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      • SCOPUSKCI등재
      • SCOPUSKCI등재

        급성 B형 간염의 회복 후 말초혈액 단핵구에서의 HBV DNA 검출

        명승재(Seung Jae Myung),이영상(Yung Sang Lee),김형건(Hyung Gun Kim),이근찬(Geun Chan Lee),박능화(Neung Hwa Park),정영화(Young Hwa Chung),서동진(Dong Jin Suh) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.1

        N/A Background/Aims: Negative seroconversion of HBsAg with the appearance of anti-HBs and normalization of serum transarninase level have been generally accepted as an evidence of a cure of hepatitis B, and viral clearance. However, there are growing evidences that the hepatitis B virus (HBV) genome persists after those events. HBV DNA could be detected from the serum, peripheral blood mononuclear cells (PBMC) and liver tissue by sensitive PCR method, even when HBsAg is undetectable from the serum during the course of chronic hepatitis B. The aim of this study is to demonstrate whether HBV might persist in the circulation after complete serologic and clinical recovery from acute hepatitis and its clinical manifestations implications. Methods: We tried to detect HBV DNA from the serum and PBMC of 24 healthy individuals (male 16, female 8) with a history of self-limited acute hepatitis B infection using the PCR-Southern hybridization. Results: The mean duration from the onset of acute hepatitis to the time of sampling was 19+11 months, and HBV DNA was undetectable from sera of the individuals with PCR and Southern hybridization. HBV PCR was performed after the separation of PBMC and DNA isulation. HBV DNA was amplifiable in 4 of 24 individuals (17%). By Southem hybridization, HBV DNA was confirmed in 4 positive samples. The duration from the onset of acute hepatitis to the sarnpling time in positive group was 7.0 3.2 montks, and was significantly shorter than DNA negative counterpart (21.5 10.5 months)(p<0.01). Conclusions: Hepatitis B virus DNA can persist in peripheral blood mononuclear cells after resolution of acute hepatitis, and it may persist only for a certain period after clearance of virus in the serurn. The role of HBV DNA in PBMC should be elucidated in the future. (Korean J Gastroenterol 1997; 29:74-84)

      • SCOPUSKCI등재

        대장암에서 Prostaglandin의 역할

        명승재 ( Seung Jae Myung ),김인화 ( In Hwa Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.5

        Colon cancer is one of the major leading causes of cancer-related deaths in the Western countries. In Korea, the incidence of colon cancer is increasing due to changes in environment and lifestyle such as diet. Chemoprevention strategy using non-steroidal anti-inflammatory drugs (NSAIDs) has been under intensive clinical and epidemiological research as these drugs suppress colorectal cancer. The best known targets of NSAIDs are cyclooxygenase (COX) enzymes, which convert arachidonic acid to prostaglandins (PGs) and thromboxane. Among these PGs, prostaglandin E2 (PGE2) can promote tumor growth by binding its receptors and activating signal pathways which control cell proliferation, migration, apoptosis, and angiogenesis. Therefore, COX inhibition is promising approach for chemoprevention of colorectal cancer. However, the prolonged use of COX-2 inhibitors is associated with unacceptable cardiovascular side effects. Thus, new targets involved in PGs metabolism are under investigation. 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key metabolic enzyme of PGE2, was up-regulated in normal colonic epithelium, but decreased in colon cancer. Recent findings suggest that 15-PGDH is involved in the neoplastic progression of initiated colonic epithelial cells. Also, new players related with PGs metabolism including prostaglandin transporter (PGT) and microsomal prostaglandin E synthase (mPGES) were reported to play a role in colorectal cancer development. This review presents current knowledge about the role of prostaglandins and associated proteins in colorectal cancer development and progression. (Korean J Gastroenterol 2008;51:274-279)

      • SCIESCOPUSKCI등재
      • KCI등재

        변비의 진단: 체계적인 문헌고찰

        명승재 ( Seung Jae Myung ),이태희 ( Tae Hee Lee ),허규찬 ( Kyu Chan Huh ),최석채 ( Suck Chei Choi ),손정일 ( Chong Il Sohn ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.5

        To diagnose constipation accurately in self-reported constipated patients is very important not to miss organic disease and prevent therapeutic abuse. To investigate the etiology of functional constipation is also important to determine the therapeutic modality of constipation. In this systemic review, the clinical usefulness of symptom evaluation, diagnostic tests to rule out organic and systemic disease, and functional tests to discriminate underlying pathophysiology in the diagnosis of constipation were discussed. No specific symptoms or tests were available to predict organic versus functional constipation or differentiate slow transit constipation versus evacuation disorder. Therefore, collaborative studies are necessary to determine the pathophysiology of this disorder. (Korean J Gastroenterol 2010;55:316-324)

      • KCI등재

        대변실금의 진단과 치료

        박수경 ( Soo Kyung Park ),명승재 ( Seung Jae Myung ) 대한내과학회 2012 대한내과학회지 Vol.83 No.5

        Fecal incontinence is a common condition, which leads to impaired quality of life and huge financial cost at an individual and societal level. Recent studies have identified novel and potentially modifiable risk factors. Newer diagnostic modalities are giving more detailed information about underlying disorders, helping to implement targeted treatment. Many therapeutic options exist, and newer treatments are changing outcomes. This article will review recent developments in mechanisms, diagnosis, and treatment of fecal incontinence. (Korean J Med 2012;83:580-584)

      • KCI등재

        비만과 대장암

        나수영 ( Soo Young Na ),명승재 ( Seung Jae Myung ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.1

        Obesity worldwide is constantly increasing. Obesity acts as an independent significant risk factor for malignant tumors of various organs including colorectal cancer. Visceral adipose tissue is physiologically more important than subcutaneous adipose tissue. The relative risk of colorectal cancer of obese patients is about 1.5 times higher than the normal-weight individuals, and obesity is also associated with premalignant colorectal adenoma. The colorectal cancer incidence of obese patients has gender-specific and site-specific characteristics that it is higher in men than women and in the colon than rectum. Obesity acts as a risk factor of colorectal carcinogenesis by several mechanisms. Isulin, insulin-like growth factor, leptin, adiponectin, microbiome, and cytokines of chronic inflammation etc. have been understood as its potential mechanisms. In addition, obesity in patients with colorectal cancer negatively affects the disease progression and response of chemotherapy. Although the evidence is not clear yet, there are some reports that weight loss as well as life-modification such as dietary change and physical activity can reduce the risk of colorectal cancer. It is very important knowledge in the point that obesity is a potentially modifiable risk factor that can alter the incidence and outcome of the colorectal cancer. (Korean J Gastroenterol 2012;59:16-26).

      • KCI등재후보

        유전 의심성 비용종증 대장암의 빈도와 임상적 특성

        양석균(Suk Kyun Yang),명승재(Seung Jae Myung),정훈용(Hwoon Yong Jung),홍원선(Weon Seon Hong),김진호(Jin Ho Kim),심기남(Ki Nam Shim),최재원(Jae Won Choe),김해경(Hae Kyung Kim),박무인,이미헌(Mi Hun Lee),김동일(Dong Il Kim),박의련(Eui Ryun 대한내과학회 2001 대한내과학회지 Vol.60 No.6

        N/A Background: The current diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is dependent on a detailed family history based on the Amsterdam criteria proposed by the International Collaborative Group on HNPCC (ICG-HNPCC) in 1990. On recognizing the shortcomings of the ICG-HNPCC criteria, the Korean Hereditary Colorectal Cancer Registry (a subdivision of the Korean Hereditary Tumor Registry) designated the term uspected HNPCC for families who do not fullfill the criteria of the ICG-HNPCC but in whom a genetic basis for colon cancer is strongly suggested. The present study was designed to determine the frequency and define the clinical characteristics of suspected HNPCC. Methods: We analysed the clinical characteristics of 42 suspected HNPCC patients and their family members and compared these characteristics with that of 1,692 non-hereditary colorectal cancer patients. Results : The frequency of suspected HNPCC was 2.4% in our study. The mean age of suspected HNPCC patients at the time of diagnosis was 45.1±9.6 years and that of non-hereditary colorectal cancer patients was 57.4±11.9 years. The incidence of synchronous colorectal cancers in HNPCC was 7.1% and that of non-hereditary colorectal cancers was 0.9%. In suspected HNPCC families, 18 patients had extracolonic malignancies and the stomach cancer was the most common (55.5%). Conclusion : The frequency of suspected HNPCC among total colorectal cancer cases was 2.4% in our study. Tumors in suspected HNPCC differed from non-hereditary colorectal cancers in an early age of onset.(Korean J Med 60:507-513, 2001)

      • 구연 : 제 1 회의장 (그랜드볼룸 1) ; 위장관 : 위암의 조기진단을 위한 위액과 위 조직에서 Telomerase 및 TERT의 유용성

        박영환 ( Young Hwan Park ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),장혜숙 ( Hye Sook Chang ),양석균 ( Suk Kyun Yang ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( Young Il Min ),오현주 ( Hyun Ju Oh ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-

        <목적> Telomerase는 세포의 사멸을 억제하는 효소로 여러 종류의 암 조직에서 활성도가 증가되어 있다. 또한 telomerase의 catalytic subunit인 telomerase reverse transcriptase (TERT)는 telomerase의 활성도를 조절하며, telomerase의 활성도가 나타나기 전에 그 활성도가 증가하는 것으로 알려져 있다. 따라서 telomerase나 TERT를 이용하여 암의 조기진단에 활용하려는 연구들이

      • KCI등재후보

        소화기 ; 3차 병원에 내원한 한국인 변비 환자의 특성

        김동회 ( Dong Hoi Kim ),명승재 ( Seung Jae Myung ),양동훈 ( Dong Hoon Yang ),윤인자 ( In Ja Yoon ),서소영 ( So Young Seo ),구현숙 ( Heun Sook Ku ),윤순만 ( Soon Man Yoon ),김경조 ( Kyung Jo Kim ),예병덕 ( Byong Duk Ye ),변정식 ( J 대한내과학회 2013 대한내과학회지 Vol.84 No.1

        목적: 변비는 흔히 호소하는 위장관 증상 중의 하나로 2.6-9.2%의 유병률이 보고되었다. 그러나 유병률은 서구에 비해 비슷하지만 한국인 변비 환자에 대한 역학적 연구는 매우 미비한 실정이며, 또한 인종과 식이습관 등의 차이, 문화적인 요소를 고려할 때 서구 환자들과 대비되는 한국인 환자들의 특성이 있을 것으로 생각된다. 따라서 이 연구에서는 3차 병원을 내원한 한국인 변비 환자들에서 역학적인 요소, 생활 습관, 기저 질환 등의 특성들을 확인하고 생리적 검사를 시행하였다. 방법: 2000년 4월부터 2005년 1월까지 서울아산병원 변비클리닉에 변비를 주소로 내원한 338명의 환자를 대상으로 하였다. 연구자에 의해 고안된 설문지로 설문을 작성하도록 하고 설문지를 바탕으로 환자의 사회 인구학적 요소들과 변비와 연관된 배변 양상, 생활 습관, 변비의 증상, 기저 질환과 그에 대해 사용 중인 약물, 변비에 대하여 사용하는 약제 및 민간 요법 등에 대해 조사하였다. 또한 배변 조영술, 대장 통과 시간 검사, 항문 직장 내압 검사를 통해 변비를 분류하여 그 양상을 확인하였다. 결과: 총 338명의 환자 중 여자가 222명(65.7%), 남자가 116명(34.3%)이었고 평균 연령은 53.8±16.3세로, 대체적으로 연령이 증가할수록 환자의 수가 증가하는 양상이고 전체 환자의 42.6%가 60세 이상이었다. 변비의 유병률이 10년 이상인 환자가 42.9%였고 변비와 연관된 증상으로 복부 팽만감 (79.7%)이 가장 많았다. 64.3%의 환자들이 다양한 민간 요법을 사용한 적이 있었고 그 중에서도 동규자차, 다시마, 알로에를 많이 사용하였다. 자의적 변비 환자 중 89.1%가 로마 진단 기준 III에 따라 기능성 변비로 진단되었으나 나머지 환자들의 84%도 생리학적 검사에서 이상소견을 보였다. 생리학적 검사 결과를 통합하였을 때, 정상 통과 시간형 변비, 서행성 변비, 골반저 조율 장애, 혼합형 변비는 각각 21%, 27%, 29%의 분포를 보였다. 직장 감각 저하가 16.9%의 환자들에서 있었고 약 25%의 환자들이 배변 조영술에서 직장류, 직장 항문 중첩증 등의 해부학적 이상소견을 나타내었다. 결론: 우리나라 변비 환자들은 민간 요법을 많이 사용하면서 정확한 진단과 치료를 지연시키는 경향이 있다. 3차 병원을 내원한 환자들의 생리학적 검사 결과를 보면 이상소견이나 해부학적인 문제의 비율이 높은 편이므로 초기에 적극적인 검사를 시행하는 것이 변비의 진단과 치료에 도움이 될 것이다. Background/Aims: Korean patients with constipation have differences, both among themselves and as compared to other populations, with regard to race, diet, and cultural factors and are expected to have different characteristics to those of western patients, but few studies have been conducted in this regard. We evaluated the epidemiological and physiological characteristics of patients with constipation who visited a tertiary referral center. Methods: A total of 338 patients with constipation were included. They completed a questionnaire and took physiological tests such as defecography, colon transit time, and anorectal manometry. We classified the types of constipation according to the physiological tests and analyzed the results. Results: The mean age of the study patients was 53.8 ± 16.3 years and 42.3% of the patients were ≥ 60 years old. Patients who had tried folk remedies reached 64.3%. Among the self-reported patients with constipation, 89.1% satisfied the Rome III criteria for constipation. However, 84% of the patients who did not satisfy the criteria showed abnormal results on the physiological tests. Patients with normal transit constipation, slow transit constipation, and dyssynergic defecation were 21%, 27%, and 29% of the all patients, respectively. Rectal hyposensitivity was found in 16.9% of patients and 25% of them revealed anatomic abnormalities on defecography. Conclusions: Korean patients with constipation have a tendency to delay an accurate diagnosis and treatment and to use folk remedies. As physiological tests for patients with constipation who visited a tertiary hospital showed a relatively high rate of abnormal results, such as dyssynergic defecation and anatomic problems, active physiological evaluations should be considered for such patients. (Korean J Med 2013;84:49-61)

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