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십이지장 궤양 발생에 있어서 H . pylori와 위상피화생의 연관에 대한 연구
박선미(Seon Mee Park),양석균(Suk Kyun Yang),홍원선(Weon Seon Hong),민영일(Young Il Min),이인철(In Chul Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6
N/A Background/Aims: H. pylori infection and gastric metaplasia are frequently associated in patients with duodenal ulcers. However, the pathogenesis of duwlenal ulcer in relation to H, pilori infecri<in and gastric metaplasia has not reacbed a consistent result, yet. The aim of this study v,as to assess whether H. pylori infection and gastric metapla.ia contrihute to duodenal ulcerogenesis. Methods: Multiple endoscopic biopsy specimens were tnken frorn duodenum and gastric antrum of ?I subjects(21 active duodenal ulcers; 30 scarred duodenal ulcers; 20 normal controls). The specimens were examined histologically for the presence ot' H. pylori, gastric metaplasia, and degree of gastritis and duodenitis. Rapid tissue urease test was performed t'or detection of H, pi krri infc cti<in. Results: The positive rate of H. pylrri in gastric antrurn was not significantly different aniong ttlTCC groups, while it was increasing in duodenum, I,e., normal controls(3%'), scarred DU's(37,r), active DU's(62%) in ascending order. The incidence of duodenal gastric metaplasia in the active DU'.I was 95.2% in contrast with the scarred duodenal ulcer's(72.07<) and the nonnal contrnls(2i.04) Diffuse gastric metaplasia lesions were more prevalent in active duodenal ulcers. 1n the duodenum, a strong association was shown between the H. pylrri and gastric rnetaplasia. The severity ot' duodenitis were significantly increased in the order ot' groups of normal controls, scarrecl duodena1 ulcers, and active duodenal ulcers. In duoclenum, there was a strong association with the grade c>f' intlammation anci H. pylori. Conclusions: These results suggest that gaslric metaplasia in the duodenum and concurrent H. pilori infection may play a synergistic role in the pathogene.I. Vt' duodenal ulcer. (Korean J Gastroenterol 199S;27: 617-62S)
Cisplatin의 투여 후 사구체여과율 및 신혈류량의 변화
홍성운(Seong Woon Hong),강태웅(Tae Woong Kang),이진오(Jhin Oh Lee),임상무(Sang Moo Lim),김용현(Young Hyun Kim),홍원선(Weon Seon Hong),송재관(Jae Kwan Song),김영환(Young Whan Kim) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.1
N/A While cisplatin has been widely used in the treatment of a variety of cancers, nephrotoxicity is one of the major problems which frequently limit clinical usefulness of cisplatin. This study has been conducted to investigate nephrotoxicity of cisplatin in terms of changes in glomerular filtration rate (GFR) and effective renal plasma flow (EFPF) measured by the simultaneous use of Tc-99m-DTPP and-131I-OIH, before and after administration of cisplatin, in 12 patients with lung cancer and four patients with esophageal cancer. Cisplatin was administrated at total doses of 75∼100 mg/㎡ with two hour hydration and diuresis method. GFR determined by the use of Tc- 99m-DTPA had a good correlation with 24-hour creatinine clearance rate (r=0.77, p〈0.001). GFR and filtration fraction decreased immediately after administration of cisplatin, however, they showed a tendency to be in completely recovered four weeks after administration. ERPF was not changed immediately after and four weeks after administration of cisplatin. GFR before and immediately after administration of cisplatin were analyzed with regard to age, sex, performance status, previous adminstration of cisplatin and method of administration. None of these factors had any influence on the rate of decrease in GFR except method of administration. Administration of cisplatin as a single dose lowered GFR more compared with that as divided doses. In this study, we have also demonstrated that the simultaneous use of Tc-99m-DTPA and 131I-OIH was a useful tool for the measurement of GFR and ERPF respectively.
정성희,정훈용,김태원,김청수,강경훈,송현순,황창연,명승재,양석균,홍원선,김진호,민영일,Jung Sung-Hee,Jung Hwoon-Yong,Kim Tae Won,Kim Chung Su,Kang Gyung Hoon,Song Hyun Sun,Hwang Chang Yeon,Myung Seung-Jae,Yang Suk-Kyun,Hong Weon-Seon,Kim J 대한위암학회 2002 대한위암학회지 Vol.2 No.1
Carcinomas of the stomach can spread to adjacent structure by local extension or metastasize to lymph nodes, peritoneum and distant organs. However, the incidence of metastatic bladder cancer originated at the stomach is very rare. A fifty-five year-old man admitted complaining of epigastric pain for 2 months. A large ulceroinfiltrative lesion was seen in the low body, which was confirmed poorly differentiated adenocarcinoma by histological examination. Abdominopelvic CT scan showed wall thickening at the greater curvature side of gastric body and urinary bladder. Urine cytology was negative. By transurethral resection of bladder, he was diagnosed as metastatic adenocarcinoma of the bladder. We report a case of stomach cancer with metastasis to urinry bladder.
궤양성 대장염에서 대장암의 조기진단을 위한 Telomerase 및 hTERT의 임상적 유용성울산대학교 의과대학 서울아산병원 소화기내과
김규종 ( Kyu Jong Kim ),명승재 ( Seung Jae Myung ),홍성수 ( Seong Soo Hong ),이선미 ( Sun Mi Lee ),변정식 ( Jeong Sik Byeon ),양석균 ( Suk Kyun Yang ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( Young Il Min ) 대한장연구학회 2004 Intestinal Research Vol.2 No.1
Clinical Usefulness of Telomerase and hTERT for the Detection of Colon Cancer in Ulcerative Colitis Background/Aims: Telomerase and telomerase reverse transcriptase (hTERT), are specifically expressed in cancer cells, making them candidate markers for the early detection of cancer. The aims of our study were to determine whether these assays may be useful in the diagnosis of colorectal cancer (CRC) developed in ulcerative colitis (UC) patients. Methods: Luminal washings and biopsies were collected during colonoscopy in 66 patients; 34 with CRC, 21 with UC, and 11 controls. Telomerase activity was detected by telomeric repeat amplification protocol (TRAP) and hTERT was assayed by RT-PCR Results: Telomerase activity was detected in biopsies from 33/34 (97%) CRC, 14/21 (67%) UC, and 3/11 (27%) controls. hTERT was positive in biopsies from 32/34 (94%) CRC, 12/21 (57%) UC, and 5/11 (45%) controls. In washing fluid, 21/34 (62%) of CRC patients were positive for telomerase, but UC patients and controls were negative. The sensitivity of telomerase for CRC was 97% in tissues and 62% in washing fluid. The specificity of telomerase in washing fluid was 100%, whereas the specificity of telomerase or hTERT mRNA in tissues was 47% each. Conclusions: The low specificity of telomerase and hTERT in colonic tissue suggest that these are not candidate markers for CRC arising in UC. Telomerase in colonoscopic luminal washings, however, may be a novel marker for early CRC in UC. (Intestinal Research 2004;2:15-20)
양석균(Suk Kyun Yang),명승재(Seung Jae Myung),정훈용(Hwoon Yong Jung),홍원선(Weon Seon Hong),김진호(Jin Ho Kim),심기남(Ki Nam Shim),최재원(Jae Won Choe),김해경(Hae Kyung Kim),박무인,이미헌(Mi Hun Lee),김동일(Dong Il Kim),박의련(Eui Ryun 대한내과학회 2001 대한내과학회지 Vol.60 No.6
N/A Background: The current diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is dependent on a detailed family history based on the Amsterdam criteria proposed by the International Collaborative Group on HNPCC (ICG-HNPCC) in 1990. On recognizing the shortcomings of the ICG-HNPCC criteria, the Korean Hereditary Colorectal Cancer Registry (a subdivision of the Korean Hereditary Tumor Registry) designated the term uspected HNPCC for families who do not fullfill the criteria of the ICG-HNPCC but in whom a genetic basis for colon cancer is strongly suggested. The present study was designed to determine the frequency and define the clinical characteristics of suspected HNPCC. Methods: We analysed the clinical characteristics of 42 suspected HNPCC patients and their family members and compared these characteristics with that of 1,692 non-hereditary colorectal cancer patients. Results : The frequency of suspected HNPCC was 2.4% in our study. The mean age of suspected HNPCC patients at the time of diagnosis was 45.1±9.6 years and that of non-hereditary colorectal cancer patients was 57.4±11.9 years. The incidence of synchronous colorectal cancers in HNPCC was 7.1% and that of non-hereditary colorectal cancers was 0.9%. In suspected HNPCC families, 18 patients had extracolonic malignancies and the stomach cancer was the most common (55.5%). Conclusion : The frequency of suspected HNPCC among total colorectal cancer cases was 2.4% in our study. Tumors in suspected HNPCC differed from non-hereditary colorectal cancers in an early age of onset.(Korean J Med 60:507-513, 2001)
한국인에서 획득한 Helicobacter pylori의 CagA에 존재하는 SHP-2 binding site의 분석
조지윤,정진용,강호영,김군도,변정식,명승재,정훈용,양석균,홍원선,김진호,이진혁,Jo Ji-Yun,Jeong Jin-Yong,Kang Ho Young,Kim Gun-Do,Byeon Jeong-Sik,Myung Seung-Jae,Jung Hwoon-Yong,Yang Suk-Kyun,Hong Weon-Seon,Kim Jin-Ho,Lee Gin Hyug 한국생명과학회 2005 생명과학회지 Vol.15 No.6
최근에 발표된 연구 결과에 의하면 pylori CagA내에 존재하는 SHP-2 binding site의 아미노산 서열을 분석한 후, 특정 서열이 위선암의 발병과 연관되어 있다고 보고하였다. 그러나 한국인을 대상으로 CagA 내 에 존재하는 SHP-2 binding site아미노산 서열의 특성을 밝힌 연구는 없다. 따라서 본 연구는 한국인에서 획득한 H. pylori의 CagA SHP-2 binding site에 대해 아미노산 서열을 분석하여 그 특성을 알아보고자 하였다. 총 62 균주의 H. pylori 를 분석한 결과 환자의 질환과 관계없이 모든 H. pylori 균주에서 East Asian (A-B상 혹은 A-B-B-D)을 보여주었다. 일본과 더불어 한국은 위선암 유병률이 높은 나라이므로, 연구 대상의 모든 한국인에서 East Asian type CagA를 가진 H. pylori가 발견된 것이 위선암 유병률과 연관될 가능이 높아 보인다. 그러나 H. pylori의 발병 기전을 보다 더 명확히 이해하기 위해서는 보다 많은 국가와 지역을 대상으로 이러한 유전형 조사가 필요할 것 같다. Recently the pathological actions of CagA of Helicobacter pylori (H. pylori) on gastric epithelial cells have been reported. CagA is directly injected into the host cytoplasm and undergoes tyrosine phosphorylation in the cells. In addition, translocated CagA forms a physical complex with SHP-2. There are two major CagA subtypes according to the amino acid sequence in the 3'region of CagA; i) the East Asian type (A-B-D of EPIYA motifs) and ii) the Western type (A-B-C of EPIYA motifs). Repeated EPIYA motifs in the 3'region of CagA are involved in the interaction with SHP-2. The East Asian type conferred stronger SHP-2 binding activity than the Westrrn type of CagA. Here we analyzed the amino acid sequences of the SHP-2 binding site of cagA gene in H. pyzori, and investigated whether there is my relationship between the diversities of cagA and the disease out-come in Korea. Most of Korean H. pylori strains showed A-B-D motifs(the East Asian type), and only one strain showed A-B-B-D motifs. In Korea, the incidence of atrophic gastritis and gastric cancer is significantly high compared with Western countries. The high frequency of the East Asian type CagA among Korean H. pylori strains would be involved in increasing the risk of gastric cancer in Korean populations.
위암환자에서 복부 임파절 전이에 대한 초음파검사 및 전산화 단층촬영의 진단적 의의
김석균(Seok Kyun Kim),현인영(In Young Hyun),차중직(Joong Jik Cha),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),백남선(Nam Sun Paik),김기환(Kie Hwan Kim),진수일(Soo Yil Chin) 대한내과학회 1990 대한내과학회지 Vol.39 No.2
N/A Preoperative findings of abdominal ultrasonography (US) and computed tomography (CT) were compared with the postoperative findings with special emphasis on abdominal lymphnode (LN) metastasis in patients with stomach cancer. The 98 patients' enrolled in this study had no evidence of LN and distant metastasis in preoperative abdominal US or CT and underwent operation from January, 1988 to December, 1988 in the Department of General Surgery III, Korea Cancer Center Hospital. Sixty-two (63%) of the 98 patients were confirmed to have LN metastasis in the postoperative pathologic examination: 62%, in 50 patients without LN metastasis in preoperative US and 65%, in 48 patients without LN metastasis in preoperative CT. The senstivity of US was similar to that of CT in predicting LN metastasis. We analyzed the effects of age, sex, abdominal pain, performance status, Borrmann type and size of the tumor on the predictability of LN metastasis, demonstrating that no significant relation- ship was found between these factors and LN metastasis except for the size of the tumor. In patients with a tumor less than 2 cm in diameter, LN metastasis was found in 25%(N1, N2, 0%); in 2-4 cm, 53% (N1, 47%, N2, 6%); in 4-6 cm, 79%(N1 62%, N2 17%); in 6-8 cm, 92% (N1 84%, N2 8%); in more than 8 cm, 839p (N1 66%, N2 17%). The incidence of early gastric cancer (EGC), diagnosed by postoperative pathologic findings, was significantly higher in small-sized tumors compared to the large-sized tumors (p<0.01): in less than 2 cm, 0%. Staging of stomach cancer was performed according to TNM staging grouping approved by UICC and AJC in 1985. The stage showed a progress with the increase in size of the tumor (p<0.01). In less than 2 cm, stage I, II, III and IV were 68, 7, 25and 0%, respectively. In 2-4 cm, stage I, II, IIIand IV were 26, 18.53and 3%, respectively. In 4-6 cm, stage I, II, IIIand IV were 8, 16, 56and 20%, respectively. In 6-H cm, stage I, II, IIIand IV were 0, 15, 75and 15%, respectively. In more than 8 cm, stage I, II, IIIand IV were 0, 0, 50and 50%, respectively. These results suggest that abdominal LN metastasis can not be predicted by US or CT alone. However, dy the addition of size of the tumor to US or CT findings, the predictability of LY, metastasis can be significantly increased in stomach cancer patients.