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남현,김지혜,황지윤,김지혜,김재완,장미,이종호,박경표,이진 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6
Patients with head and neck cancer are treated with thera-peutic irradiation, which can result in irreversible salivary gland dysfunction. Because there is no complete cure for such patients, stem cell therapy is an emerging alternative for functional restoration of salivary glands. In this study, we investigated in vitro characteristics of primarily isolated epithelial cells from human salivary gland (Epi-SGs) and in vivo formation of acini-like structures by Epi-SGs. Primarily isolated Epi-SGs showed typical epithelial cell-like morphology and expressed E-cadherin but not N-cadherin. Epi-SGs expressed epithelial stem cell (EpiSC) and embryonic stem cell (ESC) markers. During long-term culture, the expression of EpiSC and ESC markers was highly detected and maintained within the core population with small size and low cytoplasmic complexity. The core population expressed cytokeratin 7 and cytokeratin 14, known as duct markers indicating that Epi-SGs might be originated from the duct. When Epi-SGs were transplanted in vivo with Matrigel, acini-like structures were readily formed at 4 days after transplan-tation and they were maintained at 7 days after transplantation. Taken together, our data suggested that Epi-SGs might contain stem cells which were positive for EpiSC and ESC markers, and Epi-SGs might contribute to the regeneration of acini-like struc-tures in vivo. We expect that Epi-SGs will be useful source for the functional restoration of damaged salivary gland.
남현도,서성대,황정현 한국조명전기설비학회 2001 조명·전기설비학회논문지 Vol.15 No.5
본 논문에서는 화력발전소 보일러 운전원 근무실 소음제어를 위하여 협대역 능동소음 제어시스템을 제안하였다. 제안된 시스템은 기준입력으로 구형파를 사용하여 기본파는 물론 고조파까지 한꺼번에 제어할 수 있게 하였으며, adjoint LMS 알고리즘을 사용하여 기존의 filtered-X LMS 알고리즘을 사용한 경우보다 계산량을 줄였다. 컴퓨터 시뮬레이션 결과, 기존의 광대역 능동소음 제어시스템에 비해 훨씬 작은 자수의 적응 필터를 사용하였으나, 더 우수한 특성을 보였다. In this paper, a narrowband active noise control system to reduce the noise in thermal power plants is proposed. The narrowband active noise control system contains rectangular wave generator and has a multi channel feed forward adaptive algorithms which uses the adjoint LMS algorithm. Although the effectiveness have been proven in the filtered-X LMS broadband active noise control system, this algorithm has much more computational complexity than that of narrowband active noise control system. The proposed active control system that uses the adjoint LMS algorithm, compared to the previous broadband active noise control system, not only is more effective in controlling narrowband noise but also has a more stable structure. Adaptive filter contains the FIR structure and IIR structure for primary and secondary path models. The simulation proves the effectiveness of the proposed algorithm.
개선된 ARMA FTF 알고리즘을 이용한 ECG 신호의 스펙트럼 해석
남현도,안동준,이철희,Nam, Hyeon-Do,An, Dong-Jun,Lee, Cheol-Hui 대한의용생체공학회 1994 의공학회지 Vol.15 No.4
High resolution spectral analysis is essential for ECG anaysis. The fast Fourier transform has been widely used for frequency analysis of ECG signals but this procedure provides poor resolution when the data record is short and shows Gibb's phenomena. The ARMA FTF (Fast Transversal Filter) algorithm is used for high resolution spectral analysis. The reason of unsalability of this algorithm is investigated and the method for improving the numerical stability is proposed. The proposed algorithm is applied to spectral analysis of the ECG. Since this result has less variations than the FFT based results, it can be used for the computerized diagonosis of the ECG. ECG 신호해석을 위해서는 고해상도 스펙트럼 해석이 필수적이다. ECG 신호의 주파수 해석을 위하여 많이 사용된고 있는 FFT(Fast Fourier Transform)는 데이타 수가 적을때는 해상도가 나쁘고 Gibb의 현상을 보인다. ARMA 모델을 이용한 고해상도 스펙트럼 해석을 위하여 ARMA FTF(Fast Transversal Filter)알고리즘을 사용하였으며 ARMA FTF알고리즘의 불안정의 원인을 분석하고 이의 개선책을 제시하였다. 제안된 알고리즘을 사용하여 ECG 신호의 스펙트럼 해석에 적용하여 좋은 결과를 얻었다. 본 연구의 결과는 FFT를 사용한 결과보다 굴곡이 작아 컴퓨터를 이용한 진단에 유용하게 사용될 수 있으리라 생각된다.