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유방암 방사선치료시 조직등가보상체와의 비교를 통한 Brass mesh bolus의 유용성 평가
봉주연,김경태,전미진,하진숙,신동봉,김세준,김종대,Bong, Juyeon,Kim, Kyungtae,jeon, Mijin,Ha, Jinsook,Shin, Dongbong,Kim, Seijoon,Kim, Jongdae 대한방사선치료학회 2017 대한방사선치료학회지 Vol.29 No.1
목 적: 유방암 방사선 치료에서 조직등가보상체의 단점을 해결하기 위해 황동그물망보상체(Brass mesh bolus)가 최근 연구되고 있다. 본 연구의 목적은 국내에 처음 소개되는 황동그물망보상체의 안정성을 조사하고, 표면선량을 평가하고자 하였다. 대상 및 방법: 조직등가보상체 5 mm와 가장 비슷한 황동그물망보상의 두께를 확인하기 위해 표면선량을 측정하였다. 6 MV 선형가속기와 광자극형광선량계(optically stimulated luminescent dosimeter, OSLD)를 사용하였다. 흉곽팬텀을 이용한 2문 대항접선조사를 황동그물망보상체와 조직등가보상체의 비교를 통하여 연구에 적용하였다. 결 과: 표면선량 측정을 기반으로 조직등가보상체 5 mm와 가장 유사한 두께는 황동그물망보상체를 두 겹에 해당되는 3 mm였고, 평균 상대오차율은 0.38 %였다. 흉곽팬텀을 사용한 황동그물망보상체의 표면선량은 조직등가보상체에 비해 약 1.069배 증가하였다. 결 론: 본 실험에서 황동그물망보상체는 기존 조직등가보상체 선량균등도가 향상된 것으로 확인되었다. 실험을 바탕으로 황동그물망보상체가 기본 조직등가보상체를 대체 가능 할 것으로 사료된다. 하지만 다양한 임상적 평가가 필요할 것으로 사료된다. Purpose: In breast cancer radiotherapy, brass mesh bolus has been recently studied to overcome disadvantage of conventional bolus. The purpose of this study is to investigate the stability of first introduced the brass mesh in the country, and evaluate the skin surface dose of that. Materials and Methods: The measurement of skin surface dose was evaluated to verify similar thickness of the Brass mesh bolus that compared conformal tissue equivalent bolus with 5 mm thickness. We used 6 MV photons on an ELEKTA VERSA linear accelerator and optically stimulated luminescent dosimeter (OSLD). In addition, two opposed beam using IMRT phantom was applied to comparative study of brass mesh bolus between tissue equivalent bolus. Results: The results showed that similar thickness of the Brass mesh bolus was 3 mm compared with 5 mm tissue equivalent bolus by measuring the skin surface dose of solid phantom. The surface dose for IMRT thorax phantom using 3 mm brass mesh bolus was about 1.069 times greater than that using tissue equivalent bolus. Conclusion: In this study, we found that the brass mesh bolus improved better reduction of skin sparing effect and dose uniformity than tissue equivalent bolus. However evaluation for various clinic cases should be investigated.
김관,최정용,신동하,이향봉,신권수 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
A nanogap formed by a metal nanoparticle and a flat metal substrate is one kind of “hot site” for surface-enhanced Raman scattering (SERS). The characteristics of a typical nanogap formed by a planar Au and either an Au and Ag nanoparticle have been well studied using 4-aminobenzenethiol (4-ABT) as a probe. 4-ABT is, however, an unusual molecule in the sense that its SERS spectral feature is dependent not only on the kinds of SERS substrates but also on the measurement conditions; thus further characterization is required using other adsorbate molecules such as 1,4-phenylenediisocyanide (1,4-PDI). In fact, no Raman signal was observable when 1,4-PDI was selfassembled on a flat Au substrate, but a distinct spectrum was obtained when 60 nm-sized Au or Ag nanoparticles were adsorbed on the pendent –NC groups of 1,4-PDI. This is definitely due to the electromagnetic coupling between the localized surface plasmon of Au or Ag nanoparticle with the surface plasmon polariton of the planar Au substrate, allowing an intense electric field to be induced in the gap between them. A higher Raman signal was observed when Ag nanoparticles were attached to 1,4-PDI, irrespective of the excitation wavelength, and especially the highest Raman signal was measured at the 632.8 nm excitation (with the enhancement factor on the order of ~10^3), followed by the excitation at 568 and 514.5 nm, in agreement with the finite-difference timedomain calculation. From a separate potential-dependent SERS study, the voltage applied to the planar Au appeared to be transmitted without loss to the Au or Ag nanoparticles, and from the study of the effect of volatile organics, the voltage transmission from Au or Ag nanoparticles to the planar Au also appeared as equally probable to that from the planar Au to the Au or Ag nanoparticles in a nanogap electrode. The response of the Au-Ag nanogap to the external stimuli was, however, not the same as that of the Au-Au nanogap.