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이소성 ACTH 생산에 의해 야기된 Cushing 증후군이 동반된 소세포 폐암
곽영임 ( Young Im Kwak ),임영혁 ( Young Hyuck Im ),천영국 ( Young Kug Cheon ),이가희 ( Ka Hee Yi ),남현석 ( Hyeon Seok Nam ),이춘택 ( Choon Taek Lee ),강윤구 ( Yoon Koo Kang ),이진오 ( Jhin Oh Lee ),강태웅 ( Tae Woong Kang ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.6
Candida Parapsilosis 에 의한 인공판막심내막염 1 예
박영배,이영우,김재중,송재관,최윤식,오병희,서정돈,남현석 대한내과학회 1987 대한내과학회지 Vol.32 No.6
Prosthetic valve endocarditis is increasing in frequency with widespread use of valve replacement in Korea. Fungal endocarditis is very rare but demands more careful attention, berause it causes higher mortality and needs more extensive treatment including surgery. We report a case of prosthetic valve endocarditis caused by Candida parapsilosis, who had underwent aortic valve replacement about 2 months before. Nine pairs of blood cultures, urine culture and tissue culture from aortic valve vegetation all yielded Candida parapsilosis.
위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향
홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-
Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.
이상구,김형건,이진오,강태웅,손태용,유영진,천은미,권교선,남현석,이가희 대한내과학회 1995 대한내과학회지 Vol.49 No.3
Multiple endocrine neoplasia IIb is diagnosed when medullary thyroid carcinoma, pheochromocytoma and mucosal neuromas are associated, Other features of this syndrome include a marfsnoid habitus, pectus excurvatum and long, thin extremities. We found a patient with these features: medullary thyroid carcinoma pheochromocytoma, mucosal neuromas and marfanoid habitus. A 19-year old female patient was transferred to our department. for the evaluation of fluctuating blood pressure, facial flushing and abdominal pain after total thyroidectomy which revealed medullary thyroid carcinoma in the left lobe of her thyroid gland. She had long and thin extremities and marfanoid habitus. Multiple mucosal nodules were found on the tip of her tongue and pathologically confirmed as mucosal neuromas. 24 hours urine VMA and metanephrine were markedly elevated and bilateral adrenal masses were found on the abdominal CT, Bilateral adrenalectomy was performed after pretreament with phenoxybenzamine for 2 weeks, which confirmed pheochromocytoma. The screening tests of serum calcitonin for her family members were all within normal limits.