중증 임신오조에 합병된 Wernickes Encephalopathy 1 예

심재식,노인화,서경용,박창민,고일영,정창호,송진범 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.10

임신오조는 체중감소, 산-염기, 수분, 전해질의 불균형을 초래한는 심각한 상황으로 적절한 수액과 영양분의 공급이 되지 않으면 심각한 합병증을 초래하게 된다. 본 저자들은 임신오조에 합병되어 발생한 Wernicke 뇌병변 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Hyperemesis Gravidarum is definied as vomiting sufficiently pernicious to produce weight loss, dehydration, acid-base imbalance, electrolyte imbalance. In severe cases, it also leads to neurologic abnormality including confusion, gate disturbance, nystagmus, due to thiamine deficiency known as Wernickes encephalopathy. We have experienced a case of Wernickes encephalopathy associated with hyperemesis gravidarum and reviewed the Wernickes encephalopathy and new aspects of hyperemesis gravidarum.

폐경전 여성에서 자궁적출술 시행시 난소 보존여부와 관련된 비만의 관계

심재식,노인화,서경용,민지영,박창민,고일영,정창호 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.8

Objectives:To determine if hysterectomy with or without ovarian preservation is asso-ciated with obesity in premenopausal women. Methods:581 women for routine check up from Jan. 1985 to Dec. 1995 in the depart-m ent of Gynecology at Korea Veterans Hospital were included. The obesity was evaluated by BMI(body mass index) scores. 80% of hysterectomy were confirmed from the hospital records. The age, weight, height, blood pressure, menstr- ual history, history of DM and hypertension, social history of alcohol and smoking and other cardiovascular risk factors such as cholesterol, HDL-cholesterol, triglycerides were checked. The 248 women with natural postmenopausal status before hysterectomy, taking hormonal replacement therapy after hysterectomy and having performed hysterectomy due to malign- ancy were excluded. Results:All women performed hysterectomy were in premenopausal status in this study. Therefore, the final numbers of subjects included in the analysis was 333. Hysterectomy wit- hout ovarian preservation were performed in 58 cases and hysterectomy with ovarian pres- ervation were in 57 cases. The 218 premenopausal cases which did not performed hystere- ctomy were considered control group. BMI scores were higher in cases without ovarian pres- ervation than with ovarian preservation. And BMI score was associated with the postoper- ative duration in hysterectomy with ovarian preservation. Conclusions:We suggest that hysterectomy without ovarian preservation in premeno- paussal women were associated with increased obesity, especially BMI scores.

장애자의 초경 및 월경양상에 관한 연구

심재식,진영수,김형남,김중일,정시영 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.7

신체장애자의 초경 및 월경양상과 이에 영향을 미치는 요인들을 파악하기 위하여 서울 및 경기도에 있는 재활원 재활학교 및 복지원에 있는 장애자 240명과 중.고등학교 학생 174명을 대상으로 설문조사를 실시한 결과 다음과 같은 결과를 얻었다. 1. 장애자군의 초경연령 분포는 10세부터 19세 범위에 있으며 평균 초경연령은 14.22±1.76세이고 대조군은 10세부터 15세 범위에 있으며, 평균 초경 연령은 13.17±0.92세로 장애자군에서 유의하게 높았다. 2. 부모의 직업, 형제수, 유전질환 및 태어난 계절 등은 초경연령과 깊은 연관성이 있으나 다른 요인들과는 연관성이 적었다. 3. 장애자군의 월경주기는 28.2±4.1일, 월경기간은 5.2±0.9일이었으며 대조군의 월경주기는 29.5±3.7일, 월경기간은 5.68±1.5일로 의미있는 차이는 없었다. 4. 장애군에서 월경과 수반되는 증상이 하복부동통(27.1%), 피로 및 불쾌감(19.7%), 요통(14.8%), 우울 및 불안(13.5%)이었다. 5. 월경주기 양상에 관계되는 요인을 볼 때 1) 장애군에서 희발월경은 빈발월경보다 평균 초경연령이 높았다. 2) 장애군의 불규칙 월경(40.4%)은 대주군보다 높았다. 3) 긴장감 수면시간 비만 등은 월경주기 양상에 약간의 연관성을 보였으나 신체활동(체육활동), 월경증상, 약물복용, 영양상태, 생활상태, 부모의 별거 유무 등은 월경주기 양상과 연관성이 없었다. 이상의 소견을 종합해 볼 때, 초경의 연령은 신체장애에 영향을 받아 지연되고 부모의 직업, 형제수, 유전질환 및 태어난 계절과 연관성이 있었는데 이는 신체장애가 외적 환경적 요인보다는 사춘기에 내분비적으로 미성숙 상태에 있기때문인 것으로 사료된다. This study was designed to obtain the age of menarche, the factors which influence on menarche, and the menstrual patterns among handicapped persons. For the data sampling, self-administered questionnaire survey was made in March, 1990. Among 240 handicapped persons and 174 non-handicapped in Seoul, Kyung Gi Do, and analysed by the computer with SPSS bath system. Statistical methods employed were standard t-test and chisquare test. The results are as follows; 1. The mean menarcheal age was significantly different between the handicapped(14.2±1.76years) and the control (13.17±0.92 years) (p $lt;0.01). 2. The mearnrcheal age of the handicapped was significantly influenced by the occupations of the father, siblings, the genetic disease and birth season, but less influenced by others. 3. The mean menstrual period of the handicapped (28.2±4.1 days) was slightly shorter than that of the control(29.5±3.7 days), but there was no significant difference. 4. The mean duration of the menstrual flow of the hadicapped (5.2±0.9days) was slightly shorter than that of the control (5.68±1.5days) but there was no significant difference. 5. The amounts of the menstrual flow of the handicapped was more than that of the control, but there was no significant difference. 6. The menstrual symptoms were the lower abdominal pain(27.1%), fatigue and unpleasantness(19.7%), back pain(14.8%), depression and anxiety (13.5%) in the handicapped. 7. In the menstrual pattern; 1) The menarcheal age of the handicapped in oligomenorrhea was higher than that in polymenorrhea(p$lt;0.05). 2) The proportion of irregular menstrual cycle of the handicapped (40.4%) was higher than that of the control(p$lt;0.1). 3) Stress, sleeping hours and obesity were slightly associated with the menstrual pattern but physical activity, menstrual symptoms, drug medication, nutrition were not associated.

운동이 초경 및 월경에 미치는 영향에 관한 연구

심재식,진영수,임광서,김형남 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.9

운동이 초경 및 월경의 변화에 미치는 영향을 파악하기 위해서, 서울 시내 11개 여자중고등학교의 운동선수 296명과, 일반학생 675명, 총 971명을 대상으로 설문조사를 실시하여 다음과 같은 결론을 얻었다. 1. 평균 초경연령 비교에서 선수군(14.23±1.32세)이 비선수군(13.21±0.97)에 비해서 유의하게 지연되었으며(P$lt;0.005), 또한 Group I(14.56±1.00세)이 Group II(13.18±1.61세)에 비해서 유의하게 초경이 지연된 것으로 나타났다(P$lt;0.005). 2. 체지방율의 비교에서 선수군(27.32±3.71%)이 비선수군(26.20±3.74%)에 비해서 높게 나타났지만, 선수군 중 체조(22.76±2.59%), 발레(22.60±2.25%), 수영(24.34±2.98%)의 경우는 비선수군에 비해서 유의하게 낮았으며(P$lt;0.005, P$lt;0.005, P$lt;0.05), 원발성 무월경인 6명(체조;2명, 발레;4명)은(20.18±1.18%) 더 유의하게 낮았다(P$lt;0.001). 3. 월경주기의 비교에서 불규칙월경과 희발월경의 빈도는 선수군이 비선수군에 비해서 유의하게 높았으며(P$lt;0.05), Group I은 Group II에 비해서 유의하게 높게 나타났다(P$lt;0.05). 또한, 원발성 무월경은 선수군에서만 2.1%로 나타났다. 4. 월경량의 비교에서 선수군이 비선수군에 비해서 적었으며, 월경기간은 차이가 없었다. 5. 월경전 증후는 선수군과 비선수군에서 우울, 유방통, 두통의 동일한 순으로 나타났으며, 그 빈도는 선수군이 유의하게 높았다(P$lt;0.05). 6. 월경중 자각증상은 선수군과 비선수군에서 요통, 불쾌감, 복통, 전신피로감의 동일한 순으로 나타났고, 그 빈도는 유의한 차이가 없었지만, Group I에서 약간 높게 나타났다. 7. 선수군에서 운동을 시작한 이후, $quot;월경의 변화가 있었다$quot;라고 응답한 경우는 53.5%로 유의하게 높게 나타났다. 8. 집중훈련 후의 월경력 조사에서, 월경주기가 규칙적이었다가 훈련 후에 불규칙월경, 희발월경, 무월경으로 변화된 빈도는 각각 24.8%, 9.6%, 3.2%이었고, 희발월경과 무월경의 빈도는 훈련 후에 유의하게 증가되었으며(P$lt;0.05), 월경량과 월경기간은 훈련 전후에 유의한 차이가 없었으나, 생리통은 훈련에 유의하게 증가되었다. 9. 운동시합시 원경 지연을 목적으로 약물복용을 하는 선수는 22.5%였으며, 월경중에 시합이 있는 경우 12.3%가 심한 지장을 받는 것으로 나타났다. The study was designed to investigate the various influences of exercise on menarche and menstruation. For the data sampling, self-administered questionnaire survey was made in Feb. 1989 among 296 athletic and 675 nonathletic students of the 11 middle and high school in Seoul. The results were as follows. 1. The mean menarcheal age was to be significant difference between the athletic group(14.23±1.32yrs) and the nonathletic group(13.21±0.97yrs), and between Group I(14.56±1.00yrs) and Group II(13.18 ±1.61yrs).(P$lt;0.05). 2. Although the mean body fat % of the athletic group(27.32± 3.71%) was higher than that of the nonathletic group(26.20±3.74%), but the mean body fat % of gymnastics(22.76±2.59%), ballet dancers(22.60±2.25), and swimmers(24.34± 2.98%) were significantly lower than that of the nonathletic group(P$lt;0.005, P$lt;0.005, P$lt;0.05). And, that or 6 athletes who were primary amenorrhea(gymnastics; 2, ballet; 4)(20.18±1.18%), was more significantly lower than that of the nonathletic group(P$lt;0.001). 3. The proportions of irregular menstrual cycle and oligomenorrhea of the athletic group(37.3%, 9.3%) were significantly higher than those of the nonathletic group(25.1%, 0.6%). And the proportions of irregular menstrual cycle and oligomenorrhea of Group I(41.4%, 12.0%) were significantly higher than those of Group II(26.8%, 1.4%).(P$lt;0.05). And, the primary amenorrhea was found among the athletic group only(2.1%). 4. The menstrual amount of the athletic group was lesser than that of the nonathleticgroup. And, there was no difference in menstrual period. 5. The premenstrual syndrome were found to be the same orders of depression(28.4%, 18.2%), breast tenderness(20.7%, 10.9%), headache(16.0%, 8.3%) in both athletic and nonathletic groups. And, the proportions of those of the sthletic group were significantly higher than those of the nonathletic group(P$lt;0.05). 6. The subjective symptoms during menstruation were found to be same orders of back pain(66.5%, 55.7%), unpleasantness(53.5%, 55.6%), abdominal cramp(51.3%, 52.2%), fatigue(28.7%, 25.1%) in both athletic and nonathletic groups. And, the proportions of those were not to be significant difference between two groups, but found to be slightly high in Group I. 7. Of the athletic group, the proportion of the menstrual change after onset of training was significantly high(53.5%). 8. After the periods of concentrated training, the proportions of 125 athletes, who had have regular menstrual cycle, had the change of the cycle to irregular menstrual cycle, oligomenorrhea, and amenorrhea, sere 24.8%, 9.6%, 3.2% respectively. And the proportions of oligomenorrhea, amenorrhea after training were significantly increased.(P$lt;0.05). And, there was no significant difference in menstrual amount and menstrual period, but the proportion of dysmenorrhea was significantly increased after concentrated training. 9. The proportion of the athletes, who used drug to delay menstruation before the game, was 22.5%. And, the proportion of the athletes who had troubled with menstruation markedly during the game, was 12.3%.

A Four-Channel Laser Array with Four 10 Gbps Monolithic EAMs Each Integrated with a DBR Laser

심재식,김성복,권용환,백용순,류상완 한국전자통신연구원 2006 ETRI Journal Vol.28 No.4

A distributed Bragg reflector (DBR) laser and a high speed electroabsorption modulator (EAM) are integrated on the basis of the selective area growth technique. The typical threshold current is 4 to 6 mA, and the side mode suppression ratio is over 40 dB with single mode operation at 1550 nm. The DBR laser exhibits 2.5 to 3.3 mW fiber output power at a laser gain current of 100 mA, and a modulator bias voltage of 0 V. The 3 dB bandwidth is 13 GHz. A 10 Gbps non-return to zero operation with 12 dB extinction ratio is obtained. A four-channel laser array with 100 GHz wavelength spacing was fabricated and its operation at the designed wavelength was confirmed.

폭이 좁은 빔 발산을 갖는 분포귀환형 레이저 다이오드

심재식,류상완,김성복,김제하 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10

변형된 Williams 회음 질성형수술로 교정된 선천성 질결손증 환자 치험 1 례

심재식,진영수,최희경,윤덕용,오주환 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.6

Congenital absence of the uterus and vagina, Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, is a rare disorder that results from the agenesis of both mullerlian ducts or from the failure of the mullerian ducts to establish a proper communication with that part of the vagina formed from the urogenital sinus. Until recently, treatment for the patient with vaginal sgenesis has centered on the creation of a functional vagina. Many ingenious procedures have been devised for its correction; some are simple, some are complicated. We feel the procedure of choice is the simplest, least dangerous one which will give good results in the individual patient. Our experience, particularly with the modified Williams vulvovaginoplasty technique, is given and the literatures were reviewed briefly.

p-type Fe(Mn)Si2 반도체 합금 분말의 성형성과 열전 성능 (초)

심재식,천병선,홍순직 대한금속재료학회 ( 구 대한금속학회 ) 2008 대한금속재료학회 학술대회 개요집 Vol.2008 No.1

모체혈장 및 태자혈장간의 $Li^+$농도 경사의 특성에 관한 연구

심재식,성호경,Shim, Jae-Sik,Sung, Ho-Kyung 대한생리학회 1987 대한생리학회지 Vol.21 No.1

This study was carried out to investigate the characteristics of lithium concentration difference between maternal and fetal plasma and the effect of previous lithium loading on rapid transplacental transport of large amounts of lithium. Pregnant rabbits at $20{\sim}22\;days$ of gestation were divided into two groups: chronic $Li^+$ injection group and chronic plus acute $Li^+$ injection group. Small amounts of LiCl (1 mmol/kg per day) were given intraperitoneally to all rabbits of both group, for 5 days before sacrifice. The rabbits of chronic plus acute injection group, received additional intravenous injections of large amounts of LiCl (2 mmol/kg) one hour before sacrifice. Maternal arterial blood, placental sinus blood, fetal blood and amniotic fluid were drawn and analyzed for the plasma concentrations of $Li^+$, $Na^+$ and $K^+$ and for osmolartiy. Followings are the results obtained. 1) There was no difference in the $Li^+$ concentration between maternal plasma and placental sinus plasma in chronic lithium group, although the $Li^+$ concentration of placental sinus plasma was slightly lower than that of maternal arterial plasma in the chronic plus acute lithium group. 2) The $Li^+$ concentration of fetal plasma was much lower than that of placental sinus plasma in both groups, the ratio being $0.76{\pm}0.250$ ($mean{\pm}95%$ confidence interval) for the chronic $Li^+$ group and $0.78{\pm}0.366$ for the chronic plus acute $Li^+$ group. 3) The ratio of $Li^+$ concentration of fetal plasma to maternal arterial plasma was $0.71{\pm}0.196$ in the chronic group and $0.59{\pm}0.261$ in the chronic plus acute group. 4) $Li^+$ concentration of amniotic fluid was much higher than that of fetal plasma in the chronic $Li^+$ group but not significantly different in the chronic plus acute $Li^+$ group. 5) An acute loading of $Li^+$ did not produce any detectable changes in $Na^+$ and $K^+$ concentrations and osmolarity of the maternal plasma. The above results may suggest that: (a) The placental barrier maintains steady state lithium concentration gradient between placental sinus plasma and fetal plasma. (b) In rabbits chronically treated with $Li^+$ the steady state $Li^+$ gradient is established within one hour after an acute $Li^+$ loading, provided that the $Li^+$ concentration in the maternal plasma is less than 4 mmole/l.

17 세의 여성에서 발생한 난소의 점액성선암 1 예

심재식,김정례,노인화,서경용,민지영,박창민,고일영 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.6

We experienced a case of malignant mucinous tumor of ovary developed in 17-year-old nulliparous women and brief review of the case and its literature are presented.