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양측성 전정독성을 일으킨 고양이에서 온도안진, 자발안진, 두위안진, 두위 변환안진, 두진후 안진의 측정
여상원,박시내,김환재,이연수,채세용,이흥엽,오현진,서병도 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.5
Background and Objectives:Vestibular toxicity can be usually monitored by a caloric test, but measuring eye movements in-cluding nystagmus is also helpful in the evaluation of vestibulotoxic proces. To understand the vestibular signs during bilateral sing a magnetic search coil system. Materials and Method:Thre-dimensional (3-D) eye movement responses to ice water caloric stimulus and spontaneous, positional, positioning, and post head shaking nystagmus in five cats were serially evaluated at 3, 7, 10, 14, 21, 28 days, 2, 3, 4, 5, 6 months after inducing bilateral vesitibulotoxicity by subcutaneous injection of streptomycin. Histolo-gic changes of vestibular system were also observed. Results:caloric stimulus was induced within 2 weeks with streptomycin injection. Positional, positioning and post head shaking nystag-mus were present during vestibulotoxic proces. Caloric nystagmus did not reappear within 6 months and histologic finding in crista ampularis of lateral semicircular canal showed marked degeneration of the hair cels and nerves. Conclusion:Observation of positional, positioning and post head shaking nystagmus as well as ice water caloric test will be helpful to monitor vestibuloto-xic process. (Korean J Otolaryngol 2003 ;46 :364-71)