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Solid Phase Cyclic Peptide Synthesis
류세열,류선종,이윤식 한국공업화학회 1992 한국공업화학회 연구논문 초록집 Vol.1992 No.0
Cyclization reactions of model peptides were conducted on nitrobenzophenone oxime resins. Four model peptides with different chain length which contain N-terminal Met or Trp residus as an electron donor were prepared on the oxime resins. Cyclization reactions of the model peptides were monitered by reversed phase HPLC. Pseudo first order rate constants were obtained in 6 different organic solvents with various polarity. The results showed that cyclization rate constants in THF were the greatest and the one in DMF were the smallest in four model peptide cases. Good correlations were obtained between the rate constants and the E<sub>T</sub> values of the solvents. Interestingly, the rate constants were decreased with increasing temperatures, which clearly implicated that the cyclization process proceeded via charge-transfer complex formation.
선종기,김진성,한가진,오승환,손지희,강경,김주연,류봉하,Seon, Jong-Ki,Kim, Jin-Sung,Han, Ga-Jin,Oh, Seung-Whan,Son, Ji-Hee,Kang, Kyung,Kim, Ju-Yeon,Ryu, Bong-Ha 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.4
Objectives : This study was designed to investigate the clinical characteristics and usefulness of comprehensive diagnosis of Yin-deficiency and heart rate variability in patients with burning mouth syndrome (BMS). Methods : We surveyed 30 burning mouth syndrome patients visiting the Oral Diseases Clinic of Kyung Hee University Oriental Medicine Hospital from April to September of 2011. The subjects were evaluated on self-assessed severity of burning mouth syndrome and xerostomia using visual analogue scale (VAS) score and Yin-deficiency condition (based on the 10-item Yin-deficiency questionnaire). Salivary function was measured by the unstimulated salivary flow rate (USFR), and heart rate variability (HRV) parameters were recorded by SA-2000E (Medicore Co., Ltd., Korea). Results : There were substantial significant positive correlations between burning sensation VAS scores in mouth and Yin-deficiency scores. There was significant negative correlation between xerostomia VAS score and USFR. Compared to the normal range of total power (TP) in HRV parameters, the burning mouth syndrome patients showed significant lower values of TP. Conclusions : The results of this study suggest that comprehensive diagnosis of Yin-deficiecny and HRV parameters are useful in diagnosing of burning mouth syndrome patients. Therefore, we assume that improvement of Yin-deficiency condition can be a potentially effective way to treat burning mouth syndrome.