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키워드 시각화를 통한 HCI 분야의 연구 네트워크 구조화
민헌기(Hun Kee Min),김가원(Ga-Won Kim),강성진(Sung Jin Kang),권석주(Seok Joo Kwon),윤명환(Myung Hwan Yun) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.2
본 연구에서는 HCI 분야 내 연구 주제들의 변화 양상 및 연구 주제들간의 융합여부를 파악하기 위해 Keyword Positioning Algorithm 을 적용하여 HCI 분야 논문들의 키워드를 네트워크 형태로 시각화 하였다. 자료수집을 위해 2008 년부터 2013 년까지의 6 년간 HCI 분야의 5 개학회 및 저널에서 발표된 총 357 편의 논문을 수집하여 총 1987 개의 키워드들을 추출하였다. 전처리 작업은 키워드 통합 및 중복 키워드 제거, 대표 키워드 라벨 선정, 키워드 라벨 재정의라는 3 단계로 이루어졌다. 그 결과, 2008 년에는 Collaborative System 과 Usability, Context Awareness 와 NLUI 를 각각 연결시키려는 연구가 진행되었지만, 2012 년과 2013 년에는 Collaborative System, Usability Testing, Context Awareness, NLUI 를 모두 통합적으로 연구하려는 시도가 진행되고 있음을 확인할 수 있었다. 하지만 이 연구는 6 년간의 자료에만 기반하였으며, 네트워크 시각화 축 설정이 연구자의 역량에 영향을 받을 수 있다는 한계가 있다. The aim of this study is to understand research trends and to find area of disciplinary convergence using keyword network visualization. 1987 keywords were collected from 357 papers published between 2008 and 2013 in the field of HCI. Data preprocessing had three steps: to remove duplicate keywords, to select major keywords, to integrate keywords. Based on keyword positioning algorithm, the results showed that research conducted in 2013 include various keywords compared to research conducted in 2008. However, this study has several limitations due to the size of data and the subjectivity of axis in keyword network.
항 - IgG 항체에 의한 차단형 TSH 수용체 항체의 자극형 항체로의 전환
송민호(Min Ho Shong),이가희(Ka Hee Yi),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),송영기(Young Kee Shong) 대한내과학회 1991 대한내과학회지 Vol.41 No.5
N/A We examined the conversion phenomenon of thyrotropin rceptor-bound blocking type immunog-lobulin G to the stimulating type by antihuman IgG antibody for the evaluation of the mechanism involved in the conversion, in vitro. Blocking-type IgG was purified from a patient with primary myxedema. In the conversion experiment. FRTL-5 cells were first incubated with blocking-type lgG solution at 37°C for 30 min, then washed with Hanks Balanced Salt Solution and, secondly, incubated with the solution containing antihuman IgG antibody at 4°C for 1.5 h and then for 3 h at 37°C. The antihuman IgG antibody to the cell-bound blocking type IgG resulted in an increase of Camp production in a dose dependent manner. Of the several types of antihuman IgG antibodies tested, antibodies against F fragment and divalent Fab frament showed the most effective conversion, while the least effective were those against the F, fragment. IgG from patients with high titer of rheumatoid factor did not convert cell-bound blocking type IgG to the stimulating type. Antihuman IgG antibody did not interfere with the TBII activity of the blocking type IgG antibody did not interfere with the TBII activity of the blocking type IgG. Simultaneous addition of antihuman IgG antibody and TSH (0.1 Mu/ml) increased Camp production to a greater degree than the individual addition of either. These results suggest that blocking-type TSH receptor antibody and stimulating-type antibody bind to the similar epitope of TSH eceptor, and that IgG against TSH receptor antibodyr may also play a patho-physiological role in vivo.
백서 고환 간질 세포에서 TSH 와 TSH 수용체 항체에 대한 cAMP 와 Testosterone 의 반응
송영기(Young Kee Shong),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A To investigate the physiological role of TSH receptor in testes and the effect of various TSH receptor antibodies (TRAb), we measured cAMP production ad testosterone release in enzymatically dispersed rat testicular interstitial cells under the stimulation of TSH and TRAb, and compared the results with in those of tests done in FRTL-5 cells. TSH increased cAMP production and testosterone release in a dose-dependent manner similar to hCG. TSAb which stimulated thyroid adenylate cyclase (AC) were able to stimulate teaticular interstitial cell AC in 8 out of 30 patients (277p) and testosterone release in 12 out of 30(40%) patients with Graves' disease. Blocking type TRAb inhibited TSH-induced cAMP production and testosterone release in a dose-dependent manner but had no effect on basal cAMP production and testosterne release, These findings suggest that TSH receptors in testes might have a somewhat dissimilar nature from that in the thyroid and that testicular TSH receptor might be involved in testosterone production.
Graves 병 환자에서 갑상선 아전절제술 후 갑상선자극항체와 갑상선자극홀몬 결합억제 면역글로불린의 변화
송영기(Young Kee Shong),이병두(Byoung Doo Rhee),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),오승근(Seung Keun Oh) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A The authors measured changes in thyroid stimulating antibody (TSAb) and thyrotropin binding inhibitor immunoglobulin (TBII) in 15 patients with Graves' disease treated with subtotal thyroidectomy. Before surgery all 15 had detectable TBII actvities, and 11 had TSAb activities. During the 12 month postoperative follow-up, TBII disappeared in 7 out of 15, and TSAb disappeared in 6 out of 11. Twelve months after surgery, 10 patients with negative TSAb (including 4 patients whose TSAb activities were negative before surgery) remained in remission, Of 5 patients whose TSAb remained persistently positivie during the 12 month observation period, one remained in remission, two experienced relapse, and two became hypothyroid. In the persistently positive TSAb and TBII group, their activities did not change after surgery. There was no difference in clinical and laboratory findings save for the higher TSAb and TBII activity preoperatively between the persistently positive group and disappearing group. In summary, after subtotal thyroidectomy, TSAb and TBII disappeared in some of the patients. Disappearance of TSAb is associated with remission but persistence of TSAb has no prognostic implication. The production sites of thyrotropin reccptor antibody are thought to be intrathyroidal, but in some patients extrathyroidal production might contribute significantly, due to the pattern of postoperative changes in thyrotropin receptor antibody activities.
배양된 쥐 갑상선세포 성장에 미치는 각종 성장인자들과 TSH 수용체항체간의 상호작용 및 그 기전에 관한 연구
조보연(Bo Youn Cho),송영기(Young Kee Shong),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A To evaluate the interaction of various growth factors and TSH receptor antibodies (TRAb) on the growth of cultured rat thyroid cells, FRTL-5 cells, and to verify their mechanisms of action, we measured 3H-thymidine incorporation into FRTL-5 cells with various combinations of TSH, Graves' IgG and other growth stimulators (insulin, IGF-I, multiplication stimulation activity, forskolin, dBcAMP and phorbol ester). We evaluated the effects of blocking TRAb and adenosine on the growth factor-stimulated growth of FRTL-5 cells. Insulin, IGF-I and MSA increased 3H-thymidine incorporation into FRTL-5 cells and showed a synergistic effect when incubated simultaneously with TSH or Graves IgG. Forskolin, PGE2, and dBcAMP also increased 3H-thymidine incorporation by themselves and their effects were synergistically potentiated by insulin and IGF-I. Adenosine inhibited both TSH and Graves' IgG induced 3H-thymidine incorporation into FRTL-5 cells. Blocking TRAb inhibited both TSH and Graves' IgG induced 3H-thymidine incorporation, but did not inhibit the effects of insulin, IGF-I, forskolin and dBcAMP on the growth of FRTL-5 cells. Phorbol ester (TPA) did stimulate the growth of FRTL-5 cells by itself and inhibited both TSH and Graves IgG induced 3H-thymidine incorporation into FRTL-5 cells. These results suggest that 1) there might be two or more signal transduction systems for the growth of thyroid cells; TSH and Graves IgG stimulate the growth of thyroid cells through the adenylate cyclase-cAMP system, and IGF-I and other growth facors act through another system, and 2) blocking TRAb may inhibit the growth of thyroid cells by inhibiting TSH-stimulated cAMP generation.
Graves 병에서 배양된 백서 갑상선 세포 ( FRTL - 5 ) 를 이용한 갑상선 자극항체의 측정 - 기본적 검토 및 임상적 의의 -
조보연(Bo Youn Cho),송영기(Young Kee Shong),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A We tried to assess the best conditions to measure thyroid stimulating antibodies (TSAb) using cultured rat thyroid cell ling (FRTL-5), And also to evaluate the frequencies of TSAb in Graves' disease, changes of TSAb activities during antithyroid drug treatment, and whether the presence of TSAb at the end of treatment can predict the relapse, we measured TSAb using FRTL-5 cells in 40 normal controls and 179 patients with autoimmune thyroid diseases. The results are as following; 1) The cAMP responses of FRTL-5 cells to TSH and TSAb began to increase from 3 days after TSH withrawal from culture media and reached peak response at the 7th day, and thereafter decreased. 2) The cAMP responses of FRTL-5 cells to TSH and TSAb increased in relation to incubation times. 3) The dose-response curves of TSH and TSAb, stimulating cAMP production in FRTL-5 cells, showed similary sigmoid curves. The minimum levels of TSH and TSAb which showed significant increase of cAMP were 2-5 μU/ml and 0.15-0.3mg/well, respectively. 4) Intracelluar cAMP levels were correlated closely with extracelluar cAMP levels. About 75-80% of total cAMP levels was released into culture supernatant. 5) The frequencies of detectable TSAb in 57 patients with untreated Graves' disease, in 55 patients with euthyroidism under treatment and in 18 patients with remission were 93%, 56.4% and 11.1%, respectively. However, only 2 out of 21 patients with Hashimoto's thyroditis had low titers of TSAb in their sera. TSAb were not present in sera of all 28 patients with primary nongoitrous myxedema. 6) TSAb activites were singnificantly correlated with TBII activities (r=0.635, p<0.001). 7) In remission group, TSAb activities decresed significantly from 3 months after treatment, and disappeared in alomost all cases within 12 months. However, those activities were not changed significantly untill the end of treatment in relapse group. 8) The positive rate of TSAb in 27 patients who were in remission after treatment was 38.7%, however, that in 28 patients who relapse within 12 months aftr discontinuation of drugs was 77.8%. The predicitve value of TSAb for relapse was 67.7%, which was similar with that of TBII (71.4%). These findings suggest that determination of TSAb using FRTL-5 cells is very sensitive and specific method and that TSAb is one of major cause of hyperthyroidism in Graves disease, and its determination can be useful for the evaluation of clinical course and prognosis in patients with Graves disease.
박용수(Yong Soo Park),송영기(Young Kee Shong),송영욱(Yeong Wook Song),김성연(Seong Yeon Kim),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki MIn) 대한내과학회 1989 대한내과학회지 Vol.36 No.5
N/A Hypothyroidism and hyperthyroidism are both associated with a variety of muscle abnormalities, from myalgia to myopathy. There are several reports of autoimmune thyroiditis associated with various rheumatic disorders, such as systemic sclerosis. Polymyositis, however, has been reported in very few cases, if any, especially after the treatment for active hyperthyroidism. A 22-year-old woman developed idiopathic polymyositis during the treatment of Graves' disease with propylthiouracil. She developed severe proximal muscle weakness during the treatment for hyperthyroidism. Her serum creatine kinase level was elevated. Electromyography, muscle biopsy and the clinical course of the patient's illness were consistent with idiopathic polymyositis. Whether this coexistence of Graves' disease and polymyositis represents a cause-effect association or a chance occurrence is unknown.