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기업현장에서의 창의성의 암묵이론 차원도출과 창의성의 영역특수성과 일반성에 대한 논의
이홍(Lee Hong),송석종(Song Suk jong) 한국인사관리학회 2016 조직과 인사관리연구 Vol.40 No.2
기업현장에서의 구성원들이 창의성 특히 창의적 인물에 대하여 어떤 이해를 하고 있는지에 대한 연구는 매우 드물다. 본 연구는 이런 문제에 관심을 갖는다. 구체적인 연구의문은 다음과 같다. 기업현장에 종사하는 사람들의 창의성의 암묵이론은 어떤 특성 차원으로 구성되는가? 본 연구의 결과 기업현장에서의 창의적 인물의 특성은 인지적 특성의 경우는 '상상력에 기반한 독창성, 분석적 문제해결 능력, 발산적 사고전환ㆍ아이디어 유창성'의 3가지 특성으로 나타났다. 성격ㆍ동기특성에 대하여는 '모험심ㆍ호기심ㆍ성취욕구, 다양한 관심과 정보탐색, 자신감과 열정, 변화와 실험정신, 자기고집, 자기주장, 개방성'의 7개 특성이 나타났다. 이들을 기존의 명시이론 및 암묵이론 연구와 비교하였다. 여기에 더하여 창의성의 영역특수성과 일반성에 대한 논의도 진행하였다. Most of the studies regarding implicit theory of creativity have been performed in the academic area such as psychology or education. These studies have limitations in understanding people's perceptions and beliefs on creativity in the company site. This study is concerned with dealing with this problem. Research question was that what is implicit theory of creativity of people who are working for companies. The results of this study were as followings. 1) Perceived cognitive traits: originality based on imagination, analytical problem solving ability, divergent thinking and idea fluency. 2) Perceived personalty and motivational traits: venture sprit and curiosity with high achievement needs, diverse concerns and information searching, self-confidence and passion, change and experimental spirit, persistency, and openness. These traits were compared with the extant researches of explicit and implicit theory of creativity. In addition, this study discussed on domain specificity and generality of creativity.
권혁권,Mahesh Chandra Patra,신현준,Xiangai Gui,asma,Suresh Panneerselvam,김동진,송석종,홍리원,김경수,김양균,Francis Y. Lee,함대현,이상호,최상둔 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Toll-like receptors (TLRs) recognize pathogen/damage-associated molecular patterns and initiate inflammatory signaling cascades. Occasionally, overexpression of TLRs leads to the onset of numerous inflammatory diseases, necessitating the development of selective inhibitors to allow a protective yet balanced immune response. Here, we demonstrate that a novel peptide (TIP1) derived from Toll/interleukin-1 receptor (TIR) domain-containing adapter protein inhibited multiple TLR signaling pathways (MyD88-dependent and MyD88-independent) in murine and human cell lines. TIP1 also inhibited NLRP3-mediated IL-1β secretion, as we validated at both the protein and mRNA levels. Biophysical experiments confirmed that TIP1 specifically binds to the BB loop of the TLR4-TIR domain. Animal studies revealed that TIP1 inhibited the secretion of lipopolysaccharide (LPS)-induced proinflammatory cytokines in collagen-induced arthritis (CIA) and kaolin/carrageenan-induced arthritis (K/C) rodent models. TIP1 also rescued animals from sepsis and from LPS-induced kidney/liver damage. Importantly, TIP1 ameliorated the symptoms of rheumatoid arthritis in CIA and K/C rodent models, suggesting that TIP1 has therapeutic potential for the treatment of TLR-mediated autoimmune/inflammatory diseases.