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노인의 우울 • 불안 및 인지기능에 미치는 인자들의 영향에 관한 연구
류성훈,이귀행,오상우 대한신경정신의학회 1990 신경정신의학 Vol.29 No.4
This study was to investigate the influences which several sociocultural factors and physical states had on the anxiety, depression and cognition of the aged. The relationship among the anxiety, depression and cognition was also evaluated. The subjects were 509 aged who were 60 years old or more and lived in JeonJu-Iri areas. The authors employed Spielberger’ s State-Trait Anxiety Inventory for anxiety. Beck Depression Inventory for depression and Folstein’ s Mini-Mental State Examination for cognition. The duration of this study was from March 5 to April 25, 1989. The results were as follows * 1) The group of institutional residence showed lower scores state anxiety trait anxiety(p <C.05) and cognition(p<C.00l) than the group of familial residence. Both groups showed no difference on depression. 2) The group with physical illness showed higher score of state anxiety, trait anxiety and depression and lower scores of cognition than the groups without physical illness(p<C. 001). 3) Female group showed higher score of depression and lower score of cognition than male group(p〈.001). There was no difference on state anxiety and trait anxiety. 4) Education level showed negative correlation with state anxiety(p〈.05), depression(p < .00l) and positive correlation with cognition(p<.00l) and no significant correlation with trait anxiety. 5) In the group of institutional residence, the duration of institutional residence showed negative correlation with cognition(p〈.05) and no significant correlation with state anxiety, trait anxiety and depression. 6) The amount of personal expenses per month showed negative correlation with state anxiety, trait anxiety and depression and positive correlation with cognition(p〈.001). 7) State anxiety, trait anxiety and depression showed positive correlation one another and cognition showed negative correlation with anyone of the above three each other(p<C 001)
치주인대 섬유아세포에서 Osteoprotegerin과 Osteoclast Differentiation Factor의 발현
류성훈,허수례,김형섭,오귀옥,Rew, Seong-Hun,Heo, Soo-Rew,Kim, Hyung-Seop,O, Kwi-Ok 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.4
Recently, soluble TNF receptor homolog osteoprotegerin(OPG) and its membrane-bound ligand osteoclast differentiation factor(ODF) were found to regulate osteoclast formation and function, and bone metabolism. It is now well established that ODF acts via RANK expressed on hematopoietic osteoclast precursor cells to facilitate their differentiation to osteoclasts, and OPG prevents the formation of osteoclasts by interfering the binding of ODF and RANK. Expression of OPG and ODF was believed to be closely related to the pathogenesis of bone resorption and destruction from osteoporosis, periodontal diseases, malignant bone tumor, and arthritis. The periodontal ligament fibroblasts (PDLF), located between the tooth and tooth socket, has been thought to play an important role in maintaining bone homeostasis of periodontal tissues. However, the exact mechanism by which bone formation and resorption are regulated by PDLF is not well understood. In this study we have prepared primary cultures of human PDLF from periodontium of malaligned tooth extracted due to orthodontic reason, and determined steady state or inflammatory signal-induced OPG and ODF expression using RT-PCR and western blot analysis. OPG and ODF mRNA and protein were expressed constitutively in the PDLF and these expression were slightly increased by osteotropic cytokine IL-1 ${\beta}$. Lipopolysaccharide-treated PDLF showed decrease in OPG mRNA and protein expression, and increase in ODF mRNA and protein expression. These results indicated that PDLF influence the osteoclastogenesis by OPG and ODF expression in the inflammatory situation as well as physiological condition, and thereby pathogenesis of periodontal alveolar bone destruction.