경부고속도로 확장공사 임시 진·출입로 교통안전성 향상방안

서성필,강필규,이정안,박덕관 한국도로학회 2014 도로 : 도로학회지 Vol.16 No.3

Methylation Markers in Renal Cell Carcinoma

서성필,김용준 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.1

Many tumor markers in relation to renal cell carcinoma(RCC) have been evaluated for detecting and monitoring diseases outcomes. However, none of these biomarkers reported to date has shown sufficient sensitivity and specificity for as a detector and prognosticator of the whole spectrum of RCC in routine clinical practice. The limited value of the established prognostic markers requires analysis of new molecular parameters of interest in predicting the prognosis of RCC patients; in particular, the high-risk patient groups at risk of recurrence and progression. Abnormal methylation of CpG islands can efficiently repress transcription of the associated gene in a manner akin to mutations and deletions. Recent progress in the understanding of epigenetic modification and gene silencing has provided new opportunities for the detection, treatment, and prevention of cancer. Methylation is an important molecular mechanism in RCC and could be used as a diagnostic and prognostic marker. Aberrant patterns of epigenetic modification would be, in near future, crucial parameters in cancer diagnosis, prognosis and a good target for developing novel therapies while maintaining the quality of life. This review discusses the epigenetic issues involved in the detection and prediction of prognosis in RCC.

고속도로 성토층에 정착하는 가설앵커 안전성 확보를 위한 현장적용 사례

서성필,한기환,김동광,김현철,이춘재,Seo, Seong-Pil,Han, Gi-Hwan,Kim, Dong-Gwang,Kim, Hyeon-Cheol,Lee, Chun-Jae 한국지반공학회 2015 지반 : 한국지반공학회지 Vol.31 No.6

한국에서 Biochemical Recurrence의 진단에 대한 혈액 및 영상의학적 검사에 관한 비뇨기종양을 전공하는 의사의 트렌드에 대한 고찰

서성필,김원태,강호원,김용준,이상철,김원재,김소영,박종혁,윤석중 대한비뇨기종양학회 2017 대한비뇨기종양학회지 Vol.15 No.3

Purpose: The aim of this study is to investigate the criteria of biochemical recurrence (BCR) and follow-up periods and methods with and without blood and imaging test of urologic oncology before established guidelines of prostate cancer in Korea. Materials and Methods: In December 2015, we sent the questionnaire to urologic oncologist in academic hospital and received the answer from 108 urologic oncologist (50%). Also, we analyzed the data of 1,141 patients underwent radical prostatectomy in 2005 from Korean Medical Insurance. Results: In follow-up, 72 physicians (66.7%) performed blood test every 3 months, 51 physicians (47.2%) performed imaging study in case of BCR. Bone scan was the most common imaging study in the follow-up (74 physicians, 68.5%). But, bone scan was only performed in case of BCR (43 physicians, 39.8%). The criteria of BCR was PSA 0.2 ng/mL (75 physician, 69.4%), 76 physicians (70.4%) was performed different follow-up according to risk of patients. In Korean Medical Insurance data analysis, PSA were performed average 2 times every year and magnetic resonance imaging, computed tomography, Bone scan were performed average 0.1, 0.2, 0.1 times every year, respectively. Conclusions: The criteria of BCR and the follow-up of prostate cancer patients in Korea were similar Korean prostate cancer guidelines. Blood and imaging test might be increased compared to 10 years ago, it is necessary to compare the Korean Medical Insurance data between 10 years ago and present.

Clinical and demographic factors associated with compliance and subsequent urinary metabolic changes in first-time ureteral stone formers

서성필,강호원,김원태,김용준,윤석중,김원재,이상철 충북대학교 동물의학연구소 2015 Journal of Biomedical and Translational Research Vol.16 No.2

Dietary and lifestyle modifications are widely prescribed to prevent recurrence of urolithiasis, although little is known about the clinical and demographic factors associated with patient compliance and urinary metabolic changes. The present study assessed the clinical and demographic factors influencing compliance with a modified diet and lifestyle in first-time ureteric stone formers as well as determined the effects of compliance on urinary stone risk factors. We retrospectively reviewed the medical records of 53 patients presenting with ureteric calcium stones. Using a self-completed questionnaire, patients were classified according to compliance with seven recommendations for modifying diet and lifestyle into good compliance group (complied with ≥ three recommendations) and poor compliance group. Before (on a random diet) and after prescribing the modifications, 24 hour urine samples were collected from those in the good and poor compliance group. The stone size at presentation and initial treatment modality were closely associated with patient compliance (P=0.019, P=0.027, respectively). Citrate excretion significantly increased in the good compliance group after adopting modifications (P=0.012), whereas the poor compliance group did not show a statistically significant difference. Moreover, patients in the poor compliance group showed significantly increased urinary calcium excretion by the end of the study (P=0.040). After adjustments for age, sex, body mass index, and metabolic abnormality status, poor compliance was found to be an independent risk factor for persistence or development of hypocitraturia (OR: 3.885; 95% CI: 1.102~13.694; P=0.035). In conclusion, our results imply that patient education programs regarding diet and lifestyle should be tailored to the individual’s clinical and demographic characteristics.

소비자 특성에 따른 대면 및 비대면 거래채널 선택 요인 분석: 지역은행 사례를 중심으로

서성필,서주환 한국소비문화학회 2023 소비문화연구 Vol.26 No.4

Recently, due to the proliferation of offline transactions in the financial industry following digital transformation and the emergence of new competitors such as Big Tech, the proportion of sales using online channels has been increasing. This study uses a logistic regression method to empirically analyzes the factors that affect the selection of offline or online channels as transaction channels for customers who signed up for credit loan products at Bank A, based in the Busan, Gyeongnam, and Ulsan regions. The total sample data is 28,221 and includes demographic information such as gender, age, and region of residence, and transaction characteristics such as credit rating, annual income, tenure, subscription product type, and loan amount. As a result of the analysis, it was found that nine variables, which were assumed as independent variables, such as transaction period, product classification, loan amount, annual income, residential area, credit rating, gender, age, and tenure, all had a significant effect on the customers’ transaction channels. Moreover, the characteristics of customers who prefer online channels have relatively short tenure and trading periods outside of Busan, Gyeongnam, and Ulsan, the main business areas of Bank A. They have a high credit rating and are highquality borrowers with a low age and high income. Based on the characteristics of customers who prefer online and offline channels derived through this study, it is expected that continuous research on channel strategies such as online and offline in the banking industry will be conducted to respond to changes in the financial environment.

셰일층 암반비탈면 안정성 확보방안

서성필(Sung-Phil Seo),한기환(Ki-Hwan Han),김동광(Dong-Kwang Kim),김현철(Hyun-Cheol Kim),김대길(Dea-Gil Kim) 대한토목학회 2015 대한토목학회지 Vol.63 No.12

전립선암과 전립선비대증 환자에서의 하부요로증상 분석

서성필, 강호원, 김원태, 김용준, 윤석중, 이상철, 김원재 충북대학교 의과대학 충북대학교 의학연구소 2015 忠北醫大學術誌 Vol.25 No.1

연구목적: 최근들어 전립선암과 하부요로증상에 관한 관심이 증가되고 있으며, 몇 가지 연구 결과들이 발표되고 있다. 그렇지만, 아직까지는 전립선암을 진단하는 목적으로의 전립선암을 예측할 수 있는 하 부요로증상에 관한 연구에 관심이 집중되어 있으나, 이를 위해 아직까지 전립선암과 전립선비대증의 하 부요로증상의 차이점에 관한 연구는 많지 않은 실정이다. 본 연구에서는 최근들어 서서히 관심이 증가 하고 있는 전립선암의 진단을 예측하기 위해서 전립선암과 전립선비대증에서의 근본적인 하부요로증상 의 차이를 확인하고자 하였다. 대상 및 방법: 2013년 1월부터 2013년 12월까지 본원에서 전립선암이 의심되어 전립선조직생검을 시행했던 211명의 환자를 대상으로 후향적으로 분석하였다. 결과: 1년간 전립선조직생검을 시행받은 환자는 211명으로 전립선암으로 진단된 경우가 63명 (29.9%), 전립선비대증으로 진단된 경우는 148명 (70.1%)이었다. 전립선의 크기는 전립선암군은 35.46 ± 18.91 cc였고, 전립선비대증군은 43.05 ± 24.22 cc로 전립선비대증으로 진단된 환자에서 유의하게 전립선의 크기가 컸다 (p=0.028). 국제전립선증상점수표에서, 5번문항과 6번 문항에서 전 립선비대증 환자에서 유의하게 불편한 증상을 호소하였고, 5번, 6번 문항을 제외하고 두군간에 증상의 차이는 없었다. 결론: 전립선암과 전립선비대증 환자에서의 하부요로증상의 차이는 전립선의 크기가 커지는 질환인 전 립선비대증에서 유의하게 요도폐색으로 인해 발생하는 증상을 더 많이 호소하였고, 그 이외의 증상에서 는 유의한 차이가 관찰되지 않았다. 그러나, 연구 수가 적은 관계로 좀 더 대규모의 연구가 필요할 것 으로 생각된다.

T1b 병기의 신세포암에서 수술 후 예후를 예측할 수 있는 임상 및 병리학적 인자에 대한 연구

오승용, 김영원, 윤형윤, 서성필, 이상근, 김원태, 윤석중, 이상철, 김원재, 김용준 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구목적: T1병기의 국소신세포암(localized clear-cell renal cell carcinoma)은 근치적신적출술이 나 부분신절제술이 표준치료이며 수술 후 타 병기에 비해 양호한 예후를 보인다. 하지만, 많은 수의 환 자에서 추적관찰 중 재발 및 사망이 발생하는데, 이는 T1b 병기에서 더 높게 보고되고 있다. 본 연구 에서는 국소신세포암 중 T1b 병기의 신세포암에서 표준적 치료 후 환자의 예후에 영향을 주는 임상 및 병리학적 인자에 대하여 알아보고자 하였다. 대상 및 방법: 1999년부터 2011년 까지 5개 기관에서 근치적신적출술이나 부분신제술을 시행 받은 3567명의 국소신세포암 환자들 중 병리학적 병기가 T1b로 확진 된 702명을 대상으로 하였다. 이들 환자가 가지는 임상 및 병리학적 특성 [연령, 성별, 고혈압, 당뇨, 비만도, European Cooperative Oncology Group(ECOG) 수행도, 증상유무, 수술방법, 종양크기, 분화도, 조직학적 형태 등]을 이용 하여 환자의 예후 [무재발생존율(relapse-free survival), 암특이생존율(cancer-specific survival) 및 전체생존율(overall survival)]에 영향을 미치는 인자에 대하여 다양한 방법으로 비교분석 하였다. 결과: 추적 관찰 기간은 34.0개월 (중앙값, 0-152개월)이었으며, 이 기간 중 재발, 사망 및 암특이사 망은 각각 72례 (10.3%), 57례 (8.1%) 및 24례 (3.4%)에서 발생하였다. 단변량 및 다변량 Cox 비례위험회귀분석에서 다양한 인자들이 무재발생존율(당뇨 유무, 종양크기 및 Fuhrman등급), 암특이 생존율(나이, 체질량지수, 당뇨 유무, 종양크기) 및 전체생존율(나이, 체질량지수, ECOG 수행도, 종 양크기)에 영향을 줄 수 있는 독립적 예후인자였다. 결론: 본 연구결과 국소신세포암의 예후를 예측할 수 있는 다양한 임상 및 병리학적 인자를 확인 할 수 있었다. 이러한 위험인자를 가지고 있는 환자는 보다 적극적인 추적관찰을 통하여 재발을 조기에 발 견한다면 이들의 생존율 향상에 많은 기여를 할 수 있을 것으로 생각한다.

Chronological Trends in Clinical and Urinary Metabolic Features over 20 Years in Korean Urolithiasis Patients

강호원,서성필,하윤석,김원태,김용준,윤석중,김원재,이상철 대한의학회 2017 Journal of Korean medical science Vol.32 No.9

Urolithiasis is common and is becoming more prevalent worldwide. This study assessed the chronological trends in clinical and urinary metabolic features over 20 years in Korean urolithiasis patients. We performed a retrospective analysis of 4,076 patients treated at our clinic from 1996 to 2015. Urinary metabolic data and stone analysis data were available for 1,421 and 723 patients (34.9% and 17.7%), respectively. Patients were categorized into 4 groups according to the date of initial diagnosis: group 1 (1996–2000, n = 897), group 2 (2001–2005, n = 1,018), group 3 (2006–2010, n = 1,043), and group 4 (2011–2015, n = 1,118). Incidental detection of uric acid renal stones has become more prevalent in the past 10 years, accompanied by an increase in body mass index and age at diagnosis. Similarly, the prevalence of diabetes mellitus and of hypertension increased from one group to the next throughout the study period. Levels of 24-hour urinary excretion of sodium, calcium, uric acid, and oxalate have decreased significantly over the study period. The incidence of urinary metabolic abnormalities also showed an identical tendency. The proportion of stones composed of uric acid increased over the study period. In conclusion, incidental detection of uric acid renal stones has become more prevalent in Korea in the past 20 years. Urinary excretion of lithogenic constituents and the incidence of urinary metabolic abnormalities have decreased significantly over this period.