse-historical approach. Also, paying attention to the social context at the time when the craze of the Miracle Morning occurred, we looked at how the ideology of the Miracle Morning was recontextualized. As a result, this study revealed the social wrongs inherent in the ideology of industriousness promoted by the discourse of the Miracle Morning.

카카오톡 환경에서의 의사소통 방식 고찰

심주희(Sim, Juhui) 한국사회언어학회 2021 사회언어학 Vol.29 No.4

The purpose of this study is to examine how the communication style of reading and speaking appear in Kaokatalk. Especially, this article focused on how the interactive burden shapes the communication style in Kakaotalk. The results on this study are summarized in the following two ways. Fisrt, the concept of reading in Kakaotalk has a spectrum and is divided into various actions. Second, reading and speaking in Kakaotalk are selectively performed while on hold when the speaker wants them.

식당 내 호칭 '저기요', '여기요'를 대상으로 한 사회언어학적 변이 연구

심주희(Juhui Sim) 담화·인지언어학회 2023 담화와 인지 Vol.30 No.1

지역사회 거주 노인의 수면과 우울, 대사증후군과 인지의 관련성

심주희 ( Joohee Shim ),백지현 ( Jihyun Baek ) 한국보건정보통계학회(구 한국보건통계학회) 2021 보건정보통계학회지 Vol.46 No.2

Objectives: The purpose of this study was to examine the cognitive function, subjective memory, sleep, depression and metabolic syndrome in the elderly and to identify the relation between these variables. Methods: This study was descriptive research design. The data were collected from June to September 2020, 116 elderly people (aged over 65 years), who visited senior community centers. Data were analyzed using Windows SPSS Statistics 27.0 program. Collected data were analyzed using percentage, mean, standard deviation, independent t-test, one-way ANOVA, Pearson’s correlation analysis. Results: The mean score of cognitive function was 24.13±3.82, subjective memory was 2.59±2.61, depression was 7.05±7.30 and sleep was 4.49±2.82. The results showed that depression was correlated with cognitive function (r=-0.20, p=0.033) and subjective memory (r=0.31, p=0.001). Cognitive function was negatively correlated with subjective memory (r=-0.24, p=0.011) and depression (r=-0.20, p=0.033). In addition, Subjective memory was positively correlated with sleep (r=0.25, p=0.006). Conclusions: The findings of this study suggests that cognitive decline, subjective memory, and depression can be accompanied, therefore it is necessary to develop health assessment and intervention of the elderly in the community.