The Youngest Survivor with Gestational Age of 215 /7 Weeks

성세인,안소윤,유혜수,장윤실,박원순 대한의학회 2018 Journal of Korean medical science Vol.33 No.3

The decision whether or not to resuscitate extremely low gestational age (GA) infants is recommended to be individualized according to antenatal counseling with parents, neonatologists, and obstetricians. A GA of 220 /7 –236 /7 weeks is generally considered as the lower end of the range where infants can be candidates for selective resuscitation. Below this lower end of periviable gestation, resuscitation is usually not considered and survivors are rarely reported. To date, the youngest survivor is an infant with a GA of 216 /7 weeks reported in the English medical literature. Here, we report the case of a female infant, the first twin conceived through in vitro fertilization, with a GA of 215 /7 weeks, who was resuscitated initially according to strong parental wishes after antenatal counseling and is still surviving at 43 months of age with fairly good neurodevelopmental outcome.

The Impact of Surgical Intervention on Neurodevelopmental Outcomes in Very Low Birth Weight Infants: a Nationwide Cohort Study in Korea

성세인,이나현,김현호,김혜선,한예슬,양미선,안소윤,장윤실,박원순 대한의학회 2019 Journal of Korean medical science Vol.34 No.43

Background: To investigate the incidence of surgical intervention in very low birth weight (VLBW) infants and the impact of surgery on neurodevelopmental outcomes at corrected ages (CAs) of 18–24 months, using data from the Korean Neonatal Network (KNN). Methods: Data from 7,885 VLBW infants who were born and registered with the KNN between 2013 to 2016 were analyzed in this study. The incidences of various surgical interventions and related morbidities were analyzed. Long-term neurodevelopmental outcomes at CAs of 18–24 months were compared between infants (born during 2013 to 2015, n = 3,777) with and without surgery. Results: A total of 1,509 out of 7,885 (19.1%) infants received surgical interventions during neonatal intensive care unit (NICU) hospitalization. Surgical ligation of patent ductus arteriosus (n = 840) was most frequently performed, followed by laser therapy for retinopathy of prematurity and laparotomy due to intestinal perforation. Infants who underwent surgery had higher mortality rates and greater neurodevelopmental impairment than infants who did not undergo surgery (P value < 0.01, both). On multivariate analysis, single or multiple surgeries increased the risk of neurodevelopmental impairment compared to no surgery with adjusted odds ratios (ORs) of 1.6 with 95% confidence interval (CI) of 1.1–2.6 and 2.3 with 95% CI of 1.1–4.9. Conclusion: Approximately one fifth of VLBW infants underwent one or more surgical interventions during NICU hospitalization. The impact of surgical intervention on long-term neurodevelopmental outcomes was sustained over a follow-up of CA 18–24 months. Infants with multiple surgeries had an increased risk of neurodevelopmental impairment compared to infants with single surgeries or no surgeries after adjustment for possible confounders.

Insensible Water Loss during the First Week of Life of Extremely Low Birth Weight Infants Less than 25 Gestational Weeks under High Humidification

성세인,안소윤,서현주,유혜수,한영미,이명숙,장윤실,박원순 대한신생아학회 2013 Neonatal medicine Vol.20 No.1

Purpose: Extremely-low-birth-weight infants (ELBWIs), especially those ≤24 gestational weeks (GW), presented extremes in IWL and changes of water balance. The purpose of the present study was to retrospectively investigate fluid and electrolyte balance in infants of ≤24-GW during the first postnatal week under high humidification. Methods: Medical records of extremely-low-birth-weight infants (ELBWIs) who were born and admitted to the Neonatal Intensive Care Unit at Samsung Medical Center during March 2004–September 2010 were reviewed. Fluid intake, urine output, insensible water loss (IWL) and electrolyte balance of 22-GW (n=14), 23-GW (n=40) and 24-GW (n=67) infants nursed in high humidity (95%) were compared with ≥26-GW (n=65) infants nursed in 60% humidity Results: Survival rate until discharge was 33%, 82%, 75% and 89.3% in 22-GW, 23-GW, 24-GW and ≥26-GW infants, respectively. Compared to ≥26-GW infants, fluid intake and IWL was higher in 22-GW and 23-WG, but not as different in 24-GW. At postnatal day (P) 3–5, urine output was significantly lower in ≥26-GW infants than in the other age groups. Serum sodium level was significantly higher in 22-, 23- and 24-GW (P1–2) than in ≥26-GW infants. Hypernatremia (>150 mEq/dl sodium) was more frequent in 22-GW (71%), 23-GW (41%) and 24-GW (21%) than in ≥26-GW infants (14%). Conclusion: High-humidity environments significantly decreased fluid intake and improved electrolyte imbalance in 24-GW, but not in 22- and 23-GW infants. Increased IWL in the latter might be related to more immature skin, implicating the need for additional nurturing conditions.

The Timing of Surgical Ligation for Patent Ductus Arteriosus Is Associated with Neonatal Morbidity in Extremely Preterm Infants Born at 23-25 Weeks of Gestation

성세인,최수영,박재현,이명숙,유혜수,안소윤,장윤실,박원순 대한의학회 2014 Journal of Korean medical science Vol.29 No.4

The purpose of this study was to evaluate prognostic factors associated with surgicalligation for patent ductus arteriosus (PDA) in extremely preterm infants born at the limitsof viability. Ninety infants who were born at 23-25 weeks of gestation and who receivedsurgical ligation were included and their cases were retrospectively reviewed. Infants wereclassified into two different groups: survivors with no major morbidity (N), and nonsurvivorsor survivors with any major morbidity (M). Clinical characteristics were comparedbetween the groups. Possible prognostic factors were derived from this comparison andfurther tested by logistic regression analysis. The mean gestational age and the mean birthweight of M were significantly lower than those of N. Notably, the mean postnatal age attime of ligation in N was significantly later than that of the other group (17 ± 12 vs11 ± 8 days in N and M, respectively). An adjusted analysis showed that delayed ligation( > 2 weeks) was uniquely associated with a significantly decreased risk for mortality orcomposite morbidity after surgical ligation (OR, 0.105; 95% CI, 0.012-0.928). Inconclusion, delayed surgical ligation for PDA ( > 2 weeks) is associated with decreasedmortality or morbidities in extremely preterm infants born at 23-25 weeks of gestation.

차세대중형위성 1,2호 탑재체 불용광 특성 및 외부광원에 의한 복사조도 영향성 분석

성세현(Sehyun Seong),김성희(Seonghui Kim),이덕규(Deoggyu Lee) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.11

FUZZY q-IDEALS OF BCI-ALGEBRAS WITH DEGREES IN THE INTERVAL (0; 1]

성세경,안선신 충청수학회 2012 충청수학회지 Vol.25 No.2

The notion of an enlarged q-ideal and a fuzzy q-ideal in BCI-algebras with degree are introduced. Related properties of them are investigated.

두빈-존슨 증후군 환자에서 발생한 급성 A형 간염으로 인한 지속성 담즙 정체 1예

성세용,정호연,라상호,차재황,김문영,백순구,조미연 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

서론: 두빈-존슨 증후군은 선천적 고빌리루빈 혈증을 나타내는 대사 장애 중 주로 포합 빌리루빈 혈증이 관찰되며 간에서 포합된 빌리루빈이 세담관으로 분비되는 과정에 이상으로 발생하는 증후군이다. 두빈-존슨 증후군에서 빌리루빈 수치는 일반적으로 2-5 mg/dL 정도이며 다른 일반적인 간기능 검사는 정상이다. 저자들은 과거에 두빈-존슨 증후군을 진단 받은 환자에서 발생한 급성 A형 간염으로 인한 지속성 담즙 정체 1예를 경험하였기에 보고하는 바이다. 증례: 34세 남자 환자는 5일 전 발생한 열과 우상복부 통증을 주소로 본원에 내원하였다. 과거력상 1995년도에 간조직 검사를 통해 두빈-존슨 증후군을 진단 받았다. 내원 당시 활력 징후는 130/92 mmHg, 맥박 61회/분, 호흡수 18회/분, 체온 36.7℃이었다. 구역질, 전신 쇠약감 및 식욕 부진 호소하였고 신체 검진에서 전신 황달 및 공막 황달이 관찰되었고 우상복부 압통 소견이 관찰되었다. 혈액 검사상 백혈구 4030/mm3, 혈색소 15.3 g/dL, 혈소판 142000/mm3이었고 혈청 생화학 검사상 AST/ALT 11745/11779 IU/L, ALP/GGT 154/285 IU/L, CK/LDH 1024/7500 IU/L, total bilirubin/direct bilirubin 14.2/12.7 mg/dL 소견 보였다. 혈액 응고 검사상 PT INR 3.15 로 상승되었고 소변 검사상 bilirubin 2+ 소견 보였다. 면역 혈청 검사상 HAV IgM (+) 소견 보여 급성 A형 간염으로 진단하였다. 이미지 검사상 간비장 종대 이외에 특이 소견 관찰되지 않았다. 내원 후 보전적 치료 후에 증상 호전되었고, 내원 8개월째에 시행한 검사상 AST/ALT 43/22 IU/L, ALP/GGT 88/50 IU/L, PT INR은 1.10으로 급성 간염은 회복되었으나 total bilirubin/direct bilirubin은 36/30.6 mg/dL 까지 상승하였고, 급성 A형 간염 발생 10개월째, 최근 시행한 검사상 18.2/16.8 mg/dL으로 담즙 정체 지속되는 상태로 외래 추적 관찰 중이다.

국내 흰개미(Reticulitermes speratus kyushuensis Morimoto)에 의한 토양의 화학적 특성 변화

성세하 ( Se Ha Seong ),김근기 ( Keun Ki Kim ),홍창오 ( Chang Oh Hong ),박현철 ( Hyean Cheal Park ) 한국환경과학회 2017 한국환경과학회지 Vol.26 No.6

Termites (Isoptera) are classified into approximately 3,106 species. In Korea, only one species has been identified, which is Reticulitermes speratus kyushuensis Morimoto. The termite, a social insect, is known to play an important role in nutrient cycling of the ecosystem, although some species of termites are well-known pests attacking wooden structures or any plant materials. However, there is a lack of research about termites in Korea, including aspects such the taxonomy, physiology, and ecology of termites. This study was carried out to provide valuable basic data on the ecological role of termites in an ecosystem in Korea for the future studies. For the experiments, soil and termite samples were randomly collected from Mt. Hwajang located in Jikdong-ri, Eonyang-eup, Ulju-gun, Korea between October 5 and 30, 2015. Analysis results showed that there were no significant differences in soil chemical properties between the soil samples just after air-drying and one year elapsed without any treatment. The treated soil with termites showed significantly higher than the soil without termite treatment. Chemical properties of total nitrogen, organic matter, available phosphate, pH, Calcium(Ca), Potassium(K) and Magnesium(Mg) in soil treated with termites were 1.11 ± 0.3 g kg^-1, 43.3 ± 12.4 g kg^-1, 27.4 ± 2.9 mg kg^-1, 4.56 ± 0.2, 0.82 ± 0.2 cmol_c kg^-1, 3.18 ± 1.4 cmol_c kg^-1, 1.73 ± 1.1 cmol_c kg^-1, respectively. The values of soil property of without termite treatment were 0.56 ± 0.1 g kg^-1, 30.5 ± 3.1 g kg^-1, 24.0 ± 4.7 mg kg^-1, 4.09 ± 0.1, 0.71 ± 0.2 cmol_c kg^-1, 2.88 ± 1.5 cmol_c kg^-1, 1.30 ± 0.7 cmol_c kg^-1, respectively. These results suggest that inhabitation of termites could improve soil chemical properties in an ecosystem.

침출수 중 SCN^- 제거를 위한 SBR 공정의 실적용 연구

성세현,황석환,박병철 대한환경공학회 2002 대한환경공학회 학술발표논문집 Vol.2002 No.12

[특집] 유기성폐기물(Biomass)의 통합 에너지사업의 타당성

성세제 유기성자원학회 2009 유기물자원화 Vol.17 No.1