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박동일 ( Dong Il Park ),안승섭 ( Seung Seop Ahn ),고병련 ( Byong Byeon Ko ),오영훈 ( Young Hun Oh ) 한국수처리학회 2015 한국수처리학회지 Vol.23 No.5
According to the analysis on previous studies of numerical modeling and evaluation of ground water effects, most of them focused on mediating variables, rather than a grid size. The first setting for modeling is a proper grid size of an area to analyze. Therefore, this study used the three-dimensional numerical analysis model MODFLOW to vary a grid size, to estimate an observation level and a calculation level, and to compare the characteristics of ground water. As a result, when the optimal mediating variable with the grid size of 50m×50m was estimated for the initial mediating variable, Mean error was 0.159, Mean absolute error 1.072, Root mean squared error 1.489. Therefore, the target area had applicability of numerical model. In the condition where the optimal mediating variable was fixed and a grid size varied, the model was applied. As a result, just as the value of observation level, the value of determination coefficient was 0.999. It indicated that mediating variable was more sensitive to ground water modeling than a grid size. Nevertheless, in the case of modeling for wells density area or for precision, each grid size was analyzed to be determined according to well in order for more accurate analysis. Therefore, it was found that it was necessary to set a proper grid size and assign each grid size to each well in order to increase accuracy of modeling.
Mongolian gerbil에서 Helicobacter pylori 감염 후 발생되는 Microsatellite Instability에 관한 연구
박동일 ( Dong Il Park ),김민경 ( Min Kyung Kim ),김재준 ( Jae J. Kim ),유태우 ( Tae Woo Yoo ),박정호 ( Jung Ho Park ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),손정일 ( Chung Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( Byung 대한내과학회 2006 대한내과학회지 Vol.71 No.1
목적: H. pylori (HP) 감염성 위염에서 HP는 DNA 손상복구기능에 장애를 유발하여 위 상피세포의 유전자에 발생하는 돌연변이를 축적시켜 위암의 발생 위험을 증가시킬 수 있다. 본 연구는 Mongolian gerbil (MG)animal model을 이용한 in vivo 실험에서 만성적인 HP감염이 위 점막의 MSI를 발생시키는 지 알아보고자 하였다. 방법: 7주된 수컷 MG에 HP CA20 균주를 감염시킨 후 일정한 시점마다 동물을 희생시켜 위를 절제하였다. 위염부위의 위 상피를 미세박리하여 DNA를 추출한 후 Fam이나 Hex로 표지시킨 다섯 가지 gerbil MSI marker를 이용하여 중합효소연쇄반응을 실시한 후 310 genetic analyzer를 이용하여 MSI 분석을 시행하였다. 결과: MSI는 정상부위(식도)에서는 관찰되지 않았고, 위염이 없는 부위에 비해 위염부위에서 빈번히 관찰되었다(p<0.05). 위염부위 중 6예에서는 low level MSI를 1예에서는 high level MSI를 관찰하였다(p<0.05). 결론: 본 연구로 MG에서 만성적인 HP 감염이 MSI유발에 관여함을 입증하였다. 이와 같이 HP는 위상피세포내의 DNA mismatch repair 단백 발현을 저하시켜 위상피세포 유전자에 발생하는 돌연변이의 축적을 유발할 수 있을 것으로 생각한다. Background: During Helicobacter pylori (HP) gastritis, the organisms cause an impairment of DNA repair that results in accumulation of mutations in the genome of epithelial cells and an increased risk of gastric carcinoma. The aim of this study was to determine whether microsatellite instability (MSI) could be induced by chronic HP infection in the Mongolian gerbil model. Methods: Seven-weeks old, specific pathogen-free male Mongolian gerbils were infected with the HP strain CA20. They were sacrificed at the each time points (1, 2, 3, 6, 9, 12 months). Areas of gastritis were carefully microdissected. DNA from tissues was analyzed for the presence of MSI by genomic DNA amplification with five gerbil microsatellite markers per sample. Gerbil markers labelled with Fam or Hex were obtained to perform MSI analysis using the 310 Genetic Analyzer. Results: MSI was more frequent in the area of gastritis than in that of normal (p<0.05). Six showed MSI-low and one showed MSI-high within the area of gastritis (p<0.05). Conclusions: This study shows that chronic HP infection in the Mongolian gerbil induces MSI. This finding indicates that HP infection causes a decrease in DNA MMR proteins in epithelial cells of the stomach that may reach critically low levels, allowing for the accumulation of mutations such as those seen in microsatellite regions.(Korean J Med 71:17-23, 2006)
박동일 ( Dong-il Park ),안승섭 ( Seung-seop Ahn ) 한국환경기술학회 2014 한국환경기술학회지 Vol.15 No.4
수리전도도는 지하수분석에 있어 중요한 매개변수로 작용한다. 따라서 본 연구에서는 MODFLOW모형을 이용하여 수리전도도의 변화가 지하수에 미치는 영향을 분석하였다. 그 결과 수리전도도의 증가에 비해 감소 할 경우 모형 적용 오차가 점차 커지는 것으로 분석되었으며, 수리전도도 증감에 따른 영향반경의 형상이나 영향길이는 큰 변화가 없으나, 지하수위에 미치는 영향은 큰 것으로 분석되어 지하수위 해석에 있어 정확한 수리전도도의 적용이 필요한 것으로 판단된다. Hydraulic conductivity acts as an important parameter for groundwater analysis. Therefore, this study analyzed the influence of change of hydraulic conductivity on the groundwater using MODFLOW model. As a result, if reduced compared to the increase in hydraulic conductivity, it was analyzed that model applied error increased. Though there was not a change in influencing distance or a shape of capture zone due to increase or decrease of hydraulic conductivity, it was analyzed that the influence on groundwater level was large; it is determined that the application of accurate hydraulic conductivity is significant for interpretation of underground-water level.
위장암 : 대장암에서 HER-2/neu 발현에 관한 연구
박동일 ( Dong Il Park ),오석중 ( Suk Joong Oh ),박승하 ( Seung Ha Park ),윤중원 ( Jung Won Yun ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),성인경 ( In Kyung Sung ),손정일 ( Chong Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( B 대한소화기학회 2004 대한소화기학회지 Vol.44 No.3
목적: HER-2/neu 단백은 상피성장인자 수용체와 구조가 거의 일치하기 때문에 정상 세포의 성장과 증식 과정에 관여한다. 유방암에서 HER-2/neu의 과발현은 나쁜 생존율을 예상할 수 있는 예후인자일 뿐 아니라 항암화학요법이나 호르몬요법에 잘 반응하지 않는 등 치료에 대한 반응을 예측할 수 있는 인자이며 HER-2/neu에 대한 단일클론 항체인 Herceptin(R)은 림프절에 전이된 유방암 환자에서 장기 생존율을 향상시켜 임상에서 활발히 사용되고 Background/Aims: The HER-2/neu protein is involved in normal cell proliferation and tissue growth because it is extensively homologous and related to epidermal growth factor receptor. As a prognostic marker, HER-2/neu is used to forecast the clinical cour
혈관침범이 의심되는 췌장암 환자에서 절제 가능성과 생존율 분석
박동일(Dong Il Park),이종균(Jong Kyun Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),이규택(Kyu Taek Lee),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이종철(Jong Chul Rhee),최규완(Kyoo 대한내과학회 2000 대한내과학회지 Vol.58 No.6
N/A Background : One of the major limitations of curative resection in pancreatic cancer patients is local tumor extension to the mesenteric vessels. Thus, the purposes of our study were (1) to assess the clinical value of contrast enhanced spiral CT in predicting the resectability and survival of pancreatic cancer patients with suspicious vascular invasion and (2) to assess the influence of curative resection on survival in these patients.Methods : Forty cases of the pancreatic cancer patients who were suspected of having involvement of adjacent large vessels and subsequently underwent operation with curative intent were enrolled in this study. Resectability and survival were correlated with CT findings such as segment length, degree of encasement, type and number of vessel involved. Survival rate was compared between curative and palliative resection groups. And survival was also compared between resected and non-resected groups. Results : Of the 40 patients with adenocarcinoma of the pancreas, 14 patients had curative resections, and 26 patients had palliative resections. The probability of curative resection was higher in patients with segment length less than 2 cm, compared with those with more than 2 cm. However, there was no difference in survival between two groups. There were no differences of resectability and survival according to the degree of encasement, type and number of vessel involved. There were no difference in survival between curative and palliative resection groups, and between resected and non-resected groups. Conclusion : A survival benefit is not achieved by curative resection in pancreatic cancer patients with vascular invasion. So other non-operative treatments should be considered as effective tools prior to resection in these patients.(Korean J Med 58:651-656, 2000)